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Author : Alicia Mary Hoag
Publisher :
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.:/5 (516 download)
Download or read book Clearance of Amyloid Beta Protein in Alzheimer's Disease written by Alicia Mary Hoag and published by . This book was released on 2001 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert Marr
Publisher : Frontiers Media SA
ISBN 13 : 2889194434
Total Pages : 112 pages
Book Rating : 4.8/5 (891 download)
Download or read book Amyloid-beta clearance in Alzheimer’s disease written by Robert Marr and published by Frontiers Media SA. This book was released on 2015-03-24 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strong evidence continues to accumulate indicating that amyloid-beta (Aß) is a central part of Alzheimer’s disease (AD) pathogenesis in spite of the negative evidence coming from failed clinical trials. Therefore, mechanisms of clearance of Aß are of great interest in understanding AD pathogenesis and the development of effective treatments. This topic focuses on the issues related to Aß clearance in AD. The topics covered include proteases that degrade Aß and their localization, regulation, and functions. This topic also covers issues related to clearance through uptake by glia and through low-density lipoprotein (LDL) receptor mediated mechanisms. Signal transduction related to AD pathology and clearance is also addressed. Finally, immunotherapy and other novel therapeutic approaches are discussed.
Author : Mathias Jucker
Publisher : Springer Science & Business Media
ISBN 13 : 3540376526
Total Pages : 541 pages
Book Rating : 4.5/5 (43 download)
Download or read book Alzheimer: 100 Years and Beyond written by Mathias Jucker and published by Springer Science & Business Media. This book was released on 2006-11-22 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen. The celebratory event "Alzheimer 100 Years and Beyond" was organized through the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen. This volume, a collection of articles by the invited speakers and of a few other prominent researchers, is published as a record of those events.
Author : A.D. Roses
Publisher : Springer Science & Business Media
ISBN 13 : 3642801099
Total Pages : 208 pages
Book Rating : 4.6/5 (428 download)
Download or read book Apolipoprotein E and Alzheimer’s Disease written by A.D. Roses and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.
Author :
Publisher : Elsevier
ISBN 13 : 0080538495
Total Pages : 273 pages
Book Rating : 4.0/5 (85 download)
Download or read book Pathobiology of Alzheimer's Disease written by and published by Elsevier. This book was released on 1995-10-17 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience Perspectives provides multidisciplinary reviews of topics in one of the most diverse and rapidly advancing fields in the life sciences.Whether you are a new recruit to neuroscience, or an established expert, look to this series for 'one-stop' sources of the historical, physiological, pharmacological, biochemical, molecular biological and therapeutic aspects of chosen research areas.The last decade has seen tremendous advances in our understanding of the pathobiology of Alzheimer's disease. These will lead to the first generation of drugs aimed at prevention rather than cure. This book covers some of the most important and exciting of these advances, with chapters written by many of the leading researchers in the field.With genetic studies as a backbone to this volume many chapters are devoted to the function and regulation of amyloid b-protein precursor (APP) and apolipoprotein E (ApoE). Other chapters describe cell biological approaches helping to piece together the link between the genetic alterations and the phenotype we call Alzheimer's disease.Although APP and its proteolytic cleavage product, amyloid b-protein, do not answer all the questions, detailed research into this system has undoubtedly increased our knowledge of the pathobiology of AD and has lead to the identification of other risk factors. Understanding the role of ApoE in the pathology of Alzheimer's disease promises to open a whole new field in AD research. * * Reviews the current knowledge of the pathogenesis of Alzheimer's Disease from a clinical perspective to a genetic and cell biological perspective* A comprehensive description of the role of amyloid B-protein precursor in Alzheimer's disease.* Up-to-date research data* Clear illustrations complement the text
Author : Yan-Jiang Wang
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (893 download)
Download or read book Clearance of Amyloid-beta in Alzheimer's Disease written by Yan-Jiang Wang and published by . This book was released on 2006 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Davide Moretti
Publisher :
ISBN 13 : 9789535126553
Total Pages : pages
Book Rating : 4.1/5 (265 download)
Download or read book Update on Dementia written by Davide Moretti and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities."--Provided by publisher
Author : Charlotte E. Teunissen
Publisher : Humana
ISBN 13 : 9781071613214
Total Pages : 236 pages
Book Rating : 4.6/5 (132 download)
Download or read book Cerebrospinal Fluid Biomarkers written by Charlotte E. Teunissen and published by Humana. This book was released on 2022-05-19 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Author : Dennis S. Charney
Publisher : Oxford University Press, USA
ISBN 13 : 0199934959
Total Pages : 1259 pages
Book Rating : 4.1/5 (999 download)
Download or read book Neurobiology of Mental Illness written by Dennis S. Charney and published by Oxford University Press, USA. This book was released on 2013-07-04 with total page 1259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.
Author : Susan Lanelle Gillespie
Publisher :
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.:/5 (34 download)
Download or read book The Alzheimer's Amyloid Beta Protein written by Susan Lanelle Gillespie and published by . This book was released on 1995 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Robin Harris
Publisher : Springer Science & Business Media
ISBN 13 : 0387232265
Total Pages : 416 pages
Book Rating : 4.3/5 (872 download)
Download or read book Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta written by J. Robin Harris and published by Springer Science & Business Media. This book was released on 2006-11-22 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.
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Author : Jinrong Wei
Publisher :
ISBN 13 :
Total Pages : 130 pages
Book Rating : 4.:/5 (427 download)
Download or read book Clearance of Alzheimer's Amyloid [beta]-protein by Microglia in Culture written by Jinrong Wei and published by . This book was released on 1996 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Steven H. Zarit
Publisher : Springer
ISBN 13 : 9781489991515
Total Pages : 0 pages
Book Rating : 4.9/5 (915 download)
Download or read book Caregiving for Alzheimer’s Disease and Related Disorders written by Steven H. Zarit and published by Springer. This book was released on 2014-12-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assisting someone with Alzheimer’s disease or another illness that causes dementia is incredibly demanding and stressful for the family. Like many disabling conditions, Alzheimer’s disease leads to difficulty or inability to carry out common activities of daily life, and so family members take over a variety of tasks ranging from managing the person’s finances to helping with intimate activities such as bathing and dressing. Key coverage in Caregiving for Alzheimer’s Disease and Related Disorders includes: Early diagnosis and family dynamics Emotional needs of caregivers Developmentally appropriate long-term care for people with Alzheimer’s Family caregivers as members of the Alzheimer’s treatment Team Legal and ethical issues for caregivers Faith and spirituality The economics of caring for individuals with Alzheimer’s disease Cultural, racial, ethnic, and socioeconomic issues of minority caregivers Advances in Alzheimer’s disease research Caregiving for Alzheimer’s Disease and Related Disorders offers a wealth of insights and ideas for researchers, practitioners, and graduate students across the caregiving fields, including psychology, social work, public health, geriatrics and gerontology, and medicine as well as public and education policy makers.
Author : Abubakar Wani
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.2/5 (24 download)
Download or read book Autophagy-Induced Beta Amyloid Clearance in Alzheimer's Disease written by Abubakar Wani and published by . This book was released on 2024-01-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Autophagy-Induced Beta Amyloid Clearance in Alzheimer's Disease, Abubakar Wani provides a comprehensive overview of the role of autophagy in the clearance of beta-amyloid, a key pathological hallmark of Alzheimer's disease. The book presents the latest research and experimental evidence supporting the use of autophagy as a potential therapeutic target for the treatment of Alzheimer's disease. The book begins with an overview of the cellular mechanisms of autophagy and its role in protein degradation, followed by a discussion of the pathophysiology of Alzheimer's disease and the role of beta-amyloid in disease progression. Wani then explores the molecular mechanisms by which autophagy can promote the clearance of beta-amyloid, including the regulation of autophagy by different signaling pathways and the role of autophagy in mediating the turnover of different protein aggregates. The author also discusses the potential use of autophagy-inducing drugs as a therapeutic strategy for Alzheimer's disease, highlighting the current progress and challenges in the development of autophagy-targeting drugs. Additionally, the book covers the latest research on the role of autophagy in the clearance of other protein aggregates implicated in neurodegenerative diseases. Overall, Autophagy-Induced Beta Amyloid Clearance in Alzheimer's Disease is a valuable resource for researchers, clinicians, and students interested in the molecular mechanisms underlying Alzheimer's disease and the potential therapeutic applications of autophagy induction. The book provides a comprehensive and up-to-date review of the latest research in the field, making it an essential reference for anyone working in this area.
Author : Suzanne De La Monte
Publisher : IntechOpen
ISBN 13 : 9789533076904
Total Pages : 704 pages
Book Rating : 4.0/5 (769 download)
Download or read book Alzheimer's Disease Pathogenesis written by Suzanne De La Monte and published by IntechOpen. This book was released on 2011-09-12 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer's Disease Pathogenesis: Core Concepts, Shifting Paradigms, and Therapeutic Targets, delivers the concepts embodied within its title. This exciting book presents the full array of theories about the causes of Alzheimer's, including fresh concepts that have gained ground among both professionals and the lay public. Acknowledged experts provide highly informative yet critical reviews of the factors that most likely contribute to Alzheimer's, including genetics, metabolic deficiencies, oxidative stress, and possibly environmental exposures. Evidence that Alzheimer's resembles a brain form of diabetes is discussed from different perspectives, ranging from disease mechanisms to therapeutics. This book is further energized by discussions of how neurotransmitter deficits, neuro-inflammation, and oxidative stress impair neuronal plasticity and contribute to Alzheimer's neurodegeneration. The diversity of topics presented in just the right depth will interest clinicians and researchers alike. This book inspires confidence that effective treatments could be developed based upon the expanding list of potential therapeutic targets.
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Author : David Eun-Kwang Kang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (12 download)
Download or read book Genetic and Functional Characterization of the Low Density Lipoprotein Receptor-related Protein (LRP) in Clearance of Soluble Amyloid [beta] Protein in Late-onset Alzheimer's Disease written by David Eun-Kwang Kang and published by . This book was released on 1999 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
