Chemistry of Metalloproteins

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118801520
Total Pages : 448 pages
Book Rating : 4.1/5 (188 download)

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Book Synopsis Chemistry of Metalloproteins by : Joseph J. Stephanos

Download or read book Chemistry of Metalloproteins written by Joseph J. Stephanos and published by John Wiley & Sons. This book was released on 2014-07-22 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.

Encyclopedia of Metalloproteins

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Author :
Publisher : Springer
ISBN 13 : 9781461415329
Total Pages : 0 pages
Book Rating : 4.4/5 (153 download)

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Book Synopsis Encyclopedia of Metalloproteins by : Robert H. Kretsinger

Download or read book Encyclopedia of Metalloproteins written by Robert H. Kretsinger and published by Springer. This book was released on 2013-05-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.

Handbook on Metalloproteins

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Author :
Publisher : CRC Press
ISBN 13 : 148227082X
Total Pages : 1108 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Handbook on Metalloproteins by : Ivano Bertini

Download or read book Handbook on Metalloproteins written by Ivano Bertini and published by CRC Press. This book was released on 2001-06-29 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the commo

Metalloproteins

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Publisher : CRC Press
ISBN 13 : 1498759920
Total Pages : 294 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Metalloproteins by : Art E. Cho

Download or read book Metalloproteins written by Art E. Cho and published by CRC Press. This book was released on 2015-04-17 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role

Metalloprotein Active Site Assembly

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119159857
Total Pages : 424 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Metalloprotein Active Site Assembly by : Michael K. Johnson

Download or read book Metalloprotein Active Site Assembly written by Michael K. Johnson and published by John Wiley & Sons. This book was released on 2017-08-14 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizes the essential biosynthetic pathways for assembly of metal cofactor sites in functional metalloproteins Metalloprotein Active Site Assembly focuses on the processes that have evolved to orchestrate the assembly of metal cofactor sites in functional metalloproteins. It goes beyond the simple incorporation of single metal ions in a protein framework, and includes metal cluster assembly, metal-cofactor biosynthesis and insertion, and metal-based post-translational modifications of the protein environments that are necessary for function. Several examples of each of these areas have now been identified and studied; the current volume provides the current state-of-the-art understanding of the processes involved. An excellent companion to the earlier book in this series Metals in Cells—which discussed both the positive and negative effects of cellular interactions with metals—this comprehensive book provides a diverse sampling of what is known about metalloprotein active site assembly processes. It covers all major biological transition metal components (Mn, Fe, Co, Ni, Mo), as well as the other inorganic components, metal-binding organic cofactors (e.g., heme, siroheme, cobalamin, molybdopterin), and post-translationally modified metal binding sites that make up the patchwork of evolved biological catalytic sites. The book compares and contrasts the biosynthetic assembly of active sites involving all biological metals. This has never been done before since it is a relatively new, fast-developing area of research. Metalloprotein Active Site Assembly is an ideal text for practitioners of inorganic biochemistry who are studying the biosynthetic pathways and gene clusters involved in active site assembly, and for inorganic chemists who want to apply the concepts learned to potential synthetic pathways to active site mimics.

Metalloproteins

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Publisher : Humana Press
ISBN 13 : 9781493988631
Total Pages : 275 pages
Book Rating : 4.9/5 (886 download)

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Book Synopsis Metalloproteins by : Yilin Hu

Download or read book Metalloproteins written by Yilin Hu and published by Humana Press. This book was released on 2018-10-31 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an up-to-date, in-depth overview of the methods that have been applied to studying the complex metalloproteins at a molecular level. Chapters cover a wide range of approaches focusing on genetic, biochemical, spectroscopic, chemical methods, and theoretical calculations. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Metalloproteins: Methods and Protocols aims to be useful for anyone who is interested in metalloprotein research and wants to address the unanswered mechanistic and biosynthetic questions of these fascinating enzyme systems.

Protein Aggregation in Bacteria

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Publisher : Wiley
ISBN 13 : 9781118448526
Total Pages : 288 pages
Book Rating : 4.4/5 (485 download)

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Book Synopsis Protein Aggregation in Bacteria by : Silvia Maria Doglia

Download or read book Protein Aggregation in Bacteria written by Silvia Maria Doglia and published by Wiley. This book was released on 2014-04-14 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focuses on the aggregation of recombinant proteins in bacterial cells in the form of inclusion bodies—and on their use in biotechnological and medical applications The first book devoted specifically to the topic of aggregation in bacteria, Protein Aggregation in Bacteria: Functional and Structural Properties of Inclusion Bodies in Bacterial Cells provides a large overview of protein folding and aggregation, including cell biology and methodological aspects. It summarizes, for the first time in one book, ideas and technical approaches that pave the way for a direct use of inclusion bodies in biotechnological and medical applications. Protein Aggregation in Bacteria covers: Molecular and cellular mechanisms of protein folding, aggregation, and disaggregation in bacteria Physiological importance and consequences of aggregation for the bacterial cell Factors inherent to the protein sequence responsible for aggregation and evolutionary mechanisms to keep proteins soluble Structural properties of proteins expressed as soluble aggregates and as inclusion bodies within bacterial cells both from a methodological point of view and with regard to their similarity with amyloids Control of the structural and functional properties of aggregated proteins and use thereof in biotechnology and medicine Protein Aggregation in Bacteria is ideal for researchers in protein science, biochemistry, bioengineering, biophysics, microbiology, medicine, and biotechnology, particularly if they are related with the production of recombinant proteins and pharmaceutical science.

Biological Inorganic Chemistry

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Publisher : University Science Books
ISBN 13 : 9781891389436
Total Pages : 794 pages
Book Rating : 4.3/5 (894 download)

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Book Synopsis Biological Inorganic Chemistry by : Ivano Bertini

Download or read book Biological Inorganic Chemistry written by Ivano Bertini and published by University Science Books. This book was released on 2007 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part A.: Overviews of biological inorganic chemistry : 1. Bioinorganic chemistry and the biogeochemical cycles -- 2. Metal ions and proteins: binding, stability, and folding -- 3. Special cofactors and metal clusters -- 4. Transport and storage of metal ions in biology -- 5. Biominerals and biomineralization -- 6. Metals in medicine. -- Part B.: Metal ion containing biological systems : 1. Metal ion transport and storage -- 2. Hydrolytic chemistry -- 3. Electron transfer, respiration, and photosynthesis -- 4. Oxygen metabolism -- 5. Hydrogen, carbon, and sulfur metabolism -- 6. Metalloenzymes with radical intermediates -- 7. Metal ion receptors and signaling. -- Cell biology, biochemistry, and evolution: Tutorial I. -- Fundamentals of coordination chemistry: Tutorial II.

Handbook of Metalloproteins, Handbook of Metalloproteins

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Author :
Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 816 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Handbook of Metalloproteins, Handbook of Metalloproteins by : Albrecht Messerschmidt

Download or read book Handbook of Metalloproteins, Handbook of Metalloproteins written by Albrecht Messerschmidt and published by Wiley-Blackwell. This book was released on 2001 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two volumes of the "Handbook of Metalloproteins", published in 2001, focused on a number of metals, including iron, nickel, manganese, cobalt, copper and vanadium. Now we are delighted to present volume three which extends the wealth of knowledge and focuses on proteins found in the redox-inactive ions of zinc and calcium. (Midwest).

Metal Ions in Biological Systems

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Author :
Publisher : CRC Press
ISBN 13 : 1482270153
Total Pages : 744 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Metal Ions in Biological Systems by : Astrid Sigel

Download or read book Metal Ions in Biological Systems written by Astrid Sigel and published by CRC Press. This book was released on 2001-01-30 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Focuses on the vibrant area of probing enzymes or proteins by metal ions and small complexes. Offers a summary of the basic characteristics of the amide bond, emphasizing its proton and metal ion interactions, including a quantitative analysis of its hydrolysis and formation."

Handbook of Metalloproteins, 3 volume set

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Publisher : Wiley
ISBN 13 : 9780470869819
Total Pages : 2308 pages
Book Rating : 4.8/5 (698 download)

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Book Synopsis Handbook of Metalloproteins, 3 volume set by : Albrecht Messerschmidt

Download or read book Handbook of Metalloproteins, 3 volume set written by Albrecht Messerschmidt and published by Wiley. This book was released on 2004-06-28 with total page 2308 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two volumes of the "Handbook of Metalloproteins", published in 2001, focused on a number of metals, including iron, nickel, manganese, cobalt, copper and vanadium. Now we are delighted to present volume three which extends the wealth of knowledge and focuses on proteins found in the redox-inactive ions of zinc and calcium. * Colour illustrations throughout * 3D structures of modified metalloproteins for easier understanding of functions * International expert contributors The amazing new set will prove to be an essential reference providing comprehensive understanding and focused coverage of metalloproteins. "it is a pleasure to use ...this excellent, authoritative, and valuable text...I regard this work as essential for library purchase..." (Natural Products Report, Vol.19, No.4, 2002) "highly recommended as a resource for bioinorganic chemistry. It will have lasting value for researchers in the field" (The Alchemist - Chemweb, 2002)

Metal Ions in Biological Systems

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Publisher : CRC Press
ISBN 13 : 9780824790936
Total Pages : 536 pages
Book Rating : 4.7/5 (99 download)

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Book Synopsis Metal Ions in Biological Systems by : Helmut Sigel

Download or read book Metal Ions in Biological Systems written by Helmut Sigel and published by CRC Press. This book was released on 1994-02-08 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted solely to the research area of metalloenzymes involving amino acid-residue and related radicals. Topics covered include: general considerations; structure, function and engineering of peroxidases; and ribonucleotide reductase in mammalian systems.

Practical Approaches to Biological Inorganic Chemistry

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Publisher : Newnes
ISBN 13 : 0444563598
Total Pages : 329 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis Practical Approaches to Biological Inorganic Chemistry by : Robert R. Crichton

Download or read book Practical Approaches to Biological Inorganic Chemistry written by Robert R. Crichton and published by Newnes. This book was released on 2012-12-31 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book reviews the use of spectroscopic and related methods to investigate the complex structures and mechanisms of biological inorganic systems that contain metals. Each chapter presents an overview of the technique including relevant theory, clearly explains what it is and how it works and then presents how the technique is actually used to evaluate biological structures. Practical examples and problems are included to illustrate each technique and to aid understanding. Designed for students and researchers who want to learn both the basics, and more advanced aspects of bioinorganic chemistry. Many colour illustrations enable easier visualization of molecular mechanisms and structures Worked examples and problems are included to illustrate and test the reader’s understanding of each technique Written by a multi-author team who use and teach the most important techniques used today to analyse complex biological structures

Handbook of Metalloproteins, 2 Volume Set (Volumes 4 and 5)

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Author :
Publisher : Wiley-Blackwell
ISBN 13 : 9780470711996
Total Pages : 965 pages
Book Rating : 4.7/5 (119 download)

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Book Synopsis Handbook of Metalloproteins, 2 Volume Set (Volumes 4 and 5) by : Albrecht Messerschmidt

Download or read book Handbook of Metalloproteins, 2 Volume Set (Volumes 4 and 5) written by Albrecht Messerschmidt and published by Wiley-Blackwell. This book was released on 2011-04-25 with total page 965 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlights the progress made in finding new and exciting metalloproteins 10 years after the original publication of the Handbook of Metalloproteins Volumes 1 & 2, and following publication of Volume 3 in 2004, comes the latest two volumes... Presents detailed descriptions of the most exciting newly discovered metalloproteins, including: New metalloproteins involved in photosynthesis, e.g. photosystem I and II, cytochromes New Copper Metalloproteins involved in the formation of Alzheimer’s disease and are leads to new medication New metalloproteins essential in understanding the function of nerves and muscles Researching the structure and function of metalloproteins is one of the biggest challenges in modern biological chemistry – and several Nobel Prizes have been awarded to research in the field, including to the Co-Editor Robert Huber in 1988. Volumes 4 & 5 help bring together the very latest new and exciting metalloproteins in two volumes to help keep you up-to-date in this continually expanding field, including: New metalloproteins involved in photosynthesis Photosynthesis is vital for life on earth. Contributions on photosystem I and II as well as on cytochrome b6f, which are main components of the oxygenic photosynthetic machinery in plants, algae and cyanobacteria, unravel the role of metals and metal cofactors in this fascinating fundamental process New Copper Metalloproteins The role of copper in connection with the amyloid precursor protein for Alzheimer’s disease New metalloproteins essential in understanding the function of nerves and muscles Contributions on Mg2+, Na+ and K+ channels/transporters have been included to highlight their formidable significance in biological systems. Na+, K+-ATPase is e.g. very abundant in heart muscle tissues and represents the target for drugs against heart insufficiency like digitalis drugs Metalloproteins used in metal ion transport and storage Metal ion transport, storage and incorporation have been deeper considered in a row of new articles. The metal ions include iron, zinc, nickel and copper. Factor VIII Factor VIII is an essential blood clotting factor. Some defects might cause a lack of this factor and result in hemophelia A. The new two volumes contain articles published online in the Handbook of Metalloproteins (HMET) from 2007 – 2010, these cover a wide range of newly discovered and exciting metalloproteins since publication of HMET in 2006. These new additional volumes will provide essential reading to all experienced researchers in bioinorganic chemistry and should give the newcomer a good entry into the field in the following areas: Metalloproteins, Proteins, Proteomics, Coordination Chemistry, Bioinorganic Chemistry, Biochemistry, Drug Development, Enzymology.

Metalloproteins

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Author :
Publisher :
ISBN 13 :
Total Pages : 586 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Metalloproteins by : Sei Otsuka

Download or read book Metalloproteins written by Sei Otsuka and published by . This book was released on 1988 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Metal Sites in Proteins and Models

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Publisher : Springer
ISBN 13 : 9783540655527
Total Pages : 0 pages
Book Rating : 4.6/5 (555 download)

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Book Synopsis Metal Sites in Proteins and Models by : H.A.O. Hill

Download or read book Metal Sites in Proteins and Models written by H.A.O. Hill and published by Springer. This book was released on 1999-04-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological chemistry is a major frontier of inorganic chemistry. Three special volumes devoted to Metal Sites in Proteins and Models address the questions: how unusual ("entatic") are metal sites in metalloproteins and metalloenzymes compared to those in small coordination complexes? And if they are special, how do polypeptide chains and co-factors control this? The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres. They illustrate in particular how the combined armoury of genetics and structure determination at the molecular level are providing unprecedented new tools for molecular engineering.

Metal Sites in Proteins and Models

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Author :
Publisher : Springer
ISBN 13 : 9783540655565
Total Pages : 0 pages
Book Rating : 4.6/5 (555 download)

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Book Synopsis Metal Sites in Proteins and Models by : H.O.A. Hill

Download or read book Metal Sites in Proteins and Models written by H.O.A. Hill and published by Springer. This book was released on 1999-04-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological chemistry is a major frontier of inorganic chemistry. Three special volumes devoted to Metal Sites in Proteins and Models address the questions: How unusual ("entatic") are metal sites in metalloproteins and metalloenzymes compared to those in small coordination complexes? And if they are special, how do polypeptide chains and co-factors control this? The chapters deal with iron, with metal centres acting as Lewis acids, metals in phosphate enzymes, with vanadium, and with the wide variety of transition metal ions which act as redox centres. They illustrate in particular how the combined armoury of genetics and structure determination at the molecular level are providing unprecedented new tools for molecular engineering.