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Cell Receptors
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Book Synopsis The T-Cell Receptors by : Tak W. Mak
Download or read book The T-Cell Receptors written by Tak W. Mak and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of thymus-dependent cells, or T cells, in the generation of a successful immune response was first realized in the early sixties. In the follow ing two decades, a succession of elegant experiments established the antigen specificity of T cells and their ability to perform both as regulatory and effector cells. T cells were shown to be essential in most immune reactions, playing a crucial role in augmenting the activity of effector T and B cells against 'foreign' antigen, as well as in the suppression of effector activity against self antigens. The means by which T cells differentiate 'foreign' from 'self' antigens is based on their recognition of antigen almost exclusively in the context of self major histocompatibility complex products, unlike B cells, which recognize an tigen alone. It is this recognition, mediated by the T-cell receptor, that sets into motion the diverse cell-cell interactions, which control the differentiation and regulation of the immune response. Although its importance was well established, the molecular nature of the T-cell receptor remained elusive for two decades. Many hypotheses as to its structure and precise function were put forward, using immunoglobulin as a basis for conjecture, but "the Holy Grail of Immunology" remained ephemeral until three years ago. In the ensuing years, both immunologists and molecular biologists have contributed to an explosion of data unsurpassed by any previous period in the field.
Book Synopsis Cell Surface Receptors by : Lee E. Limbird
Download or read book Cell Surface Receptors written by Lee E. Limbird and published by Springer Science & Business Media. This book was released on 2006-06-02 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface Receptors: A Short Course on Theory and Methods, 3rd Edition, links theoretical insights into drug-receptor interactions described in mathematical models with the experimental strategies to characterize the biological receptor of interest. The study of receptors has changed considerably over the period of the publication of the three editions of this book. The cloning of several genomes makes it unlikely that preparations of receptors now or in the future will arise from their purification as trace proteins from native tissues, but rather from a myriad of molecular approaches. Nonetheless, understanding the molecular mechanisms and ultimately the in vivo biology of these receptors means that investigators will engage in molecular, cellular and ultimate in vivo strategies. It should be of value to investigators who want to identify, characterize and understand the biology of a receptor of interest.
Download or read book Cell Receptors written by Gerhard Seifert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: An up-to-date review of the morphology and pathological aspects of cell receptors, important because new therapies for various pathological conditions (genetic diseases, endocrine disorders, cancer, etc.) could be based on receptor interference.
Book Synopsis Cell Surface Receptors by : Lee E. Limbird
Download or read book Cell Surface Receptors written by Lee E. Limbird and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to serve as a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying prin ciples is intended to remove the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, it is hoped that the basic concepts can be emphasized. This book is meant to be a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed. I feit compelled to write this book for several reasons. The primary philosophical reason was to provide, in one volume, an overall perspective on the study ofcell surface receptors that describes their characterization from pharmacological studies in a whole organ or tissue bath (chapter 2) to studies of radioligand binding in isolated membrane and detergent-solubilized pre parations (chapters 3-5) and, back again, to studies in intact cells or tissues using morphological and biochemical techniques (chapter 6). It is my opinion that the ultimate understanding of the molecular basis for hormone or drug receptor interactions, and the physiological consequences of these inter actions, will require an assessment of cell surface receptor function at all of these experimental levels. In many cases an investigator may not choose to of investigation considered here.
Book Synopsis Cell Surface Receptors by : K. Christopher Garcia
Download or read book Cell Surface Receptors written by K. Christopher Garcia and published by Elsevier. This book was released on 2004-12-18 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Surface Receptors contains an extensive discussion of cell surface receptors in 11 chapters by experts in their field. As cell surface receptors are involved in almost every aspect of signaling throughout the body, the topic has been of high interest in the community in recent years. Selected Contents: Structures of Axon Guidance Molecules and Their Neuronal Receptors Shared Cytokine Signaling Receptor NKG2D and Related Immunoreceptors Inonotropic Glutamat Receptor Recognition and Activation Chemotaxis Receptors and Signaling
Book Synopsis Receptors of Cell Adhesion and Cellular Recognition by : A.G. Lee
Download or read book Receptors of Cell Adhesion and Cellular Recognition written by A.G. Lee and published by Elsevier. This book was released on 1996-06-25 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 3 of Biomembranes covers receptors of cell adhesion and cellular recognition. Proteins in the plasma membrane of cells are heavily involved in processes of cell adhesion, but such proteins were not actually isolated and characterized until the mid-1970s. Since then, application of the methods of molecular biology has led to the recognition of four major classes of cell adhesion molecule (CAMs), the immunoglobulin super family, the cadherins, the integrins, and the selecting. A convenient system in which to study the importance of cell adhesion is in blood platelets where aggregation eventually leads to thrombus formation in a process involving a range of surface glycoproteins. Interaction with the extracellular matrix is exemplified by CD44, the receptor for hyaluronan, and a complex carbohydrate that is a major component of the extracellular matrix surrounding migrating and proliferating cells. Membrane-associated mucins have a variety of effects on cell adhesion. The super family of immunoglobulin related proteins also include the T cell receptors and the major histocompatibility complex (MHC), which, together with the receptors for immunoglobulins (the Fc receptors), are of fundamental importance in the processes of immunity. Volume 3 of Biomembranes explores the structures and functions of the molecules involved in these important functions of the cell.
Book Synopsis Receptors For Extracellular Matrix by : John Mcdonald
Download or read book Receptors For Extracellular Matrix written by John Mcdonald and published by Academic Press. This book was released on 2012-12-02 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family. This book is of great value to cell biologists and researchers.
Book Synopsis Receptors: Models for Binding, Trafficking, and Signaling by : Douglas A. Lauffenburger
Download or read book Receptors: Models for Binding, Trafficking, and Signaling written by Douglas A. Lauffenburger and published by Oxford University Press, USA. This book was released on 1996-05-02 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a bridge at the interface between engineering and cell biology, demonstrating how a mathematical modelling approach combined with quantitative experiments can provide enhanced understanding of cell phenomena involving receptor ligand interactions. Model frameworks are described over the entire spectrum of receptor processes, from fundamental cell surface binding, intracellular trafficking, and signal transduction events to the cell behavioural functions they govern, including proliferation, adhesion, and migration.
Download or read book Cell Receptors written by Gerhard Seifert and published by Springer. This book was released on 2011-12-27 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: The methods of molecular biology, biochemistry, immunocytochem istry, and in-situ hybridization introduce new opportunities for the classification and functional characterization of cell receptors under normal conditions and for a better understanding of pathogenetic mechanisms in human diseases. The cellular localization and trans location of receptor proteins can be identified using morphological methods, and it is apparent that receptors and receptor defects play an important role in pathology, notably in genetic diseases, endocrine disorders, atherosclerosis, infections, and cancer. In this volume in ternational experts give a current review of the morphology and pathological aspects of cell receptors. The complex communication of multicellular organisms is coordi nated by two regulatory systems: neural and humoral. Both systems function via signaling substances (ligands) and signal-recognizing and -transmitting molecules, called receptors. The historical develop ment of the receptor concept is based upon Paul Ehrlich's theory of "receptors in the immune system," Langley's "receptive substances in postssynaptic membranes," and Earl Sutherland's discovery of "sec ond messengers" (cAMP and Ca2+).
Book Synopsis NK Cell Receptors: Advances in Cell Biology and Immunology by : Colton Williams
Download or read book NK Cell Receptors: Advances in Cell Biology and Immunology written by Colton Williams and published by States Academic Press. This book was released on 2021-11-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: NK cells, or natural killer cells belong to the group of innate lymphoid cells which are vital to the innate immune system. They are a type of cytotoxic lymphocytes. NK cells respond rapidly to virus infected cell and other intracellular pathogens. They also take action against the formation of tumors. There are different NK cell receptors which have different functions. They can directly cause cell death after binding themselves to Fas ligand which shows infection of a cell. The MHC-independent receptors use a different pathway to cause apoptosis in infected cells. The activation of NK cells depends on the balance of activating and inhibitory receptor stimulation. This book unfolds the innovative aspects of NK cell receptors, which will be crucial for the progress of this field in the future. It consists of contributions made by international experts. The book is appropriate for students seeking detailed information in this area as well as for experts.
Book Synopsis Cell Biology of the B Cell Receptor by : Hidde Ploegh
Download or read book Cell Biology of the B Cell Receptor written by Hidde Ploegh and published by Academic Press. This book was released on 2014-05-16 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Contributions from leading authorities Informs and updates on all the latest developments in the field
Download or read book T Cell Receptors written by John I. Bell and published by Oxford University Press, USA. This book was released on 1995 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: T cell receptors is a comprehensive treatise on the T cell receptor. It deals with the TCR protein, its functional interactions with the signal transduction machinery of the T cell and with the structure and organization of the TCR genes. It is the only comprehensive volume on the TCR and is written by leaders in the field. Particularly useful is the tabulation and nomenclature of the TCR[alpha] and [beta] variable regions and the inclusion of a plate section showing the alignments of these sequences.
Book Synopsis Immunobiology of Natural Killer Cell Receptors by : Eric Vivier
Download or read book Immunobiology of Natural Killer Cell Receptors written by Eric Vivier and published by Springer Science & Business Media. This book was released on 2005-12-20 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Killer (NK) cells are large granular lymphocytes of the innate immune system. They are widespread throughout the body, being present in both lymphoid organs and non-lymphoid peripheral tissues. NK cells are involved in direct innate immune reactions against viruses, bacteria, parasites and other triggers of pathology, such as malignant transformation, all of which cause stress in affected cells. Importantly, NK cells also link the innate and adaptive immune responses, contributing to the initiation of adaptive immune responses and executing adaptive responses using the CD16 FcgRIIIA immunoglobulin Fc receptor. Such responses are mediated through two major effector functions, the direct cytolysis of target cells and the production of cytokines and chemokines. The authors focus here on the nature of recognition events by NK cells and address how these events are integrated to trigger these distinct and graded effector functions.
Book Synopsis Surface Membrane Receptors by : Ralph Bradshaw
Download or read book Surface Membrane Receptors written by Ralph Bradshaw and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The NATO Advanced Study Institute entitled "Surface Membrane Receptors: Interface Between Cells and Environment" was held in Bellagio, Italy September 13-21, 1975. This meeting was an attempt to bring together in an international and interdisci plinary forum scientists who are studying recognitive phenomona which take place at the surface membrane of cells. While an attempt was made to restrict the subject areas covered at the meeting to those experimental systems which have been biochemi cally characterized to some extent, it will also be noted that some contributions to this volume represent a preliminary iden tification of interesting regulatory substances which might reasonably be expected to act at the cell surface. This book is divided into four sections reflecting the subject areas covered during the course of the meeting. The first section entitled "Membrane Structure and Receptor Function" is intended as an overview of the role of membrane structure in determining the regulatory properties, physical state, structure and location of cell surface receptors. It should be noted that the plasma membrane itself provided the unifying theme for the intention ally diverse contributions to this volume. The following three sections represent an arbitrary division into three levels of structural complexity of the things in their external environ ment with which cells must specifically interact.
Book Synopsis Functioning of Transmembrane Receptors in Signaling Mechanisms by : Ralph A. Bradshaw
Download or read book Functioning of Transmembrane Receptors in Signaling Mechanisms written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2011-04-05 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation. Articles written and edited by experts in the field Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease
Download or read book The Receptors written by P. Michael Conn and published by Academic Press. This book was released on 2014-05-10 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Receptors, Volume II deals with receptors for somatostatin, vitamin D, insulin, and animal viruses, as well as for the ?2-adrenergic and Ah systems. The significance of translational modifications of receptor ligands is discussed, along with the mechanisms of receptor-ligand interactions. The role of receptors in development and their regulation by tumors are also considered. Comprised of 12 chapters, this volume begins with a detailed account of the vitamin D receptor, paying particular attention to its biochemical and physical properties as well as its mechanism of action. The discussion then turns to experimental discrimination between alternative mechanistic models for the receptor-mediated stimulation of adenylate cyclase; the role of microaggregation in hormone-receptor-effector interactions; and the biology and biochemistry of the Ah receptor. Subsequent chapters explore the interactions of animal viruses with cell surface receptors; insulin receptors; determination of the size of neurotransmitter receptors by radiation inactivation-target size analysis; and protein glycosylation and receptor-ligand interactions. This book will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.
Book Synopsis Antigen Binding Molecules: Antibodies and T-Cell Receptors by :
Download or read book Antigen Binding Molecules: Antibodies and T-Cell Receptors written by and published by Academic Press. This book was released on 1996-12-13 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topics Covered Include: X-ray crystallography of ligands. Catalytic antibodies. Nature of the antigen. Antibody binding sites. Maturation of the immune response. Computational biochemistry of antibodies and T-cell receptors. Antigen-specific T-cell receptors and their reactions. Key Features * X-Ray Crystallography of Ligands * Catalytic Antibodies * Nature of the Antigen * Antibody Binding Sites * Maturtion of the Immune Response * Computational Biochemistry of Antibodies and * T-Cell Receptors * Antigen-Specific T-Cell Receptors and Their Reactions
