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Biosimulation In Biomedical Research Health Care And Drug Development
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Book Synopsis Biosimulation in Biomedical Research, Health Care and Drug Development by : Erik Mosekilde
Download or read book Biosimulation in Biomedical Research, Health Care and Drug Development written by Erik Mosekilde and published by Springer Science & Business Media. This book was released on 2011-11-01 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.
Book Synopsis Biosimulation in Biomedical Research, Health Care and Drug Development by : Erik Mosekilde
Download or read book Biosimulation in Biomedical Research, Health Care and Drug Development written by Erik Mosekilde and published by Springer. This book was released on 2011-11-09 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.
Book Synopsis Biomedical Translational Research by : R.C. Sobti
Download or read book Biomedical Translational Research written by R.C. Sobti and published by Springer Nature. This book was released on 2022-07-28 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.
Book Synopsis Biomedical Research, Medicine and Disease by : R. C. Sobti
Download or read book Biomedical Research, Medicine and Disease written by R. C. Sobti and published by Translating Animal Science Research. This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics. This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general. The volume comprehensively covers: Emerging technologies for health care Various aspects of biomedical research toward understanding of pathophysiology of the diseases Advances in improvement in diagnostic procedures and therapeutic tools The fundamental role of biomedical research in the development of new medicinal products
Book Synopsis Biomedical Research in the Drugs Field by : Richard Muscat
Download or read book Biomedical Research in the Drugs Field written by Richard Muscat and published by Council of Europe. This book was released on 2006-01-01 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Why is it that certain people use drugs in the first place and then why do some become dependent following repeated use while others do not? What are the possible implications of the current state of affairs of research from a biomedical or more aptly put, a Neuroscience perspective, including an ethical point of view? These are questions the author attempts to answer as the biomedical or neuroscience research in the drug field is a fast moving area with ethical implications that have arisen as a result of the conduct of such research.
Book Synopsis Principles of Biomedical Sciences and Industry by : Markus Hinder
Download or read book Principles of Biomedical Sciences and Industry written by Markus Hinder and published by John Wiley & Sons. This book was released on 2022-07-22 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Biomedical Sciences and Industry Improve your product development skills to bring new ideas to biomedicine The development of innovative healthcare products, such as biodegradable implants, biopharmaceuticals, or companion diagnostics, requires a multi-disciplinary approach that incorporates scientific evidence with novel and innovative ideas to create new and improved products and treatments. Indeed, product development and the integration of science with commercial aspects have become key challenges for scientists working in the pharmaceutical, biotech, and medtech industries. Using a multi-pronged approach to development, Principles of Biomedical Sciences and Industry combines ideas and methodologies from four of the central areas of focus in the biomedical arena: pharmaceuticals, diagnostics, biomaterials, and medical devices. In doing so, the book covers the entire product lifecycle, from translating a scientific idea into a prototype to product development, launch, and management. Principles of Biomedical Sciences and Industry readers will also find: Several case studies from the most important product categories (pharmaceuticals, diagnostics, medical devices, combination products) Chapters dealing with toxicology and safety risks in development, as well as regulatory approval Key business aspects including how to secure funding, managing intellectual property, and price regulation in the market An ideal resource for teachers and students that conveys the information in an easily-digestible format Ideal for advanced students and young professionals pursuing a career in the biomedical and healthcare industries, Principles of Biomedical Sciences and Industry is an essential reference for those in pharmaceutical industry, biotechnologists, medicinal chemists, bio-engineers, pharma engineers, and management consultants.
Book Synopsis Translational Systems Biology by : Yoram Vodovotz
Download or read book Translational Systems Biology written by Yoram Vodovotz and published by Elsevier. This book was released on 2014-10-08 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams
Book Synopsis Biosimulation in Drug Development by : Martin Bertau
Download or read book Biosimulation in Drug Development written by Martin Bertau and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions. Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference.
Book Synopsis Foundations of Biomedical Knowledge Representation by : Arjen Hommersom
Download or read book Foundations of Biomedical Knowledge Representation written by Arjen Hommersom and published by Springer. This book was released on 2016-01-07 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicine and health care are currently faced with a significant rise in their complexity. This is partly due to the progress made during the past three decades in the fundamental biological understanding of the causes of health and disease at the molecular, (sub)cellular, and organ level. Since the end of the 1970s, when knowledge representation and reasoning in the biomedical field became a separate area of research, huge progress has been made in the development of methods and tools that are finally able to impact on the way medicine is being practiced. Even though there are huge differences in the techniques and methods used by biomedical researchers, there is now an increasing tendency to share research results in terms of formal knowledge representation methods, such as ontologies, statistical models, network models, and mathematical models. As there is an urgent need for health-care professionals to make better decisions, computer-based support using this knowledge is now becoming increasingly important. It may also be the only way to integrate research results from the different parts of the spectrum of biomedical and clinical research. The aim of this book is to shed light on developments in knowledge representation at different levels of biomedical application, ranging from human biology to clinical guidelines, and using different techniques, from probability theory and differential equations to logic. The book starts with two introductory chapters followed by 18 contributions organized in the following topical sections: diagnosis of disease; monitoring of health and disease and conformance; assessment of health and personalization; prediction and prognosis of health and disease; treatment of disease; and recommendations.
Book Synopsis Biomedical Science and Technology by : A. Atilla Hincal
Download or read book Biomedical Science and Technology written by A. Atilla Hincal and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advancing with Biomedical Engineering Today, in most developed countries, modem hospitals have become centers of sophis ticated health care delivery using advanced technological methods. These have come from the emergence of a new interdisciplinary field and profession, commonly referred to as "Bio medical Engineering." Although what is included in the field of biomedical engineering is quite clear, there are some disagreements about its definition. In its most comprehensive meaning, biomedical engineering is the application of the principles and methods of engi neering and basic sciences to the understanding of the structure-function relationships in normal and pathological mammalian tissues, as well as the design and manufacture of prod ucts to maintain, restore, or improve tissue functions, thus assisting in the diagnosis and treat ment of patients. In this very broad definition, the field of biomedical engineering now includes: • System analysis (modeling, simulation, and control of the biological system) • Biomedical instrumentation (detection, measurement, and monitoring of physio logic signals) • Medical imaging (display of anatomic details or physiologic functions for diag nosis) • Biomaterials (development of materials used in prostheses or in medical devices) • Artificial organs (design and manufacture of devices for replacement or augmen tation of tissues or organs) • Rehabilitation (development oftherapeutic and rehabilitation procedures and de vices) • Diagnostics (development of expert systems for diagnosis of diseases) • Controlled drug delivery (development of systems for administration of drugs and other active agents in a controlled manner, preferably to the target area)
Book Synopsis Biomedical Translational Research by : R.C. Sobti
Download or read book Biomedical Translational Research written by R.C. Sobti and published by Springer Nature. This book was released on 2022-05-26 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.
Book Synopsis Bioscience - Lost in Translation? by : Richard Barker
Download or read book Bioscience - Lost in Translation? written by Richard Barker and published by Oxford University Press. This book was released on 2016 with total page 241 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the global issue of biomedical research increasingly failing to deliver patient benefits and health system improvement. The book highlights the problem and its consequences, and analyses the underlying causative factors and provides powerful prescriptions for change to close the 'innovation gap'.
Book Synopsis The Biomedical Sciences in Society by : Iain Crinson
Download or read book The Biomedical Sciences in Society written by Iain Crinson and published by Springer Nature. This book was released on 2021-03-02 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook provides a comprehensive introduction to the interdisciplinary field of the Social Studies of Science and Technology (SSST). Over the past two decades, the biomedical sciences have transformed our understanding of the relationship between the social and natural worlds, while its ‘promissory visions’ are seen to offer extraordinary opportunities for economic and social development. But alongside these scientific innovations have emerged new, and frequently unanticipated social, political, bioethical, and legal dilemmas and challenges. This cutting-edge text explores ‘post-genomic’ developments in the field of pharmacogenomics and the prospects for a new ‘precision’ or personalised medicine; the potential of environmental epigenetics to reconfigure the boundaries of the social and natural worlds; the emergence of an array of ‘neuro-disciplines’, seeking to identify the neural basis of a whole range of social and economic behaviours; and the challenges of constructing a coherent and robust governance framework for the conduct of biomedical science research and innovation, responsive to the social and health needs of the whole population.
Book Synopsis Textbook of Cortical Brain Stimulation by : Sergio Canavero
Download or read book Textbook of Cortical Brain Stimulation written by Sergio Canavero and published by Walter de Gruyter GmbH & Co KG. This book was released on 2015-01-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed over the past 25 years, Cortical Brain Stimulation has emerged as a brand new, cutting-edge option for the treatment of intractable neurological and psychiatric disorders. Devoid of the mortality and disabling morbidity that may accompany deep brain stimulation, stimulating the cortex with a minimally invasive surgical approach had initially proved its worth for the treatment of Central and other Neuropathic Pain Syndromes and later for Parkinson Disease, Dystonia, Stroke and Coma rehabilitation, Epilepsy, Depression and Tinnitus. Written by many of the pioneers in the field, this authoritative treatise is a comprehensive presentation - from surgical details, to clinical results and mechanisms of action. It also provides the busy clinician with comparisons with non-invasive cortical stimulation techniques, such as TMS and tDCS. No other book deals with this form of brain stimulation. The clinician will harness the power of this formidable new therapeutic option, which is being further refined with the advent of closed-loop stimulation. Dr Canavero deciphered the genesis of the central pain syndromes, introduced extradural cortical stimulation for Parkinson Disease and the vegetative state and co-introduced extradural cortical stimulation for stroke rehabilitation. He made worldwide news in 2008 for partially restoring consciousness in two vegetative patients, in 2013 for proposing the HEAVEN/GEMINI protocol for human head transplantation and in 2014 for pushing brain stimulation in the setting of criminal psychopathy. His books include: Central Pain Syndrome, Cambridge Univ. Press, 2011 (2nd ed.), Textbook of therapeutic cortical stimulation, Nova Sci, 2009 and two books in Italian on human sexual behavior.
Book Synopsis Advances in Cognitive Neurodynamics (V) by : Rubin Wang
Download or read book Advances in Cognitive Neurodynamics (V) written by Rubin Wang and published by Springer. This book was released on 2016-01-29 with total page 809 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proceedings contains articles submitted to the fifth International Conference on Cognitive Neurodynamics (ICCN2015). In ICCN2015, twelve invited plenary lectures were presented by the leading scientists in their respective research fields. More than 15 mini-symposiums are organized by specialists with topics covering: motor control and learning, dynamic coding in distributed neural circuits, dynamics of firing patterns and synchronization in neuronal systems, information and signal processing techniques in neurotechnology, neural oscillations and synaptic plasticity in the hippocampus, new perspective on model-based vs. model-free brain process, neural mechanisms of internal switching, neuroinformation computation, neural model and dynamics, imaging human cognitive networks, neuroinformatics, neuroergonomics & neuroengineering, dynamic brain for communication, visual information processing and functional imaging and neural mechanisms of language processing. All articles are peer-reviewed. The ICCN is a series conference held every two years since 2007.
Book Synopsis Reproducibility in Biomedical Research by : Erwin B. Montgomery Jr.
Download or read book Reproducibility in Biomedical Research written by Erwin B. Montgomery Jr. and published by Elsevier. This book was released on 2024-04-26 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproducibility in Biomedical Research: Epistemological and Statistical Problems, 2nd Ed. explores the ideas and conundrums inherent in scientific research. Reproducibility is one of the biggest challenges in biomedical research. It affects not only the ability to replicate results, but the very trust in the findings. Since published in 2019, Reproducibility of Biomedical Research: Epistemological and Statistical Problems established itself as a solid ethical reference in the area, leading to significant reflection on biomedical research. The second edition addresses new challenges to reproducibility in biosciences, namely reproducibility of machine learning Artificial Intelligence (AI), reproducibility of translation from research to medical care, and the fundamental challenges to reproducibility. All current chapters will be expanded to cover advances in the topics previously addressed. Reproducibility in Biomedical Research: Epistemological and Statistical Problems, 2nd Ed. provides biomedical researchers with a framework to better understand the reproducibility challenges in the area. Newly introduced interactive exercises and updated case studies help students understand the fundamental concepts involved in the area. Includes four new chapters and updates across the book, covering recent developments of issues affecting reproducibility in biomedical researchCovers reproducibility of results from machine learning AI algorithmsPresents new case studies to illustrate challenges in related fieldsIncludes a companion website with interactive exercises and summary tables
Book Synopsis 3D-Printed Tissue Models by : Dr James Thompson
Download or read book 3D-Printed Tissue Models written by Dr James Thompson and published by Independently Published. This book was released on 2023-10-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Embark on a groundbreaking journey into the future of biomedical research and drug discovery with "3D-Printed Tissue Models: A New Frontier in Biomedical Research and Drug Discovery." Imagine a world where diseases are understood at a cellular level, where treatments are tailored to your unique genetic code, and where life-saving organs are 3D-printed on demand. This future is not science fiction; it's the revolutionary reality of 3D-printed tissue models. In this captivating exploration, we take you from the dawn of tissue engineering to the cutting-edge of bioprinting, unveiling how 3D-printed tissues are redefining the possibilities of medicine. You'll discover the historical evolution of tissue engineering, the limitations of traditional models, and the emergence of 3D printing as the game-changer in the field. Dive into the world of precision medicine, where treatments are customized to your individual needs, thanks to the unparalleled accuracy of 3D-printed tissues. Walk hand in hand with pioneers in the field and explore how they're recreating diseases for in-depth research, designing personalized medical breakthroughs, and advancing drug discovery. This book takes you on a journey through the ethical landscape of 3D-printed tissue models, raising questions about informed consent, privacy, and the moral status of these remarkable creations. You'll also explore the collaboration between regulatory bodies and researchers, which is shaping the ethical future of biomedical research. As you peer into the horizon, discover the exciting trends and emerging technologies that promise a future where artificial intelligence, multi-organ systems, and open-source models play key roles in advancing medical science. Witness the transformation of drug discovery, the reduction of animal testing, and the creation of a more responsible and ethical research environment. "3D-Printed Tissue Models" is not just a book; it's your passport to the future of healthcare, where innovation, collaboration, and ethical considerations converge. Whether you're a student, researcher, healthcare professional, or simply curious about the possibilities of modern medicine, this book invites you to be part of a remarkable journey. Join us as we unlock the door to a future where 3D-printed tissues bring hope to patients, revolutionize drug discovery, and redefine the landscape of biomedical research. Are you ready to embark on this transformative voyage? Buy your ticket now.
