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Central Cholinergic Mechanisms And Adaptive Dysfunctions
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Book Synopsis Central Cholinergic Mechanisms and Adaptive Dysfunctions by : Man Singh
Download or read book Central Cholinergic Mechanisms and Adaptive Dysfunctions written by Man Singh and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although serious interest in studying the role of central cho linergic processes in psychopathology is just beginning to emerge, experimental literature on the part played by cholinergic mechanisms in brain behavior. reiations is quite extensive. During the past thirty years, cholinergic research has contributed significantly to the characterization and differentiation of adaptive mechanisms in volved in input selection, perception, cortical, autonomic and behav ioral activation, learning, memory, and inhibitory control of behav ioral outputs. To say that dysfunction of one or more of these mech anisms may be at the root of neuropsychiatric illnesses such as schiz ophrenia would be stating the obvious. This book examines the part cholinergic processes might play in dysfunctions of the adaptive processes involved in higher brain func tions and their significance for the pathogenesis, classification, etiology, and treatment of psychopathological conditions. In a series of wide ranging reviews of the available information, the subject is discussed from a variety of perspectives, using data derived from both experimental and clinical research. The purpose is not so much to determine whether cholinergic excess or deficiency is causal in this or that neuropsychiatric syndrome, but rather to try to understand the disease mechanisms in terms of adaptive processes in which cholinergic systems seem to play an important part.
Book Synopsis Central Cholinergic Mechanisms and Adaptive Dysfunctions by : Man Singh
Download or read book Central Cholinergic Mechanisms and Adaptive Dysfunctions written by Man Singh and published by . This book was released on 1985-01-01 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1985 with total page 1728 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Genetic Basis of Alcohol and Drug Actions by : J.C. Crabbe Jr.
Download or read book The Genetic Basis of Alcohol and Drug Actions written by J.C. Crabbe Jr. and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: HISTORICAL BACKGROUND The use of genetic animal models in neuroscience and biomedical research is showing dramatic growth. The earliest application of these models to research on drug mechanisms was in the area of alcohol research. Mardones (1951) reported successful selective breeding of rats preferring and not preferring to drink alcohol under various conditions of dietary deficiency, suggesting genetic control of alcohol drinking. McClearn and Rodgers (1959, 1961) described differences among inbred mouse strains in preference for 10Ofo ethanol solutions versus tap water. Active exploration of this phenomenon continued until the early 1970s, eventually spawning the entire range of alcohol genetic research reviewed in Chapters 2 and 3 of this volume. Notably, oral alcohol self-administration has served as the basis for the development of several rat lines bred for preference or aversion, and these lines are very actively being investigated. The pioneering research of Dr. McClearn and others was very wide ranging in its conceptual scope and at least touched on all issues currently under intense investigation. The basic approach was to identify high and low preferrers among inbred strains of mice and to search for preference correlates in other traits. One major thrust of early research was to attempt to explain strain differences in preference as a function of underlying differences in patterns of caloric utilization. Reviews of these studies concluded that nutritional factors could not completely explain preference differences (Rod gers, 1966; McClearn, 1968).
Book Synopsis Energetics and Human Information Processing by : G.M. Hockey
Download or read book Energetics and Human Information Processing written by G.M. Hockey and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central theme of this book is the role of energetical factors in the regulation of human information processing activity. This is a restatement of one of the classic problems of psychology - that of acc ounting for motivational or intensive aspects of behaviour, as opposed to structural or directional aspects. The term "energetics" was first used in the 1930's by Freeman, Duffy and others, following Cannon's energy mobilization view of emotion and motivation. The original concept had a limited life, probably because of its unnecessary focus on relativ ely peripheral processes, but it provided the foundations for the con cepts of "arousal" and "activation" which became the popular motivational constructs of the 1950's and 1960's. Now, these too are found wanting. The original assumptions of a unitary, non-specific process based on activation of the brain stem reticular formation have been shown to be misleading. Current work in neurobiology has demonstrated evidence of discrete neurotransmitter systems having quite specific information processing functions, and central roles in the regulation of behaviour. Even the venerable curvilinear relationship between motivation and per formance (the Yerkes-Dodson law) has been shown to be, at best, an unhelpful oversimplification. On a different front psychophysiologists have found complex patterns in the response of different bodily systems to external stressors and to task demands.
Download or read book Dyskinesia written by D.E. Casey and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers Presented at an International Symposium, Held in 1984 at Kollekolle, Denmark
Book Synopsis The Dynamics of Aggression by : Michael Potegal
Download or read book The Dynamics of Aggression written by Michael Potegal and published by Psychology Press. This book was released on 2013-06-17 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aggression usually involves a sequence of behaviors, reflecting escalations and de-escalations in the form or intensity of the actions taken, which play out over time. This book provides a context in which social and biological research on the aggressive behaviors of human and non-human subjects, interacting in dyads or groups, can be compared and integrated. Implicit in this juxtaposition is the major question of whether general principles governing the dynamics of aggression within and between episodes may be discerned. Aggressive behavior is described at different levels of analysis in humans and a number of other animal species. Three basic views of aggression dynamics become apparent: * The economic interpretation: Aggression will be escalated when it pays one of the combatants to do so or, more generally, when the potential benefits outweigh the risks. Decisions to escalate or de-escalate are part of a calculated "strategy", in one or another sense. This interpretation is formalized within game theoretic models as applied to animal conflicts and to international conflicts, within the chapters of this text. * The psychological process interpretation: Emphasis is placed on psychological/physiological processes within the individual. The chapters stress the importance of acute emotional states of anger and aggressive arousal and argue the role of peripheral sympathetic activation, while proposing a central neural mechanism. Children escalating their tantrums, adult humans and animals of other species intensifying their interpersonal conflicts, national leaders going to a war footing all appear to suffer a narrowing of attention and progressive failure of cognitive function under the intensifying stress of conflict. Perhaps these changes in attention, sensory and cognitive functions, and risk taking reflect a "commitment to aggression" which is necessary for organisms to engage in potentially dangerous and painful encounters. * The emergent process interpretation: Escalation emerges in a spontaneous and dynamic way as the actions of one participant elicit reactions from the other(s).
Book Synopsis Cognitive Perspectives on Emotion and Motivation by : V. Hamilton
Download or read book Cognitive Perspectives on Emotion and Motivation written by V. Hamilton and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the contributions of the members of an Advanced Research Workshop on Cogni ti ve Science Perspectives on Emotion, Motivation and Cognition. The Workshop, funded mainly by the NATO Scientific Affairs Division, together with a contribution from the (British) Economic and Social Research Council, was conducted at II Ciocco, Tuscany, Italy, 21-27 June 1987. The venue for our discussions was ideal: a quiet holiday hotel, 500m high in the Apennine mountain range, approached by a mile of perilously steep, winding narrow road. The isolation was conducive to concentrated discussions on the topics of the Workshop. The reason for the Workshop was a felt need for researchers from disparate but related approaches to cognition, emotion, and motivation to communicate their perspectives and arguments to one another. To take just one example, the framework of information processing and the metaphor of mind as a computer has wrought a major revolution in psychological theories of cogni tion. That framework has radically altered the way psychologists conceptualize perception, memory, language, thought, and action. Those advances have formed the intellectual substrate for the "cognitive science" perspective on mental life.
Book Synopsis Essentials of Pharmacotherapeutics by : F S K Barar
Download or read book Essentials of Pharmacotherapeutics written by F S K Barar and published by S. Chand Publishing. This book was released on 2000-10 with total page 639 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and well-written book presents the fundamental concepts of Pharmacotherapeutics, aiming at the safe and effective use of drugs in the treatment of disease. It is interdisciplinary in its approach and provides a basis for understanding the actions and uses of drugs in man. It is written in a simple and easy-to-understand language. The text is divided into sixteen chapters
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1985 with total page 1712 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Book Synopsis Tobacco Smoking and Nicotine by : William R. Martin
Download or read book Tobacco Smoking and Nicotine written by William R. Martin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nicotine is the major factor in the continuation of the smoking habit among humans. On December 2-4, 1985, under the sponsorship of the Tobacco and Health Research Institute in Lexington, Kentucky, leading scientists from around the world whose research efforts have focused on the role of nicotine in the tobacco habit participated in an International Symposium to provide the most comprehensive and ~xtensive coverage of this topic so far. The material discussed was in the forefront of man's knowledge about nicotine, and both lectures and question and answer sessions were stimulating and enlightening. This publication contains the manuscripts presented at the Symposium, along with an Overview prepared by selected individuals. Lecture and poster session topics are delineated more fully in the Overview. This volume is expected to serve as a definitive reference on nicotine as it relates to the tobacco habit. Symposium sessions were arranged under four headings: (1) behavioral effects of nicotine and nicotine~ependence in humans and animals, (2) neurohumoral regulation of neuroendocrine and cardiovascular function by nicotine, (3) neuropharmacology of nicotine, and (4) neurochemistry. This was the first assembly of this magnitude of scientists who had devoted years of research to nicotine and its effects. Indeed, it was a pleasure to have sponsored this important event. Dr. Lay ten Davis, Director Tobacco and Health Research Institute Cooper and Alumni Drives Lexington, KY 40546-0236 v ACKNOWLEDGMENTS The Editors of this volume express sincere appreciation to all of the contributors. Special acknowledgments are given to Ms.
Book Synopsis Neurobiology of Acetylcholine by : Nae J. Dun
Download or read book Neurobiology of Acetylcholine written by Nae J. Dun and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Festschrift volume in honor of Professor Alexander Karczmar is the outcome of a three-day symposium entitled "Neurobiology of Acetylcholine" held at Loyola University Medical Center from June 3 to 5, 1985. This volume serves two purposes. It expresses the respect and admiration of the contributors to Alex Karczmar, and it provides a forum for detailing recent advances in the cholinergic field which has attracted the undivided and untiring attention of Dr. Karczmar over some 40 years. During this period, the cholinergic system has grown from its infancy to become one of the most studied and understood transmitter systems today. Dr. Karczmar's interest in cholinergic system is appropriately reflected by the range of topics, molecular, cellular, developmental, behavioral and toxicological, that were discussed here. A detailed synopsis of Dr. Karczmar's research and his contributions to the field of cholinergic systems can be found in the following chapter by his close friend and colleague, Dr. George Koelle. We would like to take this opportunity to thank the enthusiastic responses of the participants making this Festschrift a memorable event.
Book Synopsis International Review of Neurobiology by :
Download or read book International Review of Neurobiology written by and published by Academic Press. This book was released on 1989-03-01 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Neurobiology
Book Synopsis Bipolar Disorders by : Gershon Samuel
Download or read book Bipolar Disorders written by Gershon Samuel and published by CRC Press. This book was released on 2000-04-25 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: Responding to the explosion of research on the pathophysiology and management of bipolar disorder, this completely revised Second Edition spans basic mechanisms, neuroimaging, viral etiology, neurofactors, current treatment implications, and modern theories of the neurobiology of bipolar disorder to stand as the most authoritative reference on this
Author :Alexander G. Karczmar Publisher :Springer Science & Business Media ISBN 13 :038746526X Total Pages :698 pages Book Rating :4.3/5 (874 download)
Book Synopsis Exploring the Vertebrate Central Cholinergic Nervous System by : Alexander G. Karczmar
Download or read book Exploring the Vertebrate Central Cholinergic Nervous System written by Alexander G. Karczmar and published by Springer Science & Business Media. This book was released on 2007-04-05 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even if the “weapons of mass destruction” (WMD) and, among them, stocks of organoph- phorus (OP) agents (also referred to as war gases and nerve gases) were not found in Iraq following the US-Iraq war, the relative ease with which these substances can be made from harmless precursors and the low cost of their manufacture will continue to fascinate pow- hungry, ruthless dictators, as well as multinational and international terrorists, particularly as the close relationship between the OP agents and useful insecticides makes it easy to disguise the importation and purchase of small amounts of the precursors. Indeed, the use by Saddam Hussein of a nerve gas against the Kurds and his possible employment of the OP agents during his war with Iran, and the Sarin attack in the Tokyo underground by an extremist religious set magnetized the world with respect to the OP drugs. As these drugs exert their toxicity via their cholinergic action on the nervous, particularly central nervous, system, it is no wonder that the research in the cholinergic ? eld attracts, and merits, our intense attention. These considerations underlie the signi? cance of this book, as Alex Karczmar devotes an entire chapter of Exploring the Vertebrate Central Cholinergic Nervous System to anticholinest- ases (antiChEs), and as he is an acknowledged expert in the ? eld of cholinergic toxicity as well as a consultant to the Surgeon General of the U. S. Army.
Book Synopsis Individual Differences in Hemispheric Specialization by : A. Glass
Download or read book Individual Differences in Hemispheric Specialization written by A. Glass and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume originates from a NATO Advanced Research Workshop held in Maratea. Italy from 8th-15th October 198~. Aims and contributions are described at greater length in the Introduction and the following chapters. It is hoped that this volume will provide a critical overview of hemispheric specialization in relation to individual differences, but one that is not intended to be comprehensive. Three contributions on this theme are made by authors who were invited to the Workshop but were unable to participate in it. The volume contains a critical appraisal of the differentially specialized functions of left and right human cerebral hemispheres in verbal and visuospatial domains respectively (formerly cerebral dominance). in relation to individual variation due. for example. to gender and handedness. Critical cross-comparison of several methods of assessing hemispheric specialization such as perceptual/behavioral. clinical/neurological. electrophysiological and "real time" methods of assessment of cerebral orientation have been made. Individual differences have been considered in relation to statistical concepts in the assessment of cerebral lateralization. Some emphasis has been placed on the application of these methods and concepts to psychopathology.
Book Synopsis possible long-term health effects of short-term exposure to chemical by :
Download or read book possible long-term health effects of short-term exposure to chemical written by and published by National Academies Press. This book was released on with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
