Cancer Imaging With Radiolabeled Antibodies

Download Cancer Imaging With Radiolabeled Antibodies full books in PDF, epub, and Kindle. Read online Cancer Imaging With Radiolabeled Antibodies ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Cancer Imaging with Radiolabeled Antibodies

Author : David M. Goldenberg
Publisher : Springer Science & Business Media
ISBN 13 : 1461314976
Total Pages : 469 pages
Book Rating : 4.4/5 (613 download)

DOWNLOAD NOW!

Book Synopsis Cancer Imaging with Radiolabeled Antibodies by : David M. Goldenberg

Download or read book Cancer Imaging with Radiolabeled Antibodies written by David M. Goldenberg and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology text books are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good in-depth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes that aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, and easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion: first, by dividing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc.; and second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Author : Suresh C. Srivastava
Publisher : Springer Science & Business Media
ISBN 13 : 1468455389
Total Pages : 851 pages
Book Rating : 4.4/5 (684 download)

DOWNLOAD NOW!

Book Synopsis Radiolabeled Monoclonal Antibodies for Imaging and Therapy by : Suresh C. Srivastava

Download or read book Radiolabeled Monoclonal Antibodies for Imaging and Therapy written by Suresh C. Srivastava and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 851 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.

Cancer Therapy with Radiolabeled Antibodies

Author : David M. Goldenberg
Publisher : CRC Press
ISBN 13 : 1351078852
Total Pages : 336 pages
Book Rating : 4.3/5 (51 download)

DOWNLOAD NOW!

Book Synopsis Cancer Therapy with Radiolabeled Antibodies by : David M. Goldenberg

Download or read book Cancer Therapy with Radiolabeled Antibodies written by David M. Goldenberg and published by CRC Press. This book was released on 2018-01-18 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Therapy with Radiolabeled Antibodies explores the most current experimental and clinical advances in the newly emerging field of cancer radioimmunotherapy (RAIT). Providing a multidisciplinary and international context, some of the world's leading experts examine the problems and prospects of RAIT from radiation, immunological, chemical, physical, physiological, and clinical perspectives with both overviews and original research. Discussions cover the up-to-date clinical results in the RAIT of ovarian, breast, colorectal, and brain cancers, as well as the current status of RAIT in the management of B cell lymphomas. Radiobiology, dosimetry, radiochemistry, targeting biology in experimental models, clinical experiences in hematopoietic and solid tumors, and new approaches to improve cancer radioimmunotherapy are also discussed. In addition, new dosimetry concepts, new labeling methods, new concepts of antibody pharmacokinetics, and new methods to enhance selective cancer radioimmunotherapy are included.

Cancer Immunology

Author : Nima Rezaei
Publisher :
ISBN 13 : 9783030308476
Total Pages : 802 pages
Book Rating : 4.3/5 (84 download)

DOWNLOAD NOW!

Book Synopsis Cancer Immunology by : Nima Rezaei

Download or read book Cancer Immunology written by Nima Rezaei and published by . This book was released on 2020 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book focusing on the immunopathology of cancers is published as part of the three-volume Springer series Cancer Immunology, which aims to provide an up-to-date, clinically relevant review of cancer immunology and immunotherapy. Readers will find detailed descriptions of the interactions between cancerous cells and various components of the innate and adaptive immune system. The principal focus, however, is very much on clinical aspects, the aim being to educate clinicians in the clinical implications of the latest research and novel developments in the field. In the new edition of this very well received book, first published in 2015, the original chapters have been significantly updated and additional chapters included on, for example, current knowledge on the roles of T-helper cells and NK cells in tumor immunity, the part played by oncoviruses in the development of various cancers, and the applications of fluorescent in situ hybridization, bioluminescence, and cancer molecular and functional imaging"--Publisher's description.

Radioimmunoimaging and Radioimmunotherapy

Author : Scott W. Burchiel
Publisher : Elsevier Publishing Company
ISBN 13 :
Total Pages : 484 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Radioimmunoimaging and Radioimmunotherapy by : Scott W. Burchiel

Download or read book Radioimmunoimaging and Radioimmunotherapy written by Scott W. Burchiel and published by Elsevier Publishing Company. This book was released on 1983 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tumor Imaging

Author : Scott W. Burchiel
Publisher :
ISBN 13 :
Total Pages : 284 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Tumor Imaging by : Scott W. Burchiel

Download or read book Tumor Imaging written by Scott W. Burchiel and published by . This book was released on 1982 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:

International Symposium on Labeled and Unlabeled Antibody in Cancer Diagnosis and Therapy

Author :
Publisher :
ISBN 13 :
Total Pages : 196 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!

Book Synopsis International Symposium on Labeled and Unlabeled Antibody in Cancer Diagnosis and Therapy by :

Download or read book International Symposium on Labeled and Unlabeled Antibody in Cancer Diagnosis and Therapy written by and published by . This book was released on 1987 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Preclinical Imaging of Prostate Cancer Using Radiolabeled Antibodies

Author :
Publisher :
ISBN 13 : 9789187651243
Total Pages : 58 pages
Book Rating : 4.6/5 (512 download)

DOWNLOAD NOW!

Book Synopsis Preclinical Imaging of Prostate Cancer Using Radiolabeled Antibodies by :

Download or read book Preclinical Imaging of Prostate Cancer Using Radiolabeled Antibodies written by and published by . This book was released on 2013 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Systemic Radiotherapy with Monoclonal Antibodies

Author : Marie-Luise Sautter-Bihl
Publisher : Springer Science & Business Media
ISBN 13 : 3642799523
Total Pages : 200 pages
Book Rating : 4.6/5 (427 download)

DOWNLOAD NOW!

Book Synopsis Systemic Radiotherapy with Monoclonal Antibodies by : Marie-Luise Sautter-Bihl

Download or read book Systemic Radiotherapy with Monoclonal Antibodies written by Marie-Luise Sautter-Bihl and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost a century ago Paul Ehrlich introduced the "magic bullet" concept of targeting therapeutic agents to specific tissues in order to reduce systemic toxicity. Due to the advances in hybridoma technology in the 1980s, monoclonal antibodies (MAbs) with their exquisite affinity to tumor antigens have become powerful tools in the treatment of cancer, especially when linked to therapeutic agents such as radionuclides, drugs, toxins, or enzymes. It can now be expected that such agents will lead to new cancer treatments with high therapeutic success rates. However, there are major problems in developing this therapeutic concept to a routine treatment modality. This is partly due to factors such as heterogenous distribution of tumor antigens, insufficient blood supply of tumors, high interstitial pressure, and the large interstitial space that antibodies have to traverse. This book is focused on the development in radio immunotherapy (RIT) using radio labeled monoclonal antibodies as tumoritoxic agents. This area of research has attracted the interest of clinicians and scientists from many different disciplines. It is now clear that the full potential of RIT can only be realized through the concerted efforts of laboratory scientists (molecular biologists, cell physiologists, chemists, radiation physicists, and biologists) and cancer clinicians in nuclear medicine, radiooncology, and internal oncology.

Nuclear Medicine and Immunology

Author : Sara Harsini
Publisher : Springer Nature
ISBN 13 : 3030812618
Total Pages : 532 pages
Book Rating : 4.0/5 (38 download)

DOWNLOAD NOW!

Book Synopsis Nuclear Medicine and Immunology by : Sara Harsini

Download or read book Nuclear Medicine and Immunology written by Sara Harsini and published by Springer Nature. This book was released on 2021-11-24 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the close connection between immunology and nuclear medicine, which has led to radioimmunoimaging and radioimmunotherapy (RIT). Molecular imaging with positron emission tomography (PET) and single-photon emission computed tomography (SPECT) is increasingly being used to diagnose, characterize, and monitor disease activity in the context of inflammatory disorders of known and unknown etiology, such as sarcoidosis, atherosclerosis, vasculitis, inflammatory bowel disease, rheumatoid arthritis, and degenerative joint disease. The first chapters discuss the various radiopharmaceutical agents and radiolabeled preparations that have been employed in inflammation imaging. Of these, FDG-PET imaging has been shown to have the great value in the detection of inflammation and has become the centerpiece of several initiatives over the last several years. This very powerful technique will play an increasingly important role in the management of patients with inflammatory conditions in the future. The book also explores the growing role of nuclear medicine and molecular imaging in the diagnosis and treatment of cancer. The rapid pace of change has been fueled by advances in our understanding of tumor biology, on the one hand, and the development of specifically targeted medical therapies, diagnostic agents, and radiotherapies, on the other. Written by leading international experts in the field, this book is an invaluable tool for nuclear medicine physicians, radiologists, oncologists, and immunologists.

Radiolabeled Monoclonal Antibodies for Imaging and Therapy

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (727 download)

DOWNLOAD NOW!

Book Synopsis Radiolabeled Monoclonal Antibodies for Imaging and Therapy by :

Download or read book Radiolabeled Monoclonal Antibodies for Imaging and Therapy written by and published by . This book was released on 1986 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This meeting focused on areas of research on radiolabeled monoclonal antibodies. Topics covered included the production, purification, and fragmentation of monoclonal antibodies and immunochemistry of hybridomas; the production and the chemistry of radionuclides; the radiohalogenation and radiometal labeling techniques; the in-vivo pharmacokinetics of radiolabeled antibodies; the considerations of immunoreactivity of radiolabeled preparations; the instrumentation and imaging techniques as applied to radioimmunodetection; the radiation dosimetry in diagnostic and therapeutic use of labeled antibodies; the radioimmunoscintigraphy and radioimmunotherapy studies; and perspectives and directions for future research. Tutorial as well as scientific lectures describing the latest research data on the above topics were presented. Three workshop panels were convened on ''Methods for Determining Immunoreactivity of Radiolabeled Monoclonal Antibodies - Problems and Pitfalls, '' Radiobiological and Dosimetric Considerations for Immunotherapy with Labeled Antibodies, '' and ''The Human Anti-Mouse Antibody Response in Patients.''

Radiolabeled Antibody in Tumor Imaging and Therapy

Author : Wendie Terese Anderson Berg
Publisher :
ISBN 13 :
Total Pages : 500 pages
Book Rating : 4.:/5 (821 download)

DOWNLOAD NOW!

Book Synopsis Radiolabeled Antibody in Tumor Imaging and Therapy by : Wendie Terese Anderson Berg

Download or read book Radiolabeled Antibody in Tumor Imaging and Therapy written by Wendie Terese Anderson Berg and published by . This book was released on 1987 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer

Author : Raymond M. Reilly
Publisher : John Wiley & Sons
ISBN 13 : 1118035151
Total Pages : 849 pages
Book Rating : 4.1/5 (18 download)

DOWNLOAD NOW!

Book Synopsis Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer by : Raymond M. Reilly

Download or read book Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer written by Raymond M. Reilly and published by John Wiley & Sons. This book was released on 2010-12-28 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncology Book of 2011, British Medical Association's Medical Book Awards Awarded first prize in the Oncology category at the 2011 BMA Medical Book Awards, Monoclonal Antibody and Peptide-Targeted Radiotherapy of Cancer helps readers understand this hot pharmaceutical field with up-to-date developments. Expert discussion covers a range of diverse topics associated with this field, including the optimization of design of biomolecules and radiochemistry, cell and animal models for preclinical evaluation, discoveries from key clinical trials, radiation biology and dosimetry, and considerations in regulatory approval. With chapters authored by internationally renowned experts, this book delivers a wealth of information to push future discovery.

Targeted Radionuclide Therapy

Author : Tod W. Speer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451153260
Total Pages : 564 pages
Book Rating : 4.4/5 (511 download)

DOWNLOAD NOW!

Book Synopsis Targeted Radionuclide Therapy by : Tod W. Speer

Download or read book Targeted Radionuclide Therapy written by Tod W. Speer and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radioimmunotherapy, also known as systemic targeted radiation therapy, uses antibodies, antibody fragments, or compounds as carriers to guide radiation to the targets. It is a topic rapidly increasing in importance and success in treatment of cancer patients. This book represents a comprehensive amalgamation of the radiation physics, chemistry, radiobiology, tumor models, and clinical data for targeted radionuclide therapy. It outlines the current challenges and provides a glimpse at future directions. With significant advances in cell biology and molecular engineering, many targeting constructs are now available that will safely deliver these highly cytotoxic radionuclides in a targeted fashion. A companion website includes the full text and an image bank.

Radiolabeled Compounds for Diagnosis and Treatment of Cancer

Author : Krishan Kumar
Publisher : Mdpi AG
ISBN 13 : 9783036524276
Total Pages : 262 pages
Book Rating : 4.5/5 (242 download)

DOWNLOAD NOW!

Book Synopsis Radiolabeled Compounds for Diagnosis and Treatment of Cancer by : Krishan Kumar

Download or read book Radiolabeled Compounds for Diagnosis and Treatment of Cancer written by Krishan Kumar and published by Mdpi AG. This book was released on 2021-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiopharmaceuticals are used in the diagnosis and treatment of various diseases, especially cancer. In general, radiopharmaceuticals are either salts of radionuclides or radionuclides bound to biologically active molecules, drugs, or cells. Tremendous progress has been made in discovering, developing, and commercializing numerous radiopharmaceuticals for the imaging and therapy of cancer. Significant research is ongoing in academia and the pharmaceutical industry to develop more novel radiolabeled compounds as potential radiopharmaceuticals for unmet needs. This Special Issue aims to focus on all aspects of the design, characterization, evaluation, and development of novel radiolabeled compounds for the diagnosis and treatment of cancer and the application of new radiochemistry and methodologies for the development of novel radiolabeled compounds. Outstanding contributions presented in this Special Issue will significantly add to the field of radiopharmaceuticals.

Irreversible Engineering of Antibodies for Cancer Imaging and Therapy

Author : Amir Kuseh Kalani
Publisher :
ISBN 13 :
Total Pages : 344 pages
Book Rating : 4.:/5 (83 download)

DOWNLOAD NOW!

Book Synopsis Irreversible Engineering of Antibodies for Cancer Imaging and Therapy by : Amir Kuseh Kalani

Download or read book Irreversible Engineering of Antibodies for Cancer Imaging and Therapy written by Amir Kuseh Kalani and published by . This book was released on 2009 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Radiolabeled Moieties for Molecular Imaging and Cancer Theranostics

Author : Carolina de Aguiar Ferreira
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (112 download)

DOWNLOAD NOW!

Book Synopsis Radiolabeled Moieties for Molecular Imaging and Cancer Theranostics by : Carolina de Aguiar Ferreira

Download or read book Radiolabeled Moieties for Molecular Imaging and Cancer Theranostics written by Carolina de Aguiar Ferreira and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nuclear medicine, including the use of radioactive materials for imaging and therapy, has its role well estabilished. For nuclear medicine applications, not only the choice of radioisotope with characteristics that matchs the application purpose, but also the isotope "carrier" needs to be taken into account, as it "controls" the radiotracer biodistribution and other important biological interactions. Noteworthy, these "carriers" can be of any type, such as nanomaterial or antibodybased. Since nuclear medicine can be as multidisciplinary as the biomedical engineering field, herein, I have chosen to explore both routes of achieving molecular imaging and cancer theranostics: using nanoparticle and antibody-based probes. In chapter 2, we have demonstrated the synthesis of size-optimized ultrasmall porous silica nanoparticles (UPSN), with improved pharmacokinetics, i.e. prolonged blood circulation half-life and reasonably fast systemic clearance. We have systematically investigated the influence of vascular architecture and stromal microenvironment on the accumulation and retention of as-designed UPSN in two different triplenegative breast cancer models. After successfully determining that UPSN can highly accumulate in tumor tissues through EPR effect, we decided, in chapter 3, to evaluate if the same nanoparticles could act as a nanocarrier of a theranostic isotopic pair 86/90Y. In that chapter, we demonstrated that the nanoparticles, when radiolabeled with 86Y, were selectively taken up by tumors cells and were clearly visualized through PET imaging at all time points investigated. 90YDOTA-UPSN provided promising therapeutic results by significantly reducing tumor volumes when compared to all the other groups investigated and by significantly increasing average survival. In chapter 4, we have employed a theranostic approach using the isotopic pair 86Y/90Y targeting tissue factor in a pancreatic cancer model through the use of ALT836 monoclonal antibody. We demonstrated that the anti-TF monoclonal antibody, when radiolabeled with 86Y, allowed PET imaging of pancreatic cancer tumor tissue with excellent tumor contrast and could allow for dosimetric calculation of potential dose that would be received with its isotopic pair 90Y. When radiolabeled with 90Y, ALT836 provided evidence of anti-tumor effects and increased average survival. We have evaluated and characterized the ability of 52Mn-labeled YY146, a specific antibody targeting human CD146 to act as a CD146-specific breast tumor imaging agent, with capability of delineating different CD146 expressions. PET imaging, for up to 7 days, of mice bearing three different breast tumors were carried out and revealed radiotracer uptake in tumors that strongly (r2=0.98, p