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Author : Olli Jaakkola
Publisher :
ISBN 13 :
Total Pages : 184 pages
Book Rating : 4.:/5 (36 download)
Download or read book Cellular Lipoprotein Metabolism in Atherogenesis written by Olli Jaakkola and published by . This book was released on 1989 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : T. Kita
Publisher : Springer Science & Business Media
ISBN 13 : 4431684247
Total Pages : 530 pages
Book Rating : 4.4/5 (316 download)
Download or read book Lipoprotein Metabolism and Atherogenesis written by T. Kita and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis leading to coronary heart disease and to cerebrovascular disorders is the number one cause of death in industrialized societies. For the last two decades, great ad vances have been made in understanding the pathogenesis of those disorders. Recent studies have revealed that the earliest event in atherogenesis is the adhesion of circulating leukocytes to the vascular endothelial cells and their migration into the subendothelial space. These cells are known to playa central role in the formation of a fatty streak consist ing of lipid-laden foam cells. As pathological events continue, the lesion is converted to a more fibrous lesion associated with vascular smooth muscle cells. To solve the enigma of this complicated process, intensive studies in molecular biology have disclosed the genes involved in those events. Some of the genes have been verified by creation of novel animal models, which have led to novel therapeutic strategies for subjects with atherosclerosis. This volume contains papers presented at the International Symposium on Lipoprotein Metabolism and Atherogenesis held in Kyoto December 5-8, 1998, supported in part by the Japan Intractable Diseases Research Foundation. The following three topics were the focus of the three-day program: I) The molecular approach to studying risk factors and prevention 2) The creation of novel animal models 3) Lipoprotein disorder as a cause of activation of vascular endothelial cells Thirty distinguished researchers from the United States, the United Kingdom, Austria, Finland, Australia, and Japan were invited.
Author : Christian Ehnholm
Publisher : Springer Science & Business Media
ISBN 13 : 3642003001
Total Pages : 385 pages
Book Rating : 4.6/5 (42 download)
Download or read book Cellular Lipid Metabolism written by Christian Ehnholm and published by Springer Science & Business Media. This book was released on 2009-07-07 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: For years lipids have fascinated cell biologists and biochemists due to their profound effects on cell function. "Cellular Lipid Metabolism" highlights new concepts and recent findings, but also reviews important discoveries made in the past. Outstanding international experts contribute 13 chapters on the genetics, molecular and cell biology of lipids. Presenting analyses at the molecular level they reveal the principles by which cellular lipid metabolism functions. Further, numerous intriguing observations that cannot yet be explained are identified, stimulating the readers to future studies. This book provides an invaluable source of information for biomedical researchers in energy metabolism, vascular biology, endocrinology and lipidology.
Author : David Kritchevsky
Publisher : Springer Science & Business Media
ISBN 13 : 1468409670
Total Pages : 433 pages
Book Rating : 4.4/5 (684 download)
Download or read book Drugs, Lipid Metabolism, and Atherosclerosis written by David Kritchevsky and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume comprises the proceedings of the sixth International Symposium on Drugs Affecting Lipid Meta bolism. Since the first of these symposia in 1960 these triennial meetings have been devoted to the exploration of new ideas, new data and new concepts related to lipid metabolism and atherosclerosis. The sixth Meeting was particularly stimulating in this regard. The concept of the "protective" action of HDL was thoroughly explored within the framework of its molecular biology with data on its epidemiological as well as its in vitro mechan ism(s) of action being discussed. The action of drugs on arterial and HDL metabolism was also discussed as were newer aspects of platelet aggregation, especially as related to prostaglandins. New ground was also broken in discussions of lipid mobilization and mechan isms of hypocholesteremia. We are indebted to the many organizations who con tributed generously to the support of this meeting. Among the sponsors, the assistance of the Lorenzini Foundation was especially helpful. As in all meetings of this type, the hard work of the local organizing committee was instrumental in its success. We are grateful to Mrs. Caroline Hyatt and Mr. Ralph Hollerorth for their invaluable help in the secretariat. We are also deeply indebted to Miss Jane T. Kolimaga for her expert assistance in the preparation of this volume. David Kritchevsky Rodolfo Paoletti William L. Holmes vii Contents LIPOPROTEINS AND DRUGS Lipoprotein Metabolism - New Insights from Cell Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 D. Steinberg Lipoprotein Metabolism in Man. . . . . . . . . . . . . . . . . . . .
Author : Claude L. Malmendier
Publisher : Springer Science & Business Media
ISBN 13 : 146841268X
Total Pages : 248 pages
Book Rating : 4.4/5 (684 download)
Download or read book Lipoproteins and Atherosclerosis written by Claude L. Malmendier and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atherosclerosis which accounts in Western Europe for more than 40 % of deaths, is a generalized disease that develops slowly and is symptomless until lesions have become sufficiently severe to cause myocardial or cerebral infarction. Research on specific and precocious markers of atherosclerosis and the development of non invasive techniques for their early detection represent major challenges in biomedical field. We hope that this volume of edited papers, a consequence of the third international colloquium on atherosclerosis, conducted at the University of Brussels, Belgium through the support of the "Fondation de Recherche sur l' AtherosclE,rose" will contribute to this goal. Among the topics discussed the major ones were the mechanism of action of lipolytic enzymes, the deficiency or dysregulation of cellular receptors, the genetic deficiencies of apolipoproteins, and the panoply of external factors as diet, physical exercise, drugs, which mOdify the lipoprotein metabolism. Special interest was also devoted to potent techniques as kinetic analysis of metabolic tracers and use of monoclonal antibodies. Their contribution to the detection and treatment of atherosclerosis will be obviously essential in the future.
Author : Jean-Pierre Montmayeur
Publisher : CRC Press
ISBN 13 : 1420067761
Total Pages : 646 pages
Book Rating : 4.4/5 (2 download)
Download or read book Fat Detection written by Jean-Pierre Montmayeur and published by CRC Press. This book was released on 2009-09-14 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the State-of-the-Art in Fat Taste TransductionA bite of cheese, a few potato chips, a delectable piece of bacon - a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the se
Author : Anatol Kontush
Publisher : John Wiley & Sons
ISBN 13 : 1118158660
Total Pages : 786 pages
Book Rating : 4.1/5 (181 download)
Download or read book High-Density Lipoproteins written by Anatol Kontush and published by John Wiley & Sons. This book was released on 2011-11-30 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete guide to the role of high-density lipoproteins (HDL) in new and emerging therapies With high-density lipoproteins (HDL) playing an increasing role in cardiovascular disease prevention, there is a growing need for an in-depth look at HDL and its clinical value. This book summarizes the current state of knowledge in the field, providing for the first time a comprehensive, systematic, stylistically coherent, and up-to-date review of the composition, structure, heterogeneity, metabolism, epidemiology, genetics, and function of HDL. Divided into three main parts, High-Density Lipoproteins first examines normal HDL particles, then describes defective HDL, and finally addresses the therapeutic normalization of subnormal levels and defective biological activities of this lipoprotein class. The book highlights the functional properties of HDL, which are relevant to the pathophysiology of atherosclerosis and thrombosis, and discusses the compositional and metabolic heterogeneity of HDL particles. Readers will come away with a clear understanding of the role of HDL in biological processes, the potential value of functional HDL as a therapeutic target, and how current and emerging therapies are poised to influence the treatment of heart disease in the future.
Author : Linda L. Gallo
Publisher : Springer
ISBN 13 :
Total Pages : 630 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cardiovascular Disease written by Linda L. Gallo and published by Springer. This book was released on 1987-11-30 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth Annual International Spring Symposium on Health Sciences, held in Washington, D. C. , in May 1986, brought together over 650 scientists from 19 countries to review and update research on cardiovascular disease. In this volume, which contains 59 chapters, an internationally recognized group of authors con tribute up-to-date accounts of molecular and cellular processes occurring in the vessel wall in atherogenesis and describe approaches to the prevention and treatment of atherosclerosis. The volume is divided into six major sections. Two sections deal with current aspects of lipoprotein metabolism. In Part I, we are alerted to the impact on li poprotein metabolism of structural heterogeneity within the four broad lipoprotein classes. Attention then turns to the components that orchestrate lipoprotein metab olism. Apolipoprotein identities, processing, and functions are described, as are the roles of lipid transfer proteins in plasma lipoprotein remodeling. Hepatic lipase synthesis and secretion are described. In Part II, Nobel Laureates Michael S. Brown and Joseph L. Goldstein describe mutations in the LDL receptor that reveal the functions of its various domains and point out how understanding the LDL receptor has provided a rational basis for its regulation. A discussion of the role of receptors in regulating cholesterol uptake by tissues follows, with emphasis on receptor-ligand interactions. Additional pathways for cholesterol delivery to cells are explored, as are pathways for cholesterol egress.
Author : Armin Steinmetz
Publisher : Springer Science & Business Media
ISBN 13 : 3642836658
Total Pages : 196 pages
Book Rating : 4.6/5 (428 download)
Download or read book Cholesterol Transport Systems and Their Relation to Atherosclerosis written by Armin Steinmetz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of clinical and epidemiological studies have shown that disorders of lipoprotein metabolism constitute one of the most important risk factors for the development of atherosclerosis and coronary heart disease. This volume examines the state of the art of lipoprotein subclass metabolism and its relation to these diseases. The authors also report on new developments concerning the role of lipoprotein recptors, macrophages and apolipoprotein E polymorphism in cholesterol homeostasis. The combination of general outline form and very specific aspects of cholesterol transport will interest those in other disciplines following developments in the field, as well as those directly involved in lipoprotein research.
Author : Linda L. Gallo
Publisher : Springer
ISBN 13 : 9780306425370
Total Pages : 608 pages
Book Rating : 4.4/5 (253 download)
Download or read book Cardiovascular Disease written by Linda L. Gallo and published by Springer. This book was released on 1987-11-30 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Sixth Annual International Spring Symposium on Health Sciences, held in Washington, D. C. , in May 1986, brought together over 650 scientists from 19 countries to review and update research on cardiovascular disease. In this volume, which contains 59 chapters, an internationally recognized group of authors con tribute up-to-date accounts of molecular and cellular processes occurring in the vessel wall in atherogenesis and describe approaches to the prevention and treatment of atherosclerosis. The volume is divided into six major sections. Two sections deal with current aspects of lipoprotein metabolism. In Part I, we are alerted to the impact on li poprotein metabolism of structural heterogeneity within the four broad lipoprotein classes. Attention then turns to the components that orchestrate lipoprotein metab olism. Apolipoprotein identities, processing, and functions are described, as are the roles of lipid transfer proteins in plasma lipoprotein remodeling. Hepatic lipase synthesis and secretion are described. In Part II, Nobel Laureates Michael S. Brown and Joseph L. Goldstein describe mutations in the LDL receptor that reveal the functions of its various domains and point out how understanding the LDL receptor has provided a rational basis for its regulation. A discussion of the role of receptors in regulating cholesterol uptake by tissues follows, with emphasis on receptor-ligand interactions. Additional pathways for cholesterol delivery to cells are explored, as are pathways for cholesterol egress.
Author : Antonio M. Gotto
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.3/5 (91 download)
Download or read book Plasma Lipoproteins written by Antonio M. Gotto and published by Elsevier Publishing Company. This book was released on 1987 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this rapidly evolving field of research, an enormous amount of new knowledge of lipoprotein structure, function and metabolism has emerged. The 1985 Nobel Prize-winning pioneering work of Brown and Goldstein on the LDL receptor has had a profound impact on developments in the field. This work is one of the many subjects reviewed in detail in this book. The volume begins with chapters on structure, then proceeds to analysis of lipid and lipoprotein dynamics, metabolism, function, genetics, and molecular biology. Lipoprotein genetics in molecular biology, the role of lipoprotein receptors, and Lp(a) - a topic underrepresented in volumes on lipoproteins, are another three such topics in an impressive volume. This work will mainly be of interest to researchers interested in lipid and lipoprotein structure and metabolism, but will also be of great value to clinical medicine and biology in general.
Author : M. Palkovič
Publisher : Elsevier
ISBN 13 : 1483153835
Total Pages : 557 pages
Book Rating : 4.4/5 (831 download)
Download or read book Hormones, Lipoproteins and Atherosclerosis written by M. Palkovič and published by Elsevier. This book was released on 2013-10-22 with total page 557 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormones, Lipoproteins and Atherosclerosis, Volume 35, emerged from the international symposium on ""Hormones, Lipoproteins and Atherosclerosis"" held in Bratislava, Czechoslovakia. The symposium was devoted to the problems of hormonal effects on lipoprotein metabolism and atherosclerosis, and was also concerned with problems of composition, structure, synthesis, and degradation of liporoteins, as well as with genetical and clinical aspects. The participants of the symposium have contributed to this volume not only by presenting new data but also new ideas and stimulating new trends in the research and therapy of metabolic derangements of lipoproteins and the resulting pathological conditions. The 51 contributions are organized into five parts. Part I includes papers on the metabolism of lipoproteins. Part II presents studies on hormones and lipoproteins. Part III is devoted to atherosclerosis and lipoproteins. Part IV takes up the clinical aspects of hyperlipoproteinemias. Part V on methods contains two studies—the first on the isolation of human plasma high density lipoproteins; the second on the separation of subfractions of the serum triacylglycerols.
Author : Arnold von Eckardstein
Publisher : Springer
ISBN 13 : 9783319096643
Total Pages : 0 pages
Book Rating : 4.0/5 (966 download)
Download or read book High Density Lipoproteins written by Arnold von Eckardstein and published by Springer. This book was released on 2015-01-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
Author : Robert Fitridge
Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.9/5 (22 download)
Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.
Author : Robert I. Levy
Publisher :
ISBN 13 : 9780881674026
Total Pages : 311 pages
Book Rating : 4.6/5 (74 download)
Download or read book Lipoproteins and Atherosclerosis written by Robert I. Levy and published by . This book was released on 1988 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rob Krams
Publisher : Oxford University Press
ISBN 13 : 0198755775
Total Pages : 347 pages
Book Rating : 4.1/5 (987 download)
Download or read book The ESC Textbook of Vascular Biology written by Rob Krams and published by Oxford University Press. This book was released on 2017 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and research.
Author : Heiner Greten
Publisher : Springer
ISBN 13 :
Total Pages : 324 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cellular Metabolism of the Arterial Wall and Central Nervous System written by Heiner Greten and published by Springer. This book was released on 1993-05-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: International experts review the molecular biology of ion channels, diseases of the central nervous system including Alzheimer's disease, the molecular biology of atherogenesis, plasma lipproteins, lipid transport, long chain fatty acid transport and metabolism, and lipoprotein receptors. Future directions and perspectives and common features in these important areas are discussed.
