Cell And Organ Printing

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Bioprinting

Author : Maika G. Mitchell
Publisher : Academic Press
ISBN 13 : 0128094036
Total Pages : 155 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Bioprinting by : Maika G. Mitchell

Download or read book Bioprinting written by Maika G. Mitchell and published by Academic Press. This book was released on 2017-02-17 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Innovation is added value to a known process. Bioprinting: Techniques and Risks for Regenerative Medicine aims to stimulate a scientifically grounded, interdisciplinary, multiscale debate and exchange of ideas using the techniques described in the book. 3D printing and additive manufacturing evolved from within the field of Cell Biology will have the ability to recreate cells queried from large amounts of phenotypic and molecular data. Stem Cell biologists, biotechnologists and material engineers, as well as graduate students will greatly benefit from the practical knowledge and case examples provided throughout this book. Shows the possible risk of rejection of 3D printed cells. Contains bioprinting techniques in literature plus actual 3D files adapted and created by the author using several types of 3d printers Provides information on how to convert an existing 3-D printer to bioprinter using currently available techniques Describes the increased complexity of bioprinting compared to 3D- printing Discussion on how 3D printing and additive manufacturing offers the opportunity to 3D print an entire organ, reducing the associated costs of this process when using cells as bioink

Cell and Organ Printing

Author : Bradley R. Ringeisen
Publisher : Springer Science & Business Media
ISBN 13 : 9048191459
Total Pages : 259 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Cell and Organ Printing by : Bradley R. Ringeisen

Download or read book Cell and Organ Printing written by Bradley R. Ringeisen and published by Springer Science & Business Media. This book was released on 2010-09-02 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell and organ printing has become a hot topic of scientific pursuit. Since several early publications between 2000-2003 that demonstrated proof-of-concept, cell and organ printing has blossomed into a rich area for scientific exploration that is being performed by researchers across the globe. Research has thoroughly demonstrated that living cells can be printed via a number of actuations including electrospray, extrusion via micropens and ejection through photothermal, thermal or optical mechanisms. This topic has come of age and it is ripe for exploring the underpinnings of the research to date. We have included research that uses printing technology to deposit or guide cells for tissue engineering applications and for completeness, we have also included chapters describing bacteria printing, biomolecular printing that could be used to build growth factors or recruitment macromolecules into scaffolds, tissue microdissection, as well as live cell printing. The breadth of approaches includes 3D freeform fabrication, ink jet, laser guidance and modified laser direct write techniques. We hope that this book is not the final word but the first word, defining how these tools have been used to take the first steps towards the ultimate goal of creating heterogeneous tissue constructs. Only time will tell whether cell printers will truly become organ printers, but the technologies described in this book hold promise to achieve what the field of regenerative medicine requires - functional 3D scaffolds with multiple cell types differentiated into functional tissue!

Cell and Organ Printing

Author : Bradley R Ringeisen
Publisher : Springer
ISBN 13 : 9789048191468
Total Pages : 276 pages
Book Rating : 4.1/5 (914 download)

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Book Synopsis Cell and Organ Printing by : Bradley R Ringeisen

Download or read book Cell and Organ Printing written by Bradley R Ringeisen and published by Springer. This book was released on 2010-09-04 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers the first comprehensive review of emerging cell-printing technologies, from the use of printing technology to deposit or guide cells for tissue engineering applications, to bacteria printing, biomolecular printing and live cell printing.

Organ Printing

Author : Dong-Woo Cho
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1681740796
Total Pages : 90 pages
Book Rating : 4.6/5 (817 download)

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Book Synopsis Organ Printing by : Dong-Woo Cho

Download or read book Organ Printing written by Dong-Woo Cho and published by Morgan & Claypool Publishers. This book was released on 2015-10-01 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces various 3D printing systems, biomaterials, and cells for organ printing. In view of the latest applications of several 3D printing systems, their advantages and disadvantages are also discussed. A basic understanding of the entire spectrum of organ printing provides pragmatic insight into the mechanisms, methods, and applications of this discipline. Organ printing is being applied in the tissue engineering field with the purpose of developing tissue/organ constructs for the regeneration of both hard (bone, cartilage, osteochondral) and soft tissues (heart). There are other potential application areas including tissue/organ models, disease/cancer models, and models for physiology and pathology, where in vitro 3D multicellular structures developed by organ printing are valuable.

3D Bioprinting

Author : Dong-Woo Cho
Publisher : Springer Nature
ISBN 13 : 303032222X
Total Pages : 124 pages
Book Rating : 4.0/5 (33 download)

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Book Synopsis 3D Bioprinting by : Dong-Woo Cho

Download or read book 3D Bioprinting written by Dong-Woo Cho and published by Springer Nature. This book was released on 2019-12-04 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text advances fundamental knowledge in modeling in vitro tissues/organs as an alternative to 2D cell culture and animal testing. Prior to engineering in vitro tissues/organs,the descriptions of prerequisites (from pre-processing to post-processing) in modeling in vitro tissues/organs are discussed. The most prevalent technologies that have been widely used for establishing the in vitro tissue/organ models are also described, including transwell, cell spheroids/sheets, organoids, and microfluidic-based chips. In particular, the authors focus on 3D bioprinting in vitro tissue/organ models using tissue-specific bioinks. Several representative bioprinting methods and conventional bioinks are introduced. As a bioink source, decellularized extracellular matrix (dECM) are importantly covered, including decellularization methods, evaluation methods for demonstrating successful decellularization, and material safety. Taken together, the authors delineate various application examples of 3D bioprinted in vitro tissue/organ models especially using dECM bioinks.

Bioprinting: Principles And Applications

Author : Wai Yee Yeong
Publisher : World Scientific Publishing Co Inc
ISBN 13 : 9814612138
Total Pages : 294 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Bioprinting: Principles And Applications by : Wai Yee Yeong

Download or read book Bioprinting: Principles And Applications written by Wai Yee Yeong and published by World Scientific Publishing Co Inc. This book was released on 2014-11-27 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: At labs around the world, researchers have been experimenting with bioprinting, first just to see whether it was possible to push cells through a printhead without killing them (in most cases it is), and then trying to make cartilage, bone, skin, blood vessels, small bits of liver and other tissues. There are other ways to try to “engineer” tissue — one involves creating a scaffold out of plastics or other materials and adding cells to it. In theory, at least, a bioprinter has advantages in manipulating control of the placement of cells and other components to mimic natural structures.But just as the claims made for 3-D printing technology sometimes exceed the reality, the field of bioprinting has seen its share of hype. The reality is that, although bioprinting researchers have made great strides, there are many formidable obstacles to overcome. Nobody who has any credibility claims they can print organs, or believes in their heart of hearts that that will happen in the next 20 years, but for operations like hip replacement, advance in Bio-printing has made customization of certain body parts possible.This book will start from the concept of Tissue Engineering, covering various approaches in Scaffolds for tissue engineering, Bioprinting techniques and Materials for bioprinting, Cell processing, 3D cell culture techniques, Computational design and simulation, multi-disciplinary approaches in bioprinting and finally cover the applications of bioprinting.

Cell Assembly with 3D Bioprinting

Author : Yong He
Publisher : John Wiley & Sons
ISBN 13 : 3527347968
Total Pages : 370 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Cell Assembly with 3D Bioprinting by : Yong He

Download or read book Cell Assembly with 3D Bioprinting written by Yong He and published by John Wiley & Sons. This book was released on 2022-03-14 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an up-to-date outline of cell assembly methods and applications of 3D bioprinting Cell Assembly with 3D Bioprinting provides an accesible overview of the layer-by-layer manufacturing of living structures using biomaterials. Focusing on technical implemention in medical and bioengineering applications, this practical guide summarize each key aspect of the 3D bioprinting process. Contributions from a team of leading researchers describe bioink preparation, printing method selection, experimental protocols, integration with specific applications, and more. Detailed, highly illustrated chapters cover different bioprinting approaches and their applications, including coaxial bioprinting, digital light projection, direct ink writing, liquid support bath-assisted 3D printing, and microgel-, microfiber-, and microfluidics-based biofabrication. The book includes practical examples of 3D bioprinting, a protocol for typical 3D bioprinting, and relevant experimental data drawn from recent research. * Highlights the interdisciplinary nature of 3D bioprinting and its applications in biology, medicine, and pharmaceutical science * Summarizes a variety of commonly used 3D bioprinting methods * Describes the design and preparation of various types of bioinks * Discusses applications of 3D bioprinting such as organ development, toxicological research, clinical transplantation, and tissue repair Covering a wide range of topics, Cell Assembly with 3D Bioprinting is essential reading for advanced students, academic researchers, and industry professionals in fields including biomedicine, tissue engineering, bioengineering, drug development, pharmacology, bioglogical screening, and mechanical engineering.

3D Bioprinting

Author : Ibrahim Tarik Ozbolat
Publisher : Academic Press
ISBN 13 : 0128030305
Total Pages : 358 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis 3D Bioprinting by : Ibrahim Tarik Ozbolat

Download or read book 3D Bioprinting written by Ibrahim Tarik Ozbolat and published by Academic Press. This book was released on 2016-11-21 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Bioprinting: Fundamentals, Principles and Applications provides the latest information on the fundamentals, principles, physics, and applications of 3D bioprinting. It contains descriptions of the various bioprinting processes and technologies used in additive biomanufacturing of tissue constructs, tissues, and organs using living cells. The increasing availability and decreasing costs of 3D printing technologies are driving its use to meet medical needs, and this book provides an overview of these technologies and their integration. Each chapter discusses current limitations on the relevant technology, giving future perspectives. Professor Ozbolat has pulled together expertise from the fields of bioprinting, tissue engineering, tissue fabrication, and 3D printing in his inclusive table of contents. Topics covered include raw materials, processes, machine technology, products, applications, and limitations. The information in this book will help bioengineers, tissue and manufacturing engineers, and medical doctors understand the features of each bioprinting process, as well as bioink and bioprinter types. In addition, the book presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics. Describes all aspects of the bioprinting process, from bioink processing through design for bioprinting, bioprinting techniques, bioprinter technologies, organ printing, applications, and future trends Provides a detailed description of each bioprinting technique with an in-depth understanding of its process modeling, underlying physics and characteristics, suitable bioink and cell types printed, and major accomplishments achieved thus far Explains organ printing technology in detail with a step-by-step roadmap for the 3D bioprinting of organs from isolating stem cells to the post-transplantation of organs Presents tactics that can be used to select the appropriate process for a given application, such as tissue engineering and regenerative medicine, transplantation, clinics, or pharmaceutics

Essentials of 3D Biofabrication and Translation

Author : Anthony Atala
Publisher : Academic Press
ISBN 13 : 0128010150
Total Pages : 441 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Essentials of 3D Biofabrication and Translation by : Anthony Atala

Download or read book Essentials of 3D Biofabrication and Translation written by Anthony Atala and published by Academic Press. This book was released on 2015-07-17 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Essentials of 3D Biofabrication and Translation discusses the techniques that are making bioprinting a viable alternative in regenerative medicine. The book runs the gamut of topics related to the subject, including hydrogels and polymers, nanotechnology, toxicity testing, and drug screening platforms, also introducing current applications in the cardiac, skeletal, and nervous systems, and organ construction. Leaders in clinical medicine and translational science provide a global perspective of the transformative nature of this field, including the use of cells, biomaterials, and macromolecules to create basic building blocks of tissues and organs, all of which are driving the field of biofabrication to transform regenerative medicine. Provides a new and versatile method to fabricating living tissue Discusses future applications for 3D bioprinting technologies, including use in the cardiac, skeletal, and nervous systems, and organ construction Describes current approaches and future challenges for translational science Runs the gamut of topics related to the subject, from hydrogels and polymers to nanotechnology, toxicity testing, and drug screening platforms

Organ Manufacturing

Author : Xiaohong Wang
Publisher : Nova Science Publishers
ISBN 13 : 9781634829571
Total Pages : 0 pages
Book Rating : 4.8/5 (295 download)

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Book Synopsis Organ Manufacturing by : Xiaohong Wang

Download or read book Organ Manufacturing written by Xiaohong Wang and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first time that human organs, such as the heart, liver, kidney, stomach, uterus, skin, lung, pancreas and breast can be manufactured automatically and precisely for clinical transplantation, drug screening and metabolism model establishment. Headed by Professor Xiaohong Wang (also the founder and director) in the Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, this group has focused on organ manufacturing for over ten years. A series of technical bottleneck problems, such as vascular and nerve system establishment in a construct, multiple cell types and material system incorporation, and stem cell sequential engagement, have been overcome one by one. Two technical approaches have been exploited extensively. One is multiple nozzle rapid prototyping (RP), additive manufacturing (AM), or three-dimension (3D) printing. The other is combined mold systems. More than 110 articles and 40 patents with a series of theories and practices have been published consequently. In the future, all the failed organs (including the brain) in the human body can be substituted easily like a small accessory part in a car. Everyone can get benefit from these techniques, which ultimately means that the lifespan of humans, therefore, can be greatly prolonged from this time point. This book examines the progress made in the field and the developments made by these researchers (and authors) in the field.

3D Bioprinting in Regenerative Engineering

Author : Ali Khademhosseini
Publisher : CRC Press
ISBN 13 : 1315280485
Total Pages : 385 pages
Book Rating : 4.3/5 (152 download)

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Book Synopsis 3D Bioprinting in Regenerative Engineering by : Ali Khademhosseini

Download or read book 3D Bioprinting in Regenerative Engineering written by Ali Khademhosseini and published by CRC Press. This book was released on 2018-04-17 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Regenerative engineering is the convergence of developmental biology, stem cell science and engineering, materials science, and clinical translation to provide tissue patches or constructs for diseased or damaged organs. Various methods have been introduced to create tissue constructs with clinically relevant dimensions. Among such methods, 3D bioprinting provides the versatility, speed and control over location and dimensions of the deposited structures. Three-dimensional bioprinting has leveraged the momentum in printing and tissue engineering technologies and has emerged as a versatile method of fabricating tissue blocks and patches. The flexibility of the system lies in the fact that numerous biomaterials encapsulated with living cells can be printed. This book contains an extensive collection of papers by world-renowned experts in 3D bioprinting. In addition to providing entry-level knowledge about bioprinting, the authors delve into the latest advances in this technology. Furthermore, details are included about the different technologies used in bioprinting. In addition to the equipment for bioprinting, the book also describes the different biomaterials and cells used in these approaches. This text: Presents the principles and applications of bioprinting Discusses bioinks for 3D printing Explores applications of extrusion bioprinting, including past, present, and future challenges Includes discussion on 4D Bioprinting in terms of mechanisms and applications

3D Printing in Medicine

Author : Deepak M. Kalaskar
Publisher : Woodhead Publishing
ISBN 13 : 0323902200
Total Pages : 424 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis 3D Printing in Medicine by : Deepak M. Kalaskar

Download or read book 3D Printing in Medicine written by Deepak M. Kalaskar and published by Woodhead Publishing. This book was released on 2022-10-18 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Printing in Medicine, Second Edition examines the rapidly growing market of 3D-printed biomaterials and their clinical applications. With a particular focus on both commercial and premarket tools, the book looks at their applications within medicine and the future outlook for the field. The chapters are written by field experts actively engaged in educational and research activities at the top universities in the world. The earlier chapters cover the fundamentals of 3D printing, including topics such as materials and hardware. The later chapters go on to cover innovative applications within medicine such as computational analysis of 3D printed constructs, personalized 3D printing - including 3D cell and organ printing and the role of AI - with a subsequent look at the applications of high-resolution printing, 3D printing in diagnostics, drug development, 4D printing, and much more. This updated new edition features completely revised content, with additional new chapters covering organs-on-chips, bioprinting regulations and standards, intellectual properties, and socio-ethical implications of organs-on-demand. Reviews a broad range of biomedical applications of 3D printing biomaterials and technologies Provides an interdisciplinary look at 3D printing in medicine, bridging the gap between engineering and clinical fields Includes completely updated content with additional new chapters, covering topics such as organs-on-chips, bioprinting regulations, intellectual properties, medical standards in 3D printing, and more

Bioprinting

Author : Kenneth Douglas
Publisher : Oxford University Press
ISBN 13 : 0190943564
Total Pages : 288 pages
Book Rating : 4.1/5 (99 download)

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Book Synopsis Bioprinting by : Kenneth Douglas

Download or read book Bioprinting written by Kenneth Douglas and published by Oxford University Press. This book was released on 2021-04-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the 121,000 people on donor lists in the U.S., over 100,000 need kidney transplants and thousands die each year while waiting. Bioprinting aspires to build healthy kidney tissue from a patient's own cells and transplant this to boost failing kidneys without fear of rejection... As the 21st century dawned, a handful of inspired scientists tried to use 3D printing to create living human tissue. Their vision was to restore the health of people with intractable injuries, such as worn out cartilage, severed nerves, ailing kidneys, failing heartsthe gamut of human frailties. Their modest success energized others to join the quest. Now, after two decades of ingenious effort and hard work, they have carved out a vibrant new discipline: bioprinting. In Bioprinting: To Make Ourselves Anew, physicist Kenneth Douglas casts an eye over the achievements and future of bioprinting. He explains the science with rigor but with a minimum of technical baggage. This is the first book on the subject written expressly for the lay audience: accessible and even entertaining. Douglas interviewed two dozen bioprinting researchers from around the world, and he enriches the narrative by sharing stories from the scientists behind the science. These contemporary vignettes are complemented by historical accounts of the women and men whose prescient contributions were foundational to the development of bioprinting. The book describes the challenges and accomplishments in the bioprinting of blood vessels, cartilage, skin, bone, skeletal muscle, neuromuscular junctions, liver, heart, lung, kidney, and so-called organs-on-a-chip, as well as the challenges of providing a blood supply and nerves to bioprinted tissues. This is a compelling tale of a work in progress: to imitate nature and help heal people with debilitating afflictions.

Bioprinting in Regenerative Medicine

Author : Kursad Turksen
Publisher : Springer
ISBN 13 : 3319213865
Total Pages : 148 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Bioprinting in Regenerative Medicine by : Kursad Turksen

Download or read book Bioprinting in Regenerative Medicine written by Kursad Turksen and published by Springer. This book was released on 2015-09-02 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the current state of laser-assisted bioprinting, a cutting edge tissue engineering technology. Nineteen chapters discuss the most recent developments in using this technology for engineering different types of tissue. Beginning with an overview, the discussion covers bioprinting in cell viability and pattern viability, tissue microfabrication to study cell proliferation, microenvironment for controlling stem cell fate, cell differentiation, zigzag cellular tubes, cartilage tissue engineering, osteogenesis, vessel substitutes, skin tissue and much more. Because bioprinting is on its way to becoming a dominant technology in tissue-engineering, Bioprinting in Regenerative Medicine is essential reading for those researching or working in regenerative medicine, tissue engineering or translational research. Those studying or working with stem cells who are interested in the development of the field will also find the information invaluable.

3D Bioprinting

Author : Jeremy M. Crook
Publisher : Humana
ISBN 13 : 9781071605196
Total Pages : 0 pages
Book Rating : 4.6/5 (51 download)

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Book Synopsis 3D Bioprinting by : Jeremy M. Crook

Download or read book 3D Bioprinting written by Jeremy M. Crook and published by Humana. This book was released on 2020-03-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the latest developments and contributions to the field of 3D bioprinting, and discusses its use for quality R&D and translation. The chapters in this book are divided into two parts: Part one covers generic themes in bioprinting to introduce novice readers to the field, while also providing experts with new and helpful information. Part two discusses protocols used to prepare, characterize, and print a variety of biomaterials, cells, and tissues. These chapters also emphasize methods used for printing defined and humanized constructs suitable for human tissue modelling in research and applicable to clinical product development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, 3D Bioprinting: Methods and Protocols is a valuable resource for researchers and bioprinting laboratories/facilities interested in learning more about this rapidly evolving technology.

Cardiac Regeneration

Author : Masaki Ieda
Publisher : Springer
ISBN 13 : 3319561065
Total Pages : 274 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Cardiac Regeneration by : Masaki Ieda

Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Fundamentals of Tissue Engineering and Regenerative Medicine

Author : Ulrich Meyer
Publisher : Springer Science & Business Media
ISBN 13 : 3540777555
Total Pages : 1049 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Fundamentals of Tissue Engineering and Regenerative Medicine by : Ulrich Meyer

Download or read book Fundamentals of Tissue Engineering and Regenerative Medicine written by Ulrich Meyer and published by Springer Science & Business Media. This book was released on 2009-02-11 with total page 1049 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.