Blood Cells Rheology And Aging

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Blood Cells, Rheology and Aging

Author : Dieter Platt
Publisher : Springer
ISBN 13 :
Total Pages : 242 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Blood Cells, Rheology and Aging by : Dieter Platt

Download or read book Blood Cells, Rheology and Aging written by Dieter Platt and published by Springer. This book was released on 1988 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the third Erlangen-Nuremberg symposium on experimental geronto logy we discussed the effect of aging on blood cells and rheology. Most studies with red cells have been performed on humans, rats, and rabbits. All these erythrocytes have no nucleus; the cells are therefore a model in which new synthesis of proteins is impossible. All the processes are age dependent except for exchange with the plasma. Investigations of red cells have attracted attention because of the latter's availability in large quantities from biochemists, physiologists, immunologists, and micro scopists. We now have a relative abundance of data on the biochemical and immunologic composition as well as on the ultrastructure of the cells. The second topic under discussion at the symposium was the immune system and cell receptors. One of the most apparent features of aging of the organism is progressive dysregulation of the immune system. As a result, the incidence of infection, cancer, and autoimmune and immune complex diseases increases. While we have a lot of new data on the function and differentiation of lymphoid cells, we have little informa tion on lymphocyte receptors during the aging process. Rheologic studies reflect changes in red cell deformability and blood coagulation. The erythrocyte deformability influences blood flow in all parts of the circulation. The fluidity of the red cell membranes controls whole blood viscosity. During aging, there are significant alterations in blood coagulation and hemostasis. One of the best known modifications of blood co agulation is a typical thrombophilic tendency with aging.

Blood Cells, Rheology, and Aging

Author : Dieter Platt
Publisher :
ISBN 13 : 9783642717918
Total Pages : 236 pages
Book Rating : 4.7/5 (179 download)

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Book Synopsis Blood Cells, Rheology, and Aging by : Dieter Platt

Download or read book Blood Cells, Rheology, and Aging written by Dieter Platt and published by . This book was released on 1987-12-11 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume on experimental gerontology deals with the effects of aging on blood cells and rheology. Since gerontology is an interdisciplinary science, numerous experts engaged in various disciplines present their up-to-date results related to aging. The detailed accounts compiled in this book will augment the knowledge of red cells, immunology, receptors, blood coagulation, and rheology. The volume provides a valuable basis for future scientific work in gerontological research.

Red Blood Cell Aggregation

Author : Oguz Baskurt
Publisher : CRC Press
ISBN 13 : 1439841810
Total Pages : 310 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Red Blood Cell Aggregation by : Oguz Baskurt

Download or read book Red Blood Cell Aggregation written by Oguz Baskurt and published by CRC Press. This book was released on 2011-09-28 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Red blood cells in humans-and most other mammals-have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this real

Red Blood Cell Aging

Author : Antonio De Flora
Publisher : Springer Science & Business Media
ISBN 13 : 1468459856
Total Pages : 365 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Red Blood Cell Aging by : Antonio De Flora

Download or read book Red Blood Cell Aging written by Antonio De Flora and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.

Clinical Aspects of Blood Viscosity and Cell Deformability

Author : G. D. O. Lowe
Publisher : Springer Science & Business Media
ISBN 13 : 1447131053
Total Pages : 268 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Clinical Aspects of Blood Viscosity and Cell Deformability by : G. D. O. Lowe

Download or read book Clinical Aspects of Blood Viscosity and Cell Deformability written by G. D. O. Lowe and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: After many years of relative neglect, the importance of study of factors governing blood flow has at last achieved recognition; in this volume are documented many of the techniques, and the basic scientific and clinical observations, which have helped to open up understanding of this highly important aspect of human physiology and pathology in recent years. The text is logically divided into five sections beginning with blood cell deformability, then moving on to theoretical consideration of blood rheology, followed by accounts of the interrelationships between rheology, blood flow and vascular occlusion. The final two sections deal with blood rheology in clinical practice and therapeutic aspects of the study of blood flow. As regards blood cell deformability (Section A), the basic problem is set out by Kiesewetter and colleagues in the first paragraph of chapter 1 (p. 3), in which they point out that whereas human erythrocytes at rest have a diameter of approxi mately 7. 5 /-tm, nutritive capillaries have diameters ranging from 3-5 /-tm, and chapters in section A give an account of the ways in which the red cell can undergo deformation to permit capillary perfusion and the maintenance of the microcirculation.

Handbook of Hemorheology and Hemodynamics

Author : O.K. Baskurt
Publisher : IOS Press
ISBN 13 : 1607502631
Total Pages : 468 pages
Book Rating : 4.6/5 (75 download)

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Book Synopsis Handbook of Hemorheology and Hemodynamics by : O.K. Baskurt

Download or read book Handbook of Hemorheology and Hemodynamics written by O.K. Baskurt and published by IOS Press. This book was released on 2007-10-03 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: This publication primarily focuses on the macro- and micro-rheological behavior of blood and its formed elements, on interactions between the formed elements and blood vessel walls, and on the microvascular aspects of hemodynamics. Since many aspects of hemorheology and hemodynamics are affected by disease or clinical states, these effects are discussed as are hyperviscosity syndromes, therapy for disturbed blood rheology, and methods in hemorheology and hemodynamics. Sections of the Handbook include History of Hemorheology; Hemorheology, covering basic aspects, blood composition, blood rheology, cell mechanics, pathophysiology, methods and comparative studies; Hemodynamics, covering basic principles, microcirculation, in vivo effects, endothelium and methods; and Clinical Aspects of Hemorheology, covering hyperviscosity, clinical significance and treatment. The goal is to foster greater interchange between workers in the fields so as to promote collaborative efforts and, hopefully, improved health. In selecting topics for this handbook the editors have attempted to provide a general overview of both basic science and clinical hemorheology and hemodynamics. Hemorheology and hemodynamics are closely related, the former dealing with all aspects of the flow and interactions of the individual blood cells mostly studied in vitro, the latter with the in vivo relationships among vessel architecture, driving pressure, flow rate and shear stress. The linkage between the in vitro and in vivo research described in the book will be of interest to both basic science and clinical investigators. The editors of the handbook have each been active in the fields of bio- and hemorheology for many years, and have published extensively. They have successfully achieved their objective to publish a well-written and well-edited handbook that will be valuable for researchers and students in the field.

Clinical Blood Rheology

Author : Gordon D.O. Lowe
Publisher : CRC Press
ISBN 13 : 0429523297
Total Pages : 237 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Clinical Blood Rheology by : Gordon D.O. Lowe

Download or read book Clinical Blood Rheology written by Gordon D.O. Lowe and published by CRC Press. This book was released on 2019-06-04 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published in 1988: Study of blood flow properties (rheology) has attracted growing interest from clinicians in recent years. A United Kingdom meeting and a European meeting in 1979 resulted in previous publications summarizing the literature up to that time.

Red Cell Rheology

Author : M. Bessis
Publisher : Springer Science & Business Media
ISBN 13 : 3642670598
Total Pages : 418 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Red Cell Rheology by : M. Bessis

Download or read book Red Cell Rheology written by M. Bessis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hemolysis during filtration through micropores studied by Chien et al. [I] showed a dependence on pressure gradient and pore diameter that, at the time of publication, did not permit an easy interpretation of the hemolytic mechanism. Acting on the assumption that thresholds of hemolysis are easier to correlate with physical forces than extents of hemolysis, we performed a series of experi ments repeating some of the conditions reported in [I] and then focusing on low L1P in order to define better the thresholds of hemolysis for several pore sizes. Employing a model of a deformed red cell shape at the pore entrance (based on micropipette observations) we related the force field in the fluid to a biaxial tension in the membrane. The threshold for lysis correlated with a membrane tension of 30 dynes/cm. This quantity is in agreement with lysis data from a number of other investigators employing a variety of mechanisms for introduc ing membrane tension. The sequence of events represented here is: a. Fluid forces and pressure gradients deform the cell into a new, elongated shape. b. Extent of deformation becomes limited by the resistance of the cell mem brane to undergo an increase in area. c. Fluid forces and pressure gradients acting on the deformed cell membrane cause an increase in biaxial tension in the membrane. d. When the strain caused by this tension causes pores to open in the membrane, the threshold for hemolysis has been reached [2].

Regulation of red cell life-span, erythropoiesis, senescence and clearance

Author : Lars Kaestner
Publisher : Frontiers E-books
ISBN 13 : 2889193489
Total Pages : 118 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Regulation of red cell life-span, erythropoiesis, senescence and clearance by : Lars Kaestner

Download or read book Regulation of red cell life-span, erythropoiesis, senescence and clearance written by Lars Kaestner and published by Frontiers E-books. This book was released on 2014-12-03 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human red blood cells are formed mainly in the bone marrow and are believed to have an average life span of approximately 120 days. However, is it true for all red blood cells? What are the changes associated with red cell maturation, adulthood and senescence? What are the determinants of red cell life span and clearance? What are the mechanisms in control of red cell mass in healthy humans and patients with various forms of anemia? What are the markers of circulating red cell senescence and in cells during storage and transfusion? Within the life span may properties of red cells change leading to age-mixed circulating cell populations. Although these cells appear to be genetically terminated by the time they are released into the blood stream, they undergo surprisingly versatile modifications depending on the life-style and health conditions of a “human host”. Numerous disorders are believed to be associated with facilitated ageing of red blood cells. “In vitro ageing” and damage of red blood cells during storage is yet one more important issue related to the risks and efficiency of blood transfusion. Many of the mechanisms behind such effects are far from being fully understood. In this context the Research Topic is set to include articles in the field of biochemical investigations, biophysical approaches, physiological and clinical studies related to red blood cell maturation and aging. This includes Original Research, Methods, Hypothesis and Theory, Reviews and Perspectives.

Clinical Blood Rheology

Author : Gordon D.O. Lowe
Publisher : CRC Press
ISBN 13 : 0429536771
Total Pages : 359 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Clinical Blood Rheology by : Gordon D.O. Lowe

Download or read book Clinical Blood Rheology written by Gordon D.O. Lowe and published by CRC Press. This book was released on 2019-06-04 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Published in 1988: Study of blood flow properties (rheology) has attracted growing interest from clinicians in recent years. A United Kingdom meeting and a European meeting in 1979 resulted in previous publications summarizing the literature up to that time.

Applied Physiology in Intensive Care Medicine

Author : Michael R. Pinsky
Publisher : Springer Science & Business Media
ISBN 13 : 3540373632
Total Pages : 367 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Applied Physiology in Intensive Care Medicine by : Michael R. Pinsky

Download or read book Applied Physiology in Intensive Care Medicine written by Michael R. Pinsky and published by Springer Science & Business Media. This book was released on 2007-05-19 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Te practice of intensive care medicine is at the very forefront of titration of treatment andmonitoringresponse. Te substrateofthiscareisthe criticallyill patientwho,by defnition, is at the limits of his or her physiologic reserve. Such patients need immediate, aggressive but balanced life-altering interventions to minimize the detrimental aspects of acute illness and hasten recovery. Treatmentdecisionsandresponsetotherapyareusually assessed by measures of physiologic function, such as assessed by cardio-respiratory monitoring. However, how one uses such information is ofen unclear and rarely supported by prospective clinical trials. In reality, the bedside clinician is forced to rely primarily on physiologic principles in determining the best treatments and response to therapy. However, the physiologic foundation present in practicing physicians is uneven and occasionally supported more by habit or prior training than science. A series of short papers published in Intensive Care Medicine since 2002 under the heading Physiologic Notes attempts to capture the essence of the physiologic perspectives that underpin both our understanding of disease and response to therapy. Tis present volume combines the complete list of these Physiologic Notes up until July 2006 with the ass o cia t ed r e vie w a r tic les o v er t h e s a m e in t er val t ha t a ls o addr ess e d t hes e cen tral issues.

Erythroid Cells

Author : J. Robin Harris
Publisher : Springer Science & Business Media
ISBN 13 : 1475795289
Total Pages : 547 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Erythroid Cells by : J. Robin Harris

Download or read book Erythroid Cells written by J. Robin Harris and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series of books, devoted to aspects of blood cell biochemistry, development, immu nology, and ultrastructure, has evolved and separated from the long-established Plenum series Subcellular Biochemistry. It is the intention of these volumes to draw together related areas of investigation and to provide, in the fullness of time, complete coverage of this rapidly advancing important biomedical discipline. Both fundamental and medically applied topics, dealing with normal and pathological cells, will be included. This, the first volume of the series, contains a diverse collection of chapters, all of which relate to erythroid cells. The range of material included is extremely broad and the authors have used contrasting technical approaches, both within their personal experimen tal studies and within their manuscripts. This has led to the production of a very interest ing compilation, which does, nevertheless, possess a strong overall thematic unity. As with all edited volumes, some topics of importance and interest are not included. This may be because of oversight on my part, as editor, or because the authors originally selected failed to submit their manuscript by the agreed-upon submission date. For these omissions I take full responsibility and trust that at least some of the topics omitted, for instance membrane cation transport systems, will be covered within a future volume of the series. This book commences with two chapters of a developmental nature.

Blood Viscosity Factors

Author : Leslie Simpson (Ph.D.)
Publisher :
ISBN 13 : 9780615254579
Total Pages : 0 pages
Book Rating : 4.2/5 (545 download)

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Book Synopsis Blood Viscosity Factors by : Leslie Simpson (Ph.D.)

Download or read book Blood Viscosity Factors written by Leslie Simpson (Ph.D.) and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood Viscosity Factors brings together a series of essays on the impact of various abnormalities on blood viscosity factors. It contains several hundred references to already published work in the field. Beginning with the finding that red blood cells proliferate in shape and are not just one toroidally shaped horde, the work offers unique insights into the role of ageing and disease. The work of Dr Simpson corrects the record and offers tantalising possibilities for the future. One result of the move to targeted and commercial research has been to stunt the growth of whole fields of inquiry in favour of more convenient or competitive ways of looking at a situation. The real puzzle is that the work has been done and a substantial body of peer reviewed publications attest to the quality and depth of the findings. The book is of interest to those readers who prefer a more holistic view of science and the world, than is currently offered by the standard texts.

Dynamics of Blood Cell Suspensions in Microflows

Author : Annie Viallat
Publisher : CRC Press
ISBN 13 : 1315395126
Total Pages : 476 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Dynamics of Blood Cell Suspensions in Microflows by : Annie Viallat

Download or read book Dynamics of Blood Cell Suspensions in Microflows written by Annie Viallat and published by CRC Press. This book was released on 2019-12-09 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood microcirculation is essential to our bodies for the successful supply of nutrients, waste removal, oxygen delivery, homeostasis, controlling temperature, wound healing, and active immune surveillance. This book provides a physical introduction to the subject and explores how researchers can successfully describe, understand, and predict behaviours of blood flow and blood cells that are directly linked to these important physiological functions. Using practical examples, this book explains how the key concepts of physics are related to blood microcirculation and underlie the dynamic behavior of red blood cells, leukocytes, and platelets. This interdisciplinary book will be a valuable reference for researchers and graduate students in biomechanics, fluid mechanics, biomedical engineering, biological physics, and medicine. Features: The first book to provide a physical perspective of blood microcirculation Draws attention to the potential of this physical approach for novel applications in medicine Edited by specialists in this field, with chapter contributions from subject area specialists

Gerontology

Author : Dieter Platt
Publisher : Springer Science & Business Media
ISBN 13 : 3642749968
Total Pages : 319 pages
Book Rating : 4.6/5 (427 download)

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Book Synopsis Gerontology by : Dieter Platt

Download or read book Gerontology written by Dieter Platt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the beginning of the century the average life span in developed societies was less than 50 years. It is now more than 70 years and will continue to increase in the near future. Aging is a challenge to science and society. There are several theories of aging. The programmed aging hypothesis suggests that aging cannot be altered by any external influence, that aging is programmed from the beginning of life until the end of senescence. Another theory is based on genetic instability, with repair processes correcting errors in the cells that cause aging. Aging processes manifest themselves at the molecular and cellular level, in different organs, and in the whole organism. Most older persons acquire multiple diseases, primarily chronic ones. The multimorbidity of the elderly raises many questions as to nutrition, metabolism, immunity, drug therapy, and rehabilitation. Nutrition may be able to intervene in the aging process. Aging is associated with dec lining immunity and reduced resistance to many diseases, and it is pos sible that nutritional changes in old age contribute to the declining immunity in the elderly. The elderly take 40% of the prescription drugs in Germany and adverse drug reactions are more frequent in geriatric patients. There are not only problems in drug therapy for elderly pa tients, but also in their rehabilitation. The aim of rehabilitation is the restoration of geriatric patients to their former functional and environ mental status.

Red Cell Rheology (I)

Author : Stephen B. Shohet
Publisher :
ISBN 13 :
Total Pages : 221 pages
Book Rating : 4.:/5 (157 download)

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Book Synopsis Red Cell Rheology (I) by : Stephen B. Shohet

Download or read book Red Cell Rheology (I) written by Stephen B. Shohet and published by . This book was released on 1977 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Band 3 Proteins

Author : E. Bamberg
Publisher : Elsevier
ISBN 13 : 0444599835
Total Pages : 375 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis The Band 3 Proteins by : E. Bamberg

Download or read book The Band 3 Proteins written by E. Bamberg and published by Elsevier. This book was released on 2012-12-02 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a collection of papers on the molecular biology of the band 3 proteins and their various functions: as anion transporters, binding proteins for membrane skeleton, hemoglobin and glycolytic enzymes, and as a recognition signal for the removal of senescent cells by the immuno-system of the body. The papers presented were written to provide an overview of the work carried out during the past five years in most of the laboratories engaged in research on band 3. They serve to give the reader factual information on nearly all aspects of band 3 research, to introduce him to the current literature and to give him a feeling for the philosophy behind the approaches chosen in the various laboratories.