Author : Mahwish Siddiqui
Publisher : OAE Publishing Inc.
ISBN 13 :
Total Pages : 50 pages
Book Rating : 4./5 ( download)
Book Synopsis Biotransformation studies on bioactive compounds: 25 years of interesting research at the ICCBS by : Mahwish Siddiqui
Download or read book Biotransformation studies on bioactive compounds: 25 years of interesting research at the ICCBS written by Mahwish Siddiqui and published by OAE Publishing Inc.. This book was released on 2023-05-24 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotransformation of natural, synthetic, and semi-synthetic compounds has emerged as a frontier branch of chemical sciences that is progressively being applied in numerous fields. In the present review, we have summarized our biotransformation studies on bioactive compounds from 1997 to 2022. Various microbial and plant cell cultures were used for biocatalytic structural transformations. We present here an overview of biotransformation of 53 compounds belonging to various classes of natural, synthetic, and semi-synthetic compounds, published in several leading journals. The structures of the resulting metabolites have been elucidated by detailed spectroscopic studies. Oxidation, reduction, dehydrogenation, chlorination, aromatization, methylation, demethylation, rearrangements, etc. were the main reactions that occurred during the biotransformation processes. Many of the biotransformed products exhibited interesting biological activities. Structural transformations in some cases have also led to improved pharmacokinetic profiles. This review is aimed to provide a focused account of extensive work carried out in our laboratories in this field, as well as the immense potential of biocatalytic transformations in organic chemistry.