Cellular Connectomics

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Micro-, Meso- and Macro-Connectomics of the Brain

Author : Henry Kennedy
Publisher : Springer
ISBN 13 : 3319277774
Total Pages : 173 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Micro-, Meso- and Macro-Connectomics of the Brain by : Henry Kennedy

Download or read book Micro-, Meso- and Macro-Connectomics of the Brain written by Henry Kennedy and published by Springer. This book was released on 2016-03-10 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has brought together leading investigators who work in the new arena of brain connectomics. This includes ‘macro-connectome’ efforts to comprehensively chart long-distance pathways and functional networks; ‘micro-connectome’ efforts to identify every neuron, axon, dendrite, synapse, and glial process within restricted brain regions; and ‘meso-connectome’ efforts to systematically map both local and long-distance connections using anatomical tracers. This book highlights cutting-edge methods that can accelerate progress in elucidating static ‘hard-wired’ circuits of the brain as well as dynamic interactions that are vital for brain function. The power of connectomic approaches in characterizing abnormal circuits in the many brain disorders that afflict humankind is considered. Experts in computational neuroscience and network theory provide perspectives needed for synthesizing across different scales in space and time. Altogether, this book provides an integrated view of the challenges and opportunities in deciphering brain circuits in health and disease.

Cellular Connectomics

Author : Moritz Helmstaedter
Publisher : Academic Press
ISBN 13 : 9780124103955
Total Pages : 0 pages
Book Rating : 4.1/5 (39 download)

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Book Synopsis Cellular Connectomics by : Moritz Helmstaedter

Download or read book Cellular Connectomics written by Moritz Helmstaedter and published by Academic Press. This book was released on 2016-01-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cellular connectomics is technically challenging and highly multi-disciplinary, creating need for a connectomics methods volume suitable for both researchers and students aiming to gain familiarity with the field. "Cellular Connectomics "offers just that: an accessible, practical and comprehensive introduction to the fundamental principles and practices of cellular connectomics. With the bulk of the volume written by two pioneers in the field, plus 3 chapters authored by opinion leaders offering future predictions, the volume offers readers both consistent voice/uniform structure and cutting edge insights. Focusing on "cellular" connectomics with the goal of reconstructing neuronal wiring diagrams at the level of single neurons/synapses, the volume provides a conceptual overview of the goals and challenges of this methodology. The first volume to offer a step-by-step introduction to cellular connectomics suitable for both researchers and students.Coverage includes: tissue preparation, sectioning and imaging techniques, approaches for data reconstruction, circuit analysis, and an explanation of successful connectomic reconstructions to date.Offers balanced discussion what does and does not work, as well as of the current debates about whether a connectomic era is going to replace decades of functional data collection.

Connectomic Deep Brain Stimulation

Author : Andreas Horn
Publisher : Academic Press
ISBN 13 : 0128218622
Total Pages : 602 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Connectomic Deep Brain Stimulation by : Andreas Horn

Download or read book Connectomic Deep Brain Stimulation written by Andreas Horn and published by Academic Press. This book was released on 2021-09-10 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson's Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. - Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery - Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) - Presents references (key articles, books and protocols) for additional detailed study - Provides data analysis boxes in each chapter to help with data interpretation

Fundamentals of Brain Network Analysis

Author : Alex Fornito
Publisher : Academic Press
ISBN 13 : 0124081185
Total Pages : 496 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Fundamentals of Brain Network Analysis by : Alex Fornito

Download or read book Fundamentals of Brain Network Analysis written by Alex Fornito and published by Academic Press. This book was released on 2016-03-04 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals of Brain Network Analysis is a comprehensive and accessible introduction to methods for unraveling the extraordinary complexity of neuronal connectivity. From the perspective of graph theory and network science, this book introduces, motivates and explains techniques for modeling brain networks as graphs of nodes connected by edges, and covers a diverse array of measures for quantifying their topological and spatial organization. It builds intuition for key concepts and methods by illustrating how they can be practically applied in diverse areas of neuroscience, ranging from the analysis of synaptic networks in the nematode worm to the characterization of large-scale human brain networks constructed with magnetic resonance imaging. This text is ideally suited to neuroscientists wanting to develop expertise in the rapidly developing field of neural connectomics, and to physical and computational scientists wanting to understand how these quantitative methods can be used to understand brain organization. - Winner of the 2017 PROSE Award in Biomedicine & Neuroscience and the 2017 British Medical Association (BMA) Award in Neurology - Extensively illustrated throughout by graphical representations of key mathematical concepts and their practical applications to analyses of nervous systems - Comprehensively covers graph theoretical analyses of structural and functional brain networks, from microscopic to macroscopic scales, using examples based on a wide variety of experimental methods in neuroscience - Designed to inform and empower scientists at all levels of experience, and from any specialist background, wanting to use modern methods of network science to understand the organization of the brain

Connectome

Author : Sebastian Seung
Publisher : HMH
ISBN 13 : 0547508174
Total Pages : 389 pages
Book Rating : 4.5/5 (475 download)

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Book Synopsis Connectome by : Sebastian Seung

Download or read book Connectome written by Sebastian Seung and published by HMH. This book was released on 2012-02-07 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Accessible, witty . . . an important new researcher, philosopher and popularizer of brain science . . . on par with cosmology’s Brian Greene and the late Carl Sagan” (The Plain Dealer). One of the Wall Street Journal’s 10 Best Nonfiction Books of the Year and a Publishers Weekly “Top Ten in Science” Title Every person is unique, but science has struggled to pinpoint where, precisely, that uniqueness resides. Our genome may determine our eye color and even aspects of our character. But our friendships, failures, and passions also shape who we are. The question is: How? Sebastian Seung is at the forefront of a revolution in neuroscience. He believes that our identity lies not in our genes, but in the connections between our brain cells—our particular wiring. Seung and a dedicated group of researchers are leading the effort to map these connections, neuron by neuron, synapse by synapse. It’s a monumental effort, but if they succeed, they will uncover the basis of personality, identity, intelligence, memory, and perhaps disorders such as autism and schizophrenia. Connectome is a mind-bending adventure story offering a daring scientific and technological vision for understanding what makes us who we are, as individuals and as a species. “This is complicated stuff, and it is a testament to Dr. Seung’s remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man.” —TheNew York Times “An elegant primer on what’s known about how the brain is organized and how it grows, wires its neurons, perceives its environment, modifies or repairs itself, and stores information. Seung is a clear, lively writer who chooses vivid examples.” —TheWashington Post

Discovering the Human Connectome

Author : Olaf Sporns
Publisher : MIT Press
ISBN 13 : 0262304805
Total Pages : 253 pages
Book Rating : 4.2/5 (623 download)

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Book Synopsis Discovering the Human Connectome by : Olaf Sporns

Download or read book Discovering the Human Connectome written by Olaf Sporns and published by MIT Press. This book was released on 2012-09-07 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pioneer in the field outlines new empirical and computational approaches to mapping the neural connections of the human brain. Crucial to understanding how the brain works is connectivity, and the centerpiece of brain connectivity is the connectome, a comprehensive description of how neurons and brain regions are connected. In this book, Olaf Sporns surveys current efforts to chart these connections—to map the human connectome. He argues that the nascent field of connectomics has already begun to influence the way many neuroscientists collect, analyze, and think about their data. Moreover, the idea of mapping the connections of the human brain in their entirety has captured the imaginations of researchers across several disciplines including human cognition, brain and mental disorders, and complex systems and networks. Discovering the Human Connectome offers the first comprehensive overview of current empirical and computational approaches in this rapidly developing field.

Decoding Neural Circuit Structure and Function

Author : Arzu Çelik
Publisher : Springer
ISBN 13 : 3319573632
Total Pages : 517 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Decoding Neural Circuit Structure and Function by : Arzu Çelik

Download or read book Decoding Neural Circuit Structure and Function written by Arzu Çelik and published by Springer. This book was released on 2017-07-24 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers representative examples from fly and mouse models to illustrate the ongoing success of the synergistic, state-of-the-art strategy, focusing on the ways it enhances our understanding of sensory processing. The authors focus on sensory systems (vision, olfaction), which are particularly powerful models for probing the development, connectivity, and function of neural circuits, to answer this question: How do individual nerve cells functionally cooperate to guide behavioral responses? Two genetically tractable species, mice and flies, together significantly further our understanding of these processes. Current efforts focus on integrating knowledge gained from three interrelated fields of research: (1) understanding how the fates of different cell types are specified during development, (2) revealing the synaptic connections between identified cell types (“connectomics”) using high-resolution three-dimensional circuit anatomy, and (3) causal testing of how iden tified circuit elements contribute to visual perception and behavior.

Volume Microscopy

Author : Irene Wacker
Publisher : Humana
ISBN 13 : 9781071606933
Total Pages : 306 pages
Book Rating : 4.6/5 (69 download)

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Book Synopsis Volume Microscopy by : Irene Wacker

Download or read book Volume Microscopy written by Irene Wacker and published by Humana. This book was released on 2021-07-14 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses different approaches to workflows for large volume electron microscopy - from preparation of samples to their imaging in a variety of microscopes - in some cases also applying correlative techniques. The chapters in this book cover topics such as correlative super resolution and electron microscopy to detect molecules in their native cellular context; low-threshold access to serial section arrays; improving serial blockface SEM by focal charge compensation; FIBSEM analysis of interfaces between hard technical devices and soft neuronal tissue; and image processing for volume electron microscopy. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and authoritative, Volume Microscopy: Multiscale Imaging with Photons, Electrons, and Ions is a valuable resource for novice and expert scientists interested in learning more about this evolving field.

Neural Circuits Revealed

Author : Mariano Soiza-Reilly
Publisher : Frontiers Media SA
ISBN 13 : 2889195619
Total Pages : 183 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Neural Circuits Revealed by : Mariano Soiza-Reilly

Download or read book Neural Circuits Revealed written by Mariano Soiza-Reilly and published by Frontiers Media SA. This book was released on 2015-09-14 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deciphering anatomical and functional maps in the nervous system is a main challenge for both clinical and basic neuroscience. Modern approaches to mark and manipulate neurons are bringing us closer than ever to better understand nervous system wiring diagrams. Here we present both original research and review material on current work in this area. Together, this eBook aims to provide a comprehensive snapshot of some of the tools and technologies currently available to investigate brain wiring and function, as well as discuss ongoing challenges the field will be confronted with in the future.

Electron-Microscopy-Based Tools for Imaging Cellular Circuits and Organisms

Author : Yoshiyuki Kubota
Publisher : Frontiers Media SA
ISBN 13 : 2889632571
Total Pages : 220 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Electron-Microscopy-Based Tools for Imaging Cellular Circuits and Organisms by : Yoshiyuki Kubota

Download or read book Electron-Microscopy-Based Tools for Imaging Cellular Circuits and Organisms written by Yoshiyuki Kubota and published by Frontiers Media SA. This book was released on 2019-12-30 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cortex: Statistics and Geometry of Neuronal Connectivity

Author : Valentino Braitenberg
Publisher : Springer Science & Business Media
ISBN 13 : 3662037335
Total Pages : 243 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Cortex: Statistics and Geometry of Neuronal Connectivity by : Valentino Braitenberg

Download or read book Cortex: Statistics and Geometry of Neuronal Connectivity written by Valentino Braitenberg and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: By means of quantitative analysis of the tissue components in the cortex of the mouse, this book presents an overall picture of the cortical network which is then related to various theories on cortical function. Centering around the idea of a diffuse network in a fairly homogeneous population of excitatory neurons, that of the pyramidal cells, it shows that the whole organisation in the cortical skeleton of pryramidal cells corresponds well with the idea of an associative memory and with the theory of cell assemblies. Provides the reader with information on quantitative neuroanatomy and also on the methods used, in particular those that vary from the norm.

Brain Architecture : Understanding the Basic Plan

Author : and Director NIBS Neuroscience Program University of Southern California Larry W. Swanson Milo Don and Lucille Appleman Professor of Biological Sciences
Publisher : Oxford University Press, USA
ISBN 13 : 0198026463
Total Pages : 283 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis Brain Architecture : Understanding the Basic Plan by : and Director NIBS Neuroscience Program University of Southern California Larry W. Swanson Milo Don and Lucille Appleman Professor of Biological Sciences

Download or read book Brain Architecture : Understanding the Basic Plan written by and Director NIBS Neuroscience Program University of Southern California Larry W. Swanson Milo Don and Lucille Appleman Professor of Biological Sciences and published by Oxford University Press, USA. This book was released on 2002-10-23 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: Depending on your point of view the brain is an organ, a machine, a biological computer, or simply the most important component of the nervous system. How does it work as a whole? What are its major parts and how are they interconnected to generate thinking, feelings, and behavior? This book surveys 2,500 years of scientific thinking about these profoundly important questions from the perspective of fundamental architectural principles, and then proposes a new model for the basic plan of neural systems organization based on an explosion of structural data emerging from the neuroanatomy revolution of the 1970's. The importance of a balance between theoretical and experimental morphology is stressed throughout the book. Great advances in understanding the brain's basic plan have come especially from two traditional lines of biological thought-- evolution and embryology, because each begins with the simple and progresses to the more complex. Understanding the organization of brain circuits, which contain thousands of links or pathways, is much more difficult. It is argued here that a four-system network model can explain the structure-function organization of the brain. Possible relationships between neural networks and gene networks revealed by the human genome project are explored in the final chapter. The book is written in clear and sparkling prose, and it is profusely illustrated. It is designed to be read by anyone with an interest in the basic organization of the brain, from neuroscience to philosophy to computer science to molecular biology. It is suitable for use in neuroscience core courses because it presents basic principles of the structure of the nervous system in a systematic way.

Gap Junctions in the Nervous System

Author : David C. Spray
Publisher : Springer Science & Business Media
ISBN 13 : 3662219352
Total Pages : 321 pages
Book Rating : 4.6/5 (622 download)

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Book Synopsis Gap Junctions in the Nervous System by : David C. Spray

Download or read book Gap Junctions in the Nervous System written by David C. Spray and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with the types of gap junction proteins (connexins) and their distribution within the nervous system, the physiological properties of channels formed of each connexin, and the role of gap junction channels in functions of normal and pathological brain and peripheral nerve. Although glial tissue is emphasized, additional groups of chapters deal with neurons in the central nervous system and with the retina.

Innate

Author : Kevin J. Mitchell
Publisher : Princeton University Press
ISBN 13 : 0691204152
Total Pages : 305 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Innate by : Kevin J. Mitchell

Download or read book Innate written by Kevin J. Mitchell and published by Princeton University Press. This book was released on 2020-03-31 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: "What makes you the way you are--and what makes each of us different from everyone else? In Innate, leading neuroscientist and popular science blogger Kevin Mitchell traces human diversity and individual differences to their deepest level: in the wiring of our brains. Deftly guiding us through important new research, including his own groundbreaking work, he explains how variations in the way our brains develop before birth strongly influence our psychology and behavior throughout our lives, shaping our personality, intelligence, sexuality, and even the way we perceive the world. We all share a genetic program for making a human brain, and the program for making a brain like yours is specifically encoded in your DNA. But, as Mitchell explains, the way that program plays out is affected by random processes of development that manifest uniquely in each person, even identical twins. The key insight of Innate is that the combination of these developmental and genetic variations creates innate differences in how our brains are wired--differences that impact all aspects of our psychology--and this insight promises to transform the way we see the interplay of nature and nurture. Innate also explores the genetic and neural underpinnings of disorders such as autism, schizophrenia, and epilepsy, and how our understanding of these conditions is being revolutionized. In addition, the book examines the social and ethical implications of these ideas and of new technologies that may soon offer the means to predict or manipulate human traits. Compelling and original, Innate will change the way you think about why and how we are who we are."--Provided by the publisher.

Ay's Neuroanatomy of C. Elegans for Computation

Author : Theodore B. Achacoso
Publisher : CRC Press
ISBN 13 : 9780849342349
Total Pages : 298 pages
Book Rating : 4.3/5 (423 download)

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Book Synopsis Ay's Neuroanatomy of C. Elegans for Computation by : Theodore B. Achacoso

Download or read book Ay's Neuroanatomy of C. Elegans for Computation written by Theodore B. Achacoso and published by CRC Press. This book was released on 1991-11-22 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: AY's Neuroanatomy of C. elegans for Computation provides the neural circuitry database of the nematode Caenorhabditis elegans, both in printed form and in ASCII files on 5.25-inch diskettes (for use on IBM® and compatible personal computers, Macintosh® computers, and higher level machines). Tables of connections among neuron classes, synapses among individual neurons, gap junctions among neurons, worm cells and their embryonic origin, and synthetically derived neuromuscular connections are presented together with the references from which the data were compiled and edited. Sample data files and source codes of FORTRAN and BASIC programs are provided to illustrate the use of mathematical tools for any researcher or student interested in examining a natural neural network and discovering what makes it tick.

Cellular Structure of the Human Cerebral Cortex

Author : Constantin von Economo
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 380559061X
Total Pages : 266 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Cellular Structure of the Human Cerebral Cortex by : Constantin von Economo

Download or read book Cellular Structure of the Human Cerebral Cortex written by Constantin von Economo and published by Karger Medical and Scientific Publishers. This book was released on 2009-01-01 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally published in German and French, the work is considered to be unsurpassed in both its scientific eloquence and accurate photographic documentation. Revising Brodmann's cortical parcellation system, von Economo took cytoarchitectonics to a new zenith.>The revised edition contains newly compiled tables with extensive quantitative data on the 107 cytoarchitectonic areas of Economo and Koskinas, plus all the 'transition' areas and full reproductions of the original microphotographs. It also contains the concluding chapter that appeared only in the 1929 English edition, with Economo's later views on cytoarchitectonic neuropathology and evolutionary neuroscience, enriched with material and figures from his later studies. Last but not least a newly discovered manuscript by Georg N. Koskinas, appears in English for the first time. In it, Economo's collaborator presents an insightful analysis of the 'General Part' of their larger textbook of cytoarchitectonics.

Connectome Analysis

Author : Markus D. Schirmer
Publisher : Academic Press
ISBN 13 : 0323852815
Total Pages : 480 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Connectome Analysis by : Markus D. Schirmer

Download or read book Connectome Analysis written by Markus D. Schirmer and published by Academic Press. This book was released on 2023-06-30 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connectome Analysis: Characterization, Methods, and Analysis is a comprehensive companion for the analysis of brain networks, or connectomes. The book provides sources of constituent structural and functional MRI signals, network construction and practices for analysis, cutting-edge methods that address the latest challenges in neuroscience, and the fundamentals of network theory in the context of giving practical methods for building connectomes for analysis. Emphasis is placed on quality control of the individual analysis steps. Subsequent chapters discuss networks in neuroscience in clinical and general populations, including how findings are related to underlying neurophysiology and neuropsychology. This book is aimed at students and early-career researchers in brain connectomics and neuroimaging who have a background in computer science, mathematics and physics, as well as more broadly to neuroscientists and psychologists who want to start incorporating connectomics into their research. - Provides practical recommendations on how to construct, assess and analyze brain networks - Gives an understanding of all the technical methods for connectome analysis - Presents the basic network theoretical principles typically used in neuroscience - Covers the latest tools and data repositories that are freely available for the reader to carry out connectomic analyses