Biostatistics For Bioassay

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STATISTICAL THEORY AND ANALYSIS IN BIOASSAY

Author : Uchenna Petronilla Ogoke
Publisher : IPS Intelligentsia Publishing Services
ISBN 13 : 9789912730
Total Pages : 72 pages
Book Rating : 4.7/5 (899 download)

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Book Synopsis STATISTICAL THEORY AND ANALYSIS IN BIOASSAY by : Uchenna Petronilla Ogoke

Download or read book STATISTICAL THEORY AND ANALYSIS IN BIOASSAY written by Uchenna Petronilla Ogoke and published by IPS Intelligentsia Publishing Services. This book was released on 2021-08-21 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical Theory and Analysis in Bioassay is a seven chapter monograph tailored essentially to meet the needs of graduate students, practitioners and researchers in the fields of medicine, pharmacology, biosciences/life sciences and related fields that employs the tools of biostatistics in bioassays and analysis. In this wise, we have taken time to discuss in details relevant topics; principles, methods and applications. Practice exercises are also included where necessary. The earlier chapters give background information, definition of terms, purpose, types, structure and relative potency in bioassay. An important theorem, Fieller’s theorem is proved in details with illustrative examples. The last two chapters are on dose-response relationship, fitting in parallelline assays and estimation. We are convinced that this monograph will meet the expectations of the readers while constructive criticisms that will improve another edition will be appreciated.

Bayesian Biostatistics

Author : Emmanuel Lesaffre
Publisher : John Wiley & Sons
ISBN 13 : 0470018232
Total Pages : 544 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Bayesian Biostatistics by : Emmanuel Lesaffre

Download or read book Bayesian Biostatistics written by Emmanuel Lesaffre and published by John Wiley & Sons. This book was released on 2012-08-13 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: The growth of biostatistics has been phenomenal in recent years and has been marked by considerable technical innovation in both methodology and computational practicality. One area that has experienced significant growth is Bayesian methods. The growing use of Bayesian methodology has taken place partly due to an increasing number of practitioners valuing the Bayesian paradigm as matching that of scientific discovery. In addition, computational advances have allowed for more complex models to be fitted routinely to realistic data sets. Through examples, exercises and a combination of introductory and more advanced chapters, this book provides an invaluable understanding of the complex world of biomedical statistics illustrated via a diverse range of applications taken from epidemiology, exploratory clinical studies, health promotion studies, image analysis and clinical trials. Key Features: Provides an authoritative account of Bayesian methodology, from its most basic elements to its practical implementation, with an emphasis on healthcare techniques. Contains introductory explanations of Bayesian principles common to all areas of application. Presents clear and concise examples in biostatistics applications such as clinical trials, longitudinal studies, bioassay, survival, image analysis and bioinformatics. Illustrated throughout with examples using software including WinBUGS, OpenBUGS, SAS and various dedicated R programs. Highlights the differences between the Bayesian and classical approaches. Supported by an accompanying website hosting free software and case study guides. Bayesian Biostatistics introduces the reader smoothly into the Bayesian statistical methods with chapters that gradually increase in level of complexity. Master students in biostatistics, applied statisticians and all researchers with a good background in classical statistics who have interest in Bayesian methods will find this book useful.

Biostatistics Using JMP

Author : Trevor Bihl
Publisher : SAS Institute
ISBN 13 : 1635262410
Total Pages : 472 pages
Book Rating : 4.6/5 (352 download)

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Book Synopsis Biostatistics Using JMP by : Trevor Bihl

Download or read book Biostatistics Using JMP written by Trevor Bihl and published by SAS Institute. This book was released on 2017-10-03 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analyze your biostatistics data with JMP! Trevor Bihl's Biostatistics Using JMP: A Practical Guide provides a practical introduction on using JMP, the interactive statistical discovery software, to solve biostatistical problems. Providing extensive breadth, from summary statistics to neural networks, this essential volume offers a comprehensive, step-by-step guide to using JMP to handle your data. The first biostatistical book to focus on software, Biostatistics Using JMP discusses such topics as data visualization, data wrangling, data cleaning, histograms, box plots, Pareto plots, scatter plots, hypothesis tests, confidence intervals, analysis of variance, regression, curve fitting, clustering, classification, discriminant analysis, neural networks, decision trees, logistic regression, survival analysis, control charts, and metaanalysis. Written for university students, professors, those who perform biological/biomedical experiments, laboratory managers, and research scientists, Biostatistics Using JMP provides a practical approach to using JMP to solve your biostatistical problems.

Applied Statistical Methods in Agriculture, Health and Life Sciences

Author : Bayo Lawal
Publisher : Springer
ISBN 13 : 3319055550
Total Pages : 816 pages
Book Rating : 4.3/5 (19 download)

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Book Synopsis Applied Statistical Methods in Agriculture, Health and Life Sciences by : Bayo Lawal

Download or read book Applied Statistical Methods in Agriculture, Health and Life Sciences written by Bayo Lawal and published by Springer. This book was released on 2014-09-15 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook teaches crucial statistical methods to answer research questions using a unique range of statistical software programs, including MINITAB and R. This textbook is developed for undergraduate students in agriculture, nursing, biology and biomedical research. Graduate students will also find it to be a useful way to refresh their statistics skills and to reference software options. The unique combination of examples is approached using MINITAB and R for their individual strengths. Subjects covered include among others data description, probability distributions, experimental design, regression analysis, randomized design and biological assay. Unlike other biostatistics textbooks, this text also includes outliers, influential observations in regression and an introduction to survival analysis. Material is taken from the author's extensive teaching and research in Africa, USA and the UK. Sample problems, references and electronic supplementary material accompany each chapter.

Statistical Techniques in Bioassay

Author : Z. Govindarajulu
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3805571194
Total Pages : 249 pages
Book Rating : 4.8/5 (55 download)

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Book Synopsis Statistical Techniques in Bioassay by : Z. Govindarajulu

Download or read book Statistical Techniques in Bioassay written by Z. Govindarajulu and published by Karger Medical and Scientific Publishers. This book was released on 2001 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the face of the ever-increasing importance of statistical methods in medical research and practice, the first edition of this publication has provided a sound and deep understanding of statistical methods in bioassay to many students and researchers. In addition to the profound presentation of statistical methods of the first edition, here the reader will find new material stemming from the recent statistical literature as well as data reflecting modern trends in general applied statistical research. Examples are discussions on design and planning, e.g. choices of dose levels, and additional section in the chapter on Bayes methods, and a new chapter on sequential estimation for the logistic model. The book will be a valuable source of information to students in the experimental area of statistical aspects of biological assay, professional statisticians with an interest in research in this topic, teachers in statistics and biology, and investigators in the biological and medical sciences who use bioassay in their work.

Issues in Risk Assessment

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309047862
Total Pages : 375 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Issues in Risk Assessment by : National Research Council

Download or read book Issues in Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific basis, inference assumptions, regulatory uses, and research needs in risk assessment are considered in this two-part volume. The first part, Use of Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity, focuses on whether the maximum tolerated dose should continue to be used in carcinogenesis bioassays. The committee considers several options for modifying current bioassay procedures. The second part, Two-Stage Models of Carcinogenesis, stems from efforts to identify improved means of cancer risk assessment that have resulted in the development of a mathematical dose-response model based on a paradigm for the biologic phenomena thought to be associated with carcinogenesis.

Introduction to Statistical Analysis of Laboratory Data

Author : Alfred Bartolucci
Publisher : John Wiley & Sons
ISBN 13 : 1119085004
Total Pages : 259 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Introduction to Statistical Analysis of Laboratory Data by : Alfred Bartolucci

Download or read book Introduction to Statistical Analysis of Laboratory Data written by Alfred Bartolucci and published by John Wiley & Sons. This book was released on 2015-11-02 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Statistical Analysis of Laboratory Data presents a detailed discussion of important statistical concepts and methods of data presentation and analysis Provides detailed discussions on statistical applications including a comprehensive package of statistical tools that are specific to the laboratory experiment process Introduces terminology used in many applications such as the interpretation of assay design and validation as well as “fit for purpose” procedures including real world examples Includes a rigorous review of statistical quality control procedures in laboratory methodologies and influences on capabilities Presents methodologies used in the areas such as method comparison procedures, limit and bias detection, outlier analysis and detecting sources of variation Analysis of robustness and ruggedness including multivariate influences on response are introduced to account for controllable/uncontrollable laboratory conditions

Bioassay

Author : Ralph I. Dorfman
Publisher : Elsevier
ISBN 13 : 1483272761
Total Pages : 791 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Bioassay by : Ralph I. Dorfman

Download or read book Bioassay written by Ralph I. Dorfman and published by Elsevier. This book was released on 2013-10-22 with total page 791 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Hormone Research, Volume II: Bioassay focuses on the detailed and critical account of bioassay methods, including electrolyte and carbohydrate methods, hormones, and assays. The selection first offers information on the statistical methods and steroid hormones and related substances. Topics include assays based on graded and quantal responses, measuring responses, types of estrogen, vaginal cornification, vaginal mitosis and epithelial thickness, and uterine weight. The book also ponders on anti-estrogenic compounds, progestational substances, and anti-gonadotropic steroids. The publication takes a look at androgens and anabolic agents, anti-androgenic substances, and corticoids. Discussions focus on surgical procedures, mammalian assays, bird, chick comb, electrolyte, and carbohydrate methods, adrenalectomy, and stress tests. The text then examines protein hormones and related hormones and substances, thyroidal substances, insulin, glucagon, and gonadotropins. The selection is a valuable source of data for readers interested in bioassays.

Statistical Method in Biological Assay

Author : David John Finney
Publisher :
ISBN 13 :
Total Pages : 696 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Statistical Method in Biological Assay by : David John Finney

Download or read book Statistical Method in Biological Assay written by David John Finney and published by . This book was released on 1971 with total page 696 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Author : Agency for Health Care Research and Quality (U.S.)
Publisher : Government Printing Office
ISBN 13 : 1587634236
Total Pages : 236 pages
Book Rating : 4.5/5 (876 download)

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Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)

Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

The Behavioral and Social Sciences

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309037492
Total Pages : 301 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis The Behavioral and Social Sciences by : National Research Council

Download or read book The Behavioral and Social Sciences written by National Research Council and published by National Academies Press. This book was released on 1988-02-01 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the scientific frontiers and leading edges of research across the fields of anthropology, economics, political science, psychology, sociology, history, business, education, geography, law, and psychiatry, as well as the newer, more specialized areas of artificial intelligence, child development, cognitive science, communications, demography, linguistics, and management and decision science. It includes recommendations concerning new resources, facilities, and programs that may be needed over the next several years to ensure rapid progress and provide a high level of returns to basic research.

Exploring the Biological Contributions to Human Health

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309132975
Total Pages : 287 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Exploring the Biological Contributions to Human Health by : Institute of Medicine

Download or read book Exploring the Biological Contributions to Human Health written by Institute of Medicine and published by National Academies Press. This book was released on 2001-07-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: It's obvious why only men develop prostate cancer and why only women get ovarian cancer. But it is not obvious why women are more likely to recover language ability after a stroke than men or why women are more apt to develop autoimmune diseases such as lupus. Sex differences in health throughout the lifespan have been documented. Exploring the Biological Contributions to Human Health begins to snap the pieces of the puzzle into place so that this knowledge can be used to improve health for both sexes. From behavior and cognition to metabolism and response to chemicals and infectious organisms, this book explores the health impact of sex (being male or female, according to reproductive organs and chromosomes) and gender (one's sense of self as male or female in society). Exploring the Biological Contributions to Human Health discusses basic biochemical differences in the cells of males and females and health variability between the sexes from conception throughout life. The book identifies key research needs and opportunities and addresses barriers to research. Exploring the Biological Contributions to Human Health will be important to health policy makers, basic, applied, and clinical researchers, educators, providers, and journalists-while being very accessible to interested lay readers.

Small Clinical Trials

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309171148
Total Pages : 221 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Small Clinical Trials by : Institute of Medicine

Download or read book Small Clinical Trials written by Institute of Medicine and published by National Academies Press. This book was released on 2001-01-01 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical trials are used to elucidate the most appropriate preventive, diagnostic, or treatment options for individuals with a given medical condition. Perhaps the most essential feature of a clinical trial is that it aims to use results based on a limited sample of research participants to see if the intervention is safe and effective or if it is comparable to a comparison treatment. Sample size is a crucial component of any clinical trial. A trial with a small number of research participants is more prone to variability and carries a considerable risk of failing to demonstrate the effectiveness of a given intervention when one really is present. This may occur in phase I (safety and pharmacologic profiles), II (pilot efficacy evaluation), and III (extensive assessment of safety and efficacy) trials. Although phase I and II studies may have smaller sample sizes, they usually have adequate statistical power, which is the committee's definition of a "large" trial. Sometimes a trial with eight participants may have adequate statistical power, statistical power being the probability of rejecting the null hypothesis when the hypothesis is false. Small Clinical Trials assesses the current methodologies and the appropriate situations for the conduct of clinical trials with small sample sizes. This report assesses the published literature on various strategies such as (1) meta-analysis to combine disparate information from several studies including Bayesian techniques as in the confidence profile method and (2) other alternatives such as assessing therapeutic results in a single treated population (e.g., astronauts) by sequentially measuring whether the intervention is falling above or below a preestablished probability outcome range and meeting predesigned specifications as opposed to incremental improvement.

Mathematical Problems in Biology

Author : P. van den Driessche
Publisher : Springer Science & Business Media
ISBN 13 : 3642454550
Total Pages : 290 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Mathematical Problems in Biology by : P. van den Driessche

Download or read book Mathematical Problems in Biology written by P. van den Driessche and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: A conference on "Some Mathematical Problems in Biology" was held at the University of Victoria, Victoria, B. C. , Canada, from May 7 - 10, 1973. The participants and invited speakers were mathematicians interested in problems of a biological nature, and scientists actively engaged in developing mathematical models in biological fields. One aim of the conference was to attempt to assess what the recent rapid growth of mathematical interaction with the biosciences has accomplished and may accomplish in the near future. The conference also aimed to expose the problems of communication bet~",een mathematicians and biological scientists, and in doing so to stimulate the interchange of ideas. It was recognised that the topic spans an enormous breadth, and little attempt was made to balance the very diverse areas. Widespread active interest was shown in the conference, and just over one hundred people registered. The varied departments and institutions across North America from which the participants came made it both academically and geographically mixed. The chief activity of the conference was the presentation of papers. Nine invited guest speakers (see table of contents) each gave a one hour talk. These covered a wide range of topics. There were twenty-five shorter (twenty minute) contributed papers, and almost all papers l,rere followed by a five minute question and discussion period. Duplicated abstracts of presented papers were available at the meeting. An evening informal discussion meeting of participants, chaired by Dr. A. B. Tayler, and led by Drs. E. M. Hagmeier, E. C.

Statistics in Toxicology Using R

Author : Ludwig A. Hothorn
Publisher : CRC Press
ISBN 13 : 1498701280
Total Pages : 253 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Statistics in Toxicology Using R by : Ludwig A. Hothorn

Download or read book Statistics in Toxicology Using R written by Ludwig A. Hothorn and published by CRC Press. This book was released on 2016-01-13 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: The apparent contradiction between statistical significance and biological relevance has diminished the value of statistical methods as a whole in toxicology. Moreover, recommendations for statistical analysis are imprecise in most toxicological guidelines. Addressing these dilemmas, Statistics in Toxicology Using R explains the statistical analysi

Understanding Biostatistics

Author : Anders Källén
Publisher : John Wiley & Sons
ISBN 13 : 1119993504
Total Pages : 334 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Understanding Biostatistics by : Anders Källén

Download or read book Understanding Biostatistics written by Anders Källén and published by John Wiley & Sons. This book was released on 2011-03-31 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Biostatistics looks at the fundamentals of biostatistics, using elementary statistics to explore the nature of statistical tests. This book is intended to complement first-year statistics and biostatistics textbooks. The main focus here is on ideas, rather than on methodological details. Basic concepts are illustrated with representations from history, followed by technical discussions on what different statistical methods really mean. Graphics are used extensively throughout the book in order to introduce mathematical formulae in an accessible way. Key features: Discusses confidence intervals and p-values in terms of confidence functions. Explains basic statistical methodology represented in terms of graphics rather than mathematical formulae, whilst highlighting the mathematical basis of biostatistics. Looks at problems of estimating parameters in statistical models and looks at the similarities between different models. Provides an extensive discussion on the position of statistics within the medical scientific process. Discusses distribution functions, including the Guassian distribution and its importance in biostatistics. This book will be useful for biostatisticians with little mathematical background as well as those who want to understand the connections in biostatistics and mathematical issues.

Applied Statistics in the Pharmaceutical Industry

Author : Steven P. Millard
Publisher : Springer Science & Business Media
ISBN 13 : 1475734662
Total Pages : 518 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Applied Statistics in the Pharmaceutical Industry by : Steven P. Millard

Download or read book Applied Statistics in the Pharmaceutical Industry written by Steven P. Millard and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a general guide to statistical methods used in the pharmaceutical industry, and illustrating how to use S-PLUS to implement these methods, the book explains why S-PLUS is a useful software package and discusses the results and implications of each particular application. It is targeted at graduates in biostatistics, statisticians involved in the industry as research scientists, regulators, academics, and/or consultants who want to know more about how to use S-PLUS and learn about other sub-fields within the industry, as well as statisticians in other fields who want to know more about statistical applications in the pharmaceutical industry.