Brains, Genes, and the Foundations of Human Society

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Author :
Publisher : Frontiers E-books
ISBN 13 : 2889191257
Total Pages : 114 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Brains, Genes, and the Foundations of Human Society by : Jordan Grafman

Download or read book Brains, Genes, and the Foundations of Human Society written by Jordan Grafman and published by Frontiers E-books. This book was released on with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 20 years have yielded an explosion of information from the still nascent field of social neuroscience. Studies devoted to identifying neural correlates of social cognitive and moral judgment processing have established subcortical and cortical regions that are integral for how we filter and interpret information pertinent to family and friends, our social in-group, and strangers and engage in everything from forming immediate impressions of them to judging their behavior with respect to complex moral norms. What is less clear is how neural regions involved in implicit and explicit cognitive processing, or those cognitive processes that occur almost instantaneously as opposed to those that are more controlled respectively, interact to bias perceptions and behavior. Even less is known about how genes (and their variants) critical for neural function and the structural integrity within neural regions may modulate neural interactions critical for social cognitive and moral judgment processing. Recent methodological advancements assessing how different neural regions functionally work together with others, and how different genetic variants integral for neural function alter behavior, are establishing a more comprehensive view of the implicit and explicit social brain. These advancements demonstrate that structures critical for implicit processing, e.g., the amygdala, reliably covary in their activity with structures integral for explicit processing, e.g., dorsolateral prefrontal cortex, early and often during the processing of social information of varying complexity and in different contexts. This suggests that interactions between these regions are necessary to successfully navigate and immediately adapt to one’s environment. In turn, genetic variants like those that comprise the brain-derived neurotrophic factor (BDNF) gene, oxytocin receptor gene, or serotonin transporter gene likely play an important role in modulating the interaction between and within neural regions integral for interpersonal trust, intergroup processes, person perception, theory of mind (i.e., inferring the thoughts and feelings of others), and moral judgment processing. The purpose of this Research Topic is to further our understanding of how subcortical and cortical neural regions that vary in their functional contributions to social behavior also depend upon genetic influences in shaping individuals’ perceptions, beliefs, attitudes, behaviors, and how information is attended to and encoded to influence future social behaviors. It is particularly important to demonstrate how these regions reliably interact as a function of processing speed (i.e., implicit or explicit) and/or context to predict behavior or performance. Demonstrating how different genetic factors in turn moderate this interaction, or how genetic factors alter a specific region’s interaction with other regions, is equally important. We therefore solicit original empirical work, review and opinion papers, and methodological papers that can promote our understanding of how interactions between neural regions underlying implicit and explicit processes influence social cognitive and moral judgment processing and are, in turn, modulated by genetic predispositions. This includes work that utilizes fMRI, EEG and psychophysiological methodologies, lesion samples, as well as developmental and computational approaches. This Research Topic could serve as an important step in the evolution of our understanding of the complexity of the social mind as well as illuminate the robust effects context has on the way the brain interacts with different stimuli at every level of cognitive processing.

The Gene

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Publisher : Simon and Schuster
ISBN 13 : 1476733538
Total Pages : 624 pages
Book Rating : 4.4/5 (767 download)

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Book Synopsis The Gene by : Siddhartha Mukherjee

Download or read book The Gene written by Siddhartha Mukherjee and published by Simon and Schuster. This book was released on 2016-05-17 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: The #1 NEW YORK TIMES Bestseller The basis for the PBS Ken Burns Documentary The Gene: An Intimate History Now includes an excerpt from Siddhartha Mukherjee’s new book Song of the Cell! From the Pulitzer Prize–winning author of The Emperor of All Maladies—a fascinating history of the gene and “a magisterial account of how human minds have laboriously, ingeniously picked apart what makes us tick” (Elle). “Sid Mukherjee has the uncanny ability to bring together science, history, and the future in a way that is understandable and riveting, guiding us through both time and the mystery of life itself.” —Ken Burns “Dr. Siddhartha Mukherjee dazzled readers with his Pulitzer Prize-winning The Emperor of All Maladies in 2010. That achievement was evidently just a warm-up for his virtuoso performance in The Gene: An Intimate History, in which he braids science, history, and memoir into an epic with all the range and biblical thunder of Paradise Lost” (The New York Times). In this biography Mukherjee brings to life the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices. “Mukherjee expresses abstract intellectual ideas through emotional stories…[and] swaddles his medical rigor with rhapsodic tenderness, surprising vulnerability, and occasional flashes of pure poetry” (The Washington Post). Throughout, the story of Mukherjee’s own family—with its tragic and bewildering history of mental illness—reminds us of the questions that hang over our ability to translate the science of genetics from the laboratory to the real world. In riveting and dramatic prose, he describes the centuries of research and experimentation—from Aristotle and Pythagoras to Mendel and Darwin, from Boveri and Morgan to Crick, Watson and Franklin, all the way through the revolutionary twenty-first century innovators who mapped the human genome. “A fascinating and often sobering history of how humans came to understand the roles of genes in making us who we are—and what our manipulation of those genes might mean for our future” (Milwaukee Journal-Sentinel), The Gene is the revelatory and magisterial history of a scientific idea coming to life, the most crucial science of our time, intimately explained by a master. “The Gene is a book we all should read” (USA TODAY).

From Neurons to Neighborhoods

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Publisher : National Academies Press
ISBN 13 : 0309069882
Total Pages : 610 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis From Neurons to Neighborhoods by : National Research Council

Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Brains Through Time

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Publisher : Oxford University Press, USA
ISBN 13 : 0195125681
Total Pages : 541 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis Brains Through Time by : Georg F. Striedter

Download or read book Brains Through Time written by Georg F. Striedter and published by Oxford University Press, USA. This book was released on 2020 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Much is conserved in vertebrate evolution, but significant changes in the nervous system occurred at the origin of vertebrates and in most of the major vertebrate lineages. This book examines these innovations and relates them to evolutionary changes in other organ systems, animal behavior, and ecological conditions at the time. The resulting perspective clarifies what makes the major vertebrate lineages unique and helps explain their varying degrees of ecological success. One of the book's major conclusions is that vertebrate nervous systems are more diverse than commonly assumed, at least among neurobiologists. Examples of important innovations include not only the emergence of novel brain regions, such as the cerebellum and neocortex, but also major changes in neuronal circuitry and functional organization. A second major conclusion is that many of the apparent similarities in vertebrate nervous systems resulted from convergent evolution, rather than inheritance from a common ancestor. For example, brain size and complexity increased numerous times, in many vertebrate lineages. In conjunction with these changes, olfactory inputs to the telencephalic pallium were reduced in several different lineages, and this reduction was associated with the emergence of pallial regions that process non-olfactory sensory inputs. These conclusions cast doubt on the widely held assumption that all vertebrate nervous systems are built according to a single, common plan. Instead, the book encourages readers to view both species similarities and differences as fundamental to a comprehensive understanding of nervous systems. Evolution; Phylogeny; Neuroscience; Neurobiology; Neuroanatomy; Functional Morphology; Paleoecology; Homology; Endocast; Brain"--

Discovering the Brain

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Publisher : National Academies Press
ISBN 13 : 0309045290
Total Pages : 195 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Discovering the Brain by : National Academy of Sciences

Download or read book Discovering the Brain written by National Academy of Sciences and published by National Academies Press. This book was released on 1992-01-01 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."

Genes, Brain Function, and Behavior

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Publisher : Academic Press
ISBN 13 : 0128128321
Total Pages : 300 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genes, Brain Function, and Behavior by : Douglas Wahlsten

Download or read book Genes, Brain Function, and Behavior written by Douglas Wahlsten and published by Academic Press. This book was released on 2019-03-01 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior. Presents essential background, facts, and terminology about genes, brain function, and behavior Builds clear explanations on this solid foundation while minimizing technical jargon Explores in depth several single-gene and chromosomal neurological disorders Derives lessons from these clear examples and highlights key lessons in boxes Examines the intricacies of complex traits that involve multiple genetic and environmental factors by applying lessons from simpler disorders Explains diagnosis and definition Includes a companion website with Powerpoint slides and images for each chapter for instructors and links to resources

In the Light of Evolution

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Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis In the Light of Evolution by : National Academy of Sciences

Download or read book In the Light of Evolution written by National Academy of Sciences and published by . This book was released on 2007 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Arthur M. Sackler Colloquia of the National Academy of Sciences address scientific topics of broad and current interest, cutting across the boundaries of traditional disciplines. Each year, four or five such colloquia are scheduled, typically two days in length and international in scope. Colloquia are organized by a member of the Academy, often with the assistance of an organizing committee, and feature presentations by leading scientists in the field and discussions with a hundred or more researchers with an interest in the topic. Colloquia presentations are recorded and posted on the National Academy of Sciences Sackler colloquia website and published on CD-ROM. These Colloquia are made possible by a generous gift from Mrs. Jill Sackler, in memory of her husband, Arthur M. Sackler.

Foundations in Social Neuroscience

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Publisher : MIT Press
ISBN 13 : 9780262531955
Total Pages : 1368 pages
Book Rating : 4.5/5 (319 download)

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Book Synopsis Foundations in Social Neuroscience by : John T. Cacioppo

Download or read book Foundations in Social Neuroscience written by John T. Cacioppo and published by MIT Press. This book was released on 2002 with total page 1368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive survey of the growing field of social neuroscience.

Brain and Culture

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Publisher : MIT Press
ISBN 13 : 0262265141
Total Pages : 313 pages
Book Rating : 4.2/5 (622 download)

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Book Synopsis Brain and Culture by : Bruce E. Wexler

Download or read book Brain and Culture written by Bruce E. Wexler and published by MIT Press. This book was released on 2008-08-29 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research shows that between birth and early adulthood the brain requires sensory stimulation to develop physically. The nature of the stimulation shapes the connections among neurons that create the neuronal networks necessary for thought and behavior. By changing the cultural environment, each generation shapes the brains of the next. By early adulthood, the neuroplasticity of the brain is greatly reduced, and this leads to a fundamental shift in the relationship between the individual and the environment: during the first part of life, the brain and mind shape themselves to the major recurring features of their environment; by early adulthood, the individual attempts to make the environment conform to the established internal structures of the brain and mind. In Brain and Culture, Bruce Wexler explores the social implications of the close and changing neurobiological relationship between the individual and the environment, with particular attention to the difficulties individuals face in adulthood when the environment changes beyond their ability to maintain the fit between existing internal structure and external reality. These difficulties are evident in bereavement, the meeting of different cultures, the experience of immigrants (in which children of immigrant families are more successful than their parents at the necessary internal transformations), and the phenomenon of interethnic violence. Integrating recent neurobiological research with major experimental findings in cognitive and developmental psychology—with illuminating references to psychoanalysis, literature, anthropology, history, and politics—Wexler presents a wealth of detail to support his arguments. The groundbreaking connections he makes allow for reconceptualization of the effect of cultural change on the brain and provide a new biological base from which to consider such social issues as "culture wars" and ethnic violence.

The Amazing Journey of Reason

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Publisher : Springer Nature
ISBN 13 : 3030259625
Total Pages : 125 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis The Amazing Journey of Reason by : Mario Alemi

Download or read book The Amazing Journey of Reason written by Mario Alemi and published by Springer Nature. This book was released on 2019-12-03 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Open Access book explores questions such as why and how did the first biological cells appear? And then complex organisms, brains, societies and –now– connected human societies? Physicists have good models for describing the evolution of the universe since the Big Bang, but can we apply the same concepts to the evolution of aggregated matter –living matter included? The Amazing Journey analyzes the latest results in chemistry, biology, neuroscience, anthropology and sociology under the light of the evolution of intelligence, seen as the ability of processing information. The main strength of this book is using just two concepts used in physics –information and energy– to explain: The emergence and evolution of life: procaryotes, eukaryotes and complex organisms The emergence and evolution of the brain The emergence and evolution of societies (human and not) Possible evolution of our "internet society" and the role that Artificial Intelligence is playing

The Selfish Gene

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Publisher : Oxford University Press, USA
ISBN 13 : 9780192860927
Total Pages : 372 pages
Book Rating : 4.8/5 (69 download)

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Book Synopsis The Selfish Gene by : Richard Dawkins

Download or read book The Selfish Gene written by Richard Dawkins and published by Oxford University Press, USA. This book was released on 1989 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Science need not be dull and bogged down by jargon, as Richard Dawkins proves in this entertaining look at evolution. The themes he takes up are the concepts of altruistic and selfish behaviour; the genetical definition of selfish interest; the evolution of aggressive behaviour; kinshiptheory; sex ratio theory; reciprocal altruism; deceit; and the natural selection of sex differences. 'Should be read, can be read by almost anyone. It describes with great skill a new face of the theory of evolution.' W.D. Hamilton, Science

Foundations of Human Sociality

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Publisher : Oxford University Press on Demand
ISBN 13 : 9780199262045
Total Pages : 451 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Foundations of Human Sociality by : Joseph Patrick Henrich

Download or read book Foundations of Human Sociality written by Joseph Patrick Henrich and published by Oxford University Press on Demand. This book was released on 2004 with total page 451 pages. Available in PDF, EPUB and Kindle. Book excerpt: What motives underlie the ways humans interact socially? Are these the same for all societies? Are these part of our nature, or influenced by our environments? Over the last decade, research in experimental economics has emphatically falsified the textbook representation of Homo economicus. Hundreds of experiments suggest that people care not only about their own material payoffs, but also about such things as fairness, equity, and reciprocity. However, this research left fundamental questions unanswered: Are such social preferences stable components of human nature, or are they modulated by economic, social, and cultural environments? Until now, experimental research could not address this question because virtually all subjects had been university students. Combining ethnographic and experimental approaches to fill this gap, this book breaks new ground in reporting the results of a large cross-cultural study aimed at determining the sources of social (non-selfish) preferences that underlie the diversity of human sociality. In this study, the same experiments carried out with university students were performed in fifteen small-scale societies exhibiting a wide variety of social, economic, and cultural conditions. The results show that the variation in behaviour is far greater than previously thought, and that the differences between societies in market integration and the importance of cooperation explain a substantial portion of this variation, which individual-level economic and demographic variables could not. The results also trace the extent to which experimental play mirrors patterns of interaction found in everyday life. The book includes a succinct but substantive introduction to the use of game theory as an analytical tool, and to its use in the social sciences for the rigorous testing of hypotheses about fundamental aspects of social behaviour outside artificially constructed laboratories. The editors also summarize the results of the fifteencase studies in a suggestive chapter about the scope of the project.

How People Learn

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Publisher : National Academies Press
ISBN 13 : 0309131979
Total Pages : 386 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis How People Learn by : National Research Council

Download or read book How People Learn written by National Research Council and published by National Academies Press. This book was released on 2000-08-11 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: First released in the Spring of 1999, How People Learn has been expanded to show how the theories and insights from the original book can translate into actions and practice, now making a real connection between classroom activities and learning behavior. This edition includes far-reaching suggestions for research that could increase the impact that classroom teaching has on actual learning. Like the original edition, this book offers exciting new research about the mind and the brain that provides answers to a number of compelling questions. When do infants begin to learn? How do experts learn and how is this different from non-experts? What can teachers and schools do-with curricula, classroom settings, and teaching methodsâ€"to help children learn most effectively? New evidence from many branches of science has significantly added to our understanding of what it means to know, from the neural processes that occur during learning to the influence of culture on what people see and absorb. How People Learn examines these findings and their implications for what we teach, how we teach it, and how we assess what our children learn. The book uses exemplary teaching to illustrate how approaches based on what we now know result in in-depth learning. This new knowledge calls into question concepts and practices firmly entrenched in our current education system. Topics include: How learning actually changes the physical structure of the brain. How existing knowledge affects what people notice and how they learn. What the thought processes of experts tell us about how to teach. The amazing learning potential of infants. The relationship of classroom learning and everyday settings of community and workplace. Learning needs and opportunities for teachers. A realistic look at the role of technology in education.

From DNA to Diversity

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Publisher : John Wiley & Sons
ISBN 13 : 1118685202
Total Pages : 475 pages
Book Rating : 4.1/5 (186 download)

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Book Synopsis From DNA to Diversity by : Sean B. Carroll

Download or read book From DNA to Diversity written by Sean B. Carroll and published by John Wiley & Sons. This book was released on 2013-04-25 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this landmark work, the author team led by Dr. Sean Carroll presents the general principles of the genetic basis of morphological change through a synthesis of evolutionary biology with genetics and embryology. In this extensively revised second edition, the authors delve into the latest discoveries, incorporating new coverage of comparative genomics, molecular evolution of regulatory proteins and elements, and microevolution of animal development. An accessible text, focusing on the most well-known genes, developmental processes and taxa. Builds logically from developmental genetics and regulatory mechanisms to evolution at different genetic morphological levels. Adds major insights from recent genome studies, new evo-devo biology research findings, and a new chapter on models of variation and divergence among closely related species. Provides in-depth focus on key concepts through well-developed case studies. Features clear, 4-color illustrations and photographs, chapter summaries, references and a glossary. Presents the research of Dr. Carroll, a pioneer in the field and the past president of the Society for Developmental Biology.

Brain Facts

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Publisher :
ISBN 13 : 9780916110000
Total Pages : 64 pages
Book Rating : 4.1/5 (1 download)

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Book Synopsis Brain Facts by :

Download or read book Brain Facts written by and published by . This book was released on 2002 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Connectome

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Publisher : HMH
ISBN 13 : 0547508174
Total Pages : 389 pages
Book Rating : 4.5/5 (475 download)

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Book Synopsis Connectome by : Sebastian Seung

Download or read book Connectome written by Sebastian Seung and published by HMH. This book was released on 2012-02-07 with total page 389 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Accessible, witty . . . an important new researcher, philosopher and popularizer of brain science . . . on par with cosmology’s Brian Greene and the late Carl Sagan” (The Plain Dealer). One of the Wall Street Journal’s 10 Best Nonfiction Books of the Year and a Publishers Weekly “Top Ten in Science” Title Every person is unique, but science has struggled to pinpoint where, precisely, that uniqueness resides. Our genome may determine our eye color and even aspects of our character. But our friendships, failures, and passions also shape who we are. The question is: How? Sebastian Seung is at the forefront of a revolution in neuroscience. He believes that our identity lies not in our genes, but in the connections between our brain cells—our particular wiring. Seung and a dedicated group of researchers are leading the effort to map these connections, neuron by neuron, synapse by synapse. It’s a monumental effort, but if they succeed, they will uncover the basis of personality, identity, intelligence, memory, and perhaps disorders such as autism and schizophrenia. Connectome is a mind-bending adventure story offering a daring scientific and technological vision for understanding what makes us who we are, as individuals and as a species. “This is complicated stuff, and it is a testament to Dr. Seung’s remarkable clarity of exposition that the reader is swept along with his enthusiasm, as he moves from the basics of neuroscience out to the farthest regions of the hypothetical, sketching out a spectacularly illustrated giant map of the universe of man.” —TheNew York Times “An elegant primer on what’s known about how the brain is organized and how it grows, wires its neurons, perceives its environment, modifies or repairs itself, and stores information. Seung is a clear, lively writer who chooses vivid examples.” —TheWashington Post

From Molecules to Minds

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Publisher : National Academies Press
ISBN 13 : 0309120926
Total Pages : 90 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis From Molecules to Minds by : Institute of Medicine

Download or read book From Molecules to Minds written by Institute of Medicine and published by National Academies Press. This book was released on 2008-12-07 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?