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Carbohydrate Modifications In Antisense Research
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Book Synopsis Carbohydrate Modifications in Antisense Research by : Yogesh S. Sanghvi
Download or read book Carbohydrate Modifications in Antisense Research written by Yogesh S. Sanghvi and published by . This book was released on 1994 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews recent developments and progress in the carbohydrate-related chemistry of novel nucleic acid mimics and their applications in antisense therapeutics. Discusses the use of new chemical classes to rationally design and synthesize oligonucleotides. Explores several carbohydrate modifications of the oligonucleotide to stabilize against nuclease degradation and to enhance the binding affinity for a given target. Suggests future directions of carbohydrate-related modifications for antisense molecules.
Book Synopsis Carbohydrate Modifications in Antisense Therapeutics by :
Download or read book Carbohydrate Modifications in Antisense Therapeutics written by and published by . This book was released on 1994 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antisense Research and Application by : Stanley T. Crooke
Download or read book Antisense Research and Application written by Stanley T. Crooke and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense technology may result in dramatic changes in the therapy of many diseases and may provide tools to dissect pharmacological processes and to confirm the roles of various genes. In this volume, progress in the understanding of antisense technology and its use in creating new drugs is discussed. Potential caveats, pitfalls and limitations of the technology are also presented. In the next few years the pace at which new molecular targets will be identified will increase exponentially as the sequencing of the human genome and of other genomes proceeds.
Book Synopsis Manual of Antisense Methodology by : Gunther Hartmann
Download or read book Manual of Antisense Methodology written by Gunther Hartmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past few years, antisense methodology has moved from in vitro studies to in vivo studies and first human trials. While the basic concept of antisense technology is simple, the methodological problems associated with its use are numerous and complex. Antisense- based methods have proven to be a field of research where careful attention to experimental protocols and appropriate controls is necessary. The Manual of Antisense Methodology emphasizes the application of antisense oligonucleotides, and is a guide for the identification of antisense and non-antisense effects in different experimental settings. The work is organized into three sections: antisense application in vitro, antisense application in vivo (animal models) and finally, clinical antisense studies. Where at all possible, the methods are described in sufficient detail to allow reproduction of a given experiment. The Manual of Antisense Methodology will be of interest to researchers in immunology, cancer research, pharmacology and internal medicine; and physicians conducting clinical studies in these fields.
Book Synopsis Antisense Technology, Part A, General Methods, Methods of Delivery, and RNA Studies by :
Download or read book Antisense Technology, Part A, General Methods, Methods of Delivery, and RNA Studies written by and published by Elsevier. This book was released on 1999-11-01 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antisense technology is the ability to manipulate gene expression within mammalian cells providing powerful experimental approaches for the study of gene function and gene regulation. For example, methods that inhibit gene expression permit studies which probe the normal function of a specific product within a cell. Such methodology can be used in many disciplines such as pharmacology, oncology, genetics, cell biology, developmental biology, molecular biology, biochemistry, and neurosciences. This volume will be a truly important tool in biomedical-oriented research. The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Book Synopsis Carbohydrate Chemistry by : R. J. Ferrier
Download or read book Carbohydrate Chemistry written by R. J. Ferrier and published by Royal Society of Chemistry. This book was released on 1997 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbohydrate Chemistry provides review coverage of all publications relevant to the chemistry of monosaccharides and oligosaccharides in a given year. The amount of research in this field appearing in the organic chemical literature is increasing because of the enhanced importance of the subject, especially in areas of medicinal chemistry and biology. In no part of the field is this more apparent than in the synthesis of oligosaccharides required by scientists working in glycobiology. Clycomedicinal chemistry and its reliance on carbohydrate synthesis is now very well established, for example, by the preparation of specific carbohydrate- based antigens, especially cancer-specific oligosaccharides and glycoconjugates. Coverage of topics such as nucleosides, amino-sugars, alditols and cyclitols also covers much research of relevance to biological and medicinal chemistry. Each volume of the series brings together references to all published work in given areas of the subject and serves as a comprehensive database for the active research chemist Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.
Book Synopsis Progress in drug research. 48.1997 by : Ernst Jucker
Download or read book Progress in drug research. 48.1997 written by Ernst Jucker and published by Springer Science & Business Media. This book was released on 1997 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
Book Synopsis Therapeutic Oligonucleotides by : Jens Kurreck
Download or read book Therapeutic Oligonucleotides written by Jens Kurreck and published by Royal Society of Chemistry. This book was released on 2008 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a compelling overall update on current status of RNA interference
Book Synopsis Antisense Drug Technology by : Stanley T. Crooke
Download or read book Antisense Drug Technology written by Stanley T. Crooke and published by CRC Press. This book was released on 2007-07-25 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation. Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.
Book Synopsis Nucleic Acids in Chemistry and Biology by : G Michael Blackburn
Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.
Book Synopsis Biomedical Polymers and Polymer Therapeutics by : Emo Chiellini
Download or read book Biomedical Polymers and Polymer Therapeutics written by Emo Chiellini and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Third International Symposium on Frontiers in Biomedical Polymers including Polymer Therapeutics: From Laboratory to Clinical Practice, held May 23-27, 1999, in Shiga, Japan. This book focuses on the progress and unique discoveries in the interdisciplinary scientific and technological area of biomedical application of polymers. The topics include polymeric materials for biomedical and pharmaceutical applications, as well as polymeric materials in therapeutics.
Book Synopsis Advances in Genetics by : Jeffrey C. Hall
Download or read book Advances in Genetics written by Jeffrey C. Hall and published by Elsevier. This book was released on 2011-07-29 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of genetics is rapidly evolving and new medical breakthroughs are occurring as a result of advances in knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Articles covered in this volume include Biological Activity and Biotechnological Aspects of Peptide Nucleic Acid (PNA); Changing Images of the Gene; Historical and Modern Genetics of Plant Graft Hybridization; Step into the Groove: Engineered Transcription Factors as Modulators of Gene Expression; Step Out of the Groove: Epigenetic Gene Control Systems and Engineered Transcription Factors.
Book Synopsis Ribonucleases, Part B: Artificial and Engineered Ribonucleases and Speicifc Applications by :
Download or read book Ribonucleases, Part B: Artificial and Engineered Ribonucleases and Speicifc Applications written by and published by Elsevier. This book was released on 2001-09-28 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second volume on ribonucleases provides up-to-date, methods-related information on these enzymes. Of particular interest to researchers will be the discussion of artificial and engineered ribonucleases, as well as the application of ribonucleases in medicine and biotechnology.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.
Book Synopsis Comprehensive Natural Products Chemistry by : Derek Barton
Download or read book Comprehensive Natural Products Chemistry written by Derek Barton and published by Newnes. This book was released on 1999-02-18 with total page 11380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Natural Products Chemistry
Book Synopsis Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques by : Eric J. Lien
Download or read book Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques written by Eric J. Lien and published by Birkhäuser. This book was released on 2012-12-06 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biotechnology And Safety Assessment by : J A Thomas
Download or read book Biotechnology And Safety Assessment written by J A Thomas and published by CRC Press. This book was released on 1998-11-17 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated text explains how advances in mammalian and plant genetics contribute to better therapeutics agents and more wholesome foods. It addresses such topics as new pharmaceutical agents, agribiotechnology, safety evaluation of biotechnology-derived drugs, food safety, nutritional science, and regulatory and environmental aspects of genetically-modified organisms. New to this edition are chapters on biotherapeutics and herbicide-resistant crops. It should be of interest to biotechnology, toxicologists, pharmaceutical scientists, environmental scientists and agriculturists.
Book Synopsis Antisense Oligodeoxynucleotides and Antisense RNA by : Benjamin Weiss
Download or read book Antisense Oligodeoxynucleotides and Antisense RNA written by Benjamin Weiss and published by CRC Press. This book was released on 1997-06-23 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical, up-to-date treatise on this technology and its potential application in therapeutics. It features critical analyses of the specificity of the agents, and the possibility of antisense oligomers acting through non-antisense mechanisms. The history of early development of antisense oligodeoxynucleotides and their chemical modification to increase their stability is followed by delivery and penetration into cells, non-antisense effects of antisense oligonucleotides, pharmacokinetic properties; in vitro and in vivo model systems, and clinical trials.
