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Author : Eric S. Guire
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.:/5 (72 download)
Download or read book Cellular Mechanisms of Synaptic Plasticity in Hippocampal Area CA1 written by Eric S. Guire and published by . This book was released on 2006 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Federico Bermudez-Rattoni
Publisher : CRC Press
ISBN 13 : 1420008412
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)
Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Author : Roberto De Pasquale
Publisher : Frontiers Media SA
ISBN 13 : 2889767590
Total Pages : 129 pages
Book Rating : 4.8/5 (897 download)
Download or read book Cellular and Molecular Mechanisms of Synaptic Plasticity at Hippocampal and Cortical Synapses written by Roberto De Pasquale and published by Frontiers Media SA. This book was released on 2022-08-11 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ann Emily Fink
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.:/5 (1 download)
Download or read book Mechanisms of Synaptic and Non-synaptic Plasticity in the CA 1 Region of the Hippocampus written by Ann Emily Fink and published by . This book was released on 2008 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Helmut L. Haas
Publisher : Springer Science & Business Media
ISBN 13 : 364273202X
Total Pages : 219 pages
Book Rating : 4.6/5 (427 download)
Download or read book Synaptic Plasticity in the Hippocampus written by Helmut L. Haas and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second time that I have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in Pecs. It was a pleasure to greet the participants in the hope that their valuable contributions will make this meeting a tradition in this town. As one of the hosts of the symposium, I had the sorrowful duty to remind you of the absence of a dear colleague, Professor Graham God dard. His tragic and untimely death represents the irreparable loss of both a friend and an excellent researcher. This symposium is dedicated to his memory. If I compare the topics of the lectures of this symposium with those of the previous one, a striking difference becomes apparent. A dominating tendency of the previous symposium was to attempt to define hippocam pal function or to offer data relevant to supporting or rejecting existing theoretical positions. No such tendency is reflected in the titles of the present symposium, in which most of the contributions deal with hip pocampal phenomena at the most elementary level. Electrical, biochemi cal, biophysical, and pharmacological events at the synaptic, membrane, or intracellular level are analyzed without raising the question of what kind of integral functions these elementary phenomena are a part of.
Author : Sheeja Navakkode
Publisher :
ISBN 13 : 9783836496100
Total Pages : 132 pages
Book Rating : 4.4/5 (961 download)
Download or read book Cellular Mechanisms of Hippocampal Ltp and Ltd Learning and Memory written by Sheeja Navakkode and published by . This book was released on 2008-10-01 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Processes of functional plasticity, i.e. long-lasting changes of the strength of synaptic connectivity in response to relative short-lasting afferent stimulation, are the most likely mechanisms underlying memory storage in the adult brain. The best studied models of functional plasticity are long-term potentiation (LTP) and long-term depression (LTD). Rolipram, a specific type IV- specific cAMP phosphodiesterase (PDE) inhibitor, was used in my initial studies to investigate its effect on late plastic events during functional CA1 plasticity in rat hippocampal slices in vitro. In the later part of my studies, I was interested to investigate the question of what exactly is the putative nature of the synaptic tag. Are there specific "tags" for LTP and LTD?
Author : M. Baudry
Publisher : MIT Press
ISBN 13 : 9780262023597
Total Pages : 292 pages
Book Rating : 4.0/5 (235 download)
Download or read book Synaptic Plasticity written by M. Baudry and published by MIT Press. This book was released on 1993 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date overview of the current status of research on the full scope of synaptic plasticity, including synaptic remodeling in response to damage, long-term depression and long-term potentiation, and learning and memory.Synaptic Plasticity presents an up-to-date overview of the current status of research on the full scope of synaptic plasticity, including synaptic remodeling in response to damage, long-term depression and long-term potentiation, and learning and memory. The contributions are written by leading experts in the field and cover approaches from biochemical, anatomical, physiological, behavioral, and computational levels. They offer hypotheses concerning the molecular and cellular mechanisms that are responsible for the various manifestations of synaptic plasticity and propose models explaining how these cellular events can be linked to the functional and behavioral expressions of these adaptive principles. ContentsIntroduction - Molecular Correlates of Activity-dependent Development and Synaptic Plasticity, S. Hockfield - Molecular Sorting in Neurons, 0. Steward - Molecular and Morphological Responses to Deafferentation in Rodents, C. E. Finch, T. H. McNeill - Forms of Long-term Potentiation Induced by NMDA and Non-NMDA Receptor Activation, T. Teyler, L. Grover - Long-term Potentiation: Biochemical Mechanisms, M. Baudry, G. Lynch - Cerebellar Mechanisms of Long-Term Depression, M. Ito - Long-term Depression: Related Mechanisms in Cerebellum, Neocortex, and Hippocampus, A. Artola, W. Singer - Theory of Synaptic Plasticity in Visual Cortex, N. Intrator, M. F. Bear, L. N. Cooper, M. A. Paradiso - A Theoretical and Experimental Strategy for Realizing a Biologically Based Model of the Hippocampus, T. W. Berger et al - Synaptic Plasticity, Learning, and Memory, S. P. Rose - Synaptic Plasticity and Memory Storage, R. F. Thompson et al
Author : John Badal Piro
Publisher :
ISBN 13 :
Total Pages : 110 pages
Book Rating : 4.:/5 (57 download)
Download or read book Bidirectional Plasticity in CA1 Pyramidal Neurons of the Hamster Hippocampus written by John Badal Piro and published by . This book was released on 1997 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Cary Soares
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (11 download)
Download or read book Mechanisms of Synaptic Homeostasis and Their Influence on Hebbian Plasticity at CA1 Hippocampal Synapses written by Cary Soares and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Information is transferred between neurons in the brain via electrochemical transmission at specialized cell-cell junctions called synapses. These structures are far from being static, but rather are influenced by plasticity mechanisms that alter features of synaptic transmission as means to build routes of information flow in the brain. Hebbian forms of synaptic plasticity - long-term potentiation and long-term depression - have been well studied and are considered to be the cellular basis of learning and memory, although their positive feedback nature is prone to instability. Neurons are also endowed with homeostatic mechanisms of synaptic plasticity that act to stabilize neural network functions by globally tuning synaptic drive. Precisely how neurons orchestrate this adaptive homeostatic response and how it influences Hebbian forms of synaptic plasticity, however, remains only partially understood. Using a combination of whole-cell electrophysiology, two-photon imaging and glutamate uncaging in organotypic hippocampal slices, I have expanded upon the known repertoire of homeostatic mechanisms that increase excitatory synaptic drive when CA1 hippocampal neurons experience a prolonged period of diminished activity. I found that the subunit composition of AMPA and NMDA receptors, the two major glutamate receptor subtypes at excitatory synapses, are altered which, in addition to increasing synaptic strength, are predicted to change the signaling and integrative properties of synaptic transmission. Moreover, I found that the amount of glutamate released from presynaptic terminals during evoked-transmission is enhanced and that this mechanism might, in part, underlie the uniform cell-wide homeostatic increase in synaptic strengths. Lastly, I found that homeostatic strengthening of synaptic transmission reduced the potential for CA1 synapses to exhibit long-term potentiation, and that this was caused by altered presynaptic release dynamics that impeded plasticity induction. Together, this work highlights several mechanistic strategies employed by neurons to increase excitatory synaptic drive during periods of activity deprivation which, in addition to balancing cellular excitability, alters the metaplastic state of synapses.
Author : Per Andersen
Publisher : Oxford University Press
ISBN 13 : 9780195100273
Total Pages : 892 pages
Book Rating : 4.1/5 (2 download)
Download or read book The Hippocampus Book written by Per Andersen and published by Oxford University Press. This book was released on 2007 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampus is one of a group of remarkable structures embedded within the brain's medial temporal lobe. Long known to be important for memory, it has been a prime focus of neuroscience research for many years. The Hippocampus Book promises to facilitate developments in the field in a major way by bringing together, for the first time, contributions by leading international scientists knowledgeable about hippocampal anatomy, physiology, and function. This authoritative volume offers the most comprehensive, up-to-date account of what the hippocampus does, how it does it, and what happens when things go wrong. At the same time, it illustrates how research focusing on this single brain structure has revealed principles of wider generality for the whole brain in relation to anatomical connectivity, synaptic plasticity, cognition and behavior, and computational algorithms. Well-organized in its presentation of both theory and experimental data, this peerless work vividly illustrates the astonishing progress that has been made in unraveling the workings of the brain. The Hippocampus Book is destined to take a central place on every neuroscientist's bookshelf.
Author : Neurosciences Institute (New York, N.Y.)
Publisher : Wiley-Interscience
ISBN 13 :
Total Pages : 808 pages
Book Rating : 4.3/5 (91 download)
Download or read book Synaptic Function written by Neurosciences Institute (New York, N.Y.) and published by Wiley-Interscience. This book was released on 1987 with total page 808 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book consists of five sections. The first section details methods for analyzing both presynaptic and postsynaptic function and emphasizes the molecular aspects of synapses. It describes ongoing studies of neurotransmitter release, voltage- sensitive ion channels, and electronic transmission at gap junctions. The second section focuses on the growing menagerie of neurotransmitters: their catagorization into chemical families, their relation to ion channels, their modulation by second messenger systems and their role in pharmacologic action. The third section considers the important relationship of transmitter diversity and synaptic types to the behavior of actual cellular networks. All of the studies described in these sections point to the necessity of considering interactions between anatomy, chemistry, physiology and pharmacology if synaptic function is to be understood at any one of these levels of analysis.
Author : Enrico Cherubini
Publisher : Frontiers Media SA
ISBN 13 : 2889196313
Total Pages : 167 pages
Book Rating : 4.8/5 (891 download)
Download or read book The CA3 Region of the Hippocampus: How is it? What is it for? How does it do it? written by Enrico Cherubini and published by Frontiers Media SA. This book was released on 2015-08-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CA3 hippocampal region receives information from the entorhinal cortex either directly from the perforant path or indirectly from the dentate gyrus via the mossy fibers (MFs). According to their specific targets (principal/mossy cells or interneurons), MFs terminate with large boutons or small filopodial extensions, respectively. MF-CA3 synapses are characterized by a low probability of release and pronounced frequency-dependent facilitation. In addition MF terminals are endowed with mGluRs that regulate their own release. We will describe the intrinsic membrane properties of pyramidal cells, which can sometimes fire in bursts, together with the geometry of their dendritic arborization. The single layer of pyramidal cells is quite distinct from the six-layered neocortical arrangement. The resulting aligned dendrites provides the substrate for laminated excitatory inputs. They also underlie a precise, diversity of inhibitory control which we will also describe in detail. The CA3 region has an especially rich internal connectivity, with recurrent excitatory and inhibitory loops. In recent years both in vivo and in vitro studies have allowed to better understand functional properties of the CA3 auto-associative network and its role in information processing. This circuit is implicated in encoding spatial representations and episodic memories. It generates physiological population synchronies, including gamma, theta and sharp-waves that are presumed to associate firing in selected assemblies of cells in different behavioral conditions. The CA3 region is susceptible to neurodegeneration during aging and after stresses such as infection or injury. Loss of some CA3 neurones has striking effects on mossy fiber inputs and can facilitate the generation of pathologic synchrony within the CA3 micro-circuit. The aim of this special topic is to bring together experts on the cellular and molecular mechanisms regulating the wiring properties of the CA3 hippocampal microcircuit in both physiological and pathological conditions, synaptic plasticity, behavior and cognition.We will particularly emphasize the dual glutamatergic and GABAergic phenotype of MF-CA3 synapses at early developmental stages and the steps that regulate the integration of newly generated neurons into the adult dentate gyrus-CA3 circuit.
Author : Roberto Malinow
Publisher :
ISBN 13 :
Total Pages : 302 pages
Book Rating : 4.:/5 (29 download)
Download or read book Postsynaptic Voltage-sensititve Mechanisms in Rat Hippocampal CA1 Neurons Underlying Synaptic Plasticity and Intergration written by Roberto Malinow and published by . This book was released on 1986 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tim Bliss
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (661 download)
Download or read book Synaptic Plasticity and Cellular Mechanisms of Memory written by Tim Bliss and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Melanie A. Woodin
Publisher : Springer Science & Business Media
ISBN 13 : 1441969780
Total Pages : 191 pages
Book Rating : 4.4/5 (419 download)
Download or read book Inhibitory Synaptic Plasticity written by Melanie A. Woodin and published by Springer Science & Business Media. This book was released on 2010-11-02 with total page 191 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume will explore the most recent findings on cellular mechanisms of inhibitory plasticity and its functional role in shaping neuronal circuits, their rewiring in response to experience, drug addiction and in neuropathology. Inhibitory Synaptic Plasticity will be of particular interest to neuroscientists and neurophysiologists.
Author : Ales Stuchlik
Publisher : BoD – Books on Demand
ISBN 13 : 1789233569
Total Pages : 180 pages
Book Rating : 4.7/5 (892 download)
Download or read book The Hippocampus written by Ales Stuchlik and published by BoD – Books on Demand. This book was released on 2018-07-11 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.
Author : Steve Morgan
Publisher :
ISBN 13 :
Total Pages : 428 pages
Book Rating : 4.:/5 (495 download)
Download or read book Elucidating the Mechanisms of Induction and Maintenance of Multiple Forms of Synaptic Plasticity in Area CA1 of the Hippocampus written by Steve Morgan and published by . This book was released on 2001 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
