Cancer and IgE

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Publisher : Springer Science & Business Media
ISBN 13 : 1607614510
Total Pages : 290 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Cancer and IgE by : Manuel L. Penichet

Download or read book Cancer and IgE written by Manuel L. Penichet and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Erika Jensen-Jarolim and Manuel L. Penichet 1. 1 Background Infectious diseases, being the major burden in the history of mankind worldwide th until the beginning of the 20 century, were important triggers in the understanding of immunological mechanisms. In contrast to infectious diseases, reports of all- gies and cancers were less common, but increased tremendously within the last century. Based on the US mortality data of the National Center for Health Statistics, Centers for Disease Control and Prevention 2009, a recent report from the American Cancer Society indicated that the number of cancer deaths increased approximately from 100,000 to 550,000 per year between 1930 and 2006, paralleling the increase of the total population during this period. Leading causes of death from cancer are lung and bronchus cancer, in men prostate cancer, and in women breast c- cer [1, 2]. Normalization to population size shows that the cancer death rate for most malignancies has been generally stable, although the mortality rate of certain malignancies, such as lung and bronchus cancer, has increased over the last 50 years [1-3]. In allergy, the situation is less clear, because for the time period around the turn of th the 19 century, only imprecise information is available. However, within the last 30 years the incidences of allergies has doubled not only in industrial countries, but in developing countries as well [4].

Cancer and IgE

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1607614529
Total Pages : 290 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Cancer and IgE by : Manuel L. Penichet

Download or read book Cancer and IgE written by Manuel L. Penichet and published by Springer Science & Business Media. This book was released on 2010 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Allergies are caused by a person's own IgE antibodies directed against innocuous antigens like pollen or house dust mites. Interestingly, several studies have examined the relation between allergies or level of IgE and malignancies and have found an inverse association suggesting a natural role of IgE in cancer immunosurveillance. Is it thus possible that IgE immunoglobulins could have a beneficial function against cancer besides their harmful function in allergy? If so, can we exploit this beneficial function for the development of new cancer therapies? Could oncologists learn from allergists and vice versa? This book attempts to explore step by step these interesting questions, opening a novel science field: AllergoOncology. AllergoOncology by definition aims to reveal the function of IgE-mediated immune responses against cancer cells in order to enhance the understanding of its biology and to develop novel IgE-based treatment options against malignant diseases. Cancer and IgE: Introducing the Concept of AllergoOncology opens new avenues towards IgE antibodies as key effector molecules able to confer protection against cancer development and progression. This affinity-matured class of antibody, belonging to Th2-mediated immunity, uses an exquisite panel of potent effector cells which can eradicate malignant cells. Importantly, IgE is also capable of binding to professional antigen presenting cells thereby enhancing the presentation of cancer antigens and leading to a significant anti-tumor immune response. Based on its anti-tumor efficacy, which has been shown in vitro and in preclinical models, IgE can be potentially used in human in the context passive and active cancer immunotherapy. In summary, this book, which is the first of its class, is a comprehensive volume about the evolving new field AllergoOncology.

IgE Antibodies: Generation and Function

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Publisher : Springer
ISBN 13 : 3319137255
Total Pages : 152 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis IgE Antibodies: Generation and Function by : Juan J. Lafaille

Download or read book IgE Antibodies: Generation and Function written by Juan J. Lafaille and published by Springer. This book was released on 2015-01-02 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume examines all facets of the complex biology of Immunoglobulin E (IgE) antibodies, which play an essential role in the pathophysiology of allergic diseases and immunity to parasites. It highlights the unique mechanisms involved in the regulation of IgE production at both the molecular and cellular level. Furthermore, it discusses in detail novel findings on how the affinity, specificity and cross-reactivity of IgE can fine-tune mast cell responses to allergens. The book also explores the beneficial roles of IgE antibodies in immunity to helminthes and protection against tumors, and how the properties of IgE-mediated immunity are employed in the development of IgE therapeutic antibodies. All chapters were written by respected experts in their fields and will appeal to scientists and clinicians alike.

Trends in Allergic Conditions Among Children

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Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Trends in Allergic Conditions Among Children by : Kristen D. Jackson

Download or read book Trends in Allergic Conditions Among Children written by Kristen D. Jackson and published by . This book was released on 2013 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

New Chimeric Monoclonal Antibodies Against Human Carcinomas

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Publisher :
ISBN 13 : 9789090110684
Total Pages : 141 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis New Chimeric Monoclonal Antibodies Against Human Carcinomas by : Rosalie Margaretha Luiten

Download or read book New Chimeric Monoclonal Antibodies Against Human Carcinomas written by Rosalie Margaretha Luiten and published by . This book was released on 1998 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Patient Survival

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Publisher :
ISBN 13 :
Total Pages : 322 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cancer Patient Survival by : National Cancer Institute (U.S.)

Download or read book Cancer Patient Survival written by National Cancer Institute (U.S.) and published by . This book was released on 1976 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Engineered immune cells in cancer immunotherapy (EICCI)

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Publisher : Frontiers Media SA
ISBN 13 : 2832515606
Total Pages : 659 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Engineered immune cells in cancer immunotherapy (EICCI) by : Cristina Maccalli

Download or read book Engineered immune cells in cancer immunotherapy (EICCI) written by Cristina Maccalli and published by Frontiers Media SA. This book was released on 2023-02-28 with total page 659 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Journal of the National Cancer Institute

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Publisher :
ISBN 13 :
Total Pages : 544 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Journal of the National Cancer Institute by :

Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2012 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Prevention of Allergy and Allergic Asthma

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805578105
Total Pages : 233 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Prevention of Allergy and Allergic Asthma by : S. G. O. Johansson

Download or read book Prevention of Allergy and Allergic Asthma written by S. G. O. Johansson and published by Karger Medical and Scientific Publishers. This book was released on 2004-01-01 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annotation In the western world, the prevalence of allergy and asthma has increased two- to threefold over the last 40 years and has reached epidemic proportions. This book represents the first complete document containing recommendations on the prevention of allergy and allergic asthma based on the current understanding of the immunological mechanisms of allergic reactions. Prevention of Allergy and Allergic Asthma was a collaborative project between the WAO (World Allergy Organization) and the WHO, launched in 1999. Following two interim reports, this monograph is the final report of the group of international experts involved in the project, ranging from basic immunologists to clinicians. Both theoretical and practical aspects are discussed, and constructive advice is given. Through its network of more than 70 member societies, the WAO will now promote the concept of prevention of allergies and allergic asthma worldwide to benefit patients prone to become allergic, to prevent the worsening of existing allergic diseases, and to reduce their high cost to society. This publication is recommended to specialists in allergy, pediatrics, pneumology and dermatology as well as to general practitioners, health care professionals, journalists, politicians and patients. Only by increasing the knowledge about allergic diseases throughout society can the right steps be taken for their effective prevention.

Veterans and Agent Orange

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Publisher : National Academies Press
ISBN 13 : 0309477166
Total Pages : 739 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Veterans and Agent Orange by : National Academies of Sciences, Engineering, and Medicine

Download or read book Veterans and Agent Orange written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-01-20 with total page 739 pages. Available in PDF, EPUB and Kindle. Book excerpt: From 1962 to 1971, the U.S. military sprayed herbicides over Vietnam to strip the thick jungle canopy that could conceal opposition forces, to destroy crops that those forces might depend on, and to clear tall grasses and bushes from the perimeters of US base camps and outlying fire-support bases. Mixtures of 2,4-dichlorophenoxyacetic acid (2,4-D), 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), picloram, and cacodylic acid made up the bulk of the herbicides sprayed. The main chemical mixture sprayed was Agent Orange, a 50:50 mixture of 2,4-D and 2,4,5-T. At the time of the spraying, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic form of dioxin, was an unintended contaminant generated during the production of 2,4,5-T and so was present in Agent Orange and some other formulations sprayed in Vietnam. Because of complaints from returning Vietnam veterans about their own health and that of their children combined with emerging toxicologic evidence of adverse effects of phenoxy herbicides and TCDD, the National Academies of Sciences, Engineering, and Medicine was asked to perform a comprehensive evaluation of scientific and medical information regarding the health effects of exposure to Agent Orange, other herbicides used in Vietnam, and the various components of those herbicides, including TCDD. Updated evaluations were conducted every two years to review newly available literature and draw conclusions from the overall evidence. Veterans and Agent Orange: Update 11 (2018) examines peer-reviewed scientific reports concerning associations between various health outcomes and exposure to TCDD and other chemicals in the herbicides used in Vietnam that were published between September 30, 2014, and December 31, 2017, and integrates this information with the previously established evidence database.

SITC’s Guide to Managing Immunotherapy Toxicity

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Publisher : Springer Publishing Company
ISBN 13 : 0826172156
Total Pages : 250 pages
Book Rating : 4.8/5 (261 download)

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Book Synopsis SITC’s Guide to Managing Immunotherapy Toxicity by : Marc S. Ernstoff, MD

Download or read book SITC’s Guide to Managing Immunotherapy Toxicity written by Marc S. Ernstoff, MD and published by Springer Publishing Company. This book was released on 2019-03-15 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer

Cancer and the Kidney

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Publisher : Oxford University Press, USA
ISBN 13 : 0199580197
Total Pages : 382 pages
Book Rating : 4.1/5 (995 download)

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Book Synopsis Cancer and the Kidney by : Eric P. Cohen

Download or read book Cancer and the Kidney written by Eric P. Cohen and published by Oxford University Press, USA. This book was released on 2010-11-11 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer and the Kidney covers the challenging overlap area of nephrology and oncology, both in terms of kidney problems in cancer patients, and cancer that affects kidney patients, including assessment of kidney function, to paraneoplastic disorders, acquired cysts and native kidney cancers, and all points inbetween.

Cancer Modelling and Simulation

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Publisher : CRC Press
ISBN 13 : 9780203494899
Total Pages : 456 pages
Book Rating : 4.4/5 (948 download)

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Book Synopsis Cancer Modelling and Simulation by : Luigi Preziosi

Download or read book Cancer Modelling and Simulation written by Luigi Preziosi and published by CRC Press. This book was released on 2003-06-18 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding how cancer tumours develop and spread is vital for finding treatments and cures. Cancer Modelling and Simulation demonstrates how mathematical modelling and computer simulation techniques are used to discover and gain insight into the dynamics of tumour development and growth. It highlights the benefits of tumour modelling, such as discovering optimal tumour therapy schedules, identifying the most promising candidates for further clinical investigation, and reducing the number of animal experiments. By examining the analytical, mathematical, and biological aspects of tumour growth and modelling, the book provides a common language and knowledge for professionals in several disciplines.

Anterior Skull Base Tumors

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318066702
Total Pages : 266 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Anterior Skull Base Tumors by : P. Nicolai

Download or read book Anterior Skull Base Tumors written by P. Nicolai and published by Karger Medical and Scientific Publishers. This book was released on 2020-07-30 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, interest in the management of anterior skull base tumors has been fostered by the introduction and subsequent rapid expansion of indications of transnasal endoscopic techniques. In parallel, extraordinary progress has been made in all the other disciplines which are involved in the complex process of managing anterior skull base tumors, leading to substantial improvements in diagnosis and treatment. The anterior skull base can be involved in a large variety of tumors of a varying nature and histology, which in the majority of cases originate from adjacent anatomic sites. In fact, primary lesions of the anterior skull base mainly include osteoma and other tumors originating from bone and cartilage. Tumors involving the anterior skull base have their origin prevalently in the sinonasal tract, but lesions developing on the intracranial site, such as meningiomas, may also extend caudally to encroach upon this area. All these lesions are rare, which means that the pertinent literature does not include prospective studies or treatment guidelines based on a high level of evidence. In view of the extreme histological variability of lesions involving the anterior skull base, much emphasis has been placed on addressing the different nuances of treatment in relation to histology, especially for malignant tumors. The chapters focusing on surgery provide divergent views on selection criteria for a specific surgical technique, which is the aim of this publication.

Middleton's Allergy E-Book

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Publisher : Elsevier Health Sciences
ISBN 13 : 0323546986
Total Pages : 1840 pages
Book Rating : 4.3/5 (235 download)

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Book Synopsis Middleton's Allergy E-Book by : A Wesley Burks

Download or read book Middleton's Allergy E-Book written by A Wesley Burks and published by Elsevier Health Sciences. This book was released on 2019-09-25 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through eight outstanding editions, Middleton’s Allergy: Principles and Practice has been the reference of choice for both clinicians and researchers as both a practical reference and an effective self-assessment tool for board preparation. The 9th Edition continues the tradition of excellence with comprehensive coverage of all basic science and clinical applications regarding allergy practice and disease mechanisms. It brings you fully up to date with recent innovations in the diagnosis, prevention, and management of allergic disorders, including emerging global issues, the advent of precision medicine, and new immunologic therapies. Offers unparalleled depth and up-to-date guidance on the full spectrum of allergy across the lifespan, with significant updates throughout. Contains new chapters on Innate Lymphoid Cells, Systems Biology, and Treatment of Primary Immunodeficiency Diseases. Discusses emerging topics such as epidemic thunderstorm asthma and precision medicine in allergic disorders. Features more than 730 full-color illustrations, including many new cellular and molecular drawings of disease mechanisms. Includes new Summary of Important Concepts boxes, plus new multiple-choice questions online with explanations and answers. Features a new team of expert editors and more international contributors for a global perspective of this complex field.

IgE and Anti-IgE Therapy in Asthma and Allergic Disease

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Publisher : CRC Press
ISBN 13 : 0203909003
Total Pages : 576 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis IgE and Anti-IgE Therapy in Asthma and Allergic Disease by : Robert Fick

Download or read book IgE and Anti-IgE Therapy in Asthma and Allergic Disease written by Robert Fick and published by CRC Press. This book was released on 2002-04-24 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Exploring the role of Immunoglobulin-E (IgE) in human disease, this reference summarizes current research on the mechanisms and utilization of anti-IgE therapeutics in the treatment of IgE-mediated allergic disease, inflammation, and asthma-discussing the structural composition of high- and low-affinity IgE receptors, the airway cells that express

Immunotherapy

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Publisher : Springer Nature
ISBN 13 : 3030410080
Total Pages : 339 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Immunotherapy by : Aung Naing

Download or read book Immunotherapy written by Aung Naing and published by Springer Nature. This book was released on 2020-04-16 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunotherapy is a rapidly evolving field that mandates frequent revision of the book as new insights to fight cancer emerge. The third edition of Immunotherapy is an updated overview of immuno-oncology in different cancer types and toxicities associated with immunotherapy. It explores the breath of immunotherapeutic strategies available to treat a wide range of cancers, from melanoma and non-small cell lung cancer to gastrointestinal, genitourinary, gynecologic and nervous system malignancies. With increasing use of checkpoint inhibitors as standard of care and in clinical trials, the challenges associated with their use undoubtedly increase. As objective response is limited to a subset of patients and is often associated with distinct immune related side effects that are potentially life threatening, it is essential to identify patients who are likely to respond to immunotherapy and those who are at a risk for developing treatment-related side effects. In the absence of a validated predictive biomarker, innovative technologies and assays are being used to identify critical biomarkers that drive the immune response. Hence, a chapter to provide a basic understanding of the diagnostic procedures has been included besides the chapter on the cellular components of the human immune system. This new edition will also inform readers on use of novel microbiome and imaging approaches. Finally, the book includes a chapter on patient-reported outcomes in patients treated with immunotherapies as the authors recognize the importance of including missing patient voice in clinical trials and longitudinal assessment of symptom reports. In short, the third edition of this book provides a comprehensive overview of the latest developments in the field of immune-oncology that will help health care professionals make informed treatment decisions. The book’s chapters are written by a diverse cast of experts conducting cutting-edge research, providing the reader with the most up-to-date science.