Author : Kyoungtea Kim
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)
Book Synopsis Characterization of Nanomaterial Interactions at the Biological Interfaces by : Kyoungtea Kim
Download or read book Characterization of Nanomaterial Interactions at the Biological Interfaces written by Kyoungtea Kim and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in nanomaterials has arisen from their unique physiochemical properties with applications in medicine, industrial processing, consumer goods, and agriculture due to their unique physicochemical properties and applications. With the increase in industrial scale nanomaterial synthesis and application, living cells are increasingly likely to be exposed to nanomaterials in the environment. Given that the cell membrane/wall is the initial point of contact for living cells with foreign materials, understanding nanomaterial interactions with extracellular surfaces at the molecular level is required to assess and predict the potential deleterious impacts of nanomaterials on living cells/organisms. In terms of abundance, proteins in biological fluids or serums are highly likely to interact with nanomaterials. Protein association with nanomaterials is known to accompany subsequent protein conformational changes. Considering protein conformation is finely regulated in living cells, altered protein conformations induced by interactions with nanomaterials need to be investigated to better understand potential adverse impacts on living organisms. The overarching goal of the studies presented here is to construct model biological systems and elucidate their interaction with nanomaterials. We here developed model biological interfaces, investigated their molecular level interactions with nanomaterial, and demonstrated that some of our model biological interfaces are representative of actual biological interfaces. We also summarized nanomaterial interactions with proteins and subsequent protein conformational changes. The characterization of the nano-bio interactions, at the molecular level, would contribute to establishing nanomaterial design rules to improve their properties for applications and ultimately supports the implementation of sustainable nanotechnology.