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Biology Of Trypanosoma Cruzi
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Book Synopsis Biology of Trypanosoma cruzi by : Wanderley De Souza
Download or read book Biology of Trypanosoma cruzi written by Wanderley De Souza and published by BoD – Books on Demand. This book was released on 2019-12-18 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trypanosoma cruzi, an important zoonotic protozoan that causes Chagas disease, affects at least 8 million people in Latin America. Chagas disease is an important life-long infection in humans that can be divided into distinct clinical stages: the acute phase, where patient symptoms can vary from asymptomatic to severe; the indeterminate form, which is usually asymptomatic; and the chronic phase, where cardiomyopathy and/or digestive megasyndromes appear. In addition to its medical importance, T. cruzi is an interesting biological model for studying processes such as: (1) cell differentiation, where a non-infective stage transforms into an infective one; (2) cell invasion, where the infective stages are able to penetrate into a mammalian host cell, where they multiply several times and thus amplify the infection; and (3) evasion from the immune system, using several mechanisms. This book, with 13 chapters, has been organized in four major sections: 1. "Basic Biology," 2. "Biochemistry and Molecular Biology," 3. "Parasite"Host Cell Interaction," and 4 "Chemotherapy." The chapters include basic biological information on the protozoan lifecycle, including new information on parasite genomics and proteomics. In addition, they analyze the interaction with host cells as well the immune response and evasion, ending with information on experimental chemotherapy against Chagas disease.
Book Synopsis The Biology of Trypanosomes by : Leslie Hudson
Download or read book The Biology of Trypanosomes written by Leslie Hudson and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: African and South American trypanosomiases are notable features of clinical and veterinary practice in their respective endemic areas and, as such, are of considerable economic importance. Scientifically, however, their importance ex tends beyond their clinical significance, as the trypano somes are intriguing and easily manipulated models for the study of the control of gene expression, membrane chemistry, proliferation and differentiation. It is clear from the scientific press that the rate of advance has "hotted" up in these areas of trypanosome research over the past 5 years and so a single-topic volume within the scope of the present series seemed timely. As ever, the final admix ture of review topics was a compromise between what was appropriate and what was available - fortunately with the former in vast excess. I should like to highlight two omissions, made for en tirely different reasons. The first is a detailed treatment of the molecular biology of the variant surface glycopro teins of the African trypanosomes (in particular Trypano soma brucei and T. equiperdum). This topic has been the subject of several reviews, for example, BORST and CROSS (1982)1 and TURNER (1982)2, and so was excluded from the present volume. The second omission is a review of the first-class work on genetic recombination from the group of Dr. Leo Jenni at the Schweizerisches Tropeninsti tut, Basel. This group has used isoenzyme markers to show that T.
Book Synopsis American Trypanosomiasis by : Jenny Telleria
Download or read book American Trypanosomiasis written by Jenny Telleria and published by Elsevier. This book was released on 2010-09-03 with total page 871 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chagas disease causes severe socioeconomic impact and a high medical cost in Latin America. WHO and the World Bank consider Chagas disease as the fourth most transmittable disease to have a major impact on public health in Latin America: 120 million persons are potentially exposed, 16 to 18 million of whom are presently infected, causing 45,000 to 50,000 deaths per year. It has been calculated that approximately 2.4 million potential working years are lost because of incapacity and mortality due to the disease, for an annual cost estimated at 20 billion Euros. American Trypanosomiasis provides a comprehensive overview of Chagas disease and discusses the latest discoveries concerning the three elements that compose the transmission chain of the disease: The host: human and mammalian reservoirs The insect vectors: domestic and sylvatic vectors The causative parasite: Trypanosoma cruzi Informs and updates on all the latest developments in the field Contributions from leading authorities and industry experts
Book Synopsis Unravelling T. cruzi Biology by : Nobuko Yoshida
Download or read book Unravelling T. cruzi Biology written by Nobuko Yoshida and published by Frontiers Media SA. This book was released on 2020-09-23 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis American Trypanosomiasis by : Kevin M. Tyler
Download or read book American Trypanosomiasis written by Kevin M. Tyler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: American trypanosomiasis, or Chagas disease, is caused by the protozoan parasite, Trypanosoma cruzi. Sixteen to eighteen million people are currently infected with this organism, and 45,000 deaths are attributed to the disease each year. Infection with T. cruzi is life-long, and 10-30% of persons who harbor the parasite chronically develop cardiac and gastrointestinal problems associated with the parasitosis. Although major progress has been made in recent years in reducing vector-borne and transfusion-associated transmission of T. cruzi, the burden of disability and death in persons chronically infected with the organism continues to be enormous. Eight to ten million persons born in countries in which Chagas disease is endemic currently reside in the United States, and epidemiologic and census data suggest that 50,000-100,000 are chronically infected with T. cruzi. The presence of these infected persons poses a risk of transmission of the parasite in the USA through blood transfusion and organ transplantation and several such cases have now been documented. American Trypanosomiasis, volume seven of World Class Parasites is written for students of tropical medicine, parasitology and public health, for researchers and practitioners alike who wish to bring themselves abreast of the status quo with respect to this disease. It is intended to supplement formal textbooks, in order to broaden and illuminate current areas of scientific and public health concern. Uniquely for T. cruzi, this book addresses parasite, vector and host biology, the pathogenesis of Chagas disease and current and prospective therapeutics and control strategies in a single volume.
Book Synopsis The Biology of Trypanosomes by : Leslie Hudson
Download or read book The Biology of Trypanosomes written by Leslie Hudson and published by Springer. This book was released on 2011-12-06 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: African and South American trypanosomiases are notable features of clinical and veterinary practice in their respective endemic areas and, as such, are of considerable economic importance. Scientifically, however, their importance ex tends beyond their clinical significance, as the trypano somes are intriguing and easily manipulated models for the study of the control of gene expression, membrane chemistry, proliferation and differentiation. It is clear from the scientific press that the rate of advance has "hotted" up in these areas of trypanosome research over the past 5 years and so a single-topic volume within the scope of the present series seemed timely. As ever, the final admix ture of review topics was a compromise between what was appropriate and what was available - fortunately with the former in vast excess. I should like to highlight two omissions, made for en tirely different reasons. The first is a detailed treatment of the molecular biology of the variant surface glycopro teins of the African trypanosomes (in particular Trypano soma brucei and T. equiperdum). This topic has been the subject of several reviews, for example, BORST and CROSS (1982)1 and TURNER (1982)2, and so was excluded from the present volume. The second omission is a review of the first-class work on genetic recombination from the group of Dr. Leo Jenni at the Schweizerisches Tropeninsti tut, Basel. This group has used isoenzyme markers to show that T.
Book Synopsis Molecular and Cellular Biology of Pathogenic Trypanosomatids by : Marcelo Santos da Silva
Download or read book Molecular and Cellular Biology of Pathogenic Trypanosomatids written by Marcelo Santos da Silva and published by Bentham Science Publishers. This book was released on 2017-02-16 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Frontiers in Parasitology is an Ebook series devoted to publishing the latest and the most important advances in parasitology. Eminent scientists present reviews on the microbiology, cytology, epidemiology, genomics, and molecular biology of microbial parasites and their associated infections. Additionally, the series also gives information about new diagnostic and therapeutic protocols. The Ebook series is essential reading to all scientists involved in studying harmful microbes and their impact on human health.
Book Synopsis Triatominae - The Biology of Chagas Disease Vectors by : Alessandra Guarneri
Download or read book Triatominae - The Biology of Chagas Disease Vectors written by Alessandra Guarneri and published by Springer Nature. This book was released on 2021-07-06 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to present updated knowledge on various aspects of the natural history, biology, and impact of triatomines to all interested readers. Each chapter will be written by authorities in the respective field, covering topics such as behavior, neurophysiology, immunology, ecology, and evolution. The contents will consider scientific, as well as innovative perspectives, on the problems related to the role of triatomine bugs as parasite vectors affecting millions in the Latin American region.
Book Synopsis Biological Characterization of a Strain of Trypanosoma Cruzi Chagas Isolated from a Human Case of Trypanosomiasis in California by : Jamie Deneris
Download or read book Biological Characterization of a Strain of Trypanosoma Cruzi Chagas Isolated from a Human Case of Trypanosomiasis in California written by Jamie Deneris and published by . This book was released on 1985 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Trypanosomes and Trypanosomiasis by : Stefan Magez
Download or read book Trypanosomes and Trypanosomiasis written by Stefan Magez and published by Springer Science & Business Media. This book was released on 2013-09-24 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume written by experts in the field of trypanosome research covers every aspect of trypanosome-vector-host biology. It is a must read for basic researchers working with trypanosomes and related organisms, infection and drug development as well as parasitology in a broader sense.
Book Synopsis Biology of the Trypanosoma Cruzi Genome by : Carlos Robello
Download or read book Biology of the Trypanosoma Cruzi Genome written by Carlos Robello and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genome of Trypanosoma cruzi was first made available in 2005, and the intrinsic genome complexity of this parasite has hindered high-quality genome assembly and annotation. Recent technological developments in long read sequencing allowed to circumvent this problem, showing very interesting features in the genome architecture of T. cruzi, allowing to accurately estimate gene copy numbers, abundance and distribution of repetitive sequences (including satellites and retroelements), and the complexity of multigene families implied in host-parasite interactions. The genome of T. cruzi is composed of a ,Äúcore compartment,Äù and a ,Äúdisruptive compartment,Äù which exhibit opposite GC content and gene composition, with high differences on their regulatory regions. The novel tandem and dispersed repetitive sequences identified, in addition to recombination events, allows to conclude that genome plasticity is a key survival strategy during its complex life cycle.
Book Synopsis The Trypanosomiases by : Ian Maudlin
Download or read book The Trypanosomiases written by Ian Maudlin and published by CABI. This book was released on 2004-07-09 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: This state-of-the-art reference book includes comprehensive coverage of the biology and control of African, Asian and South American trypanosomiasis ("sleeping sickness") in man and animals. It describes recent research developments in the biology and molecular biology of trypanosomes (the protozoan parasite) and their vectors, and methods in diagnosis and control, such as trapping tsetse fly vectors. Different sections of the book are devoted to biology of trypanosomes, vector biology, epidemiology and diagnosis, pathogenesis, disease impact, chemotherapy and disease control, and vector control. The book contains contributions from leading experts from Europe, North and South America, and Africa.
Book Synopsis Chagas Disease by : María-Jesús Pinazo Delgado
Download or read book Chagas Disease written by María-Jesús Pinazo Delgado and published by Springer Nature. This book was released on 2020-07-20 with total page 253 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive resource on various aspects of the parasite Trypanosoma cruzi and the neglected tropical disease Chagas disease (American trypanosomiasis), the disorder resulting from infection with the parasite. Topics include the biological description and taxonomy of the parasite, epidemiology and transmission routes, laboratory techniques in use when working with the parasite, as well as diagnostic measures and treatment of Chagas disease. Furthermore, a chapter with life stories of people in contact with the disease in endemic as well as non-endemic countries is included. The book is therefore a valuable source for individuals engaged in basic research as well as patient care and health management related to American trypanosomiasis.
Book Synopsis Trypanosoma cruzi as a Foodborne Pathogen by : Belkisyolé de Noya
Download or read book Trypanosoma cruzi as a Foodborne Pathogen written by Belkisyolé de Noya and published by Springer. This book was released on 2015-11-09 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Brief provides a comprehensive overview of Trypanosoma cruzi, a parasite that is traditionally considered as exclusively vectorborne, but can be foodborne, and may lead to outbreaks of Chagas disease in consumers. The characteristics of Trypanosoma cruzi and the clinical effects of the disease are covered, including documented outbreaks, regional patterns, and epidemiology. The various transmission routes are outlined, but with specific focus on foodborne transmission. A major emphasis of this text is contamination of fruit juices with Trypanosoma cruzi in, a transmission vehicle with increasing significance in the spread of this parasite. Also outlined is the difficulty of establishing a protocol for detection in food samples. Results on survival of Trypanosoma cruzi in food matrices is considered, as well as current risk assessment procedures and regulations. Different approaches to preventing transmission, including inactivation and decontamination are introduced, but also the importance of targeted educational initiatives, and also with a focus on future detection, prevention, and prevention of contamination of foods with this parasite.
Book Synopsis Proteins and Proteomics of Leishmania and Trypanosoma by : André L.S. Santos
Download or read book Proteins and Proteomics of Leishmania and Trypanosoma written by André L.S. Santos and published by Springer Science & Business Media. This book was released on 2013-11-22 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a collection of critical reviews on the expression of biologically functional proteins in Leishmania and Trypanosoma, which was written by renowned researchers on this field. Species belonging to these trypanosomatids’ genera are etiological agents of leishmaniasis, Chagas’ disease and sleeping sickness that are extremely debilitating human infection diseases, which remain a major health problem especially in countries from Latin America, Africa and Middle East. Substantiating the problem, the currently accepted drugs for these diseases are quiet unsatisfying due to their low efficacy and high toxicity. In order to solve these real problems, several research groups around the world have become involved in the study and identification of novel potential targets in the trypanosomatid cell. Since proteins are key macromolecules involved in crucial metabolic processes of all living cells, studies have focused on the expression of specific proteins produced by Leishmania and Trypanosoma by means of different biochemical, molecular and proteomic approaches in order to explore them as targets for understanding the parasite life cycle and developing new strategies against trypanosomiasis. With these proposals in mind, the book “Proteins and Proteomics of Leishmania and Trypanosoma” encompasses (i) an integrated view about the biochemistry of parasites belonging to the Leishmania and Trypanosoma genera; (ii) an updated review on the expression of biologically relevant proteins by human pathogenic trypanosomatids and their possible role in the interaction with host cells/molecules as well as a target for development of both alternative chemotherapies and vaccine; and (iii) several pictures, diagrams and tables that can be used to illustrate both undergraduate and postgraduate teaching as well as scientific lectures, being a useful resource for students and researchers.
Book Synopsis T. Cruzi Infection by : Karina Andrea Gómez
Download or read book T. Cruzi Infection written by Karina Andrea Gómez and published by . This book was released on 2019 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cell Culture and Maintenance of the Evolutionary Forms of Trypanosoma Cruzi for Studies of Parasitic Biology by : Marcelo Silva
Download or read book Cell Culture and Maintenance of the Evolutionary Forms of Trypanosoma Cruzi for Studies of Parasitic Biology written by Marcelo Silva and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This chapter aims to present and discuss the main cell culture techniques used for the growth and maintenance of the different evolutionary forms of the protozoan Trypanosoma cruzi, the etiologic agent of the Chagas disease. Chagas disease is a neglected tropical disease endemic in several Latin American countries. Here, we intend to present the main difficulties, advantages, and disadvantages of using Trypanosoma cruzi cell culture in parasitic biology. Finally, we present the main research opportunities in the context of Trypanosoma cruzi parasitic biology using cell culture techniques, such as drug development, characterization of pharmacological targets, molecular markers for diagnosis, structural biology, and many other biomedical applications.
