Cancer Biology and the Nuclear Envelope

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1489980326
Total Pages : 610 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Cancer Biology and the Nuclear Envelope by : Eric C. Schirmer

Download or read book Cancer Biology and the Nuclear Envelope written by Eric C. Schirmer and published by Springer Science & Business Media. This book was released on 2014-02-22 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NE is a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer."

The Nuclear Envelope

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Author :
Publisher : Garland Science
ISBN 13 : 0203643399
Total Pages : 320 pages
Book Rating : 4.2/5 (36 download)

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Book Synopsis The Nuclear Envelope by : David Evans

Download or read book The Nuclear Envelope written by David Evans and published by Garland Science. This book was released on 2004-09-01 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Nuclear Envelope brings together the major current topics in nuclear envelope structure, transport, transcriptional regulation and cell signaling. The volume is divided into four sections: 1. Proteins of the nuclear envelope, including nuclear envelope proteomics, structure and function. 2. Nuclear pores and transport at the nuclear envelope, including pore complex structure, assembly and function and import and export pathways. 3. Nuclear envelope dynamics, including dynamics of lamina assembly and disassembly. 4. Nuclear signaling and transcription regulation, including signaling to the nucleus and spectrin repeat proteins and their implications or communication between the nucleus and cytoplasm.

Advances in Nuclear Envelope Research and Application: 2012 Edition

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Author :
Publisher : ScholarlyEditions
ISBN 13 : 1481613391
Total Pages : 50 pages
Book Rating : 4.4/5 (816 download)

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Book Synopsis Advances in Nuclear Envelope Research and Application: 2012 Edition by :

Download or read book Advances in Nuclear Envelope Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nuclear Envelope Research and Application / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Nuclear Envelope in a concise format. The editors have built Advances in Nuclear Envelope Research and Application / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nuclear Envelope in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Nuclear Envelope Research and Application / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

The Molecular Biology of Cancer

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Publisher :
ISBN 13 :
Total Pages : 664 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Molecular Biology of Cancer by : Harris Busch

Download or read book The Molecular Biology of Cancer written by Harris Busch and published by . This book was released on 1974 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Molecular Biology of Cancer discusses the state of progress in the molecular biology of cancer. The book describes the effects of anticancer agents on nucleolar ultrastructure; the role of chromosomes in the causation and progression of cancer and leukemia; the replication, modification, and repair of DNA. The text also describes the metabolism and utilization of messenger RNA and other high molecular weight RNA and low molecular weight nuclear RNA; the characteristics, structures, and functions of nuclear proteins; and the process of protein synthesis. Nucleotides are reviewed with regard ...

Molecular Biology of the Cell

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Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer, the Misguided Cell

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Author :
Publisher : Pegasus Publications
ISBN 13 :
Total Pages : 222 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Cancer, the Misguided Cell by : David M. Prescott

Download or read book Cancer, the Misguided Cell written by David M. Prescott and published by Pegasus Publications. This book was released on 1973 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Biology

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Publisher : Pearson Education
ISBN 13 : 9780131294547
Total Pages : 316 pages
Book Rating : 4.2/5 (945 download)

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Book Synopsis Cancer Biology by : Roger John Benjamin King

Download or read book Cancer Biology written by Roger John Benjamin King and published by Pearson Education. This book was released on 2006 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing an introduction of the biological principles of the causes and treatment of cancer, this book covers key topics in cancer biology. It is useful for students of cell biology, biochemistry, molecular biology, genetics and biomedical sciences, and postgraduate students moving into cancer research.

Comparative Oncology

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Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs

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Publisher : Springer
ISBN 13 : 3319715534
Total Pages : 310 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs by : Sundas Fayyaz

Download or read book Recent Trends in Cancer Biology: Spotlight on Signaling Cascades and microRNAs written by Sundas Fayyaz and published by Springer. This book was released on 2018-03-07 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a multifaceted disease and overwhelmingly increasing experimental evidence has helped us to develop a deeper understanding of the role of signal transduction cascades in cancer development and progression. Tissue microarrays and next generation sequencing technologies have assisted us to gather missing pieces of jigsaw puzzle and we now know that deregulation of spatio-temporally controlled signaling cascades play fundamental role in metastasis and resistance against wide ranging therapeutics. This book offers a balanced overview of the rapidly emerging cutting edge research in molecular oncology and good source of knowledge for established oncologists, basic and medical students and pharmaceutical industry associated R&D departments.

Nuclear-Cytoplasmic Transport

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Publisher : Springer
ISBN 13 : 3319773097
Total Pages : 277 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Nuclear-Cytoplasmic Transport by : Weidong Yang

Download or read book Nuclear-Cytoplasmic Transport written by Weidong Yang and published by Springer. This book was released on 2018-07-27 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.

The nuclear envelope

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Author :
Publisher :
ISBN 13 : 9780415346450
Total Pages : pages
Book Rating : 4.3/5 (464 download)

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Book Synopsis The nuclear envelope by :

Download or read book The nuclear envelope written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Oxford Textbook of Cancer Biology

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Author :
Publisher : Oxford University Press
ISBN 13 : 0198779453
Total Pages : 505 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Oxford Textbook of Cancer Biology by : Francesco Pezzella

Download or read book Oxford Textbook of Cancer Biology written by Francesco Pezzella and published by Oxford University Press. This book was released on 2019-05-02 with total page 505 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of the biology of tumours has grown to become markedly interdisciplinary, involving chemists, statisticians, epidemiologists, mathematicians, bioinformaticians, and computer scientists alongside biologists, geneticists, and clinicians. The Oxford Textbook of Cancer Biology brings together the most up-to-date developments from different branches of research into one coherent volume, providing a comprehensive and current account of this rapidly evolving field. Structured in eight sections, the book starts with a review of the development and biology of multi-cellular organisms, how they maintain a healthy homeostasis in an individual, and a description of the molecular basis of cancer development. The book then illustrates, as once cells become neoplastic, their signalling network is altered and pathological behaviour follows. It explores the changes that cancer cells can induce in nearby normal tissue, the new relationship established between them and the stroma, and the interaction between the immune system and tumour growth. The authors illustrate the contribution provided by high throughput techniques to map cancer at different levels, from genomic sequencing to cellular metabolic functions, and how information technology, with its vast amounts of data, is integrated with traditional cell biology to provide a global view of the disease. The effect of the different types of treatments on the biology of the neoplastic cells are explored to understand on the one side, why some treatments succeed, and on the other, how they can affect the biology of resistant and recurrent disease. The book concludes by summarizing what we know to date about cancer, and in what direction our understanding of cancer is moving. Edited by leading authorities in the field with an international team of contributors, this book is an essential resource for scholars and professionals working in the wide variety of sub-disciplines that make up today's cancer research and treatment community. It is written not only for consultation, but also for easy cover-to-cover reading.

Cancer Cell Signaling

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Publisher : Springer Science & Business Media
ISBN 13 : 1592593569
Total Pages : 330 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cancer Cell Signaling by : David M. Terrian

Download or read book Cancer Cell Signaling written by David M. Terrian and published by Springer Science & Business Media. This book was released on 2008-02-05 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells respond to environmental cues through a complex and dynamic network of signaling pathways that normally maintain a critical balance between cellular proliferation, differentiation, senescence, and death. One current research challenge is to identify those aberrations in signal transd- tion that directly contribute to a loss of this division-limited equilibrium and the progression to malignant transformation. The study of cell-signaling m- ecules in this context is a central component of cancer research. From the knowledge of such targets, investigators have been able to productively advance many insightful hypotheses about how a particular cancer cell may misinterpret, or respond inappropriately to, growth regulatory cues in their environment. Despite these key insights, the rapidly evolving nature of cell signaling research in cancer has necessitated a continuous revision of these theoretical constructs and the updating of methods used in their study. One contemporary example of the evolution of this field is provided by an analysis of the Human Genome Project data, which reveal a previously unsuspected diversity in the multigene families encoding for most signaling pathway int- mediates. In assessing the usefulness of a particular methodological approach, therefore, we will need to keep in mind that there is a premium on those p- tocols that can be easily adapted for the analysis of multiple members within a gene family. Cancer Cell Signaling: Methods and Protocols brings together several such methods in cell signaling research that are scientifically grounded within the cancer biology field.

Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine

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Author :
Publisher : Springer Nature
ISBN 13 : 3031065735
Total Pages : 657 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine by : Malgorzata Kloc

Download or read book Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine written by Malgorzata Kloc and published by Springer Nature. This book was released on 2022-11-08 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume reviews the latest research on the functional implications of nuclear, chromosomal and genomic organization and architecture on cell and organismal biology, and development and progression of diseases. The architecture of the cell nucleus and non-random arrangement of chromosomes, genes, and the non-membranous nuclear bodies in the three-dimensional (3D) space alters in response to the environmental, mechanical, chemical, and temporal cues. The changes in the nuclear, chromosomal, or genomic compaction and configuration modify the gene expression program and induce or inhibit epigenetic modifications. The intrinsically programmed rearrangements of the nuclear architecture are necessary for cell differentiation, the establishment of cell fate during development and maturation of tissues and organs including the immune, muscle, and nervous systems. The non-programmed changes in the nuclear architecture can lead to fragmentation of the nucleus and instability of the genome and thus cause cancer. Microbial and viral infections can lead to a clustering of centromeres, telomeres and ribosomal DNA and alter the properties of the nuclear membrane, allowing large immobile macromolecules to enter the nucleus. Recent advances in next-generation sequencing technologies combined with nucleus/chromosome conformation capture, super-resolution imaging, chromosomal contact maps methods, integrative modeling, and genetic approaches, are uncovering novel features and importance of nuclear, chromosomal and genomic architecture. This book is an interesting read for cell biologists, researchers studying the structure and function of chromosomes, and anyone else who wants to get an overview of the field of nuclear, chromosomal and genomic architecture.

Pathology of the Nucleus

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Publisher : Springer Science & Business Media
ISBN 13 : 3642746683
Total Pages : 491 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Pathology of the Nucleus by : James C.E. Underwood

Download or read book Pathology of the Nucleus written by James C.E. Underwood and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: New techniques make it possible for investigators to examine and sometimes quantify various aspects of nuclear morphology and function; now they can derive clinically and biologically useful information about the nucleus. This book draws together a series of techniques which have been successfully applied to the study of the nucleus of tumour cells. These are of fundamental importance to researchers in tumour histopathology and medical oncology. Detailed reviews are given of various aspects of the morphology, ploidy and karyotypic status and function of the nuclei in the cells of tumours and preneoplastic lesions. Topics covered include nuclear morphology in tumour diagnosis, the ultrastructure of the nucleus, karyotypic analyses of solid tumours, flow cytometric assessment of nuclear ploidy and other parameters, histomorphometry of the nucleus, and in situ hybridisation.

The LINC Complex

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Publisher :
ISBN 13 : 9781493986910
Total Pages : 338 pages
Book Rating : 4.9/5 (869 download)

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Book Synopsis The LINC Complex by : Gregg G. Gundersen

Download or read book The LINC Complex written by Gregg G. Gundersen and published by . This book was released on 2018 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Tumor Biology

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Publisher : Springer
ISBN 13 :
Total Pages : 352 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Tumor Biology by : Asterios S. Tsiftsoglou

Download or read book Tumor Biology written by Asterios S. Tsiftsoglou and published by Springer. This book was released on 1996 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the NATO Science Institute "Regulation of Cell Growth, Differentiation and Genetics in Cancer", held at Porto Carras, Halkidiki, Greece, September 1-12, 1995