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Author : Tony M. Mertz
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.:/5 (947 download)
Download or read book Characterization of Cancer-associated DNA Polymerase Delta Variants written by Tony M. Mertz and published by . This book was released on 2015 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ulrich Hübscher
Publisher : World Scientific
ISBN 13 : 9814299170
Total Pages : 338 pages
Book Rating : 4.8/5 (142 download)
Download or read book DNA Polymerases written by Ulrich Hübscher and published by World Scientific. This book was released on 2010 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.
![Download Biochemical Characterization of DNA Polymerase [delta] and Cloning of Its CDNA from the Glycine Max Cell Line SB-M PDF Online Free](https://books.google.com/books/content/images/frontcover/HdZbNwAACAAJ?fife=w200-h370)
Author : Jeannie T. B. Collins
Publisher :
ISBN 13 :
Total Pages : 226 pages
Book Rating : 4.:/5 (415 download)
Download or read book Biochemical Characterization of DNA Polymerase [delta] and Cloning of Its CDNA from the Glycine Max Cell Line SB-M written by Jeannie T. B. Collins and published by . This book was released on 1998 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download DNA Polymerase [delta] PDF Online Free](https://books.google.com/books/content/images/frontcover/czWiXwAACAAJ?fife=w200-h370)
Author : Robert Jacques Hindges
Publisher :
ISBN 13 :
Total Pages : 99 pages
Book Rating : 4.:/5 (636 download)
Download or read book DNA Polymerase [delta] written by Robert Jacques Hindges and published by . This book was released on 1996 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nayef Ali Mazloum
Publisher :
ISBN 13 :
Total Pages : 162 pages
Book Rating : 4.:/5 (192 download)
Download or read book Reconstitution and Characterization of Human DNA Polymerase Delta Four Subunit Holoenzyme and Proteomic Analysis of DNA Polymerase Delta Complex written by Nayef Ali Mazloum and published by . This book was released on 2002 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cindy M. Jaime
Publisher :
ISBN 13 :
Total Pages : 69 pages
Book Rating : 4.:/5 (495 download)
Download or read book Characterization of the DNA Polymerase Delta Multiprotein Complex by Two-dimensional Gel Electrophoresis and Affinity Chromatography written by Cindy M. Jaime and published by . This book was released on 2001 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Mutation Analysis of the DNA Polymerase Δ-gene [delta]-gene in Human Sporadic Colorectal Cancer PDF Online Free](https://books.google.com/books/content/images/frontcover/e_HTzQEACAAJ?fife=w200-h370)
Author : Jia-Chun Dai
Publisher :
ISBN 13 :
Total Pages : 224 pages
Book Rating : 4.:/5 (118 download)
Download or read book Mutation Analysis of the DNA Polymerase Δ-gene [delta]-gene in Human Sporadic Colorectal Cancer written by Jia-Chun Dai and published by . This book was released on 1999 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sophia Toumazou
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (131 download)
Download or read book Characterisation of DNA Polymerase Δ Exonuclease Domain Mutations Associated with Cancer Predisposition Using Fission Yeast written by Sophia Toumazou and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 5 pages
Book Rating : 4.:/5 (871 download)
Download or read book Characterization of the Mammalian DNA Polymerase Gene(s) and Enzyme(s). Annual Progress Report written by and published by . This book was released on 1995 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two Genes for DNA polymerase delta were identified from the wild type Chinese hamster ovary cells. These genes were cloned via RT-PCR from mRNA prepared the Chinese hamster ovary cells using primers specific to conserved sequences of the DNA polymerase [delta] gene. The first gene encodes a PCNA dependent DNA polymerase [delta] gene whereas the second gene encodes a PCNA independent DNA polymerase [delta] gene. Methods were developed to clone these genes in expression vector and host systems. The role of the two genes in DNA replication and repair was determined.
Author : Florian D. Hastert
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (113 download)
Download or read book Characterization of the Cancer-associated Short Isoform of Tet1 in DNA Replication written by Florian D. Hastert and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tairisoa S. Andrianarijaona
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (495 download)
Download or read book Mutational Analysis of the Catalytic Subunit of Human DNA Polymerase Delta from Breast Cancer Cells written by Tairisoa S. Andrianarijaona and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Li Liu
Publisher :
ISBN 13 :
Total Pages : 330 pages
Book Rating : 4.:/5 (448 download)
Download or read book Cloning and Characterization of Novel Proteins which Associate with Mammalian DNA Polymerase Delta written by Li Liu and published by . This book was released on 1999 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download Purification and Characterization of Recombinant Human DNA Polymerase [delta] Expressed in Baculovirus-infected Insect Cells PDF Online Free](https://books.google.com/books/content/images/frontcover/j3rGNwAACAAJ?fife=w200-h370)
Author : Jin-Qiu Zhou
Publisher :
ISBN 13 :
Total Pages : 180 pages
Book Rating : 4.:/5 (382 download)
Download or read book Purification and Characterization of Recombinant Human DNA Polymerase [delta] Expressed in Baculovirus-infected Insect Cells written by Jin-Qiu Zhou and published by . This book was released on 1997 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 6 pages
Book Rating : 4.:/5 (873 download)
Download or read book Characterization of the Mammalian DNA Polymerase Gene and Protein. Annual Progress Report written by and published by . This book was released on 1992 with total page 6 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have purified and characterized at least three DNA polymerases from Chinese hamster ovary (CHO) cell line Kl in order to evaluate the roles of different polymerases in eukaryotic DNA replication. Pol [alpha] was the most abundant among different polymerase activities and it was neutralized by a monoclonal antibody raised against human pol [alpha]. Pol {var_epsilon} was separated from pol [alpha] and pol [delta] activities using DEAE Sephacell, phosphocellulose and hydroxylapatite columns. The enzyme proved to be sensitive to aphidicolin and carbonyldiphosphonate and was not stimulated by PCNA- Pol [delta] was the least abundant among the three enzymes. It was sensitive to aphidicolin and carbonyidiphosphonate and was stimulated by PCNA. it had a preference for template/primer poly (dA-dT). Based on DNA sequence data of different eukaryotic polymerases PCR primers complementary to two neighboring synthesized. In PCR experiments several products were obtained which are assumed to be specific for the CHO polymerases. We have also analyzed a large number of aphidicolin resistant mutants of CHO to identify mutants with altered DNA polymerases.
![Download Identification and Characterization of a Novel Protein that Interacts with the 50-kDa Subunit of Human DNA Polymerase [delta] and PCNA PDF Online Free](https://books.google.com/books/content/images/frontcover/lkr1tgAACAAJ?fife=w200-h370)
Author : Hua He
Publisher :
ISBN 13 :
Total Pages : 214 pages
Book Rating : 4.:/5 (472 download)
Download or read book Identification and Characterization of a Novel Protein that Interacts with the 50-kDa Subunit of Human DNA Polymerase [delta] and PCNA written by Hua He and published by . This book was released on 2000 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ramaswamy Govindan, MD
Publisher : Springer Publishing Company
ISBN 13 : 082616868X
Total Pages : 184 pages
Book Rating : 4.8/5 (261 download)
Download or read book Cancer Genomics for the Clinician written by Ramaswamy Govindan, MD and published by Springer Publishing Company. This book was released on 2019-01-28 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Genomics for the Clinician is a practical guide to cancer genomics and its application to cancer diagnosis and care. The book begins with a brief overview of the various types of genetic alterations that are encountered in cancer, followed by accessible and applicable information on next generation sequencing technology and bioinformatics; tumor heterogeneity; whole genome, exome, and transcriptome sequencing; epigenomics; and data analysis and interpretation. Each chapter provides essential explanations of concepts, terminology, and methods. Also included are tips for interpreting and analyzing molecular data, as well as a discussion of molecular predictors for targeted therapies covering hematologic malignancies and solid tumors. The final chapter explains the use of FDA-approved genomic-based targeted therapies for breast cancer, lung cancer, sarcomas, gastrointestinal cancers, urologic cancers, head and neck cancer, thyroid cancer, and many more. Assembled in an accessible format specifically designed for the non-expert, this book provides the clinical oncologist, early career practitioner, and trainee with an essential understanding of the molecular and genetic basis of cancer and the clinical aspects that have led to advancements in diagnosis and treatment. With this resource, physicians and trainees will increase their breadth of knowledge and be better equipped to educate patients and families who want to know more about their genetic predispositions to cancer and the targeted therapies that could be considered and prescribed. Key Features: Describes how cancer genomics and next generation sequencing informs cancer screening, risk factors, therapeutic options, and clinical management across cancer types Explains what mutations are, what tests are needed, and how to interpret the results Provides information on FDA-approved targeted therapies that are being used in the clinic Covers different sequencing platforms and technologies and how they perform in research settings Includes access to the fully searchable eBook
Author : David C. Amberg
Publisher : CSHL Press
ISBN 13 : 0879697288
Total Pages : 250 pages
Book Rating : 4.8/5 (796 download)
Download or read book Methods in Yeast Genetics written by David C. Amberg and published by CSHL Press. This book was released on 2005 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Methods in Yeast Genetics" is a course that has been offered annually at Cold Spring Harbor for the last 30 years. This provides a set of teaching experiments along with the protocols and recipes for the standard techniques and reagents used in the study of yeast biology.
