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Characterization Of The T Cell And T Cell Receptor Repertoire Involved In Human Kidney Allograft Rejection
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Book Synopsis Characterization of the T Cell and T Cell Receptor Repertoire Involved in Human Kidney Allograft Rejection by : M. Carrie Miceli
Download or read book Characterization of the T Cell and T Cell Receptor Repertoire Involved in Human Kidney Allograft Rejection written by M. Carrie Miceli and published by . This book was released on 1988 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Human T-Cell Receptor Repertoire and Transplantation by : Peter van den Elsen
Download or read book The Human T-Cell Receptor Repertoire and Transplantation written by Peter van den Elsen and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: these analyses it became clear that the MHC class I molecule com prised a distinct groove on the external side of the molecule. The sides of the groove are formed by the a-helical structures of the a and a 1 2 domains and a floor which is formed by 8 anti-parallel 13 strands. The various polymorphic residues, as determined from DNA sequence analysis, are localized within these a-helices and 13-plated sheets within the groove. More importantly, these analyses also revealed the presence of elec tron-dense material in the groove. This material was subsequently iden 568 10 tified as a linear peptide of 8-10 amino acids long. • •- High resolu tion crystallographic analyses of the class I MHC structure have revealed the existence of so-called pockets within the grooves of the MHC class I molecules. These pockets designated A-F, exhibited allele-specificity and are directly involved in the binding of the peptide, primarily through interaction with the dominant anchor residues as found in MHC class I associated pep tides. 6,7,9,11 The class II MHC antigens consist on the cell surface of a 34 kD a chain non-covalently associated with a 28 kD 13 chain. With the excep tion of the DR a-chain, all other MHC class II a and 13 chains are poly morphic.
Book Synopsis Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations by : Giorgio Raimondi
Download or read book Transplant Rejection and Tolerance: Advancing the Field through Integration of Computational and Experimental Investigations written by Giorgio Raimondi and published by Frontiers Media SA. This book was released on 2017-12-15 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ transplantation is a life-saving surgical procedure through which the functionality of a failing organ system can be restored. However, without the life-long administration of immunosuppressive drugs, the recipient’s immune system will launch a massive immune attack that will ultimately destroy the graft. Although successful at protecting the graft from an immune attack, long-term use of immunosuppressive drugs leads to serious complications (e.g., increased risk of infection, diabetes, hypertension, cardiovascular disease, and cancer). Moreover, recipients suffer from limited long-term graft survival rates due to the inability of current treatments to establish tolerance to the transplanted tissues. Thus, there is a great medical need to understand the complex network of immune system interactions that lead to transplant rejection so that new strategies of intervention can be determined that will redirect the system toward transplant acceptance while preserving immune competence against offending agents. In the past 20 years, the discovery and growing understanding of the positive and negative regulators of the activation of the immune system have fostered new interventional procedures targeting one or the other. While pre-clinical results proved the validity of these strategies, their clinical implementation has been troublesome. These results underscore the need for additional methods to determine the most effective interventions to prevent long-term transplant rejection. New tools of genomics, proteomics and metabolomics are being implemented in powerful analyses that promise the development of better, safer personalized treatments. In parallel, theoretical modeling has emerged as a tool that transcends investigations of individual mechanistic processes and instead unravels the relevant mechanisms of complex systems such as the immune response triggered by a transplant. In this way, theoretical models can be used to identify important behavior that arises from complex systems and thereby delineate emergent properties of biological systems that could not be identified studying single components. Employing this approach, interdisciplinary collaborations among immunologists, mathematicians, and system biologists will yield novel perspectives in the development of more effective strategies of intervention. The aim of this Research Topic is to demonstrate how new insight and methods from theoretical and experimental studies of the immune response can aid in identifying new research directions in transplant immunology. First, techniques from various theoretical and experimental studies with applications to the immune response will be reviewed to determine how they can be adapted to explore the complexity of transplant rejection. Second, recent advances in the acquisition and mining of large data sets related to transplant genomics, proteomics, and metabolomics will be discussed in the context of their predictive power and potential for optimizing and personalizing patient treatment. Last, new perspectives will be offered on the integration of computational immune modeling with transplant and omics data to establish more effective strategies of intervention that promote transplant tolerance.
Book Synopsis Kidney Transplantation by : Claudio Ronco
Download or read book Kidney Transplantation written by Claudio Ronco and published by Karger Medical and Scientific Publishers. This book was released on 2005-01-01 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transplantation is today firmly established as the therapy of choice for end-stage organ failure. However, despite recent developments, this therapy is still not without challenges and risks: The necessity to take immunosuppressive drugs for the rest of one's life to prevent allograft rejection trades the morbidity and mortality of organ failure for the risks of infection and cancer as well as for an increased mortality from cardiovascular disease. Thus, there is an urgent need for optimizing the outcome of transplantation by achieving long-term, drug-free graft acceptance with normal organ function.Recently, numerous insights into the dynamic inter-relationship of host immune responses elicited by donor antigen presentation have substantially broadened our understanding of the cascade of events resulting in the acquisition of tolerance. With the pharmacopoeia of the transplant biologist continually expanding, the potential treatment combinations have become baffling and their impact on strategies to induce tolerance even more complex.This book presents novel insights into the pathways of acute rejection and their monitoring through molecular tests, new immunosuppressive agents currently under development as well as the most recent and promising approaches to induce tolerance that have emerged from experimental animal studies.
Book Synopsis Kidney Transplant Rejection by : James F. Burdick
Download or read book Kidney Transplant Rejection written by James F. Burdick and published by . This book was released on 1992 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 26 chapters several new, including one on HIV and several on noninvasive evaluation of the transplant, and the others updated present a broad look at the various forms of kidney rejection, viewing the special problems of infections that occur after transplantation as issues that are integral to
Book Synopsis Engineering Human Single-chain T Cell Receptors by : David H. Aggen
Download or read book Engineering Human Single-chain T Cell Receptors written by David H. Aggen and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The alpha-beta T cell receptor (TCR) is responsible for mediating T cell recognition of self and non-self tissues, through recognition between a complex of a peptide and a product of the major histocompatibility complex (pepMHC) on target cells. In the immune response to cancerous tissue, the immune repertoire of T cells is often insufficient to target pepMHC complexes associated with cancer cells, as these tumor antigens have often induced tolerance or the tumor microenvironment promotes immunosuppression of T cells. To improve the response to tumors, gene therapy with tumor specific T cell receptors provides an attractive approach to effectively arm patient0́9s T cells for cancer cell destruction. An inherent difficulty, however, is generation of T cell receptors of sufficient affinity to redirect both CD4+ and CD8+ T cells. This thesis describes the development of engineering strategies for human single-chain T cell receptor variable fragments (scTv), with the goal of understanding the properties that allow scTv to be expressed and deployed in a therapeutic mode. Stable scTv receptors can be used to generate high-affinity TCRs specific for disease-associated pepMHC complexes and produced in soluble expression systems for subsequent biochemical and biophysical characterization. This work also develops scTv and scFv (antibody variable fragments) as fusion proteins, collectively called chimeric antigen receptors, for cell mediated therapies to redirect T cells to specific antigens In chapter 2, two human Valpha2+ T cell receptors specific for human immunodeficiency virus and human T cell lymphotrophic virus derived pepMHC complexes were engineered for improved stability as scTv proteins, consisting of only the variable domains of the T cell receptor attached by a flexible linker. High-affinity, stabilized scTv proteins could be expressed as soluble proteins in E. coli and used for detection of low levels of HIV pepMHC antigens, suggesting that these receptors have potential diagnostic applications for the detection of HIV infected cells. Finally, the results suggest that other V1̐Ł2+ TCRs with different specificities can be engineered for enhanced affinity by yeast display. Chapter 3 describes the development of chimeric antigen receptors, that consist of scTv-fusion proteins, for T cell targeting of tumor antigens. scTv proteins engineered for improved stability by yeast display were fused to the intracellular signaling domains of CD28,CD3zeta, and LCK and introduced into murine T cells. The high affinity scTv, called m33, that is specific for the pepMHC SIY/Kb was used to redirect T cells with similar antigen sensitivity to the full-length m33 TCR. An inherent problem with full-length TCR gene therapy is the generation of receptors of unknown specificity through mispairing between introduced and endogenous TCR, leading to graft versus host disease or autoimmunity. I show that the scTv-fusions avoided mispairing with endogenous alpha-beta TCRs and allowed for endogenous TCR surface expression at high levels. A human HIV-specific scTv (chapter 2) was also expressed as a fusion to intracellular signaling domains and it also mediated antigen specific T cell activity. In chapter 4, the murine m33 scTv fusion was compared to an antibody derived chimeric antigen receptor called 237. The 237 antibody single-chain fragment variable (scFv) is specific for a tumor antigen resulting from a glycopeptide defect that is created by a mutant chaperone protein. Fusion of the 237 scFv to intracellular domains, as with the m33 scTv, mediated T cell activity against tumor cells that expressed the glycopeptide defect. Results with T cells transduced with chimeric antigen receptor in the absence or presence of coreceptor CD8, showed that CD8 could contribute to target cell recognition, presumably through its interactions with MHC molecules that are proximal to the antigen epitope. Chapter 5 describes the engineering of a murine T cell receptor, called 3D, for enhanced affinity to the model Wilm0́9s tumor antigen (WT-1/Db). Using a novel T cell display system, mutated TCR libraries were displayed on the surface of T cell hybridomas in the absence of the coreceptor CD8. Selection with fluorescently labeled dimers of WT-1/Db resulted in the isolation of two high affinity 3D TCR variants, one which mediated T cell activity in the absence of CD8. Analysis of the TCR residues used by human and murine TCRs specific for the identical WT-1 peptide suggested that there is homology between human and mouse TCR CDR3 sequences, indicating that these residues have strong selective pressures to bind to the identical peptide epitope. Thus, one may be able to engineer high-affinity TCRs in the human TCR based on knowledge from the mouse TCRs.
Book Synopsis Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation by : Narinder K. Mehra
Download or read book Antibody Repertoire and Graft Outcome Following Solid Organ Transplantation written by Narinder K. Mehra and published by Frontiers Media SA. This book was released on 2017-07-25 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first real major breakthrough that laid the basis of HLA antibody detection in the field of solid organ transplantation, came with the introduction of the complement dependent cytotoxicity (CDC) test in 1964 by Terasaki and McClelland. Since then, methods for antibody detection have evolved remarkably from conventional cell-based assays to the current advanced solid phase systems on the Luminex platform, with increasing degree of sensitivity and specificity. The latter have been indispensable for more accurate identification of donor specific HLA antibodies in broadly reactive allo antisera, and to guide donor selection and kidney paired exchange programs through virtual crossmatching, in addition to serving as excellent tools for initiating pre-transplant desensitization and post- transplant antibody monitoring. Consensus is evolving on the optimal routine employment of these methods in donor selection strategies along with an understanding of the clinical relevance of antibodies detected by each of them. The immunoassays based on the Luminex platform and flow cytometric beads are however unable to discriminate complement fixing from non-complement fixing HLA antibodies. This is important because the former are considered clinically more pertinent in the peri-transplant period. The C1q assay which is a modification of the solid phase assay based on Luminex single antigen beads, which can be used effectively to monitor high dose IVIG desensitization is essentially a surrogate complement fixing assay, retaining the exquisite sensitivity and specificity of the Luminex platform. Currently, information obtained from these assays is preliminary and much needs to be done to standardize technologies and set a consensus ‘MFI cut off’ for antibody positivity. Besides the overriding influence of anti-HLA antibodies on overall solid organ graft survival, immune response to non-HLA antigens has become a topic of substantial interest in recent years. An ever expanding list of non-HLA antigens has been implicated in graft rejection for various organs, of which the most noted are the Major Histocompatibility Complex class I chain-related molecule A (MICA), Vimentin, Myosin, Angiotensin II type 1 receptor (AT1R), Tubulin and Collagen. MICA is one of the most polymorphic and extensively studied non-HLA antigenic targets especially in renal transplantation. Although there are clear indications of MICA antibodies being associated with adverse graft outcome, to date a definitive consensus on this relationship has not been agreed. Because MICA molecules are not expressed constitutively on immunocompetent cells such as T and B lymphocytes, it is of utmost importance to address the impact of MICA donor specific antibodies (DSA) as compared to those that are non- donor specific (NDSA) on graft outcome. The soluble isoform of MICA molecule (sMICA) that is derived from the proteolytic shedding of membrane bound molecules has the potential to engage the NK-cell activating receptor NKG2D and down-regulate its expression. Consequent to the interaction of NKG2D by sMICA, the receptor ligand complex is endocytosed and degraded and thus suppresses NKG2D mediated lysis of the target by NK cells. Thus interaction between NKG2D and sMICA leads to expansion of immunosuppressive/anergic T cells thereby resulting in suppression of NKG2D mediated host innate immunity. These concept support the possible involvement of an immunosuppressive role for sMICA during allotransplantation as shown recently for heart transplantation. This research topic focusses on the clinical utility of investigating the complete antibody repertoire in solid organ transplantation.
Book Synopsis Immunogenetic Characterization of the T Cell Receptor Repertoire in Healthy and Diseased Conditions by : Eliana Ruggiero
Download or read book Immunogenetic Characterization of the T Cell Receptor Repertoire in Healthy and Diseased Conditions written by Eliana Ruggiero and published by . This book was released on 2013 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Heptinstall's Pathology of the Kidney by : J. Charles Jennette
Download or read book Heptinstall's Pathology of the Kidney written by J. Charles Jennette and published by Lippincott Williams & Wilkins. This book was released on 2014-07-11 with total page 4413 pages. Available in PDF, EPUB and Kindle. Book excerpt: If you’re looking to deepen your understanding of kidney disease, look no further than Heptinstall’s Pathology of the Kidney, 7th Edition. Authored by the world’s most accomplished renal pathologists, this image-rich text conveys the intricacies and comprehensiveness of renal disease, offering powerful diagnostic and treatment recommendations from decades of clinical research. Stay up to date on the cutting edge of kidney research and treatment and offer your patients the best therapeutic options and preventative measures available today.
Book Synopsis Characterizing the Role of the T Cell Receptor Repertoire in T Cell Development and Function by : Benjamin David Solomon
Download or read book Characterizing the Role of the T Cell Receptor Repertoire in T Cell Development and Function written by Benjamin David Solomon and published by . This book was released on 2018 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expansion and memory of immune cells in response to stimulation of diversified antigen receptors is the hallmark of adaptive immunity. Here, we use antigen receptor sequencing and in vivo analysis of monoclonal cell populations to elucidate the development and function of two T cell populations: Foxp3+ROR[gamma]t+ CD4+ T cells and [gamma][delta] T cells. Foxp3+ROR[gamma]t+ T cells have recently been characterized as an immunoregulatory population highly enriched in the colon lamina propria. However, their developmental origin and relation to ROR[gamma]t- Treg and ROR[gamma]t+ TH17 cells remains unclear. Here, we show that despite sharing a subset of TCR specificities with TH17 cells, Foxp3+ROR[gamma]t+ T cells first acquire a Foxp3+ROR[gamma]t- phenotype before co-expressing ROR[gamma]t, suggesting that Foxp3+ROR[gamma]t+ cell development can occur via an ROR[gamma]t- Treg intermediate. While [gamma][delta] T cells are considerably well studied relative to Foxp3+ROR[gamma]t+ T cells, the importance antigen receptor diversification to [gamma][delta] T cell function is still poorly understood. In order to comprehensively assess the paired-chain [gamma][delta] T cell repertoire during inflammation, we developed a fixed-TCR[delta] system. We show that experimental autoimmune encephalomyelitis (EAE) results in dramatic clonal expansion of [gamma][delta] T cells and that a single expanded TCR clone is sufficient to exacerbate immune pathology. Together, this suggests that [gamma][delta] T cells can exhibit the clonal expansion characteristic of an adaptive immune response and that this response is physiologically significant to the outcome of EAE.
Download or read book Research Awards Index written by and published by . This book was released on 1988 with total page 874 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modelling and Characterisation of in Vivo Human Skin Graft Rejection for the Investigation of Regulatory T Cell Therapy in Vascularised Composite Allotransplantation by : Fadi Issa
Download or read book Modelling and Characterisation of in Vivo Human Skin Graft Rejection for the Investigation of Regulatory T Cell Therapy in Vascularised Composite Allotransplantation written by Fadi Issa and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascularised composite allograft (VCA) transplantation is revolutionising the field of plastic surgery. It reconstructs the most complex tissue defects effectively, achieving a new functional and cosmetic gold standard. However, VCA transplantation is currently limited by high rates of acute rejection and the need for patients without life-threatening conditions to be maintained on immunosuppression for life. Skin is the most problematic component of VCA transplants. It stimulates a vigorous immune response and is highly susceptible to rejection, even in the presence of potent immunosuppression. In order to expand the field of VCA transplantation and improve outcomes, the morbidity and mortality associated with immunosuppression need to be minimised or eliminated. This would require manipulation of the immune response to allow long-term survival in the absence of immunosuppression, in other words tolerance. A particular focus on the immune response directed against skin is required. Tolerance to skin allografts may be achievable with the use of regulatory T cells (Treg). Due to relatively few clinical cases, human skin transplantation is a poorly investigated area. The studies in this thesis were therefore designed to elucidate the characteristics of human skin rejection using a novel humanised mouse model, testing the hypothesis that human Treg could prevent human skin rejection in vivo. In Chapters 3 and 4 we develop a system whereby human skin rejection may be modelled effectively in vivo. Subsequently we investigate the unique characteristics of human skin rejection using this model. In Chapter 5 we demonstrate the capacity for Treg to prevent human skin rejection and investigate the systemic and local cellular changes resulting from Treg therapy. These changes include a reduction in the number of circulating proliferating T cells, a preservation of skin microvasculature, and a reduction in skin-infiltrating CD8+ leukocytes. Treg migrate to the allograft-draining lymph node and into the skin allograft to regulate immune responses. We demonstrate the importance of expansion or activation of Treg for their suppressive activity and the requirement for these cells to be derived from the allograft recipient for efficient regulation to be achieved. Treg cellular therapy has already been trialed clinically for the prevention of graft- versus-host disease after haematopoietic stem cell transplantation. The use of Treg in transplantation is therefore on the horizon. The unique translational data from this study bridge a critical gap between laboratory observations and the clinic. These data therefore form the basis upon which future clinical trials of Treg in skin or VCA transplantation may be performed.
Book Synopsis Critical Analysis of Monoclonal Antibody Therapy in Transplantation by : William J. Burlingham
Download or read book Critical Analysis of Monoclonal Antibody Therapy in Transplantation written by William J. Burlingham and published by CRC Press. This book was released on 1991-12-18 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical Analysis of Monoclonal Antibody Therapy in Transplantation provides a critical analysis of monoclonal antibody therapies in transplantation. The book presents diverse approaches to monoclonal antibody therapy in transplantation and addresses some of the serious obstacles that remain both in understanding these mechanisms and in successfully applying them in clinical situations. The background and rationale for OKT3 therapy are examined and an extensive clinical experience with OKT3 induction therapy in cardiac transplantation is reviewed. The book also examines the background and rationale for the use of anti-TcR (??), anti-IL-2R, and anti-LFA-1 monoclonal antibodies in clinical transplantations. Other topics include the use of monclonal antibodies to CD4 and CD8 for the induction of adult transplantation tolerance in rodents and the possibilities for applying anti-idiotypical strategies that have proven useful in autoimmunity models to transplant recipients. Researchers and basic scientists involved in this field will find the book a fascinating and useful resource for their investigations.
Book Synopsis The Laboratory Rat by : Mark A. Suckow
Download or read book The Laboratory Rat written by Mark A. Suckow and published by Elsevier. This book was released on 2005-12-20 with total page 929 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Laboratory Rat, Second Edition features updated information on a variety of topics including: rat genetics and genomics, both spontaneous and induced disease; state-of-the-art technology for housing and husbandry; occupational health, and experimental models. A premier source of information on the laboratory rat that will be of interest to veterinary and medical students, senior graduate, graduate students, post-docs and researchers who utilize animals in biomedical research. At least 50% new information than first edition Includes topics on rat genetics and genomics, occupational health, and experimental models The premier source of information on the laboratory rat
Book Synopsis Characterizing Antigen-specific CD4 T Cells Using HLA-DR Oligomers by : Thomas Owen Cameron
Download or read book Characterizing Antigen-specific CD4 T Cells Using HLA-DR Oligomers written by Thomas Owen Cameron and published by . This book was released on 2002 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cells are activated by the engagement of their surface T cell receptors (TCR) by antigenic peptide bound to major histocompatibility complex (MHC). The success or failure of this TCR to MHC-peptide interaction determines the specificity of T cell action, and thus plays a central role in proper immune function. In this thesis, soluble oligomers of MHC-peptide complex were used to investigate several aspects of the T cell immune response. Soluble fluorescent oligomers of human class II MHC were produced and used to detect CD4+ T cells of particular specificities. The critical parameters of this interaction were determined, and differing behaviors of various T cell clones were observed. The implications of these results are discussed, and MHC oligomers are suggested as powerful tools for the investigation T cell avidity modulation. Using a novel methodology for the analysis of the antigen-specific TCR repertoire which includes identification by MHC oligomers, T cells specific for a peptide derived from influenza were isolated, cloned and sequenced. This pool of sequences was observed to be extremely diverse in both VP usage and CDR3 sequence. These results are discussed with regard to the TCR repertoire, structural aspects of TCR/MHC-peptide interaction, and future studies of TCR repertoire analysis. Other studies investigating the triggering mechanism of TCR are summarized and implications of these results for various models of transmembrane activation are discussed. A novel mechanism is proposed involving the reorganization of a receptor oligomer from a specific inhibited state into an uninhibited state. Future directions of research based on the work presented in this thesis are suggested.
Book Synopsis Kidney Transplantation - Principles and Practice E-Book by : Stuart J. Knechtle
Download or read book Kidney Transplantation - Principles and Practice E-Book written by Stuart J. Knechtle and published by Elsevier Health Sciences. This book was released on 2019-08-31 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offering practical guidance for all members of the transplant team, Kidney Transplantation, Principles and Practice, 8th Edition, provides the balanced, up-to-date information you need to achieve optimal outcomes for your patients. A global team of internationally renowned surgeons and nephrologists, many new to this edition, offers fresh perspectives on everything from applied science and surgical techniques to immunosuppressive methods, outcomes, risks, and medical considerations related to kidney transplantation, in both adults and children. Offers state-of-the-art coverage of all areas of kidney transplantation such as preservation of kidneys; mechanisms of rejection and the induction of tolerance; techniques of laparoscopic live donor nephrectomy; and immunosuppression. Contains up-to-date outcomes data and analysis of the evidence supporting current practice in the field. Includes new information on desensitization and considerable new data on the clinical use of costimulation blockade. Keeps you current with new chapters on kidney allocation policy that reflects the ethical and societal values of different countries and populations; and biomarkers of kidney injury and rejection, including the need for better monitoring tools to guide therapy and patient management. Covers hot topics such as management of chronic allograft failure, the sensitized patient and antibody-mediated rejection, and paired exchange principles. Features hundreds of superb illustrations to help you visualize key concepts and nuances of renal transplantation. Provides dynamic visual guidance with new real-time video coverage of ultrasound-guided pancreas allograft biopsy; a new animation of calcineurin inhibitor mechanism of action animation; and videos that demonstrate the formation of an immune synapse, 3-D rotational images of immune synapses, an NK cell killing its target, peritoneal dialysis-catheter insertion techniques, laparoendoscopic single site (LESS) donor nephrectomy, and more.
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
