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Cellular Quiescence
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Book Synopsis Cellular Quiescence by : H. Daniel Lacorazza
Download or read book Cellular Quiescence written by H. Daniel Lacorazza and published by Humana Press. This book was released on 2017-10-18 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores methods and protocols that aim to increase our understanding of how cells enter a quiescent state during homeostasis and how cells exit quiescence and re-enter differentiating cell divisions to restore damaged tissues, essential for developing new approaches in regenerative medicine in the future. The chapters in this book were designed to address cellular quiescence in prokaryote and eukaryote organisms, detection of quiescence (Hoechst/pyronin Y, FUCCI, CFSE, BrdU, H2B-GFP, CyTOF), quiescence in stem cells (skin, intestinal, neuronal, hematopoietic), genomic regulation (gene expression, transcription factors, lncRNA, RNA methylation), as well as analysis of the heterogeneity of quiescence by computer modeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cellular Quiescence: Methods and Protocols offers a broad view of basic and cutting-edge technology to inspire research in this emerging field of cell biology.
Book Synopsis Tumor Dormancy, Quiescence, and Senescence, Volume 1 by : M.A. Hayat
Download or read book Tumor Dormancy, Quiescence, and Senescence, Volume 1 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a particular emphasis on tumor dormancy in breast, lung, prostate, and liver cancers, as well as in melanoma, this first volume of a new Springer series focuses on the interrelationship between biological processes of aging and tumors—both dormant and quiescent. With detail supplied by numerous international researchers at the forefront of cancer research, the book examines a host of differing aspects of the topic. Featured contributions analyze the role of the quiescent state in regulating hematopoietic and muscle stem cells. They also explore the mediation, by the kinase, in the reversible quiescent state of a subset of ovarian, pancreatic, and colon cancers. The book includes key research on the molecular mechanisms underlying stress-induced cellular senescence, in addition to those governing the accumulation of reactive oxygen species, and the induction of premature senescence. It also provides information on suppressing cellular senescence in the most common, and most aggressive malignant primary brain tumor in humans, glioblastoma multiforme. With comprehensive and cutting-edge information on therapeutic interventions and on the correct diagnosis of relevant neoplasms, and with numerous color illustrations, this is the most up-to-date assessment of current medical knowledge in this crucial area of medical research.
Book Synopsis Tumor Dormancy, Quiescence, and Senescence, Volume 2 by : M.A. Hayat
Download or read book Tumor Dormancy, Quiescence, and Senescence, Volume 2 written by M.A. Hayat and published by Springer Science & Business Media. This book was released on 2013-11-29 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this second volume in the series exploring Tumor Dormancy, Quiescence, and Cellular Senescence, discussion is focused on the role of tumor dormancy in diseases such as breast cancer, melanoma, prostate cancer, liver cancer and lung cancer. M. A. Hayat, the series editor, writes in the preface that little is known of factors regulating the transition of residual cancer into a dormant state or the subsequent reinitiation of growth. A majority of us, he says, have in situ tumors that may remain dormant or may progress into a lethal form of cancer; the former are prevented from recruiting their own blood supply. Section I covers Molecular Mechanisms, with chapters on the role of NAE inhibitor MLN4924; oncogene-induced senescence; the role played by mitogen-activated protein kinase in the induction of cellular senescence; mechanisms of premature cell senescence and other topics. Section II examines Tumor and Cancer, discussing defects in chromatin structure and diseases; the role of fibrosis in tumor progression and the dormant to proliferative switch; the function of ING proteins in cancer and senescence and more. The final section is devoted to Stem Cells and Cancer Stem Cells, featuring chapters showing that senescent-derived pluripotent stem cells are able to redifferentiate into fully rejuvenated cells; that the transcription factor Gata2 regulates quiescence in haematopoietic stem and progenitor cells; and discussing dormancy and recurrence of cancer stem cells in bone. The contributors point out that the quiescent state regulates hematopoietic stem cells and muscle stem cells, and detail the role of kinase in the mediation of reversible quiescent state in a subset of ovarian, pancreatic, and colon cancers. Molecular mechanisms underlying stress-induced cellular senescence and accumulation of reactive oxygen species and induction of premature senescence are also presented. Discussion includes the important role of microRNAs in oxidative stress-induced apoptosis and senescence and the effect of microRNA as a modulator of cell proliferation in lung cancer. The book includes an explanation of the suppression of cellular senescence in glioblastoma brain tumor. Taking a broad and varied perspective, this volume was written by 70 contributors representing 11 countries.
Book Synopsis The Process of Cellular Quiescence and the Potential for a GO Cyclin/Cdk in Mammalian Fibroblasts by : Christopher M. Hull
Download or read book The Process of Cellular Quiescence and the Potential for a GO Cyclin/Cdk in Mammalian Fibroblasts written by Christopher M. Hull and published by . This book was released on 1998 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cellular Dormancy: State Determination and Plasticity by : Guang Yao
Download or read book Cellular Dormancy: State Determination and Plasticity written by Guang Yao and published by Frontiers Media SA. This book was released on 2022-09-15 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Process of Cellular Quiescence and the Potential for a G0 Cyclin/Cdk in Mammalian Fibroblasts by : Christopher M. Hull
Download or read book The Process of Cellular Quiescence and the Potential for a G0 Cyclin/Cdk in Mammalian Fibroblasts written by Christopher M. Hull and published by . This book was released on 1998 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Primary Cilia written by and published by Academic Press. This book was released on 2009-11-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the role of cilia in the study of health, development and disease has been increasingly clear, and new discoveries have made this an exciting and important field of research. This comprehensive volume, a complement to the new three-volume treatment of cilia and flagella by King and Pazour, presents easy-to-follow protocols and detailed background information for researchers working with cilia and flagella. Covers protocols for primary cilia across several systems and species Both classic and state-of-the-art methods readily adaptable across model systems, and designed to last the test of time Relevant to clinicians and scientists working in a wide range of fields
Author :Errol C. Friedberg Publisher :American Society for Microbiology Press ISBN 13 :1555813194 Total Pages :2587 pages Book Rating :4.5/5 (558 download)
Book Synopsis DNA Repair and Mutagenesis by : Errol C. Friedberg
Download or read book DNA Repair and Mutagenesis written by Errol C. Friedberg and published by American Society for Microbiology Press. This book was released on 2005-11-22 with total page 2587 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential resource for all scientists researching cellular responses to DNA damage. • Introduces important new material reflective of the major changes and developments that have occurred in the field over the last decade. • Discussed the field within a strong historical framework, and all aspects of biological responses to DNA damage are detailed. • Provides information on covering sources and consequences of DNA damage; correcting altered bases in DNA: DNA repair; DNA damage tolerance and mutagenesis; regulatory responses to DNA damage in eukaryotes; and disease states associated with defective biological responses to DNA damage.
Book Synopsis The Process of Cellular Quiescence and the Potential for a G0 Cyclin/Cdk in Mammalian Fibroblasts by :
Download or read book The Process of Cellular Quiescence and the Potential for a G0 Cyclin/Cdk in Mammalian Fibroblasts written by and published by . This book was released on 1999 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tumor Dormancy, Quiescence, and Senescence, Vol. 3 by : M.A. Hayat
Download or read book Tumor Dormancy, Quiescence, and Senescence, Vol. 3 written by M.A. Hayat and published by Springer. This book was released on 2014-09-12 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third volume in the series Tumor Dormancy, Quiescence, and Senescence discusses the role of tumor dormancy and senescence in a number of diseases, including breast cancer, ovarian cancer and leukemia. The contents are organized under five subheadings: General Applications, Role in Breast Cancer, Role in Ovarian Cancer, Role in Leukemia and Role in Cardiovascular Disease. The first section includes basic information on the definition of dormancy, how cells become senescent and what they do, along with an appraisal of the current state of research on dormancy. Section Two explores dormancy in breast cancer, including the progression of hormone-dependent mammary tumors after dormancy. Section Three details the resistance of Type II ovarian tumors, in which the resistant tumor cell population persists after chemotherapy in a state of dormancy, with recurrent tumors arising upon transformation of such dormant cells back to malignant growth. This section explains how lineage, histological subtypes and grade influence the differential response of ovarian cancer resistance to platinum drugs. The fourth section explores leukemia, discussing regulation of the promyelocytic leukemia protein and its role in premature senescence. The final section explores the role of senescence and autophagy in age-related cardiovascular diseases and the observation that autophagy seems to retard cardiac senescence. Like the two preceding volumes in the series, Volume 3 stands out for its comprehensive approach, its roster of some 26 expert contributors representing seven different countries and its up-to-date review of leading-edge technology and methods.
Book Synopsis Characterization of "par-4-"dependent Germ Line Stem Cell Quiescence in Caenorhabditis Elegans by : Rita Chaouni
Download or read book Characterization of "par-4-"dependent Germ Line Stem Cell Quiescence in Caenorhabditis Elegans written by Rita Chaouni and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Upon encountering harsh environmental conditions, Caenorhabditis elegans larvae are able to alter their developmental program and enter the dauer diapause, an alternative developmental stage that enables larvae to endure long periods of stress. During this arrested state, the germ line stem cells, which normally divide during reproductive development, halt their proliferation and are consequently rendered quiescent. Previous work has implicated a role for PAR-4/LKB1 in germ line stem cell quiescence. Inactivating mutations in par-4 result in aberrant germ line stem cell proliferation during the dauer diapause, suggesting that PAR-4 is required for germ cell cycle arrest. LKB1 is a tumor suppressor protein kinase that is implicated in the rare, autosomal dominant disease Peutz-Jeghers syndrome (PJS). In order to better understand its function in tumorigenesis, we characterized its role in regulating cellular quiescence in developmentally arrested larvae using a genome-wide, RNA interference-based screen to identify suppressors of PAR-4-dependent germ line hyperplasia. We identified 50 genes whose loss-of-function was found to rescue the germ line hyperplasia observed in par-4 dauer larvae, suggesting that their expression is misregulated in the absence of PAR-4/LKB1. In addition, we demonstrated the importance of PAR-4-dependent germ line arrest by characterizing the post-dauer, reproductive capacity of par-4 mutants, which was significantly reduced. Future endeavors include the characterization of key candidates--many of which impinge on the cytoskeleton and the extracellular matrix--as well as the post-dauer germ line defects observed in par-4 animals. " --
Book Synopsis MicroRNAs and the Regulation of Cellular Quiescence by : Talia R. Chapman
Download or read book MicroRNAs and the Regulation of Cellular Quiescence written by Talia R. Chapman and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Tumor Dormancy and Cellular Quiescence and Senescence by :
Download or read book Tumor Dormancy and Cellular Quiescence and Senescence written by and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lymphocyte Updates by : Gheorghita Isvoranu
Download or read book Lymphocyte Updates written by Gheorghita Isvoranu and published by BoD – Books on Demand. This book was released on 2017-07-12 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.
Book Synopsis Studies of Cellular Quiescence in Photosynthetic Eukaryotes Using Chlamydomonas Reinhardtii as a Reference Model by : Chia-Hong Tsai
Download or read book Studies of Cellular Quiescence in Photosynthetic Eukaryotes Using Chlamydomonas Reinhardtii as a Reference Model written by Chia-Hong Tsai and published by . This book was released on 2014 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Plant Cell Cycle written by Dirk Inzé and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the study of the plant cell cycle has become of major interest, not only to scientists working on cell division sensu strictu , but also to scientists dealing with plant hormones, development and environmental effects on growth. The book The Plant Cell Cycle is a very timely contribution to this exploding field. Outstanding contributors reviewed, not only knowledge on the most important classes of cell cycle regulators, but also summarized the various processes in which cell cycle control plays a pivotal role. The central role of the cell cycle makes this book an absolute must for plant molecular biologists.
Book Synopsis Targeted Cancer Treatment in Silico by : Natalia L. Komarova
Download or read book Targeted Cancer Treatment in Silico written by Natalia L. Komarova and published by Springer Science & Business Media. This book was released on 2013-11-19 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: Countless medical researchers over the past century have been occupied by the search for a cure of cancer. So far, they have developed and implemented a wide range of treatment techniques, including surgery, chemo- and radiotherapy, antiangiogenic drugs, small molecule inhibitors, and oncolytic viruses. However, patterns of these treatments' effectiveness remain largely unclear, and a better understanding of how cancer therapies work has become a key research goal. Cancer Treatment in Silico provides the first in-depth study of approaching this understanding by modeling cancer treatments, both mathematically and through computer simulations. The main goal of this book is to help expose students and researchers to in silico methods of studying cancer. It is intended for both the applied mathematics and experimental oncology communities, as mathematical models are playing an increasingly important role to supplement laboratory biology in the fight against cancer. Written at a level that generally requires little technical background, the work will be a valuable resource for scientists and students alike.
