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Carbohydrate Silica Nanoparticles For Sirna Delivery
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Book Synopsis Carbohydrate-silica Nanoparticles for Sirna Delivery by : Olivia Mariel Chesniak
Download or read book Carbohydrate-silica Nanoparticles for Sirna Delivery written by Olivia Mariel Chesniak and published by . This book was released on 2019 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA interference (RNAi) has long been pursued for its therapeutic potential. Sequence-specific knockdown of gene expression requires that small interfering RNA (siRNA) gain access to cellular cytoplasm, presenting difficulties for both the transport of nucleic acids to cells and their voyage across cellular membranes. Numerous materials are under development as siRNA delivery vehicles to address this need. The carbohydrate dextran has been incorporated into amine-functionalized sil- ica nanoparticles (Dex-SiO2-NPs), enhancing their biocompatibility and success as siRNA delivery vehicles. Inspired by the work of Stober and others, reagent concentrations in the synthesis of Dex- SiO2-NPs have been adjusted to tune nanoparticle diameter. The size, shape, and morphology of Dex-SiO2-NPs have been characterized using transmission electron microscopy (TEM) and energy dispersive x-ray spectroscopy (EDS). These methods have revealed that Dex-SiO2-NPs decrease in silicon density toward their centers, when compared with SiO2-NPs. Thermal and porosity analysis were used to profile Dex-SiO2-NPs both containing dextran and after its removal by calcination. Having measured an increase in mesopores and decrease in micropores with calcination, it has been concluded that dextran serves as a porogen in Dex-SiO2-NP synthesis. Not only does dextran imbue these materials with unique morphology, it also enhances their function as delivery vehicles. Dex-SiO2-NPs improve enhanced green fluorescent protein (EGFP) supression compared to silica nanoparticles synthesized in the absence of dextran in human lung and kidney cells in vitro.
Book Synopsis Delivery of Fluorouracil and SiRNA by Mesoporous Silica Nanoparticles to Drug Resistant Colorectal Cancer by : Lijue Chen
Download or read book Delivery of Fluorouracil and SiRNA by Mesoporous Silica Nanoparticles to Drug Resistant Colorectal Cancer written by Lijue Chen and published by . This book was released on 2015 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous silica nanoparticle based drug and gene delivery system was developed to overcome the acquired drug resistance in colorectal cancer by targeted delivery of anti-cancer drug in the cytoplasm of the cancer cells and silencing the gene expression related to drug resistance.
Book Synopsis Exploiting the Antioxidant Potential and SiRNA Delivery Function of Mesoporous Silica Nanoparticles for the Treatment of Skin Fibrosis and Breast Cancer Metastasis by : Jingga Morry
Download or read book Exploiting the Antioxidant Potential and SiRNA Delivery Function of Mesoporous Silica Nanoparticles for the Treatment of Skin Fibrosis and Breast Cancer Metastasis written by Jingga Morry and published by . This book was released on 2016 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Assessment of a Number of Different Mesoporous Silica Nanoparticles for Delivery of Chemotherapeutics and SiRNAs by : Xinyue Huang
Download or read book The Assessment of a Number of Different Mesoporous Silica Nanoparticles for Delivery of Chemotherapeutics and SiRNAs written by Xinyue Huang and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part A by :
Download or read book Mesoporous Silica-based Nanomaterials and Biomedical Applications - Part A written by and published by Academic Press. This book was released on 2018-09-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Therapy and Diagnosis, Part A, Volume 43 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on Mesoporous silica nanoparticle synthesis, Periodic mesoporous organosilica, Nanovalves and other nanomachine-equipped nanoparticles and controlled release, Two-photon light control and photodynamic therapy, Biodegradable PMO nanoparticles, Cationic mesoporous silica and protein delivery, Drug loading, stimuli-responsive delivery and cancer treatment, Animal models and cancer therapy, siRNA delivery and TWIST shutdown for ovarian cancer treatment, and TBC (mesoporous silica nanoparticles and cancer therapy or biodistribution of MSN).
Book Synopsis Silica Nanoparticles for the Delivery of DNA and RNAi in Cancer Treatment by : Michael Aaron Vrolijk
Download or read book Silica Nanoparticles for the Delivery of DNA and RNAi in Cancer Treatment written by Michael Aaron Vrolijk and published by . This book was released on 2017 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA and interfering RNA (RNAi) -- short interfering RNA (siRNA) and micro RNA (miRNA) -- are promising new cancer therapies, especially for drug resistant lines. However, they require a delivery system in vivo to prevent degradation and off target effects. Silica based nanoparticles, both solid and mesoporous, are a promising option due to their biocompatibility, ease of preparation and morphology control, reproducibility, and facile addition of functional groups including targeting ligands. After a brief introduction to cancer treatment and review of the current nanoparticle treatments undergoing clinical trials, this thesis details the many methods explored over the past ten years to fine-tune particle preparation, pore size, functionalization, and delivery strategies. The majority of both solid and mesoporous silica nanoparticles are synthesized using the sol-gel method and then various functionalization techniques are employed to load and protect the oligonucleotides. Externally loaded systems generally use a combination of polyethylenimine (PEI) and polyethylene glycol (PEG). Mesoporous silica nanoparticles internally load the DNA or RNAi, resulting in the added variable of pore size. Several groups have investigated how pore size alters loading and release kinetics to perfect this variable. Many groups have also tested ligands targeting for over expressed proteins on the intended cancer, triggered release techniques, cell-penetrating peptides in order to create a viable in vivo delivery system. By compiling the techniques employed by researchers over the past ten years, this thesis will elucidate which approaches are most promising for future research. Furthermore, overall strategies within the field are suggested to more easily compare studies and evaluate methods.
Book Synopsis Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine by : Erem Bilensoy
Download or read book Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine written by Erem Bilensoy and published by John Wiley & Sons. This book was released on 2011-04-27 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cyclodextrins in Pharmaceutics, Cosmetics, and Biomedicine covers a wide range of knowledge on cyclodextrins, from an overview of molecular and supramolecular aspects of cyclodextrin physicochemistry, to the latest outcomes in cyclodextrin use and future possibilities in the employment of these systems. This book focuses on the derivatives and physicochemical and biological properties of cyclodextrins, and considers drug delivery through topical, mucosal, and oral via cyclodextrin complexes.
Book Synopsis Handbook of Nanomaterials for Cancer Theranostics by : Joao Conde
Download or read book Handbook of Nanomaterials for Cancer Theranostics written by Joao Conde and published by Elsevier. This book was released on 2018-06-27 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nanomaterials for Cancer Theranostics focuses on recent developments in advanced theranostic nanomedicines from a chemical and biological perspective where the advantages of theranostics are achieved by combining multiple components. The authors explore the pros and cons of theranostic nanomaterials developed in cancer research in the last 15 years, with the different strategies compared and scrutinized. In addition, the book explores how nanomaterials may overcome the regulatory hurdles facing theranostic nanomedicines. This is an important research reference for postgraduates and researchers in nanomedicine and cancer research who want to learn more on how nanomaterials can help create more effective cancer treatments. Highlights the development of smart theranostic nanomaterials to tackle biomedical problems in cancer therapy and diagnostics Explores the regulatory hurdles facing theranostic nanomedicine Discusses how the use of nanomaterials can help create more effective cancer treatments
Book Synopsis Therapeutic Oligonucleotides by : Jens Kurreck
Download or read book Therapeutic Oligonucleotides written by Jens Kurreck and published by Royal Society of Chemistry. This book was released on 2008 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a compelling overall update on current status of RNA interference
Book Synopsis Nanopharmaceuticals: Principles and Applications Vol. 3 by : Vinod Kumar Yata
Download or read book Nanopharmaceuticals: Principles and Applications Vol. 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.
Book Synopsis Silk-based Drug Delivery Systems by : Elia Bari
Download or read book Silk-based Drug Delivery Systems written by Elia Bari and published by Royal Society of Chemistry. This book was released on 2020-10-07 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering spider silk and silk worm cocoons, the editors elucidate the extraction, structure and properties of silk sericin and silk fibroin.
Book Synopsis Stimuli-Responsive Nanomedicine by : Lin Zhu
Download or read book Stimuli-Responsive Nanomedicine written by Lin Zhu and published by CRC Press. This book was released on 2021-03-24 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The response to environmental and internal stimuli is one of the basic characteristics of living organisms. Inspired by this natural strategy and fast-developing nanotechnology and materials science, stimuli-responsive nanomedicine has emerged as an active and important field of nanomedicine. This book offers a fundamental and comprehensive overview of stimuli-responsive nanomedicine and compiles and details the recent cutting-edge findings and most impressive achievements in biomedical applications, from a pharmaceutical science perspective, making it the first book of its kind in this field. By providing readers a broad and in-depth coverage of endogenous and exogenous stimuli as well as their applicable nanomedicines, this book is valuable for students, researchers, and educators in biomedical sciences or anyone interested in this burgeoning field.
Book Synopsis Nanostructured Polymer Composites for Biomedical Applications by : Sarat Kumar Swain
Download or read book Nanostructured Polymer Composites for Biomedical Applications written by Sarat Kumar Swain and published by Elsevier. This book was released on 2019-06-15 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanostructured Polymer Composites for Biomedical Applications addresses the challenges researchers face regarding the creation of nanostructured polymer composites that not only have superior performance and mechanical properties, but also have acceptable biological function. This book discusses current efforts to meet this challenge by discussing the multidisciplinary nature of nanostructured polymer composite biomaterials from various fields, including materials science, polymer science, biomedical engineering and biomedicine. This compilation of existing knowledge will lead to the generation of new terminology and definitions across individual disciplines. As such, this book will help researchers and engineers develop new products and devices for use in effective medical treatment. Summarizes the most recent strategies to develop nanostructured polymer composite biomaterials for biomedicine Outlines the major preparation and characterization techniques for a range of polymer nanocomposites used in biomedicine Explores the design of new types of nanostructured polymer composites for applications in drug delivery, tissue engineering, gene therapy and bone replacement
Book Synopsis Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance by : Muthupandian Saravanan
Download or read book Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance written by Muthupandian Saravanan and published by Elsevier. This book was released on 2022-06-22 with total page 790 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Nanomaterials and Nano-based Drug Delivery Approaches to Combat Antimicrobial Resistance focuses on recent and emerging trends surrounding nanomaterials and nano-drug delivery approaches to combat antimicrobial resistance. The relationship between nanomaterials and antimicrobial activity needs to be deeply explored to meet the challenges of combating antimicrobial resistance. The content of this book is divided into three main topic areas, including (i) how to overcome the existing traditional approaches to combat antimicrobial resistance, (ii) applying multiple drug delivery mechanisms to target multi-drug resistant microbes, and (iii) how nanomaterials can be used as drug carriers. This is an important reference source for those looking to understand how nanotechnology plays an important role in combatting disease and infection. As antimicrobial resistance threatens the effective prevention and treatment of an ever-increasing range of infections caused by bacteria, parasites, viruses, and fungi, this is a timely resource. Outlines how to overcome existing traditional approaches to combatting antimicrobial resistance Explains how to apply multiple drug delivery mechanisms (MDR) to the target area in order to better combat antimicrobial resistance Shows how nanomaterials are used as drug carriers in this context
Book Synopsis Advanced Drug Delivery Systems in the Management of Cancer by : Kamal Dua
Download or read book Advanced Drug Delivery Systems in the Management of Cancer written by Kamal Dua and published by Elsevier. This book was released on 2021-06-24 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems
Book Synopsis Chitin and Chitosan by : Lambertus A. M. van den Broek
Download or read book Chitin and Chitosan written by Lambertus A. M. van den Broek and published by John Wiley & Sons. This book was released on 2020-01-21 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a comprehensive guide to the isolation, properties and applications of chitin and chitosan Chitin and Chitosan: Properties and Applications presents a comprehensive review of the isolation, properties and applications of chitin and chitosan. These promising biomaterials have the potential to be broadly applied and there is a growing market for these biopolymers in areas such as medical and pharmaceutical, packaging, agricultural, textile, cosmetics, nanoparticles and more. The authors – noted experts in the field – explore the isolation, characterization and the physical and chemical properties of chitin and chitosan. They also examine their properties such as hydrogels, immunomodulation and biotechnology, antimicrobial activity and chemical enzymatic modifications. The book offers an analysis of the myriad medical and pharmaceutical applications as well as a review of applications in other areas. In addition, the authors discuss regulations, markets and perspectives for the use of chitin and chitosan. This important book: Offers a thorough review of the isolation, properties and applications of chitin and chitosan. Contains information on the wide-ranging applications and growing market demand for chitin and chitosan Includes a discussion of current regulations and the outlook for the future Written for Researchers in academia and industry who are working in the fields of chitin and chitosan, Chitin and Chitosan: Properties and Applications offers a review of these promising biomaterials that have great potential due to their material properties and biological functionalities.
Book Synopsis Applications of Targeted Nano Drugs and Delivery Systems by : Shyam Mohapatra
Download or read book Applications of Targeted Nano Drugs and Delivery Systems written by Shyam Mohapatra and published by Elsevier. This book was released on 2018-10-05 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applications of Targeted Nano-Drugs and Delivery Systems: Nanoscience and Nanotechnology in Drug Delivery explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major diseases. The book explores how nanotechnology can be deployed in developing new drug delivery systems and how they enable pharmaceutical companies to reformulate existing drugs on the market, thereby extending the lifetime of products and enhancing performance by increasing effectiveness, safety and patient adherence, and ultimately reducing healthcare cost. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields. Readers will find a reference and practical source of guidance for researchers, students and scientists working in the fields of nanotechnology, materials science, and technology and biomedical science. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Explores the applications of Nano-drugs and their delivery systems, investigating the role they can play in key body systems and major disease types
