Cell Signaling During Mammalian Early Embryo Development

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Publisher : Springer
ISBN 13 : 149392480X
Total Pages : 216 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Cell Signaling During Mammalian Early Embryo Development by : Henry J. Leese

Download or read book Cell Signaling During Mammalian Early Embryo Development written by Henry J. Leese and published by Springer. This book was released on 2015-05-08 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.

Signalling Pathways in Embryonic Development

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889453464
Total Pages : 179 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Signalling Pathways in Embryonic Development by : Juan J. Sanz-Ezquerro

Download or read book Signalling Pathways in Embryonic Development written by Juan J. Sanz-Ezquerro and published by Frontiers Media SA. This book was released on 2017-11-30 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of a complex multicellular organism from a single cell is one of the most amazing processes of biology. Embryonic development is characterised by the careful regulation of cellular behaviours such that cells proliferate, migrate, differentiate and form tissues at the correct place and time. These processes are genetically controlled and depend both on the history of cells, their lineage, and on the activities of signalling pathways, which coordinate the cell interactions leading to organogenesis. The aim of the Frontiers research topic “Signalling pathways in embryonic development” has been to provide a forum for experts in cell and developmental biology to share recent advances in the field of signalling during embryonic development. Sixteen articles in a variety of formats are united in this Topic, offering a valuable collection for researchers looking for an update in the knowledge of signalling pathways operating during embryogenesis. The works, focused mainly on vertebrates, explore different aspects of this theme from cell communication to organ formation and have implications for areas as distant as evolution or pathology. Understanding developmental signalling pathways is important for several reasons. It gives us information about basic mechanisms of cell function and interactions needed for morphogenesis and organogenesis. It uncovers the basis of congenital malformations, since errors at any step of cell signalling during development are a major cause of defects. This fundamental insight gives us clues to understand the mechanisms operating in evolution that explain diversity in form and function. And finally, it allows the identification of possible causes of disease in the adult organism (such as cancer or degenerative diseases) pinpointing possible targets for therapeutic approaches.

Mammalian Development

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Author :
Publisher :
ISBN 13 : 9781936113248
Total Pages : 0 pages
Book Rating : 4.1/5 (132 download)

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Book Synopsis Mammalian Development by : Patrick P. L. Tam

Download or read book Mammalian Development written by Patrick P. L. Tam and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: "A subject collection from Cold Spring Harbor perspectives in biology."

Early Mammalian Development

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Author :
Publisher : CUP Archive
ISBN 13 : 9780521254496
Total Pages : 296 pages
Book Rating : 4.2/5 (544 download)

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Book Synopsis Early Mammalian Development by : Matthew H. Kaufman

Download or read book Early Mammalian Development written by Matthew H. Kaufman and published by CUP Archive. This book was released on 1983-10-06 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cell Fate in Mammalian Development

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Author :
Publisher : Academic Press
ISBN 13 : 0128043350
Total Pages : 347 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Cell Fate in Mammalian Development by :

Download or read book Cell Fate in Mammalian Development written by and published by Academic Press. This book was released on 2018-02-21 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Fate in Mammalian Development, Volume 128, the latest release in the Current Topics in Developmental Biology series, provides reviews on cell fate in mammalian development. Each chapter is written by an international board of authors, with this release including sections on the Specification of extra-embryonic lineages during mouse pre-implantation development, Cell polarity and fate specification, The circuitry that drives trophectoderm identity, Breaking symmetry and the dynamics of transcription factors directing cell fate specification, Mechanics and cell fate, How physical properties of cells change in development and their effect on cell fate decisions, and more. Provides the authority and expertise of leading contributors from an international board of authors Includes new sections on the specification of extra-embryonic lineages during mouse pre-implantation development, cell polarity and fate specification, the circuitry that drives trophectoderm identity, and more Presents the latest release in the Current Topics in Developmental Biology series

Examining the State of the Science of Mammalian Embryo Model Systems

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Publisher : National Academies Press
ISBN 13 : 0309676711
Total Pages : 155 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Examining the State of the Science of Mammalian Embryo Model Systems by : National Academies of Sciences, Engineering, and Medicine

Download or read book Examining the State of the Science of Mammalian Embryo Model Systems written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-31 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because of the recent advances in embryo modeling techniques, and at the request of the Office of Science Policy in the Office of the Director at the National Institutes of Health, the National Academies of Sciences, Engineering, hosted a 1-day public workshop that would explore the state of the science of mammalian embryo model systems. The workshop, which took place on January 17, 2020, featured a combination of presentations, panels, and general discussions, during which panelists and participants offered a broad range of perspectives. Participants considered whether embryo model systems - especially those that use nonhuman primate cells - can be used to predict the function of systems made with human cells. Presentations provided an overview of the current state of the science of in vitro development of human trophoblast. This publication summarizes the presentation and discussion of the workshop.

Stem Cells and the Future of Regenerative Medicine

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Publisher : National Academies Press
ISBN 13 : 0309170427
Total Pages : 112 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Stem Cells and the Future of Regenerative Medicine by : Institute of Medicine

Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.

Mammalian Preimplantation Development

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Author :
Publisher : Academic Press
ISBN 13 : 0128016175
Total Pages : 478 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mammalian Preimplantation Development by :

Download or read book Mammalian Preimplantation Development written by and published by Academic Press. This book was released on 2016-07-26 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mammalian Preimplantation Development, the latest volume in the Current Topics in Developmental Biology series covers mammalian preimplantation development, and includes contributions from an international board of authors. The book's chapters provide a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance. Covers the area of mammalian preimplantation development Includes contributions from an International board of authors Provides a comprehensive set of reviews covering such topics as cell proliferation, cell differentiation, and biological significance

Cell Movements

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Publisher : Garland Science
ISBN 13 : 9780815332824
Total Pages : 396 pages
Book Rating : 4.3/5 (328 download)

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Book Synopsis Cell Movements by : Dennis Bray

Download or read book Cell Movements written by Dennis Bray and published by Garland Science. This book was released on 2001 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book vividly describes how complex and integrated movements can arise from the properties and behaviors of biological molecules. It provides a uniquely integrated account in which the latest findings from biophysics and molecular biology are put into the context of living cells. This second edition is updated throughout with recent advances in the field and has a completely revised and redrawn art program. The text is suitable for advanced undergraduates, graduate students, and for professionals wishing for an overview of this field.

Analysis of Growth Factor Signaling in Embryos

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Publisher : CRC Press
ISBN 13 : 9780849331657
Total Pages : 435 pages
Book Rating : 4.3/5 (316 download)

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Book Synopsis Analysis of Growth Factor Signaling in Embryos by : Malcolm Whitman

Download or read book Analysis of Growth Factor Signaling in Embryos written by Malcolm Whitman and published by CRC Press. This book was released on 2006-08-15 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental biologists have been driven to investigate growth factor signaling in embryos in order to understand the regulatory mechanisms underlying a given developmental process. Thus, it is critical to explore the technical methods and experimental designs for growth factor signaling in embryos. Focusing on specific pathways or pathway components, Analysis of Growth Factor Signaling in Embryos provides the methods and guidelines for experimental design to study major aspects of cell signaling in vertebrate embryos. The book covers a broad range of topics in signaling and a variety of current model organisms. Section I explores specific signaling pathways or pathway components. In this section, some chapters highlight the biochemistry of signaling pathways during development, which is often distinctive from that observed in cell culture systems. Section II discusses ionic regulatory mechanisms and the two chapters in Section III examine ways of investigating gene regulation in response to extracellular signals. Finally, Section IV addresses emerging strategies that facilitate integrated analyses of cell signaling in vivo in embryonic systems. Featuring contributions from expert researchers, Analysis of Growth Factor Signaling in Embryos will provide a foundation for further explorations of the cellular regulatory mechanisms governing vertebrate embryonic development.

Maternal Control of Development in Vertebrates

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Publisher : Morgan & Claypool Publishers
ISBN 13 : 161504051X
Total Pages : 221 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Maternal Control of Development in Vertebrates by : Florence Louise Marlow

Download or read book Maternal Control of Development in Vertebrates written by Florence Louise Marlow and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Eggs of all animals contain mRNAs and proteins that are supplied to or deposited in the egg as it develops during oogenesis. These maternal gene products regulate all aspects of oocyte development, and an embryo fully relies on these maternal gene products for all aspects of its early development, including fertilization, transitions between meiotic and mitotic cell cycles, and activation of its own genome. Given the diverse processes required to produce a developmentally competent egg and embryo, it is not surprising that maternal gene products are not only essential for normal embryonic development but also for fertility. This review provides an overview of fundamental aspects of oocyte and early embryonic development and the interference and genetic approaches that have provided access to maternally regulated aspects of vertebrate development. Some of the pathways and molecules highlighted in this review, in particular, Bmps, Wnts, small GTPases, cytoskeletal components, and cell cycle regulators, are well known and are essential regulators of multiple aspects of animal development, including oogenesis, early embryogenesis, organogenesis, and reproductive fitness of the adult animal. Specific examples of developmental processes under maternal control and the essential proteins will be explored in each chapter, and where known conserved aspects or divergent roles for these maternal regulators of early vertebrate development will be discussed throughout this review. Table of Contents: Introduction / Oogenesis: From Germline Stem Cells to Germline Cysts / Oocyte Polarity and the Embryonic Axes: The Balbiani Body, an Ancient Oocyte Asymmetry / Preparing Developmentally Competent Eggs / Egg Activation / Blocking Polyspermy / Cleavage/ Mitosis: Going Multicellular / Maternal-Zygotic Transition / Reprogramming: Epigenetic Modifications and Zygotic Genome Activation / Dorsal-Ventral Axis Formation before Zygotic Genome Activation in Zebrafish and Frogs / Maternal TGF-β and the Dorsal-Ventral Embryonic Axis / Maternal Control After Zygotic Genome Activation / Compensation by Stable Maternal Proteins / Maternal Contributions to Germline Establishment or Maintenance / Perspective / Acknowledgments / References

Concepts in Mammalian Embryogenesis

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Publisher : MIT Press (MA)
ISBN 13 : 9780262191586
Total Pages : 404 pages
Book Rating : 4.1/5 (915 download)

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Book Synopsis Concepts in Mammalian Embryogenesis by : Michael I. Sherman

Download or read book Concepts in Mammalian Embryogenesis written by Michael I. Sherman and published by MIT Press (MA). This book was released on 1977-01 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume, the first in the MIT Cell Monograph Series, offers a thorough overview of a few selected topics in mammalian embryogenesis that are of current interest and interrelate well with each other. Most of the studies described deal with the mouse embryo, since laboratory maintenance of mice is convenient and the genetics of the mouse are well established. One of the underlying themes throughout the chapters is the programming of events in early embryogenesis. The activation of &"new&" genes, which begins early in embryogenesis, complements preexisting gene action and helps to provide the developing embryo with the machinery necessary for DNA, RNA, and protein synthesis, and with the enzymes required for intermediary metabolism (&"maintenance&" gene products). The synthesis of &"differentiative&" gene products, those which irreversibly route cells along different developmental pathways, must also be taking place prior to, or at, implantation. These new gene products, and what we know of their functions, are discussed in detail. Another, less understood area explored is the role of the genes that initiate differentiation in early embryonic cells. Recent biological studies have revealed that a relationship exists between the position of a cell relative to other cells in the embryo and its ultimate fate; however, embryologists have yet to explain how the microenvironment can trigger a cell to embark on a specific course of differentiation. Various methods used in investigating this problem&-such as microanalytic techniques or the study of similar phenomena in teratocarcinomas&-are described, and the relationships between embryos and teratocarcinomas are thoroughly considered. A chapter on T mutations in the mouse has been included because of the potential of this system for contributing to our knowledge of the mechanisms involved in development of the mammalian embryo. The use of recent immunological, histochemical, and biochemical studies of cell surface properties as markers of genetic programming during embryogenesis is described; and a chapter on the possible role of viruses in the control of embryonic development completes the volume. &"In summary,&" the editor states, &"the chapters in this monograph demonstrate that mammalian embryologists are now equipped with morphological, biochemical, and molecular biological markers of early embryonic development and differentiation. Model systems are available for testing ideas of genetic and epigenetic control mechanisms. With proper use of these resources, our understanding of mammalian embryogenesis could be revolutionized within the next decade.&"

Scientific Frontiers in Developmental Toxicology and Risk Assessment

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Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

The Mammalian Preimplantation Embryo

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Author :
Publisher : Springer
ISBN 13 :
Total Pages : 410 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Mammalian Preimplantation Embryo by : Barry D. Bavister

Download or read book The Mammalian Preimplantation Embryo written by Barry D. Bavister and published by Springer. This book was released on 1987-06-30 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a few notable exceptions, mammalian preimplantation embryos grown in vitro are likely to exhibit sub-optimal or retarded development. This may be manifested in different ways, depending on the species and on the stage(s) of embryonic development that are being examined. For example, bovine embryos often experience difficulty in cleaving under in vitro conditions, and usually cease development at about the 8-cell stage (Wright and Bondioli, 1981). The block to development is stage-dependent; embryos cultured for 24 hr from the I-cell stage are much more capable of developing into viable blastocysts after transfer to oviducts than embryos cultured for 24 hr from the 4-cell stage prior to transfer (Eyestone et oZ. , 1985). Similar problems with in vitro embryo development are encountered in other species. Pig embryos can be grown up to the 4-cell stage in vitro but usually no further (Davis and Day, 1978). In the golden hamster, in the rat and in many outbred strains of mice, development of zygotes in vitro is blocked at the 2-cell stage (Yanagimachi and Chang, 1964; Whittingham, 1975). Even with some inbred mouse strains, embryo development is reduced if very early cleavage stages are used as the starting point for in vitro culture (Spielmann et oZ. , 1980). A common finding is that embryos grown in vitro have reduced cell counts (Harlow and Quinn, 1982; Kane, 1985) and their viability is reduced (Bowman and McLaren, 1970; Papaioannou and Ebert, 1986) compared to equivalent developmental stages recovered from mated animals.

The Vertebrate Organizer

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540140320
Total Pages : 456 pages
Book Rating : 4.1/5 (43 download)

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Book Synopsis The Vertebrate Organizer by : Horst Grunz

Download or read book The Vertebrate Organizer written by Horst Grunz and published by Springer Science & Business Media. This book was released on 2004-02-20 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The organizer area plays a central role in the formation of the embryonic axis and the central nervous system of all vertebrates including the human fetus. In The Vertebrate Organizer outstanding molecular development biologists and embryologists report their latest approaches in this fascinating research area using different vertebrate model organisms. The presented data are of central importance for the understanding of early human embryogenesis.

Preimplantation Embryo Development

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Publisher : Springer Science & Business Media
ISBN 13 : 1461393175
Total Pages : 359 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Preimplantation Embryo Development by : Barry D. Bavister

Download or read book Preimplantation Embryo Development written by Barry D. Bavister and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the Proceedings of the Serono Symposium on Pre implantation Embryo Development, held in Newton, Massachusetts, in 1991. The idea for the symposium grew out of the 1989 Serono Symposium on Fertilization in Mammals* at which preimplantation development was the predominant suggestion for a follow-up topic. This was indeed a timely subject in view of the recent resurgence of interest in this funda mental phase of embryogenesis and its relevance to basic research and applied fertility studies in humans, food-producing animals, and endangered species. The symposium brought together speakers from a broad range of disciplines in order to focus on key regulatory mechanisms in embryo development, using a wide variety of animal models, and on representative topics in human preimplantation embryogenesis. The culmination of preimplantation development is a blastocyst con taining the first differentiated embryonic tissues and capable of initiating and sustaining pregnancy. The central objective of the symposium was to throw light on the regulation of cellular and molecular events underlying blastocyst formation. It was particularly appropriate that the date of the symposium marked the 20th anniversary of the publication of the classic volume Biology of the Blastocyst, the proceedings of an international workshop held in 1970. This book, which summarized most of the information then available on this topic in mammals, was edited by the pioneer in blastocyst research, Dr. Richard B1andau, who was the guest speaker at the symposium.

The Nematode Caenorhabditis Elegans

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Publisher :
ISBN 13 :
Total Pages : 694 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Nematode Caenorhabditis Elegans by : William Barry Wood

Download or read book The Nematode Caenorhabditis Elegans written by William Barry Wood and published by . This book was released on 1988 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: