Cholinesterases And Anticholinesterase Agents

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Cholinesterases and Anticholinesterase Agents

Author : George B. Koelle
Publisher : Springer Science & Business Media
ISBN 13 : 3642998755
Total Pages : 1228 pages
Book Rating : 4.6/5 (429 download)

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Book Synopsis Cholinesterases and Anticholinesterase Agents by : George B. Koelle

Download or read book Cholinesterases and Anticholinesterase Agents written by George B. Koelle and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 1228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the anticholinesterase (anti-ChE) agents have only limited applica tions in therapy, and from the viewpoint of practical significance they are more appropriately classified as toxic compounds or insecticides than as drugs, in their capacity of pharmacological tools they have few equals. The concept of neuro humoral transmission was originally established largely from experiments in which physostigmine, or eserine, was employed to protect acetylcholine (ACh), the trans mitter of the cholinergic nerves, from rapid hydrolytic destruction by acetyl cholinesterase (AChE) and other cholinesterases (ChE's). Since then, a great num ber of additional reversible and irreversible anti-ChE agents also have been indis pensable in studies of synaptic and neuroeffector transmission, and of other physiological processes. At the same time, there is practically no other class of compounds for which a mechanism of pharmacological action can be described in such concrete biochemical and physiological terms. Consequently, it is not sur prising that a huge literature has developed on these several closely interdependent topics. The assembling anrl proper correlation of this material for the present volume has taken the collaborative efforts of over two dozen . investigators. It iR believed that their contributions to this end will prove invaluable to future in vestigators in providing a ready, inclusive source of established information, in defining areas where further studies are indicated, and in preventing unnecessary duplication of past work. How well these aims have been accomplished will be for time and the reader to judge.

Possible Long-term Health Effects of Short-term Exposure to Chemical Agents

Author :
Publisher : National Academies
ISBN 13 :
Total Pages : 118 pages
Book Rating : 4.1/5 (622 download)

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Book Synopsis Possible Long-term Health Effects of Short-term Exposure to Chemical Agents by :

Download or read book Possible Long-term Health Effects of Short-term Exposure to Chemical Agents written by and published by National Academies. This book was released on 1982 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Human Cholinesterases and Anticholinesterases

Author : Hermona Soreq
Publisher : Academic Press
ISBN 13 : 0323155731
Total Pages : 331 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Human Cholinesterases and Anticholinesterases by : Hermona Soreq

Download or read book Human Cholinesterases and Anticholinesterases written by Hermona Soreq and published by Academic Press. This book was released on 2012-12-02 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human Cholinesterases and Anticholinesterases summarizes the many fundamental concepts of human cholinesterases (ChEs) and their inhibitors. This book is divided into three chapters that represent human cholinesterase research studies from different points of view. Chapter 1 deals with the biochemical and biological background of human ChEs. This chapter also examines the molecular polymorphism, genomic origin, genetic variants, and biological roles of these enzymes. Chapter 2 provides the molecular characterization of human ChE genes and their multileveled regulation, with a special emphasis on butyrylcholinesterase. Chapter 3 discusses the scientific, ecological, and clinical implications of the studies presented in the previous chapters. Protein scientists, engineers, and researchers will find this work invaluable.

Cholinesterases and Anticholinesterase Agents

Author : Klas-Bertil Augustinsson
Publisher :
ISBN 13 :
Total Pages : 1220 pages
Book Rating : 4.:/5 (49 download)

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Book Synopsis Cholinesterases and Anticholinesterase Agents by : Klas-Bertil Augustinsson

Download or read book Cholinesterases and Anticholinesterase Agents written by Klas-Bertil Augustinsson and published by . This book was released on 1963 with total page 1220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Enzymes of the Cholinesterase Family

Author : A.S. Balasubramanian
Publisher : Springer Science & Business Media
ISBN 13 : 1489910514
Total Pages : 524 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Enzymes of the Cholinesterase Family by : A.S. Balasubramanian

Download or read book Enzymes of the Cholinesterase Family written by A.S. Balasubramanian and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifth International Meeting on Cholinesterases convened in Madras, India, in September of 1994. The long and rich history and culture of India provided an excellent setting for the meeting. More than 120 delegates from Asia, Australia, Europe and North America heard 54 oral presentations and viewed 54 posters on current research on enzymes of the cholinesterase family. The aim of this book is to compile the presentations of the Fifth International Meeting on Cholinesterases into a volume that describes recent investigations on the structure and catalytic function of acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and related enzymes, as well as studies on the molecular and cellular biology of these enzymes and the genes which encode them. Cholinesterases enjoy a long and storied history in diverse areas. In basic biochemical research, AChE is one of the best studied, though yet enigmatic, of enzymes. The efficient catalytic function of this enzyme presents the biochemist with a fundamental challenge in understanding the relationship between structure and function. AChE and BuChE belong to a family of proteins, the alB hydrolase fold family, whose constituents evolutionarily diverged from a common ancestor. Proteins in this family have a wide range of physiological functions. In commerce, AChE is a prime target for agricultural insect control, and for the development of therapeutic agents for Alzheimer's disease.

Cholinesterases: Advances in Research and Application: 2011 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464925550
Total Pages : 182 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Cholinesterases: Advances in Research and Application: 2011 Edition by :

Download or read book Cholinesterases: Advances in Research and Application: 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cholinesterases: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cholinesterases. The editors have built Cholinesterases: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cholinesterases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cholinesterases: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cholinesterases—Advances in Research and Application: 2013 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481686585
Total Pages : 233 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Cholinesterases—Advances in Research and Application: 2013 Edition by :

Download or read book Cholinesterases—Advances in Research and Application: 2013 Edition written by and published by ScholarlyEditions. This book was released on 2013-06-21 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cholinesterases—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Butyrylcholinesterase. The editors have built Cholinesterases—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Butyrylcholinesterase in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cholinesterases—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Quantitative Functional Brain Imaging with Positron Emission Tomography

Author : Richard E. Carson
Publisher : Elsevier
ISBN 13 : 0080540112
Total Pages : 535 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Quantitative Functional Brain Imaging with Positron Emission Tomography by : Richard E. Carson

Download or read book Quantitative Functional Brain Imaging with Positron Emission Tomography written by Richard E. Carson and published by Elsevier. This book was released on 1998-09-08 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest scientific developments in the field of positron emission tomography (PET) dealing with data acquisition, image processing, applications, statistical analysis, tracer development, parameter estimation, and kinetic modeling. It covers improved methodology and the application of existing techniques to new areas. The text also describes new approaches in scanner design and image processing, and the latest techniques for modeling and statistical analyses. This volume will be a useful reference for the active brain PET scientist, as well as a valuable introduction for students and researchers who wish to take advantage of the capabilities of PET to study the normal and diseased brain. - Authored by international authorities in PET - Provides the latest up-to-date techniques and applications - Covers all fundamental disciplines of PET in one volume - A comprehensive resource for students, clinicians, and new PET researchers

Methods of Behavior Analysis in Neuroscience

Author : Jerry J. Buccafusco
Publisher : CRC Press
ISBN 13 : 1420041819
Total Pages : 341 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Methods of Behavior Analysis in Neuroscience by : Jerry J. Buccafusco

Download or read book Methods of Behavior Analysis in Neuroscience written by Jerry J. Buccafusco and published by CRC Press. This book was released on 2000-08-29 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: Using the most well-studied behavioral analyses of animal subjects to promote a better understanding of the effects of disease and the effects of new therapeutic treatments on human cognition, Methods of Behavior Analysis in Neuroscience provides a reference manual for molecular and cellular research scientists in both academia and the pharmaceutic

Cholinesterases—Advances in Research and Application: 2012 Edition

Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464996210
Total Pages : 263 pages
Book Rating : 4.4/5 (649 download)

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Book Synopsis Cholinesterases—Advances in Research and Application: 2012 Edition by :

Download or read book Cholinesterases—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cholinesterases—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cholinesterases. The editors have built Cholinesterases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cholinesterases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cholinesterases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Toxicology of Organophosphate and Carbamate Compounds

Author : Ramesh C Gupta
Publisher : Academic Press
ISBN 13 : 0080543103
Total Pages : 781 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Toxicology of Organophosphate and Carbamate Compounds by : Ramesh C Gupta

Download or read book Toxicology of Organophosphate and Carbamate Compounds written by Ramesh C Gupta and published by Academic Press. This book was released on 2011-04-28 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. - Describes everything you need to know about Organophosphates and Carbamates - Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants - Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates - Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases - Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity - Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis - Provides in vitro and in vivo models for neurotoxicity testing - Integrates knowledge of studies in lab animals and humans - Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues - Describes management of Anticholinesterase poisoning in humans

Diagnosis and Therapy for Anticholinesterase Poisoning and Other Chemicals Used in Warfare

Author : Van Murray Sim
Publisher :
ISBN 13 :
Total Pages : 50 pages
Book Rating : 4.:/5 (54 download)

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Book Synopsis Diagnosis and Therapy for Anticholinesterase Poisoning and Other Chemicals Used in Warfare by : Van Murray Sim

Download or read book Diagnosis and Therapy for Anticholinesterase Poisoning and Other Chemicals Used in Warfare written by Van Murray Sim and published by . This book was released on 1971 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta

Author : J. Robin Harris
Publisher : Springer Science & Business Media
ISBN 13 : 9780387232256
Total Pages : 442 pages
Book Rating : 4.2/5 (322 download)

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Book Synopsis Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta by : J. Robin Harris

Download or read book Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta written by J. Robin Harris and published by Springer Science & Business Media. This book was released on 2004-12-17 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

Smith and Aitkenhead's Textbook of Anaesthesia E-Book

Author : Alan R. Aitkenhead
Publisher : Elsevier Health Sciences
ISBN 13 : 0702051128
Total Pages : 1085 pages
Book Rating : 4.7/5 (2 download)

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Book Synopsis Smith and Aitkenhead's Textbook of Anaesthesia E-Book by : Alan R. Aitkenhead

Download or read book Smith and Aitkenhead's Textbook of Anaesthesia E-Book written by Alan R. Aitkenhead and published by Elsevier Health Sciences. This book was released on 2013-08-08 with total page 1085 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook of Anaesthesia has become the book of choice for trainee anaesthetists beginning their career in the specialty. It is highly suitable for part 1 of the Fellowship of the Royal College of Anaesthetists and similar examinations. It is also a practical guide for all anaesthetists and other health care professionals involved in the perioperative period.

Synthesis of Essential Drugs

Author : Ruben Vardanyan
Publisher : Elsevier
ISBN 13 : 008046212X
Total Pages : 635 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Synthesis of Essential Drugs by : Ruben Vardanyan

Download or read book Synthesis of Essential Drugs written by Ruben Vardanyan and published by Elsevier. This book was released on 2006-03-10 with total page 635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis of Essential Drugs describes methods of synthesis, activity and implementation of diversity of all drug types and classes. With over 2300 references, mainly patent, for the methods of synthesis for over 700 drugs, along with the most widespread synonyms for these drugs, this book fills the gap that exists in the literature of drug synthesis. It provides the kind of information that will be of interest to those who work, or plan to begin work, in the areas of biologically active compounds and the synthesis of medicinal drugs. This book presents the synthesis of various groups of drugs in an order similar to that traditionally presented in a pharmacology curriculum. This was done with a very specific goal in mind – to harmonize the chemical aspects with the pharmacology curriculum in a manner useful to chemists. Practically every chapter begins with an accepted brief definition and description of a particular group of drugs, proposes their classification, and briefly explains the present model of their action. This is followed by a detailed discussion of methods for their synthesis. Of the thousands of drugs existing on the pharmaceutical market, the book mainly covers generic drugs that are included in the WHO's Essential List of Drugs. For practically all of the 700+ drugs described in the book, references (around 2350) to the methods of their synthesis are given along with the most widespread synonyms. Synthesis of Essential Drugs is an excellent handbook for chemists, biochemists, medicinal chemists, pharmacists, pharmacologists, scientists, professionals, students, university libraries, researchers, medical doctors and students, and professionals working in medicinal chemistry. * Provides a brief description of methods of synthesis, activity and implementation of all drug types* Includes synonyms* Includes over 2300 references

Molecular Properties of Cholinesterases

Author : Ole Svensmark
Publisher :
ISBN 13 :
Total Pages : 80 pages
Book Rating : 4.:/5 (26 download)

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Book Synopsis Molecular Properties of Cholinesterases by : Ole Svensmark

Download or read book Molecular Properties of Cholinesterases written by Ole Svensmark and published by . This book was released on 1965 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Muscle Relaxants

Author : Kazuaki Fukushima
Publisher : Springer Science & Business Media
ISBN 13 : 4431668969
Total Pages : 412 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Muscle Relaxants by : Kazuaki Fukushima

Download or read book Muscle Relaxants written by Kazuaki Fukushima and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the Fifth International Neuromuscular Meeting held in Tokyo in 1994, leading experts in the field came together to discuss the physiology and pharmacology of neuromuscular receptor sites and neuromuscular blocking agents (NBAs). The proceedings of the meeting present a review of the history of muscle relaxants and a comprehensive examination of recent research, with a primary focus on clinical considerations. Among the topics covered by specific chapters are aspects of the neuromuscular junction (NMJ), pharmacokinetics, metabolism and metabolites of neuromuscular blocking agents, and drug interaction. Presenting the most up-to-date knowledge of the physiology and pharmacology of the NMJ and NBAs, this volume will be highly valuable to clinicians and researchers in anesthesiology, physiology, and pharmacology.