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Chemical Investigation Of Three Antarctic Marine Sponges
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Book Synopsis Chemical Investigation of Three Antarctic Marine Sponges by : Young Chul Park
Download or read book Chemical Investigation of Three Antarctic Marine Sponges written by Young Chul Park and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: This thesis describes the chemical investigation of three marine sponges from Antarctica and the total syntheses of natural products erebusinone (12) and its derivative, erebusinonamine (52). Investigation of the yellow Antarctic marine sponge Isodictya setifera resulted in the isolation of two secondary metabolites, purine analog (32) and 3-hydroxykynurenine (24). Chemical investigation of Isodictya setifera led to the isolation of six secondary metabolites which included 5-methyl-2-deoxycytidine (25), uridine (28), 2-deoxycytidine (31), homarine (37), hydroxyquinoline (33), 3-hydroxykynurenine (24). The latter two compounds were found to be intermediates of tryptophan catabolism in crustaceans. From the Antarctic marine sponge Isodictya antractica ceramide analog (39) was isolated and its chemical structure was assigned by a combination of spectroscopic and chemical analyses.
Book Synopsis Chemical Investigation of the Antarctic Sponge Dendrilla Membranosa by : Robert William Kopitzke
Download or read book Chemical Investigation of the Antarctic Sponge Dendrilla Membranosa written by Robert William Kopitzke and published by . This book was released on 1995 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Aspects of the Chemical Ecology of Antarctic Marine Sponges by : Christopher B. Moeller
Download or read book Aspects of the Chemical Ecology of Antarctic Marine Sponges written by Christopher B. Moeller and published by . This book was released on 1998 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Investigation of the Antarctic Sponge Isodictya Erinacea and Synthesis of a Novel Alkaloid Eribusinone by : Byoungho Moon
Download or read book Chemical Investigation of the Antarctic Sponge Isodictya Erinacea and Synthesis of a Novel Alkaloid Eribusinone written by Byoungho Moon and published by . This book was released on 1997 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Marine Chemical Ecology by : James B. McClintock
Download or read book Marine Chemical Ecology written by James B. McClintock and published by CRC Press. This book was released on 2001-06-13 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interdisciplinary field of marine chemical ecology is an expanding and dynamic science. It is no surprise that the breadth of marine organisms studied expanded in concert with developments in underwater technology. With its up-to-date subject reviews by experts, Marine Chemical Ecology is the most current, comprehensive book on the subject. The
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2004 with total page 788 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Investigation of Australian Marine Sponges by : John Alexander Kalaitzis
Download or read book Chemical Investigation of Australian Marine Sponges written by John Alexander Kalaitzis and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract:This thesis describes the isolation and structure elucidation of a series of natural products from six different marine sponges collected from Australian waters. A total of nineteen sponge metabolites were isolated, four of which had not been reported previously. The structures of these compounds were elucidated by spectroscopic methods. An investigation into two sponges from the Adocia genus revealed a series of novel compounds related to the proton pump inhibitor adociasulfate 1 (3.22). Adociasulfates 7 (3.24) and 8 (3.25), along with adociasulfate 1 were isolated from an Adocia aculeata collected from Lizard Island. Another sample of Adocia aculeata collected from Cormorant Pass, North Great Barrier Reef, yielded adociasulfates 5 (3.23) and 9 (3.26). In the course of the study it was found that the adociasulfates were present only in the extracts of Adocia aculeata samples and not other Adocia species, thus revealing a possible chemotaxonomical relationship. The investigation of three sponges, whose extracts showed inhibition of [3H]DPCPX binding to rat-brain adenosine A1 receptors, yielded ten compounds, one of which was novel. An investigation into a Pseudoceratina sp. collected from Swain Reefs, Queensland resulted in the isolation of the new bromotyrosine derived ianthesine E (4.24) and the known related compounds aerothionin (4.20), 11-hydroxyaerothionin (4.21), 19-deoxyfistularin 3 (4.22), and 11,19-dideoxyfistularin 3 (4.23). Aerothionin was found to be the most active of this series of compounds, inhibiting 67% binding of [3H]DPCPX at 100 M︡. Interpretation of HMBC NMR spectra of these compounds and comparison with data reported previously for related bromotyrosine compounds revealed that some data in the literature had been misassigned. Investigations into a Xestospongia pacifica and a Phakellia flabellata collected from Swain Reefs resulted in the isolation of a series of five known metabolites. Debromohymenialdsine (4.71) was isolated from Phakellia flabellata and was found to be the most effective inhibitor of [3H]DPCPX binding (79% at 100M︡) to the adenosine A1 receptor of all of the compounds tested as part of this research. Also isolated from this sponge were aldisine (4.69) and norzooanemonin (4.70). 1,3-dimethylguanine (4.48) was isolated from Xestospongia pacifica, and this compound showed 61% inhibition of [3H]DPCPX binding to the adenosine A1 receptor at 100M︡. N-methyltaurine (4.55) was also isolated from this sponge in a crystalline form. The XRD analysis of the crystal revealed extensive hydrogen bonding interactions between the amine H atoms and sulfonyl O atoms in the zwitterionic molecule. Chemical investigation of a Mycale sp. collected from Stephen's Rock, Darwin, Northern Territory resulted in the isolation of the nucleosides uridine (5.13), 2'- deoxyuridine (5.14), 2'-deoxyinosine (5.16) and the pyrimidine base thymine (5.15). Uridine and 2-deoxyinosine were tested for inhibition of [3H]DPCPX binding to adenosine A1 receptors. Uridine inhibited 45% of binding at 100M︡ while 2- deoxyinosine inhibited 34% binding at the same concentration. Cytotoxicity screening of the sponge metabolites against the HeLa cell line revealed that 11,19-dideoxyfistularin-3 with an EC50 of 2.6 M︡ was the most potent cytotoxin of all of the compounds isolated. Aerothionin was the next potent with an EC50 of 42 M︡ while adociasulfate 8 was found to be the most cytotoxic of the four adociasulfates screened with an EC50 of 68 M︡.
Book Synopsis Marine Sponges: Chemicobiological and Biomedical Applications by : Ramjee Pallela
Download or read book Marine Sponges: Chemicobiological and Biomedical Applications written by Ramjee Pallela and published by Springer. This book was released on 2016-11-17 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main focus of this book entitled is to provide an up-to-date coverage of marine sponges and their significance in the current era. This book is an attempt to compile an outline of marine sponge research to date, with specific detail on these bioactive compounds, and their pharmacological and biomedical applications. The book encompasses twenty chapters covering various topics related to Marine Sponges. Initial couple of chapters deal about the worldwide status of marine sponge research, the recent findings regarding dynamics of sponges, and several interesting research areas, that are believed to be deserving of increased attention. Variety of sponges, their toxicology, metagenomics, pharmaceutical significance and their possible applications in biomedicine has been discussed in detail. The second half of this part includes chapters on chemical ecology of marine sponges followed by the discussion on importance of bioeroding sponges in aquaculture systems. The following four chapters of the book deal majorly with the chemical molecules of marine sponges. In the fifth chapter, marine sponge-associated actinobacteria and their pysicochemical properties have been discussed followed by their bioactive potential. The biological application of marine sponges has been presented in later chapters with the classification of biologically active compounds being explored in detail. The second half of the book presents the vast repertoire of secondary metabolites from marine sponges, which include terpenoids, heterocycles, acetylenic compounds, steroids and nucleosides. Further, the bioactive potential of these compounds has also been discussed. One of the constituent chapter elaborates the bioactive alkaloids from marine sponges namely, pyridoacridine, indole, isoquinolene, piperidene, quinolizidine, steroidal and bromotyrosine alkaloids isolated from them. In the next couple of chapters, important sponge polymers and the anticancer effects of marine sponge compounds have been presented. The most interesting aspect of sponge biology is their use in biomedical arena. An effort has been made in this book, to cover the major constituents of sponges and their biomedical potentials. The major portion of sponge body is composed of collagen and silica and used in tissue engineering as scaffold material. This part of the book compiles chapters delineating the isolation of sponge biomaterials including collagen and their use in medical diagnostics. Overall, this book would be an important read for novice and experts in the field of sponge biology.
Book Synopsis Chemical Investigation of Three Marine Invertebrates by : Mariette Niranjala Cooray
Download or read book Chemical Investigation of Three Marine Invertebrates written by Mariette Niranjala Cooray and published by . This book was released on 1989 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigation Of Bioactive Metabolites From The Antarctic Sponge Dendrilla Membranosa And Marine Microorganisms by : Chris Witowski
Download or read book Investigation Of Bioactive Metabolites From The Antarctic Sponge Dendrilla Membranosa And Marine Microorganisms written by Chris Witowski and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products continue to be a valuable source of compounds in research involving chemical ecology and drug discovery. Secondary metabolites are biosynthesized to benefit the host organism in its environment (feeding deterrence from predators, antibiotic properties to avoid infection, etc.) but these compounds also serve as useful scaffolds in drug discovery applications. The research herein describes both aspects of these two branches of natural products chemistry. The Antarctic sponge Dendrilla membranosa produces diterpenes, of which membranolide A, deters feeding of the predatory amphipod Gondogenia antarctica. A metabolomic study of several sponges was undertaken to determine environmental factors that govern the metabolism of D. membranosa. Habitat specificity, above or below the algal canopy, was a significant factor for the chemical clustering of sponges as well as the abundance of potential amphipod predators that are prevalent within the canopy. Another D. membranosa diterpene, aplysulphurin, undergoes degradation upon methanolic treatment to form the methoxy membranolides B-H. An investigation of these artifacts reveals potent activity against the leishmaniasis-causing parasite Leishmania donovani. Microorganisms also generate a significant number of bioactive natural products. Biotic and abiotic culture stressors such as co-culturing and epigenetic modification, respectively, will be explored to turn on cryptic biosynthetic pathways. These techniques are shown to produce unique secondary metabolites from cultures and further reinforce the one strain many compounds approach to the versatile and formidable microbial domain.
Book Synopsis Antarctic Journal of the United States by :
Download or read book Antarctic Journal of the United States written by and published by . This book was released on 1997 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Investigation Of Antarctic Marine Organisms & Their Role In Modern Drug Discovery by : Jacqueline Lee Fries
Download or read book Chemical Investigation Of Antarctic Marine Organisms & Their Role In Modern Drug Discovery written by Jacqueline Lee Fries and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemicals produced by biological systems, whether proteins, peptides, or terpenes, will always provide an intriguing topic for researchers. Invisibly controlling every aspect of nature, these molecules are responsible for life, evolution, and death. Specifically, here is described the secondary metabolites produced by Antarctic marine organisms as well as others, and how they are used to defend or attract other animals while potentially providing health benefits to mankind. This is done through collection, extraction, and separation of individual specimens. The respective mixtures of compounds after isolation are then analyzed via spectroscopic methods such as nuclear magnetic resonance spectroscopy, mass spectrometry, and X-ray crystallography. Once identified, these compounds are tested in biological assays to provide a hypothesis for their use in nature or evidence that there may be a use for them in medicine. For this thesis, the Antarctic organisms described are an alga, Pocamium cartilagineum, an amphipod, Paradexamine fissicauda, a sponge, Dendrilla membranosa, and one undescribed and two known deep sea coral species, Briareopsis aegeon and Plumarella delicatissima. Beyond these specific specimens, their chemistry as well as natural products from other origins were combined to create a diverse compound library for biological screening against human pathogens. This was done using computational modeling and statistical analysis of the compound library and its comparison to other known chemical libraries. The diversity and impact of these molecules are assessed.
Book Synopsis Marine Sponges and Symbionts by : Eric Whitney Schmidt
Download or read book Marine Sponges and Symbionts written by Eric Whitney Schmidt and published by . This book was released on 1999 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical and Biological Studies of the Antarctic Sponge Latrunculia Apicalis by : Aimin Yang
Download or read book Chemical and Biological Studies of the Antarctic Sponge Latrunculia Apicalis written by Aimin Yang and published by . This book was released on 1994 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemical Ecology by : Melany P. Puglisi
Download or read book Chemical Ecology written by Melany P. Puglisi and published by CRC Press. This book was released on 2018-08-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past 20 years, marine chemical ecology has emerged as a respected field of study providing a better understanding of the role natural products play in organisms and their environments. Ample data in this book advocates the conservation of marine environments for future drug discovery efforts while sustaining their overall health. Marine chemical ecology has expanded to include research in the areas of predator–prey interactions, marine microbial chemical ecology, and seasonal and geographical distribution of marine natural products.
Book Synopsis Advances in Sponge Science: Phylogeny, Systematics, Ecology by :
Download or read book Advances in Sponge Science: Phylogeny, Systematics, Ecology written by and published by Academic Press. This book was released on 2012-09-01 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: On of two special issues of Advances in Marine Biology focusing on sponge science it features comprehensive reviews of the latest studies that are advancing our understanding of the fascinating marine phylum Porifera. The selected contributors are internationally renowned researchers in their respective fields and provide a thorough overview of the state-of-the-art of sponge science This volume will become a reference to marine biologists with interest in benthic ecology and biotic interactions, including symbiosis chemical and molecular ecology systematics, phylogeny, and evolution sponge culture and tissue engineering
Book Synopsis Marine Ecosystems by : Antonio Cruzado
Download or read book Marine Ecosystems written by Antonio Cruzado and published by BoD – Books on Demand. This book was released on 2012-03-02 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine ecosystems, a very wide topic, includes many different processes, groups of organisms and geographical peculiarities. The objective of this book is to present various topics of great importance for understanding the marine ecosystems, what they are, how they work and how we can model them in order to forecast their behaviour under changing conditions. They have been thoroughly reviewed and accepted for publication. The chapters cover aspects such as: Threats to ultraoligotrophic marine ecosystems (Ch. 1); Modelling the pelagic ecosystem dynamics: the NW Mediterranean (Ch. 2); The marine ecosystem of the Sub-antarctic, Prince Edward Islands (Ch. 3); Meiofauna as a tool for marine ecosystem biomonitoring (Ch. 4); Chemical interactions in Antarctic marine benthic ecosystems (Ch. 5); An Interdisciplinary Approach on Erosion Mitigation for Coral Reef Protection- A Case Study from the Eastern Caribbean (Ch. 6); A revisit to the evolution and ecophysiology of the Labyrinthulomycetes (Ch. 7); Seabed mapping and marine spatial planning: a case-study from a Swedish marine protected area (Ch. 8); Management strategies to limit the impact of bottom trawling on VMEs in the High Seas of the SW Atlantic (Ch. 9); Hydrocarbon contamination and the swimming behavior of the estuarine copepod Eurytemora affinis (Ch. 10), and Interactions between marine ecosystems and tourism on the Adriatic and Mediterranean (Ch. 11).
