Chelation Therapy In The Treatment Of Metal Intoxication

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Chelation Therapy in the Treatment of Metal Intoxication

Author : Jan Aaseth
Publisher : Academic Press
ISBN 13 : 0128030739
Total Pages : 390 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Chelation Therapy in the Treatment of Metal Intoxication by : Jan Aaseth

Download or read book Chelation Therapy in the Treatment of Metal Intoxication written by Jan Aaseth and published by Academic Press. This book was released on 2016-04-18 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chelation Therapy in the Treatment of Metal Intoxication presents a practical guide to the use of chelation therapy, from its basic chemistry, to available chelating antidotes, and the application of chelating agents. Several metals have long been known to be toxic to humans, and continue to pose great difficulty to treat. These challenges pose particular problems in industrial settings, with lead smelting known to be associated with hemopoietic alterations and paralyses, and the inhalation of mercury vapor in mercury mining being extremely detrimental to the central nervous system. Clinical experience has demonstrated that acute and chronic human intoxications with a range of metals can be treated efficiently by administration of chelating agents. Chelation Therapy in the Treatment of Metal Intoxication describes the chemical and biological principles of chelation in the treatment of these toxic metal compounds, including new chelators such as meso-2,3-dimercaptosuccinic acid (DMSA) and D,L-2,3-dimercapto-1-propanesulfonic acid (DMPS). - Presents all the current findings on the potential for chelation as a therapy for metal intoxication - Presents practical guidelines for selecting the most appropriate chelating agent - Includes coverage on radionuclide exposure and metal storage diseases - Describes the chemical and biological principles of chelation in the treatment of toxic metal compounds

Iron Chelation Therapy

Author : Chaim Hershko
Publisher : Taylor & Francis US
ISBN 13 : 9780306467851
Total Pages : 290 pages
Book Rating : 4.4/5 (678 download)

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Book Synopsis Iron Chelation Therapy by : Chaim Hershko

Download or read book Iron Chelation Therapy written by Chaim Hershko and published by Taylor & Francis US. This book was released on 2002 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the last few years, iron research has yielded exciting new insights into the understanding of normal iron homeostasis. Such development, and the evolution of improved strategies of Iron Chelating Therapy require better understanding of the pathophysiology of iron toxicity and the mechanism of action of iron chelating drugs. The timeliness of the present volume is underlined by several significant developments in recent years. New insights have been gained into the molecular basis of aberrant iron handling in hereditary disorders and the pathophysiology of iron overload. This volume highlights the impact of long term Iron Celating Therapy using deferoxamine or the new, but controversial oral iron chelator deferiprone based on experience gained by multicenter trails, with special emphasis on survival, morbidity and drug toxicity; it reviews the development of the new and improved orally effective chelators suitable for clinical use in the near future and examines novel strategies of iron chelating treatment for the control of cell proliferation in malignant disease or malaria.

Hepatotoxicity

Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781719520
Total Pages : 850 pages
Book Rating : 4.7/5 (195 download)

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Book Synopsis Hepatotoxicity by : Hyman J. Zimmerman

Download or read book Hepatotoxicity written by Hyman J. Zimmerman and published by Lippincott Williams & Wilkins. This book was released on 1999 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic

Author : Peggy L. Carver
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110526980
Total Pages : 640 pages
Book Rating : 4.1/5 (15 download)

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Book Synopsis Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic by : Peggy L. Carver

Download or read book Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic written by Peggy L. Carver and published by Walter de Gruyter GmbH & Co KG. This book was released on 2019-01-14 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 19, entitled Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic of the series Metal Ions in Life Sciences centers on the role of metal ions in clinical medicine. Metal ions are tightly regulated in human health: while essential to life, they can be toxic as well. Following an introductory chapter briefly discussing several important metal-related drugs and diseases and a chapter about drug development, the focus is fi rst on iron: its essentiality for pathogens and humans as well as its toxicity. Chelation therapy is addressed in the context of thalassemia, its relationship to neurodegenerative diseases and also the risks connected with iron administration are pointed out. A subject of intense debate is the essentiality of chromium and vanadium. For example, chromium(III) compounds are taken as a nutritional supplement by athletes and bodybuilders; in contrast, chromate, Cr(VI), is toxic and a carcinogen for humans. The benefi cial and toxic effects of manganese, cobalt, and copper on humans are discussed. The need for antiparasitic agents is emphasized as well as the clinical aspects of metal-containing antidotes for cyanide poisoning. In addition to the essential and possibly essential ones, also other metal ions play important roles in human health, causing harm (like the metalloid arsenic, lead or cadmium) or being used in diagnosis or treatment of human diseases, like gadolinium, gallium, lithium, gold, silver or platinum. The impact of this vibrant research area on metals in the clinic is provided in 14 stimulating chapters, written by internationally recognized experts from the Americas, Europe and China, and is manifested by approximately 2000 references, and about 90 illustrations and tables. Essential Metals in Medicine: Therapeutic Use and Toxicity of Metal Ions in the Clinic is an essential resource for scientists working in the wide range from pharmacology, enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine ... not forgetting that it also provides excellent information for teaching.

Lead Toxicity

Author : Sarah E. Royce
Publisher :
ISBN 13 :
Total Pages : 60 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Lead Toxicity by : Sarah E. Royce

Download or read book Lead Toxicity written by Sarah E. Royce and published by . This book was released on 2000 with total page 60 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Introduction to Basics of Pharmacology and Toxicology

Author : Gerard Marshall Raj
Publisher : Springer Nature
ISBN 13 : 9813297794
Total Pages : 410 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Introduction to Basics of Pharmacology and Toxicology by : Gerard Marshall Raj

Download or read book Introduction to Basics of Pharmacology and Toxicology written by Gerard Marshall Raj and published by Springer Nature. This book was released on 2019-11-16 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates, in a comprehensive manner, the most crucial principles involved in pharmacology and allied sciences. The title begins by discussing the historical aspects of drug discovery, with up to date knowledge on Nobel Laureates in pharmacology and their significant discoveries. It then examines the general pharmacological principles - pharmacokinetics and pharmacodynamics, with in-depth information on drug transporters and interactions. In the remaining chapters, the book covers a definitive collection of topics containing essential information on the basic principles of pharmacology and how they are employed for the treatment of diseases. Readers will learn about special topics in pharmacology that are hard to find elsewhere, including issues related to environmental toxicology and the latest information on drug poisoning and treatment, analytical toxicology, toxicovigilance, and the use of molecular biology techniques in pharmacology. The book offers a valuable resource for researchers in the fields of pharmacology and toxicology, as well as students pursuing a degree in or with an interest in pharmacology.

Metal Chelation in Medicine

Author : Robert R Crichton
Publisher : Royal Society of Chemistry
ISBN 13 : 1782623892
Total Pages : 336 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Metal Chelation in Medicine by : Robert R Crichton

Download or read book Metal Chelation in Medicine written by Robert R Crichton and published by Royal Society of Chemistry. This book was released on 2016-10-18 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metal chelators are emerging as versatile tool with many medical applications. Their versatility allows them to be used in chelation therapy for treating diseases caused by toxic and heavy metal poisoning, chelating agents are capable of binding to toxic metal ions to form complex structures which are easily excreted from the body removing them from intracellular or extracellular spaces. In addition, metal chelators can also be applied as contrast agents in MRI scanning. Metal Chelation in Medicine provides a clear and timely perspective on the role of chelating agents in the management of metal intoxications and storage diseases. Written by leaders in the field of chelators, this publication is at the cutting-edge of the subject. It covers a broad range of topics such as the use of metal chelators in non-invasive assessment of brain iron overload, and the treatment of systemic iron overload and neurodegenerative diseases. As such it is particularly valuable to clinicians treating metal poisonings and metal storage diseases. However, it is also a useful text for researchers, industry professionals and university students with a specific interest in medicinal chemistry, chelation, metal ions, imaging and non-invasive techniques.

Handbook of Neurological Therapy

Author : Carlo Colosimo
Publisher : Oxford University Press, USA
ISBN 13 : 0199862923
Total Pages : 481 pages
Book Rating : 4.1/5 (998 download)

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Book Synopsis Handbook of Neurological Therapy by : Carlo Colosimo

Download or read book Handbook of Neurological Therapy written by Carlo Colosimo and published by Oxford University Press, USA. This book was released on 2015 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a practical book on neurological therapy. It is aimed at giving concise and updated answers to busy practicing clinicians in the clinic, ward, or emergency department. An evidence-based approach is used, but when there is no evidence or the data are inconclusive, an expert opinion is always given in order to meet the expectations of the reader. All neurological conditions, common and less common, are discussed; each chapter has a similar format, and contains an initial brief introduction on the epidemiology and clinical features of each disease. The therapy is then discussed, including pharmacological and non-pharmacological, with wide use of Tables & Figures. Flowcharts are also included in most of the chapters.

The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine

Author : Richard Eugene Frye
Publisher : Springer
ISBN 13 : 9811053111
Total Pages : 392 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine by : Richard Eugene Frye

Download or read book The Therapeutic Use of N-Acetylcysteine (NAC) in Medicine written by Richard Eugene Frye and published by Springer. This book was released on 2018-09-20 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on the practical use of N-Acetyl-Cysteine (NAC) in medicine, this book provides a comprehensive review of the basic biological and clinical studies documenting its benefits in treating medical disease. NAC is perhaps best known as an antidote for acetaminophen, but its therapeutic effect in a wide range of medical diseases has recently been realized. In addition to its well recognized use in radiological contrast prophylaxis for renal disease and pulmonary disorders, studies have suggested significant promise in psychiatric and neurological disorders such as addiction, Alzheimer’s disease, ataxia, autism, bipolar disorder, depression, epilepsy, neuropathy, obsessive-compulsive disorder, schizophrenia, traumatic brain injury and trichotillomania in addition to promising studies in audiology, cardiology, exercise physiology, gastroenterology, hematology, infectious disease, infertility and ophthalmology. Given the promising studies for a wide range of medical conditions, coupled with a excellent safety profile, the potential for NAC in the treatment of human disease appears considerable. Dr Leonore A Herzenberg from Stanford University, a pioneer of redox physiology and the use of NAC, provides a succinct history of the development of the therapeutic use of NAC for medical disease. This is followed by a series of basic science chapters outlining the role of NAC in important physiological processes, including modulation of dopamine and glutamate neurotransmitter systems, redox and mitochondrial metabolism, apoptosis and inflammation. The last section of the book is dedicated to clinically oriented chapters that comprehensively review the literature on medical disorders in which NAC has been found to be effective, including toxicity and cardiovascular, gastrointestinal, neurological, psychiatric, pulmonary and renal disorders. Each chapter reviews the theoretical biological mechanisms of NAC for the specific diseases reviewed, rates the clinical studies using a standardized criteria in order to provide an objective level of evidence and grade of recommendation for the use of NAC for specific medical conditions and outlines the ongoing clinical trials examining NAC for the treatment of specific diseases. Final chapters review the clinical evidence verifying that specific theoretical biological mechanisms are actually being targeted by NAC in medical disease. Studies on the pharmacology, formulation and potential adverse effects of NAC are also reviewed. A final chapter synthesizes the clinical studies to suggest that the effectiveness of NAC may signal a new basic physiological disorder, glutathione deficiency, which may be an important pathophysiological mechanism of many diseases.

Contemporary Practice in Clinical Chemistry

Author : William Clarke
Publisher : Academic Press
ISBN 13 : 0128158336
Total Pages : 1070 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Contemporary Practice in Clinical Chemistry by : William Clarke

Download or read book Contemporary Practice in Clinical Chemistry written by William Clarke and published by Academic Press. This book was released on 2020-06-11 with total page 1070 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contemporary Practice in Clinical Chemistry, Fourth Edition, provides a clear and concise overview of important topics in the field. This new edition is useful for students, residents and fellows in clinical chemistry and pathology, presenting an introduction and overview of the field to assist readers as they in review and prepare for board certification examinations. For new medical technologists, the book provides context for understanding the clinical utility of tests that they perform or use in other areas in the clinical laboratory. For experienced laboratorians, this revision continues to provide an opportunity for exposure to more recent trends and developments in clinical chemistry. - Includes enhanced illustration and new and revised color figures - Provides improved self-assessment questions and end-of-chapter assessment questions

Handbook of Arsenic Toxicology

Author : Swaran Jeet Singh Flora
Publisher : Academic Press
ISBN 13 : 0124199550
Total Pages : 752 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Handbook of Arsenic Toxicology by : Swaran Jeet Singh Flora

Download or read book Handbook of Arsenic Toxicology written by Swaran Jeet Singh Flora and published by Academic Press. This book was released on 2014-12-26 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout history, arsenic has been used as an effective and lethal poison. Today, arsenic continues to present a real threat to human health all over the world, as it contaminates groundwater and food supplies. Handbook of Arsenic Toxicology presents the latest findings on arsenic, its chemistry, its sources and its acute and chronic effects on the environment and human health. The book takes readings systematically through the target organs, before detailing current preventative and counter measures. This reference enables readers to effectively assess the risks related to arsenic, and provide a comprehensive look at arsenic exposure, toxicity and toxicity prevention. - Brings together current findings on the effects of arsenic on the environment and human health - Includes state-of-the-art techniques in arsenic toxicokinetics, speciation and molecular mechanisms - Provides all the information needed for effective risk assessment, prevention and countermeasure

Environmental Medicine

Author : Committee on Curriculum Development in Environmental Medicine
Publisher : National Academies Press
ISBN 13 : 0309568722
Total Pages : 988 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Environmental Medicine by : Committee on Curriculum Development in Environmental Medicine

Download or read book Environmental Medicine written by Committee on Curriculum Development in Environmental Medicine and published by National Academies Press. This book was released on 1995-05-12 with total page 988 pages. Available in PDF, EPUB and Kindle. Book excerpt: People are increasingly concerned about potential environmental health hazards and often ask their physicians questions such as: "Is the tap water safe to drink?" "Is it safe to live near power lines?" Unfortunately, physicians often lack the information and training related to environmental health risks needed to answer such questions. This book discusses six competency based learning objectives for all medical school students, discusses the relevance of environmental health to specific courses and clerkships, and demonstrates how to integrate environmental health into the curriculum through published case studies, some of which are included in one of the book's three appendices. Also included is a guide on where to obtain additional information for treatment, referral, and follow-up for diseases with possible environmental and/or occupational origins.

Poisoning in the Modern World

Author : Ozgur Karcioglu
Publisher : BoD – Books on Demand
ISBN 13 : 1838807853
Total Pages : 130 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Poisoning in the Modern World by : Ozgur Karcioglu

Download or read book Poisoning in the Modern World written by Ozgur Karcioglu and published by BoD – Books on Demand. This book was released on 2019-06-19 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 400 years ago, Swiss alchemist and physician Paracelsus (1493-1541) cited: "All substances are poisons; there is none that is not a poison. The right dose differentiates a poison from a remedy." This is often condensed to: "The dose makes the poison." So, why are we overtly anxious about intoxications?In fact, poisons became a global problem with the industrial revolution. Pesticides, asbestos, occupational chemicals, air pollution, and heavy metal toxicity maintain high priority worldwide, especially in developing countries. Children between 0 and 5 years old are the most vulnerable to both acute and chronic poisonings, while older adults suffer from the chronic effects of chemicals. This book aims to raise awareness about the challenges of poisons, to help clinicians understand current issues in toxicology.

Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose

Author : Michael W. Shannon
Publisher : Saunders
ISBN 13 : 9780721606934
Total Pages : 0 pages
Book Rating : 4.6/5 (69 download)

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Book Synopsis Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose by : Michael W. Shannon

Download or read book Haddad and Winchester's Clinical Management of Poisoning and Drug Overdose written by Michael W. Shannon and published by Saunders. This book was released on 2007 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition is a reference for information related to the clinical management of children and adults whose health has been effected or potentially effected by toxic agents, including drugs, environmental threats, and natural toxins.

Zinc Signaling

Author : Toshiyuki Fukada
Publisher : Springer Nature
ISBN 13 : 9811505578
Total Pages : 412 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Zinc Signaling by : Toshiyuki Fukada

Download or read book Zinc Signaling written by Toshiyuki Fukada and published by Springer Nature. This book was released on 2019-12-13 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in an extensively revised second edition, describes the crucial role of zinc signaling in biological processes on a molecular and physiological basis. Global leaders in the field review the latest knowledge, including the very significant advances in understanding that have been achieved since publication of the first edition. Detailed information is provided on all the essentials of zinc signaling, covering molecular aspects and the roles of zinc transporters, the zinc sensing receptor, and metallothioneins. Detection techniques for zinc signals, involving genetically encoded and chemical probes, are also described. The critical contributions of the zinc signal in maintaining health and the adverse consequences of any imbalance in the signal are then thoroughly addressed. Here, readers will find up-to-date information on the significance of the zinc signal in a wide range of conditions, including cardiovascular disorders, neurodegenerative diseases, diabetes, autoimmune diseases, inflammatory conditions, skin disease, osteoarthritis, and cancer. The book will be of value for researchers, clinicians, and advanced students.

Metal Related Neurodegenerative Disease

Author :
Publisher : Academic Press
ISBN 13 : 0124105351
Total Pages : 443 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Metal Related Neurodegenerative Disease by :

Download or read book Metal Related Neurodegenerative Disease written by and published by Academic Press. This book was released on 2013-11-07 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue reviews the role of metals in neurodegenerative diseases; including Parkinson's and Huntington's disease; restless leg syndrome and NBIA disorders; and Wilson's disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. - This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease - It reviews the role of metals in neurodegenerative diseases, including Parkinson's and Huntington's disease; restless leg syndrome and NBIA disorders; and Wilson's disease and manganese and calcium accumulation disorders - An update on advances in neuroimaging and pathology of metal related disease is also presented

Biomedical Applications of Metals

Author : Mahendra Rai
Publisher : Springer
ISBN 13 : 3319748149
Total Pages : 332 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Biomedical Applications of Metals by : Mahendra Rai

Download or read book Biomedical Applications of Metals written by Mahendra Rai and published by Springer. This book was released on 2018-02-24 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused more specifically on the recent advances in applications of various metals and their complexes used in biomedicine, particularly in the diagnosis and treatment of chronic diseases. The editors give equal importance to other key aspects such as toxicological issues and safety concerns. The application of metals in the biomedical field is highly interdisciplinary and has a broad appeal across all biomedical specialties. Biomedical Applications of Metals is particularly focused on covering the role of metals in medicine and the development of novel therapeutic products and solutions in the form of alternative medicines, and some topics on Indian traditional medicine i.e., “Ayurveda”. In Section I, the book discusses the role of metals in medicines and include chapters on nanoparticles, noble metals, medical devices, copper. selenium, silver, and microbial pathogens; while Section II includes topics on metals toxicity including heavy metals, carcinogens, cancer therapy, Bhasma’s and chelating agents used in Ayurveda, and biochemical and molecular targets including actions of metals. These new and emerging concepts of applications of metals in medicine, their crucial role in management of microbial resistance, and their use in the treatment of various chronic diseases is essential information for toxicologists, and clinical and biomedical researchers.