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Cell Commitment And Differentiation
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Book Synopsis Cell Commitment and Differentiation by : Norman Maclean
Download or read book Cell Commitment and Differentiation written by Norman Maclean and published by CUP Archive. This book was released on 1987-08-13 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about how cells differentiate; it describes the way in which cells in animal and plant bodies take on their specialised fates.
Book Synopsis Molecular Mechanisms of Cell Differentiation in Gonad Development by : Rafal P. Piprek
Download or read book Molecular Mechanisms of Cell Differentiation in Gonad Development written by Rafal P. Piprek and published by Springer. This book was released on 2016-06-14 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the current state of knowledge on the origin and differentiation of cell lines involved in the development of the vertebrate male and female gonads with particular emphasis on the mouse. It also discusses the processes leading to the testis- and ovary-specific structures and functions. The individual chapters review the origin and differentiation of the somatic cells of the genital ridges; the formation and migration of primordial germ cells in mouse and man; the gonadal supporting cell lineage and mammalian sex determination; differentiation of Sertoli and granulosa cells; mesonephric cell migration into the gonads and vascularization; origin and differentiation of androgen-producing cells in the gonads; germ cell commitment to the oogenic versus spermatogenic pathway and the role of retinoic acid; ovarian folliculogenesis; control of oocyte growth and development by intercellular communication within the follicular niche; biology of the Sertoli cell in the fetal, pubertal and adult mammalian testis; mechanisms regulating spermatogonial differentiation; stem cells in mammalian gonads; the role of microRNAs in cell differentiation during gonad development; human sex development and its disorders; as well as methods for the study of gonadal development.
Book Synopsis Commitment and Instability in Cell Differentiation by : H. Kondoh
Download or read book Commitment and Instability in Cell Differentiation written by H. Kondoh and published by . This book was released on 1986 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Germ-plasm written by August Weismann and published by . This book was released on 1898 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis New Cell Differentiation Research Topics by : Hitoshi Saitama
Download or read book New Cell Differentiation Research Topics written by Hitoshi Saitama and published by Nova Publishers. This book was released on 2007 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book presents research developments from around the globe in the field of cellular differentiation which is a concept from developmental biology describing the process by which cells acquire a 'type'. The morphology of a cell may change dramatically during differentiation, but the genetic material remains the same, with few exceptions. A cell that is able to differentiate into many cell types is known as pluripotent. These cells are called stem cells in animals and meristematic cells in higher plants. A cell that is able to differentiate into all cell types is known as totipotent. In mammals, only the zygote and early embryonic cells are totipotent, while in plants, many differentiated cells can become totipotent with simple laboratory techniques.
Book Synopsis Differentiation of Embryonic Stem Cells by :
Download or read book Differentiation of Embryonic Stem Cells written by and published by Elsevier. This book was released on 2003-12-18 with total page 577 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers all aspects of embryonic stem cell differentiation, including mouse embryonic stem cells, mouse embryonic germ cells, monkey and human embryonic stem cells, and gene discovery.* Early commitment steps and generation of chimeric mice* Differentiation to mesoderm derivatives* Gene discovery by manipulation of mouse embryonic stem cells
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Stem Cells and the Future of Regenerative Medicine by : Institute of Medicine
Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Book Synopsis Experimental Embryology by : Thomas Hunt Morgan
Download or read book Experimental Embryology written by Thomas Hunt Morgan and published by . This book was released on 1927 with total page 794 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experimentelle Embryologie.
Author :Thomas M. (Thomas Michael) Schmitt Publisher :Library and Archives Canada = Bibliothèque et Archives Canada ISBN 13 :9780612943834 Total Pages :282 pages Book Rating :4.9/5 (438 download)
Book Synopsis The Role of Notch Signaling During T Cell Commitment and Differentiation [microform] by : Thomas M. (Thomas Michael) Schmitt
Download or read book The Role of Notch Signaling During T Cell Commitment and Differentiation [microform] written by Thomas M. (Thomas Michael) Schmitt and published by Library and Archives Canada = Bibliothèque et Archives Canada. This book was released on 2004 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: The nature of the molecular interactions provided by the thymus that predicate T cell development remains obscure. In this thesis, I demonstrate that the bone marrow (BM) stromal cell line OP9, when made to express the Notch ligand Delta-like-1 (Dll1), loses its ability to support B cell lymphopoiesis, and acquires the capacity to induce the development of CD4 CD8 double- and single-positive T cells from various hematopoietic progenitor cells. Both gammadelta-TCR + and alphabeta-TCR+ T cells are generated, and CD4- CD8+ TCRhi cells produce gamma-interferon following CD3/TCR stimulation. Dll1 expressed on OP9 cells provides the necessary signals to induce T cell commitment, stage-specific progenitor expansion, TCR gene rearrangement, and T cell differentiation in-vitro. A normal program of T cell differentiation was also observed from embryonic stem cells (ESCs) cultured on these OP9 cells, which expressed multiple T lineage-associated genes in response to Notch receptor-Dll1 interactions. Furthermore, ESC-derived T cell progenitors effectively reconstituted the T cell compartment of immunodeficient mice, and were capable of generating an antigen specific response to a viral challenge. Using this culture system, I demonstrate that a substantial proportion of early thymocytes retain NK cell lineage potential, and that Notch signals act prior to T cell lineage commitment to maintain T cell lineage specification in early thymocytes. Furthermore, Notch receptor-ligand interactions are shown to be critical throughout T cell development. Thus, it is likely that the expression of Delta-like ligands in the thymus underpins its unique ability to promote T cell lineage commitment and differentiation.
Book Synopsis Stem Cells and Lineage Commitment by : Kursad Turksen
Download or read book Stem Cells and Lineage Commitment written by Kursad Turksen and published by Springer Nature. This book was released on 2023-12-09 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed volume explores a variety of techniques used to study lineage commitment in stem cells. Further elucidation of the process that stem cells undergo on their way to becoming more specified cell types is vital for a more complete understanding of cell biology and overall physiology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, as well as tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Stem Cells and Lineage Commitment: Methods and Protocols serves as an ideal guide for experts and novices in the field of stem cell biology.
Book Synopsis Stem Cells in Reproductive Medicine by : Carlos Simón
Download or read book Stem Cells in Reproductive Medicine written by Carlos Simón and published by Cambridge University Press. This book was released on 2013-07-04 with total page 199 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stem cell science has the potential to impact human reproductive medicine significantly - cutting edge technologies allow the production and regeneration of viable gametes from human stem cells offering potential to preciously infertile patients. Written by leading experts in the field Stem Cells in Reproductive Medicine brings together chapters on the genetics and epigenetics of both the male and female gametes as well as advice on the production and regeneration of gene cells in men and women, trophoblasts and endometrium from human embryonic and adult stem cells. Although focussing mainly on the practical elements of the use of stem cells in reproductive medicine, the book also contains a section on new developments in stem cell research. The book is essential reading for reproductive medicine clinicians, gynecologists and embryologists who want to keep abreast of practical developments in this rapidly developing field.
Book Synopsis Methods of Tissue Engineering by : Anthony Atala
Download or read book Methods of Tissue Engineering written by Anthony Atala and published by Gulf Professional Publishing. This book was released on 2001-10-12 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference book combines the tools, experimental protocols, detailed descriptions and know-how for the successful engineering of tissues and organs in one volume.
Book Synopsis pH of the Skin: Issues and Challenges by : C. Surber
Download or read book pH of the Skin: Issues and Challenges written by C. Surber and published by Karger Medical and Scientific Publishers. This book was released on 2018-08-21 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of expressing acidity as the negative logarithm of the hydrogen ion concentration was defined and termed pH in the beginning of the 20th century. The general usefulness of the pH concept for life science was recognized and later gained importance to analytical research. Reports on results of pH measurements from living skin established the term acid mantle - the skin's own protective shield that maintains a naturally acid pH. It is invisible to the eye but crucial to the overall wellbeing of skin. Chronic alkalization can throw this acid mantle out of balance, leading to inflammation, dermatitis, and atopic skin diseases. It is therefore no surprise, that skin pH shifts have been observed in various skin pathologies. It is also obvious that the pH in topically applied preparations may play an important role. Optimal pH and buffer capacity within topical preparations not only support stability of active ingredients and auxiliary materials, but may also increase absorption of the non-ionized species of an acidic or a basic active ingredient. They may even open up opportunities to modify and "correct" skin pH and hence accelerate barrier recovery and maintain or enhance barrier integrity. Further efforts are needed to standardize and improve pH measurements in biological media or pharmaceutical/cosmetic vehicles to increase and ensure quality, comparability, and relevance of research data. In this volume, we present a unique collection of papers that address past, present and future issues of the pH of healthy and diseased skin. It is hoped that this collection will foster future efforts in clinical and experimental skin research.
Book Synopsis Embryonic Stem Cell Protocols by : Kursad Turksen
Download or read book Embryonic Stem Cell Protocols written by Kursad Turksen and published by Springer Science & Business Media. This book was released on 2008-02-04 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in two volumes, this completely updated and expanded edition of Embryonic Stem Cells: Methods and Protocols provides a diverse collection of readily reproducible cellular and molecular protocols for the manipulation of nonhuman embryonic stem cells. Volume one, Embryonic Stem Cell Protocols: Isolation and Characterization, Second Edition, provides a diverse collection of readily reproducible cellular and molecular protocols for the isolation, maintenance, and characterization of embryonic stem cells. The second volume, Embryonic Stem Cell Protocols: Differentiation Models, Second Edition, covers state-of-the-art methods for deriving many types of differentiating cells from ES cells. Together, the two volumes illuminate for both novices and experts our current understanding of the biology of embryonic stem cells and their utility in normal tissue homeostasis and regenerative medicine applications.
Book Synopsis Mechanisms of Differentiation by : Paul B. Fisher
Download or read book Mechanisms of Differentiation written by Paul B. Fisher and published by CRC Press. This book was released on 1990-08-27 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant recent advances in cell culture technology now permit a detailed biochemical and molecular analysis of differentiation in both normal and tumor cells. These studies are important in attempting to understand the complex factors involved in normal growth and development, as well as the abnormalities associated with carcinogenesis. Mechanisms of Differentiation, Volumes I and II, is comprised of review chapters addressing various topics of current interest in this important area of research. Topics discussed include genes controlling differentiation, changes in gene expression during differentiation, induction of differentiation, induction of differentiation as a mode of action of chemotherapeutic agents, and the effect of cell shape, growth factors and differentiation modulating agents on the differentiated cell phenotype. Mechanisms of Differentiation is valuable to researchers involved in differentiation and development, carcinogenesis, cell biology, chemotherapy, and immunology.
Book Synopsis Handbook of Benign Hematology by : Martha Pritchett Mims, MD, PhD
Download or read book Handbook of Benign Hematology written by Martha Pritchett Mims, MD, PhD and published by Springer Publishing Company. This book was released on 2019-12-11 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Benign Hematology is a practical guide to the diagnosis and management of benign hematologic conditions. The book begins with a chapter on normal hematopoiesis and follows with chapters devoted to groups of blood disorders and syndromes including neutrophil disorders, nonmalignant myeloid disorders, bone marrow failure syndromes, myeloproliferative disorders, anemias, iron metabolism disorders, platelet disorders, hemostasis and coagulation defects, and thrombosis. Each disorder subtype covered features a clinical case, an introduction to the condition, details on diagnosis including applicable criteria and lab work needed, key diagnostic dilemmas, prognosis, treatment options, details on clinical trials and emerging clinical strategies, and bulleted key points to highlight clinical pearls and common pitfalls. The final chapters provide best practices for transfusion medicine and a guide to pharmacologic agents and their uses in clinical practice for adult and pediatric patients. The handbook is filled with tables and illustrations which highlight FDA-approved drug information, clinical trials data, hematopathologic characteristics of different disorders, important management criteria and more, making it the ideal handbook for those in practice or for review. The Editors and chapter authors are experienced academic practitioners in the fields of adult and pediatric hematology, pathology, blood banking, and pharmacology. Emphasizing best practices for patient management, this handbook is essential for oncologists, hematologists, trainees, and other practitioners who regularly or increasingly receive referrals to diagnose and treat adults or children with nonmalignant hematologic conditions. Key Features: Includes dozens of clinical cases covering all nonmalignant blood disorders Emphasizes patient management and best practices for disorders seen in adults and children Contains over 30 color images and numerous tables for quick reference Presents important details of all pharmacologic agents used to treat or manage hematologic disorders and their complications Purchase includes access to the ebook for use on most mobile devices or computers
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