BIOMAT 2010

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Author :
Publisher : World Scientific
ISBN 13 : 9814343420
Total Pages : 411 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis BIOMAT 2010 by : Rubem P. Mondaini

Download or read book BIOMAT 2010 written by Rubem P. Mondaini and published by World Scientific. This book was released on 2011 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the selected contributed papers of the BIOMAT 2010 International Symposium which has been organized as a joint conference with the 2010 Annual Meeting of the Society for Mathematical Biology (http: //www.smb.org) by invitation of the Director Board of this Society. The works presented at Tutorial and Plenary Sessions by expert keynote speakers have been also been included. This book contains state-of-the-art articles on special research topics on mathematical biology, biological physics and mathematical modelling of biosystems; comprehensive reviews on interdisciplinary areas written by prominent leaders of scientific research groups. The treatment is both pedagogical and sufficiently advanced to enhance future scientific research.

BIOMAT 2010

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Author :
Publisher : World Scientific
ISBN 13 : 9814460672
Total Pages : 412 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis BIOMAT 2010 by : Rubem P Mondaini

Download or read book BIOMAT 2010 written by Rubem P Mondaini and published by World Scientific. This book was released on 2011-03-11 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the selected contributed papers of the BIOMAT 2010 International Symposium which has been organized as a joint conference with the 2010 Annual Meeting of the Society for Mathematical Biology (http://www.smb.org) by invitation of the Director Board of this Society. The works presented at Tutorial and Plenary Sessions by expert keynote speakers have been also included. This book contains state-of-the-art articles on special research topics on mathematical biology, biological physics and mathematical modelling of biosystems; comprehensive reviews on interdisciplinary areas written by prominent leaders of scientific research groups. The treatment is both pedagogical and sufficiently advanced to enhance future scientific research. Contents:MorphologyMolecular BiophysicsMathematical EpidemiologyPopulation DynamicsPopulation BiologyTheoretical ImmunologyComputational BiologyMathematical Aspects of BioprocessesPopulation GeneticsSystems Biology Readership: Mathematicians, biologists, physicists; graduate and undergraduate students interested in biomathematics. Keywords:Mathematical Biology;Biological Physics;Mathematical Modelling of Biosystems

BIOMAT 2010

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Author :
Publisher : World Scientific
ISBN 13 : 9814343439
Total Pages : 411 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis BIOMAT 2010 by : Rubem P. Mondaini

Download or read book BIOMAT 2010 written by Rubem P. Mondaini and published by World Scientific. This book was released on 2011 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the selected contributed papers of the BIOMAT 2010 International Symposium which has been organized as a joint conference with the 2010 Annual Meeting of the Society for Mathematical Biology (http: //www.smb.org) by invitation of the Director Board of this Society. The works presented at Tutorial and Plenary Sessions by expert keynote speakers have been also included. This book contains state-of-the-art articles on special research topics on mathematical biology, biological physics and mathematical modelling of biosystems; comprehensive reviews on interdisciplinary areas written by prominent leaders of scientific research groups. The treatment is both pedagogical and sufficiently advanced to enhance future scientific research

BIOMAT 2011

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Author :
Publisher : World Scientific
ISBN 13 : 9814397717
Total Pages : 409 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis BIOMAT 2011 by : Rubem Mondaini

Download or read book BIOMAT 2011 written by Rubem Mondaini and published by World Scientific. This book was released on 2012 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains a selection of articles on special research topics on Mathematical Biology and the interdisciplinary fields of mathematical modelling of biosystems. The treatment is both pedagogical and advanced to enhance future scientific research. We include comprehensive reviews written by prominent leaders of scientific research groups, new results on Population Dynamics such as Hybrid Discrete-Continuous Models of Cell Populations and the Hopf bifurcation on Predator-Prey Models, and some state of the art research on Medical Physics such as Optimization Methods applied to Raman Spectroscopy. Other topics covered focus on evolution biology, infectious diseases, DNA structure and many more.

Biomaterials from Nature for Advanced Devices and Therapies

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1119178088
Total Pages : 704 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Biomaterials from Nature for Advanced Devices and Therapies by : Nuno M. Neves

Download or read book Biomaterials from Nature for Advanced Devices and Therapies written by Nuno M. Neves and published by John Wiley & Sons. This book was released on 2016-10-07 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: In-depth information on natural biomaterials and their applications for translational medicine! Undiluted expertise: edited by world-leading experts with contributions from top-notch international scientists, collating experience and cutting-edge knowledge on natural biomaterials from all over the world A must-have on the shelf in every biomaterials lab: graduate and PhD students beginning their career in biomaterials science and experienced researchers and practitioners alike will turn to this comprehensive reference in their daily work Link to clinical practice: chapters on translational research make readers aware of what needs to be considered when a biomaterial leaves the lab to be routinely used

Biomat 2011 - International Symposium On Mathematical And Computational Biology

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Author :
Publisher : World Scientific
ISBN 13 : 9814397725
Total Pages : 408 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Biomat 2011 - International Symposium On Mathematical And Computational Biology by : Rubem P Mondaini

Download or read book Biomat 2011 - International Symposium On Mathematical And Computational Biology written by Rubem P Mondaini and published by World Scientific. This book was released on 2012-03-14 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book contains a selection of articles on special research topics on Mathematical Biology and the interdisciplinary fields of mathematical modelling of biosystems. The treatment is both pedagogical and advanced to enhance future scientific research. We include comprehensive reviews written by prominent leaders of scientific research groups, new results on Population Dynamics such as Hybrid Discrete-Continuous Models of Cell Populations and the Hopf bifurcation on Predator-Prey Models, and some state of the art research on Medical Physics such as Optimization Methods applied to Raman Spectroscopy. Other topics covered focus on evolution biology, infectious diseases, DNA structure and many more.

The Chemistry of Inorganic Biomaterials

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Author :
Publisher : Royal Society of Chemistry
ISBN 13 : 1788019830
Total Pages : 323 pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis The Chemistry of Inorganic Biomaterials by : Christopher Spicer

Download or read book The Chemistry of Inorganic Biomaterials written by Christopher Spicer and published by Royal Society of Chemistry. This book was released on 2021-08-09 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials offer the potential to restore and supplement the function of tissues and organs following injury or disease. The use of inorganic materials in the clinic to date has been widespread, in the form of metallic joint replacements and ceramic dental and bone implants. Exciting new medical applications continue to emerge, enabled by innovative materials for neural interfaces and as anti-fouling agents. The Chemistry of Inorganic Biomaterials overviews the underlying chemistry behind the most common and cutting-edge inorganic materials in current use, or approaching use, in vivo. Framed from the context of the overarching material class/application, it provides a balanced and critical overview of the field by bringing together experts in both the fundamental inorganic and material chemistry, as well as key clinical considerations for biomedical applications. Written in an accessible style, this book will be of interest to advanced undergraduates, postgraduates and researchers in biomaterials, inorganic materials and materials chemistry.

Biomaterials and Engineering for Implantology

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Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110740133
Total Pages : 571 pages
Book Rating : 4.1/5 (17 download)

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Book Synopsis Biomaterials and Engineering for Implantology by : Yoshiki Oshida

Download or read book Biomaterials and Engineering for Implantology written by Yoshiki Oshida and published by Walter de Gruyter GmbH & Co KG. This book was released on 2022-02-07 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials are composed of metallic materials, ceramics, polymers, composites and hybrid materials. Biomaterials used in human beings require safety regulations, toxicity, allergic reaction, etc. When used as implantable materials their biological compatibility, biomechanical compatibility, and morphological compatibility must be acessed. This book explores the design and requirements of biomaterials for the use in implantology.

Biomaterials for Vasculogenesis and Angiogenesis

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Author :
Publisher : Woodhead Publishing
ISBN 13 : 0128218681
Total Pages : 522 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Biomaterials for Vasculogenesis and Angiogenesis by : Saeid Kargozar

Download or read book Biomaterials for Vasculogenesis and Angiogenesis written by Saeid Kargozar and published by Woodhead Publishing. This book was released on 2022-05-19 with total page 522 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials for Angiogenesis and Vasculogenesis covers the application of materials designed to encourage new blood vessel formation. Angiogenesis and vasculogenesis play an important role in tissue engineering and regenerative medicine research by promoting vascular networks inside engineered tissues and thereby increasing tissue healing and regeneration. However, researchers are faced with the challenge of finding suitable materials for improving angiogenesis and vascular formation in assays. This book reviews a broad range of biomaterials for the promotion of blood vessel genesis, from polymers and bioactive glass, to nanomaterial scaffolds and 3D angiogenic constructs. In addition, the book covers a variety of applications for biomaterials in tissue repair and regeneration, including cardiovascular regeneration, liver tissue engineering and much more. It will serve as a detailed reference for researchers in academia and industry, working in the fields of biomedical science and engineering, materials science, regenerative medicine and translational medicine. Introduces readers to the molecular and cellular basis of angiogenesis and vasculogenesis Helps researchers find suitable biomaterials to promote angiogenesis in engineered tissues and assays Describes a range of biomaterials and their properties, including glass-ceramics, nano-carriers, polymers, and more

BIOMAT 2013

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Author :
Publisher : World Scientific
ISBN 13 : 981460223X
Total Pages : 428 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis BIOMAT 2013 by : Rubem P Mondaini

Download or read book BIOMAT 2013 written by Rubem P Mondaini and published by World Scientific. This book was released on 2014-03-18 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a book of a series on interdisciplinary topics on the Biological and Mathematical Sciences. The chapters correspond to selected papers on special research themes, which have been presented at BIOMAT 2013 International Symposium on Mathematical and Computational Biology which was held in the Fields Institute for Research in Mathematical Sciences, Toronto, Ontario, Canada, on November 04 – 08, 2013. The treatment is both pedagogical and advanced in order to motivate research students as well as to fulfill the requirements of professional practitioners. There are comprehensive reviews written by prominent scientific leaders of famous research groups. Contents:Population Dynamics:The Princess and the Pea: The Unexpected Importance of Movement Algorithms (Rebecca Tyson)Plankton Nutrient Interaction Model with Harvesting under Constant Environment (Samares Pal and A Chatterjee)Traveling Wave Solutions for a Chemotaxis System (F Catrina and V M Reyes G)Dynamics of a General Stage Structured N Parallel Food Chains (Isam Al-Darabsah and Yuan Yuan)Pattern Recognition of Biological Phenomena:Complex Data Clustering: From Neural Network Architecture to Theory and Applications of Nonlinear Dynamics of Pattern Recognition (Guojun Gan, Jialun Yin, Yulia Wang and Jianhong Wu)Dynamic and Geometric Modelling of Biomolecular Structures:A Two-Step Kinetic Model of Insulin Aggregation with a Competitive Inhibitor (Mark Whidden, Allison Ho and Santiago Schnell)Optimal Control Techniques in Mathematical Modelling of Biological Phenomena:Optimal Control of Resource Coefficient in a Parabolic Population Model (J Bintz, H Finotti and S Lenhart)Optimization of Costs for Combating Aedes Aegypti in Optimal Time-Windows (W O Dias, G A Xavier, D A P Lima, E F Wanner and R T N Cardoso)Dynamics of a Varroa-Infested Honey Bee Colonies Model (K O Okosun)Computational Biology:Probability Distributions of GC Content Reflect the Evolution of Primate Species (Marco V José, Qi Lu and Juan R Bobadilla)Mining the Constraints of Protein Evolution (Fernando Encinas and Antonio Basilio de Miranda)Entropy Measures Based Methods for the Classification of Protein Domains into Families and Clans (Nicolas Carels, Cecilia F Mondaini and Rubem P Mondaini)Modelling Physiological Disorders:Modelling of Porous Elastic and Viscoelastic Media and Its Application to the Brain (R Begg, J Murley, M. Kohandel and S Sivaloganathan)The Mathematics of Liver Transplantation (F A B Coutinho, E Chaib, M Amaku, M M Burattini and E Massad)Complexity of Molecular Signaling Networks for Various Types of Cancer and Neurological Diseases Correlates with Patient Survivability (D Breitkreutz, E A Rietman, P Hinow, M Healey and J A Tuszynski)Mathematical Modelling of Infectious Diseases:Modelling Malaria Dynamics in Temperate Regions with Long Term Incubation Period (Kyeongah Nah, Gergely Röst and Yongkuk Kim)A Simulation of the U S Influenza Outbreak in 2009–2010 Using a Patch SIR Model based on Airport Transportation Data (D L Wallace and M Chen)Modelling Directly Transmitted Infections considering Age-structured Contact Rate and Vaccination (H M Yang and C H Dezotti)A General Framework for Agent-Based Modelling with Applications to Infectious Disease Dynamics (Marek Laskowski and Seyed M Moghadas)Analysis of the Basic Reproduction Number from the Initial Growth Phase of the Outbreak in Diseases Caused by Vectors (R P Sanches and E Massad)Parameter Estimation of a Tuberculosis Model in a Patchy Environment: Case of Cameroon (D P Moualeu, S Bowong and J Kürts)An Agent-Based Modelling Framework for Tuberculosis Infection with Drug-Resistance (Aquino L Espindola, A S Martinez and Seyed M Moghadas)Some Extensions of the Classical Epidemic Models (Fred Brauer) Readership: Undergraduates, graduates, researchers and all practitioners on the interdisciplinary fields of Mathematical Biology, Biological Physics and Mathematical Modelling of Biosystems. Keywords:Mathematical Biology;Biomathematics;Mathematical Modelling of Biosystems;Biological Physics;Biophysics;Computational Biology;Bioinformatics

Nanostructured Biomaterials for Overcoming Biological Barriers

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Publisher : Royal Society of Chemistry
ISBN 13 : 1849735298
Total Pages : 336 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis Nanostructured Biomaterials for Overcoming Biological Barriers by : Maria Jose Alonso

Download or read book Nanostructured Biomaterials for Overcoming Biological Barriers written by Maria Jose Alonso and published by Royal Society of Chemistry. This book was released on 2012-06-30 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a critical overview of the advances being made towards overcoming biological barriers through the contribution of nanosciences and nanotechnologies. Overcoming these barriers is of primary importance for solving the problems of many current drugs and vaccines and it is also especially relevant for the commercial exploitation of new therapeutic strategies i.e. gene and cellular therapies. Despite important information that has been covered in recently published books related to nanomedicine (mainly oriented to technologies and applications), there is still an important gap related to the relationship between the chemical properties of nanobiomaterials and their interaction with the biological environment. Thus, this comprehensive new book that is presented with a clear and organised structure dedicated to the different biological barriers relevant for drug delivery applications will focus on (i) mechanistic issues related to the interaction between drug delivery systems and biological barriers and (ii) the analysis of the critical factors determining the efficacy of nanobiomaterials for specific applications. Moreover, this field has become highly multidisciplinary over the last decade, leading to the development of new products, as well as to significant advances from the regulatory point of view. Moreover, this book will also provide an up-to-date view on the clinical relevance of nanomedicine and on its possible impact on global health.

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

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Author :
Publisher : CRC Press
ISBN 13 : 135165120X
Total Pages : 2856 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials by : Munmaya Mishra

Download or read book Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials written by Munmaya Mishra and published by CRC Press. This book was released on 2017-08-16 with total page 2856 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Unfolding the Biopolymer Landscape

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Publisher : Bentham Science Publishers
ISBN 13 : 1681081954
Total Pages : 469 pages
Book Rating : 4.6/5 (81 download)

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Book Synopsis Unfolding the Biopolymer Landscape by : Viness Pillay

Download or read book Unfolding the Biopolymer Landscape written by Viness Pillay and published by Bentham Science Publishers. This book was released on 2016-01-25 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The need for the development of biomaterials as scaffold for tissue regeneration is driven by the increasing demands for materials that mimic functions of extracellular matrices of body tissues. Unfolding the Biopolymer Landscape provides a unique account of “biopolymeric interventions” inherent to biotechnological applications, soft tissue engineering, ophthalmic drug delivery, biotextiles, environmentally responsive systems, neurotherapeutics, and emulsions-based formulations for food and pharmaceutical applications. Chapters in this volume also cover biomedical applications and implications of cationic polymers, collagen-based substrates, multifunctional polymers, shape memory biopolymers, hybrid semisynthetic biomaterials, microbial exopolysaccharides, biomaterials mimicking the extracellular microenvironment, derivatized polysaccharides, and metallic biomaterials. Each chapter is distinctly written by experts in the respective fields and emphasis is given on the mechanistic profile of the performance of biopolymers and biomedical applications. This book provides both basic and advanced biopolymer information for scientific experts and early career researchers in the field of drug delivery, tissue engineering, nanomedicine, food technology, peptide science, biomaterial design, and nutrition. This volume provides a unique account of “biopolymeric interventions” inherent to biotechnological applications, soft tissue engineering, ophthalmic drug delivery, biotextiles, environmentally responsive systems, neurotherapeutics, and emulsions-based formulations for food and pharmaceutical applications.

Trends in Biomathematics: Stability and Oscillations in Environmental, Social, and Biological Models

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Publisher : Springer Nature
ISBN 13 : 3031125150
Total Pages : 421 pages
Book Rating : 4.0/5 (311 download)

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Book Synopsis Trends in Biomathematics: Stability and Oscillations in Environmental, Social, and Biological Models by : Rubem P. Mondaini

Download or read book Trends in Biomathematics: Stability and Oscillations in Environmental, Social, and Biological Models written by Rubem P. Mondaini and published by Springer Nature. This book was released on 2023-01-01 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume convenes selected, peer-reviewed works presented at the BIOMAT 2021 International Symposium, which was virtually held on November 1–5, 2021, with its organization staff based in Rio de Janeiro, Brazil. In this volume the reader will find applications of mathematical modeling on health, ecology, and social interactions, addressing topics like probability distributions of mutations in different cancer cell types; oscillations in biological systems; modeling of marine ecosystems; mathematical modeling of organs and tissues at the cellular level; as well as studies on novel challenges related to COVID-19, including the mathematical analysis of a pandemic model targeting effective vaccination strategy and the modeling of the role of media coverage on mitigating the spread of infectious diseases. Held every year since 2001, the BIOMAT International Symposium gathers together, in a single conference, researchers from Mathematics, Physics, Biology, and affine fields to promote the interdisciplinary exchange of results, ideas and techniques, promoting truly international cooperation for problem discussion. BIOMAT volumes published from 2017 to 2020 are also available by Springer.

Kidney Transplantation, Bioengineering, and Regeneration

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Publisher : Academic Press
ISBN 13 : 0128018364
Total Pages : 1252 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Kidney Transplantation, Bioengineering, and Regeneration by : Giuseppe Orlando

Download or read book Kidney Transplantation, Bioengineering, and Regeneration written by Giuseppe Orlando and published by Academic Press. This book was released on 2017-06-08 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

Nanofiber Research

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 9535125281
Total Pages : 256 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Nanofiber Research by : Mohammed Rahman

Download or read book Nanofiber Research written by Mohammed Rahman and published by BoD – Books on Demand. This book was released on 2016-10-19 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book titled Nanofiber Research - Reaching New Heights contains a number of latest research results on growth and developments on material fibers in nanoscale. It is a promising novel research area that has received a lot of interest in recent years. This book includes interesting reports on cutting-edge science and technology related to synthesis, morphology, control, self-assembly and prospective application of nanofibers. I hope that the book will lead to systematization of nanofiber science, creation of new nanofiber research field and further promotion of nanofiber technology. This potentially unique work offers various approaches on the implementation of nanofibers. As it is widely known, nanotechnology presents the control of matter at the nanoscale and nano-dimensions within few nanometers, whereas this exclusive phenomenon enables us to regulate and control novel applications with nanofibers. This book presents an overview of recent and current nanofibers fundamental, significant applications and implementation research worldwide. It examined the methods of nanofiber synthesis, types of fibers used and potential applications associated with nanofiber researches. It is an important booklet for research organizations, governmental research centers, academic libraries and R

Degenerative Aortic Valve Disease, its Mechanism on Progression, its Effect on the Left Ventricle and the Postoperative Results

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Publisher : Bentham Science Publishers
ISBN 13 : 1608052877
Total Pages : 332 pages
Book Rating : 4.6/5 (8 download)

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Book Synopsis Degenerative Aortic Valve Disease, its Mechanism on Progression, its Effect on the Left Ventricle and the Postoperative Results by : Wilhelm Peter Mistiaen

Download or read book Degenerative Aortic Valve Disease, its Mechanism on Progression, its Effect on the Left Ventricle and the Postoperative Results written by Wilhelm Peter Mistiaen and published by Bentham Science Publishers. This book was released on 2013-01-10 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Degenerative aortic valve disease is the most prominent cardiac valve disease in Western societies. This volume describes some of the more important issues and problems for this condition: its progressive character and the underlying mechanisms of this progression diagnostic difficulties 1) ascertainment of valvular origin of symptoms in elderly; 2) the challenge of the low output – low gradient syndrome; 3) moderate aortic valve calcification during CABG; 4) prediction of the rate of progression (who will need surgery on short term and who not). the burden on the left ventricle and its consequences (danger of postponement of surgery) the effect and the modalities (access, types of valves) of surgical treatment on survival (and QoL) the mode of registering postoperative complications determining predictors for valve related, non-valve related cardiac and non-cardiac postoperative complications. The e-book is a unique presentation, specific to degenerative aortic valve disease and its treatment including information about ways to deal with the progressive character of the disease (autophagy as a mode of cell death). Cardiologists still avoid or delay referring patients to the surgeon for the sake of age, left ventricular function or co-morbidity. Therefore, the e-book benefits readers by addressing the above issue and providing critical information for changing referral policy, which would ultimately enhance postoperative survival of patients suffering from heart valve disease."