Biomedical Translational Research

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Biomedical Translational Research

Author : R.C. Sobti
Publisher : Springer Nature
ISBN 13 : 9811688451
Total Pages : 493 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Biomedical Translational Research by : R.C. Sobti

Download or read book Biomedical Translational Research written by R.C. Sobti and published by Springer Nature. This book was released on 2022-06-14 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second volume of the Biomedical translational research discusses advancements in biomedical research for understanding the pathophysiology of various diseases towards improving diagnosis and treatment. It presents the integration of molecular-based technologies, clinical genomics, and medical informatics to improve diagnostic and treatment strategies. Further, the book reviews molecular genomics approaches for diagnosis and managing tuberculosis. It also covers the innovative strategies for cancer treatment through targeting metabolic pathways, tumor microenvironment, cancer stem cells, and immune cells. It also illuminates novel strategies for heart failure diagnosis and therapeutic approaches for the treatment of heart failure. It discusses improvements in translational research for discovery of new diagnostic tests, identifying novel biomarkers and drugable targets, and predicting optimal treatments based on understanding the underlying molecular basis of the disease. Lastly, it reviews the preclinical models of restenosis and their application and limitation in the evaluation of device-based interventional technologies for the treatment of coronary artery diseases.

Translational Research in Biomedical Sciences: Recent Progress and future prospects

Author : Krupakar Parthasarathy
Publisher : Springer
ISBN 13 : 9789819717767
Total Pages : 0 pages
Book Rating : 4.7/5 (177 download)

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Book Synopsis Translational Research in Biomedical Sciences: Recent Progress and future prospects by : Krupakar Parthasarathy

Download or read book Translational Research in Biomedical Sciences: Recent Progress and future prospects written by Krupakar Parthasarathy and published by Springer. This book was released on 2024-06-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main objective of translational health science is to concentrate on discovering healthcare products for all people where care gaps exist. This book examines the applications of translational research, identifies its difficulties, outlines its essential characteristics, considers healthcare management strategies, and examines the public's perspectives today. This book assists aspiring implementation scientists in researching this area because the discipline is still relatively young for the wide range of researchers tackling the challenge of clinical and translational science, a field dedicated to examining human health and disease, interventions, and outcomes to develop new treatment approaches, devices, and modalities to improve health. This book Edition is the most authoritative and timely resource that introduces new physiological and therapeutic processes to engage the fastest-growing scientific outcomes from academic and industrial research. The chapters in this book give insights into perspectives on the field of clinical and translational science and discuss artificial intelligence in drug development and conventional and novel clinical trial designs. There is a lot of hope that using artificial intelligence (AI) will significantly advance all facets of healthcare, from diagnosis to therapy. AI is prepared to assist medical staff with various duties, including administrative workflow, clinical documentation, patient outreach, and specialist support like image analysis, medical device automation, and patient monitoring. Some of the most important uses of AI in healthcare will be covered in this book by eminent Scientists, Academicians, and Industrial persons from both clinical and non-clinical fields.

Biomedical Translational Research

Author : R.C. Sobti
Publisher : Springer Nature
ISBN 13 : 9811692327
Total Pages : 597 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Biomedical Translational Research by : R.C. Sobti

Download or read book Biomedical Translational Research written by R.C. Sobti and published by Springer Nature. This book was released on 2022-07-28 with total page 597 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which is the third volume of Biomedical translational research, focuses on the fundamental role of biomedical research in developing new medicinal products. It emphasizes the importance of understanding biological and pathophysiological mechanisms underlying the disease to discover and develop new biological agents. The book uniquely explores the genomic computational integrative approach for drug repositioning. Further, it discusses the health benefits of nutraceuticals and their application in human diseases. Further, the book comprehensively reviews different computational approaches that employ GWAS data to guide drug repositioning. Finally, it summarizes the major challenges in drug development and the strategies for the rational design of the next generation more effective but less toxic therapeutic agents.

Biomedical Translational Research

Author : R.C. Sobti
Publisher : Springer Nature
ISBN 13 : 9811643458
Total Pages : 500 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Biomedical Translational Research by : R.C. Sobti

Download or read book Biomedical Translational Research written by R.C. Sobti and published by Springer Nature. This book was released on 2022-05-26 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, which is the first volume of Biomedical Translational Research, summarizes emerging technologies in healthcare. The book reviews the advancements in biomedical sciences in genomics, immunology, stem cell, tissue engineering, nanotechnology, computational and structural biology, biomedical engineering, and telemedicine biology. The book highlights the applications of artificial intelligence in the diagnosis of infectious diseases and examines the role of system biology approaches for understanding human complexity, variability, and its influence on health and diseases. It presents the applications of flow cytometry in monitoring the progression and treatment of disease. It covers emerging technologies in cancer research, including CRISPR-Cas9, NGS, and nanotechnology. This book is a useful source of information for clinical researchers, basic scientists, biomedical engineers, and computational biologists.

Lost in Translation

Author : Rakesh K. Srivastava
Publisher : World Scientific
ISBN 13 : 9814489077
Total Pages : 766 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Lost in Translation by : Rakesh K. Srivastava

Download or read book Lost in Translation written by Rakesh K. Srivastava and published by World Scientific. This book was released on 2014 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses. Sample Chapter(s). Foreword (41 KB). Chapter 1: Translational Research: Lost in Complexity (305 KB). Contents: Barriers to Incentives for Translational Research; Integrating Emerging Science into Clinical Practice; Organization, Prioritization, Review and Funding for the Translational Research; Translational Sciences in Cancer Research; Translational Science in Infectious Diseases; Translation Research in Endocrinology and Nutrition; Translation Research and Neuroscience; Stem Cells and Translation Research; The Role of Translational Research in Public Health and Behavioral Sciences; Translational Epidemiology, Biostatistics and Informatics; Translational Research Outcomes and Resources. Readership: Graduate students and researchers in cancer research, pharmacology/drug discovery/pharmaceuticals, immunology, infectious diseases and public health.

Cures vs. Profits

Author : James Lyons-Weiler
Publisher : World Scientific
ISBN 13 : 9814730165
Total Pages : 360 pages
Book Rating : 4.8/5 (147 download)

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Book Synopsis Cures vs. Profits by : James Lyons-Weiler

Download or read book Cures vs. Profits written by James Lyons-Weiler and published by World Scientific. This book was released on 2016-03-28 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Did you ever wonder whether doctors want cures, or just treatments? Did you know ... Grapefruit can interact with over 100 drugs, but it may be useful for reducing blood pressure and for weight loss?ADHD over diagnosis is now recognized widely as a fact, and there are existing — and new ways — to avoid a misdiagnosis?Studies have been conducted demonstrating the utility of Omega 3 fatty acids, meditation, yoga, and melatonin for some important symptoms of ADHD, including executive functions?Vaccines have saved millions of lives in the last decade? But are they safe?Breast cancer rates are declining in the US, but have been steadily increasing in Japan?Doctors are getting better at predicting which chemotherapy will, and will not work, on certain cancers?There are vaccines against cancer? This book reviews recent key, hard-won successes and findings from recent biomedical research. Written by one of the most ardent defenders of the public trust in science, it provides an accessible, detailed look at successes in translational biomedical and clinical research. The author provides an optimistic, forward-looking view for the possibility of change for the public good, cutting through the controversy and gets to very core of each topic. The public can be optimistic about the future of medicine, but only if they learn the facts of these advances, and learn what their doctors should be expected to know. Highly referenced, and filled with interviews from experts and people directly involved in the research behind the new facts in each chapter, this book is a rich source of information on advances in biomedicine that you will want to share with your family & friends. Contents: PrefaceAbuses in MedicineOutrageous Acts of PseudoscienceWait ... Grapefruit is Bad for You?Hormone Receptor Status and Breast Cancer TreatmentFecal Microbiota TransplantationOverdiagnosis of ADHD: It's Their Mind, Not YoursVaccination Programs: Eradication of Infectious DiseasesChemosensitivity and Chemoresistance Assays in CancerA Very Special Kind of Brain Cancer SurgeryGenomics and Personalized MedicineRobot-Assisted SurgeryHallmarks and Principles of Translational Research SuccessFuture Medicine 1: Early Detection and Cures for Alzheimer's DiseaseFuture Medicine 2: Cancer VaccinesThe Future of Translational Research Readership: Lay public, scientists, doctors, politicians, policy makers, public health workers, health care worker, investors.

Principles of Translational Science in Medicine

Author : Martin Wehling
Publisher : Academic Press
ISBN 13 : 9780128006870
Total Pages : 0 pages
Book Rating : 4.0/5 (68 download)

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Book Synopsis Principles of Translational Science in Medicine by : Martin Wehling

Download or read book Principles of Translational Science in Medicine written by Martin Wehling and published by Academic Press. This book was released on 2015-04-07 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Translational Science in Medicine: From Bench to Bedside, Second Edition, provides an update on major achievements in the translation of research into medically relevant results and therapeutics. The book presents a thorough discussion of biomarkers, early human trials, and networking models, and includes institutional and industrial support systems. It also covers algorithms that have influenced all major areas of biomedical research in recent years, resulting in an increasing numbers of new chemical/biological entities (NCEs or NBEs) as shown in FDA statistics. The book is ideal for use as a guide for biomedical scientists to establish a systematic approach to translational medicine.

Biomedical Informatics in Translational Research

Author : Hai Hu
Publisher : Artech House
ISBN 13 : 159693039X
Total Pages : 279 pages
Book Rating : 4.5/5 (969 download)

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Book Synopsis Biomedical Informatics in Translational Research by : Hai Hu

Download or read book Biomedical Informatics in Translational Research written by Hai Hu and published by Artech House. This book was released on 2008 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: This trailblazing resource on biomedical informatics provides medical researchers with innovative techniques for integrating and federating data from clinical and molecular studies. This volume helps researchers manage data, expedite their efforts, and make the most of targeted basic research.

Translational Biotechnology

Author : Yasha Hasija
Publisher : Academic Press
ISBN 13 : 0128219734
Total Pages : 453 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Translational Biotechnology by : Yasha Hasija

Download or read book Translational Biotechnology written by Yasha Hasija and published by Academic Press. This book was released on 2021-01-17 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Biotechnology: A Journey from Laboratory to Clinics presents an integrative and multidisciplinary approach to biotechnology to help readers bridge the gaps between fundamental and functional research. The book provides state-of-the-art and integrative views of translational biotechnology by covering topics from basic concepts to novel methodologies. Topics discussed include biotechnology-based therapeutics, pathway and target discovery, biological therapeutic modalities, translational bioinformatics, and system and synthetic biology. Additional sections cover drug discovery, precision medicine and the socioeconomic impact of translational biotechnology. This book is valuable for bioinformaticians, biotechnologists, and members of the biomedical field who are interested in learning more about this promising field. Explains biotechnology in a different light by using an application-oriented approach Discusses practical approaches in the development of precision medicine tools, systems and dynamical medicine approaches Promotes research in the field of biotechnology that is translational in nature, cost-effective and readily available to the community

Translational Medicine

Author : James Mittra
Publisher : CRC Press
ISBN 13 : 9814364843
Total Pages : 294 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Translational Medicine by : James Mittra

Download or read book Translational Medicine written by James Mittra and published by CRC Press. This book was released on 2016-04-19 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Translational Informatics

Author : Philip R.O. Payne
Publisher : Springer
ISBN 13 : 1447146468
Total Pages : 185 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Translational Informatics by : Philip R.O. Payne

Download or read book Translational Informatics written by Philip R.O. Payne and published by Springer. This book was released on 2014-08-23 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrative and translational methodologies and frameworks have transformed modern biomedical research and the delivery of clinical care. This shift has been manifested in a number of ways, including the rapid growth and increasing availability of high-throughput bio-molecular instrumentation and analysis platforms, innovative clinical research programs intended to accelerate knowledge translation, and initial efforts to deliver personalized healthcare informed by the genomic profiles of patients. A common theme of reports and publications concerned with such transformative changes in the biomedical and healthcare domains is concerned with the challenges and opportunities related to the collection, management, integration, analysis, and dissemination of large-scale, heterogeneous biomedical data sets. In particular, the absence of well-established and adopted theoretical and practical frameworks intended to address such needs is a major impediment to the realization of translational and knowledge-driven healthcare, in which the best possible scientific evidence is used to inform the care of every patient. In this vacuum, the development of integrative clinical or translational research paradigms is significantly limited by the propagation of both data and expertise silos. This book details for the first time the current state of this extremely potent area of healthcare innovation and policy and defines the interaction between clinical/translational science and biomedical informatics.

Translational Biomedical Informatics

Author : Bairong Shen
Publisher : Springer
ISBN 13 : 9811015031
Total Pages : 332 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Translational Biomedical Informatics by : Bairong Shen

Download or read book Translational Biomedical Informatics written by Bairong Shen and published by Springer. This book was released on 2016-10-31 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to essential methods and applications in translational biomedical informatics, which include biomedical big data, cloud computing and algorithms for understanding omics data, imaging data, electronic health records and public health data. The storage, retrieval, mining and knowledge discovery of biomedical big data will be among the key challenges for future translational research. The paradigm for precision medicine and healthcare needs to integratively analyze not only the data at the same level – e.g. different omics data at the molecular level – but also data from different levels – the molecular, cellular, tissue, clinical and public health level. This book discusses the following major aspects: the structure of cross-level data; clinical patient information and its shareability; and standardization and privacy. It offers a valuable guide for all biologists, biomedical informaticians and clinicians with an interest in Precision Medicine Informatics.

Biomedical Research, Medicine, and Disease

Author : RC Sobti
Publisher : CRC Press
ISBN 13 : 1000811190
Total Pages : 665 pages
Book Rating : 4.0/5 (8 download)

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Book Synopsis Biomedical Research, Medicine, and Disease by : RC Sobti

Download or read book Biomedical Research, Medicine, and Disease written by RC Sobti and published by CRC Press. This book was released on 2023-04-04 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical research is the first step towards the creation of new medications and treatments that help to manage different types of health conditions and diseases. The prevention and cure of diseases would be practically impossible without such type of research. Although the drug discovery and development processes are far too costly, time-consuming, prone to failure, and have low success rate, today the term "translational research or medicine" seems to have become trendy, yet it is insufficient. The present book is a sincere attempt by dedicated researchers to convey the importance of translational biomedical research, medicine, and disease, primarily, basic and clinical difficulties in the translation of diagnostic measures, pharmaceutical advances, biomarkers, diagnostics, and therapeutics. This book is meant for researchers, scientists, healthcare professionals, industry, innovators, and students of biomedical sciences, as well as for those involved in the basic sciences, biochemistry, biotechnology, biophysics, and life sciences in general. The volume comprehensively covers: Emerging technologies for health care Various aspects of biomedical research toward understanding of pathophysiology of the diseases Advances in improvement in diagnostic procedures and therapeutic tools The fundamental role of biomedical research in the development of new medicinal products

Lost in Translation

Author : Rakesh Srivastava
Publisher : World Scientific
ISBN 13 : 9814489085
Total Pages : 768 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Lost in Translation by : Rakesh Srivastava

Download or read book Lost in Translation written by Rakesh Srivastava and published by World Scientific. This book was released on 2014-03-14 with total page 768 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses. Contents:Barriers to Incentives for Translational ResearchIntegrating Emerging Science into Clinical PracticeOrganization, Prioritization, Review and Funding for the Translational ResearchTranslational Sciences in Cancer ResearchTranslational Science in Infectious DiseasesTranslation Research in Endocrinology and NutritionTranslation Research and NeuroscienceStem Cells and Translation ResearchThe Role of Translational Research in Public Health and Behavioral SciencesTranslational Epidemiology, Biostatistics and InformaticsTranslational Research Outcomes and Resources Readership: Graduate students and researchers in cancer research, pharmacology/drug discovery/pharmaceuticals, immunology, infectious diseases and public health. Keywords:Translational Research;Basic and Clinical Sciences;Prevention;Population SciencesKey Features:International team of prominent co-authorsUnique and widely treated topicsNew hypotheses, data and analyses

Clinical and Translational Science

Author : David Robertson
Publisher : Academic Press
ISBN 13 : 012802111X
Total Pages : 812 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Clinical and Translational Science by : David Robertson

Download or read book Clinical and Translational Science written by David Robertson and published by Academic Press. This book was released on 2016-11-25 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

Translational Biology in Medicine

Author : M. Montano
Publisher : Elsevier
ISBN 13 : 1908818654
Total Pages : 228 pages
Book Rating : 4.9/5 (88 download)

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Book Synopsis Translational Biology in Medicine by : M. Montano

Download or read book Translational Biology in Medicine written by M. Montano and published by Elsevier. This book was released on 2014-12-08 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent emphasis in biomedical research on translational biology and personalized medicine is revolutionizing conceptual and experimental approaches to understanding and improving human health. Translational Biology in Medicine begins with an introduction to experimental model systems for disease, such as cell lines, primary cells, stem cells and animal models for disease, followed by a systematic description of genetic and genomic profiling and biomarker validation currently used in biomedical research. Examples of translation studies that have used these models and methods are presented, including studies in aging, tissue repair and chronic infection, each with an emphasis on how personalized medicine is transforming biomedicine. Bioethical considerations in translational study design and bioethical considerations in biomedical research are then covered, before concluding remarks, and a look towards the future of personalized medicine. Describes cellular and animal model systems used in translational research Discusses the use of blood, genetic and genomic biomarkers for disease Presents translational studies in aging, tissue repair and infectious disease biomedicine

Translational Systems Biology

Author : Yoram Vodovotz
Publisher : Elsevier
ISBN 13 : 0123978904
Total Pages : 178 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Translational Systems Biology by : Yoram Vodovotz

Download or read book Translational Systems Biology written by Yoram Vodovotz and published by Elsevier. This book was released on 2014-10-08 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money’s worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation. Provides an explicit, reasoned, and systematic approach to dealing with the challenges of translational science across disciplines Establishes the case for including computational modeling at all stages of biomedical research and healthcare delivery, from early pre-clinical studies to long-term care, by clearly delineating efficiency and costs saving important to business investment Guides readers on how to communicate across domains and disciplines, particularly between biologists and computational researchers, to effectively develop multi- and trans-disciplinary research teams