Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

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Publisher : Springer Science & Business Media
ISBN 13 : 4431273786
Total Pages : 233 pages
Book Rating : 4.4/5 (312 download)

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Book Synopsis Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches by : Hidezo Mori

Download or read book Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches written by Hidezo Mori and published by Springer Science & Business Media. This book was released on 2006-06-18 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cardiovascular system transports oxygen and nutrients to all parts of the body; therefore, any impediment to this system through, for example, a circulatory disorder, represents a serious threat to organs, tissues, and cells. Obstructive diseases of vessels with a diameter of more than 1 mm can be treated by conventional surgical and interventional approaches; however, blockages in small vessels with a diameter of less than 1 mm cannot be treated by conventional methods. As a consequence, therapeutic ang- genesis and vasculogenesis for the treatment of ischemic diseases have been widely studied in the last decade. These methods may contribute to the re pair of intractable cardiovascular diseases with a main vascular involvement in the body's smallest vessels. In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering. The Ministry of Health, Labor, and Welfare of Japan has been encouraging the National Cardiovascular Center Research Institute to promote cardiovascular regeneration therapies using such ap proaches. Therefore, it is with the financial aid and support of research grants, such as that for Cardiovascular Disease (13C-1 and I6C-6), Health and Labor Sciences Research Grants (RHGTEFB-genome-005, RHGTEFB-saisei-003, and CRCD-junkanki-009) and a grant from NEDO of Japan, that significant progress has been possible.

Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches

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Author :
Publisher : Springer
ISBN 13 : 9784431239253
Total Pages : 238 pages
Book Rating : 4.2/5 (392 download)

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Book Synopsis Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches by : Hidezo Mori

Download or read book Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches written by Hidezo Mori and published by Springer. This book was released on 2005-02-23 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cardiovascular system transports oxygen and nutrients to all parts of the body; therefore, any impediment to this system through, for example, a circulatory disorder, represents a serious threat to organs, tissues, and cells. Obstructive diseases of vessels with a diameter of more than 1 mm can be treated by conventional surgical and interventional approaches; however, blockages in small vessels with a diameter of less than 1 mm cannot be treated by conventional methods. As a consequence, therapeutic ang- genesis and vasculogenesis for the treatment of ischemic diseases have been widely studied in the last decade. These methods may contribute to the re pair of intractable cardiovascular diseases with a main vascular involvement in the body's smallest vessels. In this book, Hikaru Matsuda and I have tried to summarize recent Japanese developments in the field of cardiovascular regeneration therapies using tissue engineering. The Ministry of Health, Labor, and Welfare of Japan has been encouraging the National Cardiovascular Center Research Institute to promote cardiovascular regeneration therapies using such ap proaches. Therefore, it is with the financial aid and support of research grants, such as that for Cardiovascular Disease (13C-1 and I6C-6), Health and Labor Sciences Research Grants (RHGTEFB-genome-005, RHGTEFB-saisei-003, and CRCD-junkanki-009) and a grant from NEDO of Japan, that significant progress has been possible.

Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches (2005).

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Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (785 download)

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Book Synopsis Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches (2005). by :

Download or read book Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches (2005). written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cardiovascular Regenerative Medicine

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Author :
Publisher : Springer
ISBN 13 : 3030200477
Total Pages : 233 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Cardiovascular Regenerative Medicine by : Vahid Serpooshan

Download or read book Cardiovascular Regenerative Medicine written by Vahid Serpooshan and published by Springer. This book was released on 2019-06-29 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive and up-to-date resource on the use of regenerative medicine for the treatment of cardiovascular disease. It provides a much-needed review of the rapid development and evolution of bio-fabrication techniques to engineer cardiovascular tissues as well as their use in clinical settings. The book incorporates recent advances in the biology, biomaterial design, and manufacturing of bioengineered cardiovascular tissue with their clinical applications to bridge the basic sciences to current and future cardiovascular treatment. The book begins with an examination of state-of-the-art cellular, biomaterial, and macromolecular technologies for the repair and regeneration of diseased heart tissue. It discusses advances in nanotechnology and bioengineering of cardiac microtissues using acoustic assembly. Subsequent chapters explore the clinical applications and translational potential of current technologies such as cardiac patch-based treatments, cell-based regenerative therapies, and injectable hydrogels. The book examines how these methodologies are used to treat a variety of cardiovascular diseases including myocardial infarction, congenital heart disease, and ischemic heart injuries. Finally, the volume concludes with a summary of the most prominent challenges and perspectives on the field of cardiovascular tissue engineering and clinical cardiovascular regenerative medicine. Cardiovascular Regenerative Medicine is an essential resource for physicians, residents, fellows, and medical students in cardiology and cardiovascular regeneration as well as clinical and basic researchers in bioengineering, nanomaterial and technology, and cardiovascular biology.

Regenerating the Heart

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Publisher : Springer Science & Business Media
ISBN 13 : 1617790214
Total Pages : 555 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Regenerating the Heart by : Ira S. Cohen

Download or read book Regenerating the Heart written by Ira S. Cohen and published by Springer Science & Business Media. This book was released on 2011-03-23 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical research made huge strides in treating heart disease in the 20th century, from drug-eluding stents to automatic internal defibrillators. Public awareness of the dangers of heart disease has never been more pervasive. Now, though, ten years into a new millennium, scientists are gearing up for the next great challenges in tackling this pervasive condition. Cell therapy is going to be a key weapon in the fight against heart disease. It has the potential to address many cardiovascular conditions. From heart failure to atrioventricular nodal dysfunction, the young but promising field of cell therapy is set to play a significant role in developing the cures that the upcoming decades of hard work will yield. Regenerating the Heart: Stem Cells and the Cardiovascular System organizes the field into a digestible body of knowledge. Its four sections cover mechanical regeneration, electrical regeneration, cardiac tissues and in vivo stem cell therapies. An array of talented researchers share the fruits of their labors, with chapters covering such crucial issues as the cardiogenic potential of varying stem cell types, the ways in which they might be used to tackle arrhythmias, their possible application to biological replacements for cardiac tissues such as valves, and the varying approaches used in the in vivo evaluation of stem cell therapies, including methods of delivering stem cells to the myocardium. This comprehensive survey of an area of research with such exciting potential is an invaluable resource both for veteran stem cell researchers who need to monitor fresh developments, and for newly minted investigators seeking inspirational examples.

Advanced Therapies for Cardiac Regeneration

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Publisher : Frontiers Media SA
ISBN 13 : 2889666956
Total Pages : 324 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Advanced Therapies for Cardiac Regeneration by : Valeria Chiono

Download or read book Advanced Therapies for Cardiac Regeneration written by Valeria Chiono and published by Frontiers Media SA. This book was released on 2021-04-13 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Research Topic is organized in the framework of the project BIORECAR (grant number: 772168; http://www.biorecar.polito.it/index.html)

Cardiac Regeneration and Repair

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Publisher : Elsevier
ISBN 13 : 0857096710
Total Pages : 509 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Cardiac Regeneration and Repair by : Ren-Ke Li

Download or read book Cardiac Regeneration and Repair written by Ren-Ke Li and published by Elsevier. This book was released on 2014-02-17 with total page 509 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Regeneration and Repair, Volume Two reviews the use of biomaterials, alone or combined with cell therapy, in providing tissue-engineered constructs to repair the injured heart and prevent or reverse heart failure. Part one explores the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Further chapters explore the use of biomaterials to enhance stem cell therapy for restoring ventricular function and generating stem cell-modified intravascular stents. Part two focuses on tissue engineering for cardiac repair, including chapters on decellularized biologic scaffolds, synthetic scaffolds, cell sheet engineering, maturation of functional cardiac tissue patches, vascularized engineered tissues for in vivo and in vitro applications, and clinical considerations for cardiac tissue engineering. Finally, part three explores vascular remodeling, including chapters highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels. Cardiac Regeneration and Repair, Volume Two is complemented by an initial volume covering pathology and therapies. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Surveys the variety of biomaterials available for cardiac repair, including nanomaterials and hydrogels. Focuses on tissue engineering for cardiac repair including clinical considerations for cardiac tissue engineering Explores vascular remodeling, highlighting aortic extracellular matrix remodeling, cell-biomaterial interactions for blood vessel formation, and stem cells for tissue-engineered blood vessels

Cardiac Regeneration

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Publisher : Springer
ISBN 13 : 3319561065
Total Pages : 274 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Cardiac Regeneration by : Masaki Ieda

Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.

Tissue Engineering Approaches to Post-infarction Cardiovascular Regeneration Using Self-assembling Peptide Nanofibers

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Publisher :
ISBN 13 :
Total Pages : 111 pages
Book Rating : 4.:/5 (778 download)

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Book Synopsis Tissue Engineering Approaches to Post-infarction Cardiovascular Regeneration Using Self-assembling Peptide Nanofibers by : 林意棟

Download or read book Tissue Engineering Approaches to Post-infarction Cardiovascular Regeneration Using Self-assembling Peptide Nanofibers written by 林意棟 and published by . This book was released on 2011 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair

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Publisher : Springer Science & Business Media
ISBN 13 : 038730939X
Total Pages : 332 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair by : Nabil Dib

Download or read book Stem Cell Therapy and Tissue Engineering for Cardiovascular Repair written by Nabil Dib and published by Springer Science & Business Media. This book was released on 2006-04-09 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: In excess of 7 million people worldwide die of coronary heart disease each year. Only one-third of these heart attack victims recover completely. The remainder suffer the consequences of myocardial infarction and its ill fated remodeling process, resulting in chronic congestive heart failure. This malady alone is the leading cause of hospital admissions in the United States. New breakthroughs in stem cell therapy and tissue engineering have promised to reverse this dismal outcome by cardiovascular repair. World authorities, including scientists and regulatory authorities, have joined in a collaborative effort to present for the reader the first collective review of stem cell therapy for the treatment of cardiovascular disease. These contributions in basic science, pre-clinical and clinical experience guided by the regulatory pathways, assure a rapid course of translational research and clinical trials. The contents of this publication will become a prerequisite for those preparing to meet the challenges of this exciting and potentially rewarding field of stem cell research.

Cardiac Regeneration and Repair

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Author :
Publisher : Elsevier
ISBN 13 : 0857096702
Total Pages : 459 pages
Book Rating : 4.8/5 (57 download)

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Book Synopsis Cardiac Regeneration and Repair by : Ren-Ke Li

Download or read book Cardiac Regeneration and Repair written by Ren-Ke Li and published by Elsevier. This book was released on 2014-02-16 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Regeneration and Repair, Volume One reviews the pathology of cardiac injury and the latest advances in cell therapy. Chapters in part one explore the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function. Part two highlights new approaches to cell therapy for cardiac regeneration, and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function. Chapters in part three move on to highlight novel stem cells for cardiac repair, including human embryonic stem cells and human pluripotent stem cells, and detail their current status and future potential for cardiac therapy. Finally, part four explores gene therapy, and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration. Cardiac Regeneration and Repair, Volume One is complemented by a second volume covering biomaterials and tissue engineering. Together, the two volumes of Cardiac Regeneration and Repair provide a comprehensive resource for clinicians, scientists, or academicians fascinated with cardiac regeneration, including those interested in cell therapy, tissue engineering, or biomaterials. Explores the pathogenesis of congestive heart failure, the mechanisms responsible for adverse cardiac matrix remodeling, and potential interventions to restore ventricular function Highlights new approaches to cell therapy for cardiac regeneration and includes chapters covering alternative routes of cell delivery, monitoring cell engraftment, and the feasibility of using allogeneic stem cells to restore cardiac function Explores gene therapy and includes ultrasound-targeted or direct gene delivery as well as cell-based gene therapy for cardiac regeneration

Cardiac Regeneration using Stem Cells

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Publisher : CRC Press
ISBN 13 : 1466578394
Total Pages : 376 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Cardiac Regeneration using Stem Cells by : Keiichi Fukuda

Download or read book Cardiac Regeneration using Stem Cells written by Keiichi Fukuda and published by CRC Press. This book was released on 2013-04-10 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: To achieve cardiac regeneration using pluripotent stem (iPS) cells, researchers must understand iPS cell generation methods, cardiomyocyte differentiation protocols, cardiomyocyte characterization methods, and tissue engineering. This book presents the current status and future possibilities in cardiac regeneration using iPS cells. Written by top researchers who present new data in these fields, this book reviews cardiac cell therapy for ischemic heart disease and explores in vitro generation of efficacious platelets from iPS cells. It also discusses modeling arrhythmogenic heart disease with patient-specific induced pluripotent stem cells.

Cardiac Tissue Engineering

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Author :
Publisher : Springer Nature
ISBN 13 : 3031025849
Total Pages : 190 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Cardiac Tissue Engineering by : Smadar Cohen

Download or read book Cardiac Tissue Engineering written by Smadar Cohen and published by Springer Nature. This book was released on 2022-06-01 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac tissue engineering aims at repairing damaged heart muscle and producing human cardiac tissues for application in drug toxicity studies. This book offers a comprehensive overview of the cardiac tissue engineering strategies, including presenting and discussing the various concepts in use, research directions and applications. Essential basic information on the major components in cardiac tissue engineering, namely cell sources and biomaterials, is firstly presented to the readers, followed by a detailed description of their implementation in different strategies, broadly divided to cellular and acellular ones. In cellular approaches, the biomaterials are used to increase cell retention after implantation or as scaffolds when bioengineering the cardiac patch, in vitro. In acellular approaches, the biomaterials are used as ECM replacement for damaged cardiac ECM after MI, or, in combination with growth factors, the biomaterials assume an additional function as a depot for prolonged factor activity for the effective recruitment of repairing cells. The book also presents technological innovations aimed to improve the quality of the cardiac patches, such as bioreactor applications, stimulation patterns and prevascularization. This book could be of interest not only from an educational perspective (i.e. for graduate students), but also for researchers and medical professionals, to offer them fresh views on novel and powerful treatment strategies. We hope that the reader will find a broad spectrum of ideas and possibilities described in this book both interesting and convincing. Table of Contents: Introduction / The Heart: Structure, Cardiovascular Diseases, and Regeneration / Cell Sources for Cardiac Tissue Engineering / Biomaterials: Polymers, Scaffolds, and Basic Design Criteria / Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct / Bioengineering of Cardiac Patches, In Vitro / Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering / Vascularization of Cardiac Patches / Acellular Biomaterials for Cardiac Repair / Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration

Tissue Engineering Strategies for Cardiac Regeneration

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Publisher :
ISBN 13 :
Total Pages : 157 pages
Book Rating : 4.:/5 (776 download)

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Book Synopsis Tissue Engineering Strategies for Cardiac Regeneration by : Jennifer R. Hurley

Download or read book Tissue Engineering Strategies for Cardiac Regeneration written by Jennifer R. Hurley and published by . This book was released on 2011 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiovascular disease (CVD) is a significant health burden and is the leading cause of death in the United States. Cardiac pathologies which lead to cardiovascular disease, including myocardial infarction and diabetes, often result in damaged, ischemic and/or fibrotic tissue and would benefit from a therapeutic approach to promote cardiac regeneration. The use of a tissue engineering approach, where the principles of biology and engineering are combined to develop functional tissue substitutes, is a very promising and active field of study. However, cardiac tissue engineering approaches to date have been limited due to 1) insufficient vascularization of engineered tissues (essential for the supply of oxygen, nutrients, and immune cells and waste removal) and 2) impaired regulation of extracellular matrix remodeling and turnover (leading to damaging structural, geometric and functional changes in the heart). Therefore, promoting both vascularization and reparative matrix remodeling is one of the key requirements for successful cardiac regeneration via cardiac tissue engineering approaches. Our long-term goal is to develop a new cardiac tissue engineering approach to treat cardiovascular diseases, including myocardial infarction and diabetic cardiomyopathy, by applying recent advances in nanobiotechnology to modify the microenvironment of heart muscle and promote cardiac regeneration. The studies in this dissertation contribute to this goal by investigating the interactions between cardiac cells, including endothelial cells and fibroblasts, as well as the use of RAD16-II peptide nanofibers and mechanical strain to promote angiogenesis and reparative matrix remodeling by these cells in vitro. The central hypothesis of this research is that RAD16-II peptide nanofibers can be used as a microenvironment for a cardiac tissue engineering approach which promotes cardiac regeneration via revascularization and reparative matrix remodeling by cardiac fibroblasts. The results from this dissertation research help identify the role of fibroblasts in temporal regulation of the angiogenic process and in reparative matrix remodeling. Additionally, the effects of diabetes on the matrix remodeling response by fibroblasts and potential compensatory tissue engineering strategies (i.e. mechanical stretch, peptide nanofiber microenvironment) were investigated as well. The culture system of RAD16-II nanofibers was utilized as both a controlled microenvironment for study and as a system which supports matrix metalloproteinase-mediated extracellular matrix remodeling by cardiac fibroblasts in vitro. The findings of this research will contribute towards developing an optimal microenvironment to enhance cardiac regeneration after injury and for cardiac tissue engineering applications.

Cardiac Tissue Engineering

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Author :
Publisher : Humana Press
ISBN 13 : 9781493910465
Total Pages : 0 pages
Book Rating : 4.9/5 (14 download)

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Book Synopsis Cardiac Tissue Engineering by : Milica Radisic

Download or read book Cardiac Tissue Engineering written by Milica Radisic and published by Humana Press. This book was released on 2014-07-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac Tissue Engineering: Methods and Protocols presents a collection of protocols on cardiac tissue engineering from pioneering and leading researchers around the globe. These include methods and protocols for cell preparation, biomaterial preparation, cell seeding, and cultivation in various systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Cardiac Tissue Engineering: Methods and Protocols highlights the major techniques, both experimental and computational, for the study of cardiovascular tissue engineering.

Cardiac Tissue Engineering

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Author :
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1608452050
Total Pages : 202 pages
Book Rating : 4.6/5 (84 download)

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Book Synopsis Cardiac Tissue Engineering by : Smadar Cohen

Download or read book Cardiac Tissue Engineering written by Smadar Cohen and published by Morgan & Claypool Publishers. This book was released on 2012-10-01 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cardiac tissue engineering aims at repairing damaged heart muscle and producing human cardiac tissues for application in drug toxicity studies. This book offers a comprehensive overview of the cardiac tissue engineering strategies, including presenting and discussing the various concepts in use, research directions and applications. Essential basic information on the major components in cardiac tissue engineering, namely cell sources and biomaterials, is firstly presented to the readers, followed by a detailed description of their implementation in different strategies, broadly divided to cellular and acellular ones. In cellular approaches, the biomaterials are used to increase cell retention after implantation or as scaffolds when bioengineering the cardiac patch, in vitro. In acellular approaches, the biomaterials are used as ECM replacement for damaged cardiac ECM after MI, or, in combination with growth factors, the biomaterials assume an additional function as a depot for prolonged factor activity for the effective recruitment of repairing cells. The book also presents technological innovations aimed to improve the quality of the cardiac patches, such as bioreactor applications, stimulation patterns and prevascularization. This book could be of interest not only from an educational perspective (i.e. for graduate students), but also for researchers and medical professionals, to offer them fresh views on novel and powerful treatment strategies. We hope that the reader will find a broad spectrum of ideas and possibilities described in this book both interesting and convincing. Table of Contents: Introduction / The Heart: Structure, Cardiovascular Diseases, and Regeneration / Cell Sources for Cardiac Tissue Engineering / Biomaterials: Polymers, Scaffolds, and Basic Design Criteria / Biomaterials as Vehicles for Stem Cell Delivery and Retention in the Infarct / Bioengineering of Cardiac Patches, In Vitro / Perfusion Bioreactors and Stimulation Patterns in Cardiac Tissue Engineering / Vascularization of Cardiac Patches / Acellular Biomaterials for Cardiac Repair / Biomaterial-based Controlled Delivery of Bioactive Molecules for Myocardial Regeneration

Tissue Engineering for the Heart

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Author :
Publisher : Springer
ISBN 13 : 3319415042
Total Pages : 256 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Tissue Engineering for the Heart by : Ravi Birla

Download or read book Tissue Engineering for the Heart written by Ravi Birla and published by Springer. This book was released on 2016-09-26 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the fundamentals of tissue engineering for the heart, starting with the basics of organ generation, sensors in tissue and organ fabrication, and the current state-of-the-art in stem cell engineering for the heart. With this foundation in place, the remaining chapters focus on specific aspects of the cardiovascular system, starting with heart muscle, then biological pumps, followed by bioartificial ventricles, and finally, bioartificial hearts. Throughout the course of this book, twenty-two in-depth case studies are presented. Each case study has been selected to illustrate specific design schemes for tissue and organ fabrication. This is an ideal book for upper-level undergraduate and graduate students studying tissue engineering and organ regeneration, especially those focused on cardiac regeneration. This book also: Includes twenty-two case studies that illustrate specific design schemes for engineering the heart Provides open-ended discussion questions at the end of each chapter as well as a detailed reference list to encourage further research and reading Covers the basics of organ fabrication as well as sensor technology and genetic engineering as they relate to tissue and organ fabrication