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Cell Based Therapies In Stroke
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Book Synopsis Cell-Based Therapies in Stroke by : Jukka Jolkkonen
Download or read book Cell-Based Therapies in Stroke written by Jukka Jolkkonen and published by Springer Science & Business Media. This book was released on 2013-01-30 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke remains one of the main causes of death and disability worldwide. While effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.
Book Synopsis Cell-based Therapies for Stroke: Promising Solution or Dead End? by : Paulo Henrique Rosado-de-Castro
Download or read book Cell-based Therapies for Stroke: Promising Solution or Dead End? written by Paulo Henrique Rosado-de-Castro and published by Frontiers Media SA. This book was released on 2020-05-22 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regenerative Therapies in Ischemic Stroke Recovery by : Syed Shadab Raza
Download or read book Regenerative Therapies in Ischemic Stroke Recovery written by Syed Shadab Raza and published by Springer Nature. This book was released on 2022-07-09 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the importance and significance of regenerative medicine in stroke recovery. It discusses stem-cell-based treatment strategies and offers mechanistic insights into their role in neurological recovery. It also examines the challenges and advances in using adult stem cells for enhanced therapeutic efficacy. Further, it presents the strategies as well as the strengths and weaknesses of various delivery methods to administer stem cells in ischemic stroke. It examines the role of non-coding RNA in our understanding the stroke pathogenesis, their regulatory role in ischemic stroke and potential as biomarkers and therapeutic targets. Lastly, it explores exosomes in the treatment of stroke, and the underlying mechanism of their action as therapeutic vectors for stroke. Given its scope, it is an excellent resource for neurologists, neuroscientists and researchers involved in regenerative therapy for stroke.
Book Synopsis Bone marrow stem cell therapy for stroke by : Kunlin Jin
Download or read book Bone marrow stem cell therapy for stroke written by Kunlin Jin and published by Springer. This book was released on 2016-12-13 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers recent advances in all aspects of bone marrow-derived stem cells (BMSCs) for stroke treatment, while also providing comprehensive information on human clinical trials and animal models of stroke. In addition, it reviews the optimal conditions of transplantation for stroke therapy and potential mechanisms underlying transplanted cell-mediated functional recovery after stroke. As the first book to focus on BMSC therapy for stroke, it also discusses in depth the unique challenges of BMSCs-based therapy in this context.
Book Synopsis Stroke Recovery with Cellular Therapies by : Sean I. Savitz
Download or read book Stroke Recovery with Cellular Therapies written by Sean I. Savitz and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stroke is the leading cause of serious, long term disability. This book proposes different cellular therapies under investigation to promote neural regeneration after stroke. Authored by an international panel of scientists and clinicians, this volume is a vital, one-of-a-kind resource for all scientists interested in regenerative medicine.
Book Synopsis Cellular Therapy for Stroke and CNS Injuries by : Li-Ru Zhao
Download or read book Cellular Therapy for Stroke and CNS Injuries written by Li-Ru Zhao and published by Springer. This book was released on 2014-11-24 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cellular therapy for stroke and neural trauma has gained worldwide attention during the last decade and has shown some promising results. Various cells, including neural stem cells, bone marrow stem cells, endothelial progenitor cells, and many others have had protective or regenerative effects in animal models. The proposed book will address recent research on all relevant cell types. In addition, it will provide information on cell isolation and culture skills, transplantation methods, and neurological functional evaluations. This is the first book to focus on cellular therapy for stroke and other CNS injuries.
Book Synopsis Stem Cell Therapy for Vascular Diseases by : Tulio Pinho Navarro
Download or read book Stem Cell Therapy for Vascular Diseases written by Tulio Pinho Navarro and published by Springer Nature. This book was released on 2020-11-05 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular diseases are the leading cause of death worldwide. Distinguished clinical and surgical approaches have attempted to overcome its morbidity and mortality; still 17.9 million people die every year due to vascular affections. Stem cell therapy has emerged as a promising therapeutic strategy. Stem cells synthesize and secrete cytokines that promote cell recruitment, immunomodulation, extracellular matrix remodeling, angiogenesis, and neuroregeneration, all of which promote regeneration. Besides that, stem cells are also capable of differentiating in various cell types, being employed in tissue engineering. Preclinical and clinical investigations have reported efficacy of stem cell therapy for various vascular diseases. Even though results are encouraging, the studies demonstrate variation in stem cell type and origin, route and protocol for administration, and concomitant use of other treatment strategies, impairing easy interpretation of results and clinical application. The purpose of this book is to compile and comprise the current state of the evidence regarding stem cell therapy for each vascular disease, elucidating possible clinical applications. More than an objective guide for readers on the use of this novel treatment strategy, this publication will advocate for stem cell therapy use and development and will be of significant interest to physicians in a wide range of disciplines as well as researchers.
Book Synopsis Cell Therapy Against Cerebral Stroke by : Kiyohiro Houkin
Download or read book Cell Therapy Against Cerebral Stroke written by Kiyohiro Houkin and published by Springer. This book was released on 2017-01-06 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents comprehensive reviews for both translational research and clinical trials on cell therapy for stroke. Cerebral stroke is still a leading cause of death and disability. However, despite intensive research, few treatment options are available. The therapeutic potential of cell transplantation has been studied for various pathological conditions of the central nervous system (CNS) including traumatic brain injury, traumatic spinal cord injury, degenerative disease, demyelinating disease and ischemic stroke, as the injured neural tissue in the CNS has only a limited regenerative capacity. Recently, a growing body of evidence in this field suggests that cell transplantation holds great potential as a form of stroke therapy. The authors, who are experts in the field of neurosurgery, review and discuss optimal cell sources and various issues involved in translational research; further, they outline ongoing clinical trials in Japan.
Book Synopsis Cellular and Molecular Approaches to Regeneration and Repair by : Paul A. Lapchak
Download or read book Cellular and Molecular Approaches to Regeneration and Repair written by Paul A. Lapchak and published by Springer. This book was released on 2017-11-04 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses recent advances in the field of translational stroke research. The editors have designed the book to provide new insight into the importance of regeneration and repair mechanisms for stroke victims. The editors have brought together a talented group of international stroke researchers and clinicians to contribute to this volume, which is written for students, researchers and physicians in biotechnology, neurosciences, neurology, neuroradiology and neurosurgery. Throughout the world, stroke is still a leading cause of mortality and morbidity; there are 152,000 strokes in the United Kingdom, 62,000 in Canada, and approximately 15 million people worldwide. Large communities of stroke survivors are eagerly awaiting scientific advances in translational stroke research related to regeneration and recovery of function that would offer new therapeutics for rehabilitation and regeneration utilizing novel stem cell and molecular-based approaches. This volume will allow the reader to undersnd the future of stroke treatment from its inception in the laboratory through to clinical trial design. The reader will learn about the recent advances made in these areas related to basic and applied stroke research and their translational potential. Dr. Paul A. Lapchak is Professor of Neurology and Director of Translational Research in the Departments of Neurology & Neurosurgery at Cedars-Sinai Medical Center in Los Angeles CA, USA. Dr. Lapchak is an internationally recognized expert conducting translational drug development research for ischemic and hemorrhagic stroke. Dr. John H. Zhang is Professor of Anesthesiology, Neurosurgery, Neurology, and Physiology, and Director, Center for Neuroscience Research at Loma Linda University School of Medicine, Loma Linda, CA, USA. Dr. Zhang is an internationally recognized expert working on drug development for hemorrhagic stroke.
Book Synopsis Cell Therapy for Brain Injury by : David C. Hess
Download or read book Cell Therapy for Brain Injury written by David C. Hess and published by Springer. This book was released on 2015-05-15 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Therapy for Brain Injury is a thorough examination of using state-of-the-art cell therapy in the treatment of strokes and other traumatic brain injuries. This invaluable book covers this niche topic in depth from basic stem cell biology and principles of cell therapy through proposed mechanisms of action of cell therapy in stroke, pre-clinical data in stroke models, ongoing clinical trials, imaging and tracking of cells with MRI, neural stem cells in stroke and the "big pharma" perspective of cell therapy. Each chapter is written by well-known leaders in each field, thus providing a wealth of expertise. The breadth of this book makes it essential reading for neuroscientists, stem cell biologists, researchers or clinical trialists at pharmaceutical or biotechnology companies. It also serves as a thorough introduction for graduate students or post-doctoral fellows who hope to work in these fields.
Book Synopsis Brain Repair After Stroke by : Steven C. Cramer
Download or read book Brain Repair After Stroke written by Steven C. Cramer and published by Cambridge University Press. This book was released on 2010-10-28 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Increasing evidence identifies the possibility of restoring function to the damaged brain via exogenous therapies. One major target for these advances is stroke, where most patients can be left with significant disability. Treatments have the potential to improve the victim's quality of life significantly and reduce the time and expense of rehabilitation. Brain Repair After Stroke reviews the biology of spontaneous brain repair after stroke in animal models and in humans. Detailed chapters cover the many forms of therapy being explored to promote brain repair and consider clinical trial issues in this context. This book provides a summary of the neurobiology of innate and treatment-induced repair mechanisms after hypoxia and reviews the state of the art for human therapeutics in relation to promoting behavioral recovery after stroke. Essential reading for stroke physicians, neurologists, rehabilitation physicians and neuropsychologists.
Book Synopsis Regenerative Rehabilitation by : Sarah M. Greising
Download or read book Regenerative Rehabilitation written by Sarah M. Greising and published by Springer Nature. This book was released on 2022-06-01 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume presents the current state of research on regenerative rehabilitation across a broad range of neuro- and musculoskeletal tissues. At its core, the primary goal of regenerative rehabilitation is to restore function after damage to bones, skeletal muscles, cartilage, ligaments/tendons, or tissues of the central and peripheral nervous systems. The authors describe the physiology of these neuro- and musculoskeletal tissue types and their inherent plasticity. The latter quality is what enables these tissues to adapt to mechanical and/or chemical cues to improve functional capacity. As a result, readers will learn how regenerative rehabilitation exploits that quality, to trigger positive changes in tissue function. Combining basic, translational, and clinical aspects of the topic, the book offers a valuable resource for both scientists and clinicians in the regenerative rehabilitation field.
Book Synopsis Stroke Recovery and Rehabilitation by : Richard L. Harvey, MD
Download or read book Stroke Recovery and Rehabilitation written by Richard L. Harvey, MD and published by Demos Medical Publishing. This book was released on 2008-11-20 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Doody's Core Title 2012 Stroke Recovery and Rehabilitation is the new gold standard comprehensive guide to the management of stroke patients. Beginning with detailed information on risk factors, epidemiology, prevention, and neurophysiology, the book details the acute and long-term treatment of all stroke-related impairments and complications. Additional sections discuss psychological issues, outcomes, community reintegration, and new research. Written by dozens of acknowledged leaders in the field, and containing hundreds of tables, graphs, and photographic images, Stroke Recovery and Rehabilitation features: The first full-length discussion of the most commonly-encountered component of neurorehabilitation Multi-specialty coverage of issues in rehabilitation, neurology, PT, OT, speech therapy, and nursing Focus on therapeutic management of stroke related impairments and complications An international perspective from dozens of foremost authorities on stroke Cutting edge, practical information on new developments and research trends Stroke Recovery and Rehabilitation is a valuable reference for clinicians and academics in rehabilitation and neurology, and professionals in all disciplines who serve the needs of stroke survivors.
Book Synopsis Neural Crest Stem Cells by : Maya Sieber-Blum
Download or read book Neural Crest Stem Cells written by Maya Sieber-Blum and published by World Scientific. This book was released on 2012 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers readers an understanding of the development of neural crest cells, which is crucial as many birth defects and tumours are of neural crest origin. Delving into stem cells from different locations of the body, this book explores the best possible source of such cells for the use in medical applications.
Book Synopsis Spinal Cord Injury (SCI) Repair Strategies by : Giuseppe Perale
Download or read book Spinal Cord Injury (SCI) Repair Strategies written by Giuseppe Perale and published by Woodhead Publishing. This book was released on 2019-10-30 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering
Book Synopsis Stem Cells and the Future of Regenerative Medicine by : Institute of Medicine
Download or read book Stem Cells and the Future of Regenerative Medicine written by Institute of Medicine and published by National Academies Press. This book was released on 2002-01-25 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent scientific breakthroughs, celebrity patient advocates, and conflicting religious beliefs have come together to bring the state of stem cell researchâ€"specifically embryonic stem cell researchâ€"into the political crosshairs. President Bush's watershed policy statement allows federal funding for embryonic stem cell research but only on a limited number of stem cell lines. Millions of Americans could be affected by the continuing political debate among policymakers and the public. Stem Cells and the Future of Regenerative Medicine provides a deeper exploration of the biological, ethical, and funding questions prompted by the therapeutic potential of undifferentiated human cells. In terms accessible to lay readers, the book summarizes what we know about adult and embryonic stem cells and discusses how to go about the transition from mouse studies to research that has therapeutic implications for people. Perhaps most important, Stem Cells and the Future of Regenerative Medicine also provides an overview of the moral and ethical problems that arise from the use of embryonic stem cells. This timely book compares the impact of public and private research funding and discusses approaches to appropriate research oversight. Based on the insights of leading scientists, ethicists, and other authorities, the book offers authoritative recommendations regarding the use of existing stem cell lines versus new lines in research, the important role of the federal government in this field of research, and other fundamental issues.
Book Synopsis Progenitor Cell Therapy for Neurological Injury by : Charles S. Cox, Jr.
Download or read book Progenitor Cell Therapy for Neurological Injury written by Charles S. Cox, Jr. and published by Springer Science & Business Media. This book was released on 2010-11-25 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are currently no reparative therapies for severe neurological injury, including brain injury, spinal cord injury and stroke. Actually, most treatments are designed simply to limit secondary damage. However, pre-clinical data supports the idea that exogenous stem and progenitor cells have the potential to promote a reparative response to severe neurological injuries. Progenitor Cell Therapy for Neurological Injury is a compilation of seminal essays that explore many unique aspects of neurological injury, focusing on the critical translational issues of cell delivery. Specifically, it discusses routes of administration, types of progenitor cells (alone and/or in combinations), timing of delivery and adjuncts to promote cell engraftment, survival and effectiveness. In addition, many chapters address measuring the effects of transplanted cells and cell tracking. The paradigms of how cell-based therapeutics affect neurological injury is changing rapidly. The developments in this field may ultimately offer realistic hope for improvement in patients with severe injuries. This book is a vital key toward unlocking those future treatments.
