Biology and Pathogenesis of Rhabdo- and Filoviruses

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Author :
Publisher : World Scientific
ISBN 13 : 9814635359
Total Pages : 640 pages
Book Rating : 4.8/5 (146 download)

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Book Synopsis Biology and Pathogenesis of Rhabdo- and Filoviruses by : Asit K Pattnaik

Download or read book Biology and Pathogenesis of Rhabdo- and Filoviruses written by Asit K Pattnaik and published by World Scientific. This book was released on 2014-12-30 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rhabdoviruses and Filoviruses are single-stranded, non-segmented, negative-strand RNA viruses, many of which cause significant morbidity and mortality in humans and animals. Certain members of these virus families have been used as excellent model systems to understand the molecular biology of replication, host responses to infections, and viral countermeasures. Rhabdoviruses have also been used as vaccine vectors as well as oncolytic agents. Studies on Filoviruses have now provided significant insights into how they enter susceptible cells, replicate and cause disease, and also how they evade the host's immune mechanisms. This book addresses the most recent findings on Rhabdovirus and Filovirus structure, replication mechanisms, host cell responses to virus infections and viral countermeasures. Chapters on emerging viruses as well as approaches for therapeutic interventions have also been included. This book represents an authoritative text that brings together the most recent advances on the cellular and molecular biology of Rhabdo- and Filoviruses, including mechanisms of pathogenesis. Contents:Overview of Rhabdo– and Filoviruses (Asit K Pattnaik and Michael A Whitt)Rhabdovirus Structure (Ming Luo)The Pathway of VSV Entry into Cells (Shem Johnson and Jean Gruenberg)Rhabdovirus Glycoproteins (Yves Gaudin and Michael A Whitt)VSV RNA Transcription and Replication (Jacques Perrault)Host Cell Functions in Vesicular Stomatitis Virus Replication (Phat X Dinh, Anshuman Das, and Asit K Pattnaik)Cytopathogenesis of Rhabdoviruses (Douglas S Lyles)Assembly and Budding of Rhabdo– and Filoviruses (Ziying Han and Ronald N Harty)Rhabdoviruses as Vaccine Vectors: From Initial Development to Clinical Trials (John K Rose and David K Clarke)Oncolytic Rhabdoviruses (Nicole E Forbes and John C Bell)Use of Rhabdoviruses to Study Neural Circuitry (Melanie Ginger, Guillaume Bony, Matthias Haberl, and Andreas Frick)Evolution of Rhabdo– and Filoviruses (Isabel S Novella, John B Presloid, and R Travis Taylor)Emerging Rhabdoviruses (Imke Steffen and Graham Simmons)Rabies Virus Replication and Pathogenesis (Andrew W Hudacek and Matthias J Schnell)Activation and Evasion of Innate Immune Response by Rhabdoviruses (Karl-Klaus Conzelmann)Rabies Virus Vaccines (Ying Huang, Clement W Gnanadurai, and Zhen F Fu)Filovirus Structure and Morphogenesis (Timothy F Booth, Daniel R Beniac, Melissa J Rabb, and Lindsey L Lamboo)Epidemiology and Pathogenesis of Filovirus Infections (Logan Banadyga and Hideki Ebihara)Filovirus Entry into Susceptible Cells (Rohit K Jangra, Eva Mittler, and Kartik Chandran)Filovirus Transcription & Replication (Kristina Brauburger, Laure R Deflubé, and Elke Muhlberger)Innate Immune Evasion Mechanisms of Filoviruses (Christopher F Basler, Gaya K Amarasinghe, and Daisy W Leung)Vaccines and Antivirals for Filoviruses (Chad E Mire and Thomas W Geisbe) Readership: Investigators, graduate students, and post-graduate researchers in the field of RNA virology. Key Features:The book describes the most recent advances in our understanding of cellular and molecular aspects of replication and pathogenic mechanisms of these two important viral pathogensUnlike other existing textbooks published earlier, this book brings together several major topics of research such as replication, host response to viral replication and viral countermeasures, viral evolution and emerging viruses, viral vectors, vaccines and antivirals, etcThe chapters in the book are written by renowned researchers in these fieldsKeywords:Negative-Strand RNA Virus;Mononegavirales;Rhabdovirus;Filovirus;VSV;Rabies Virus;Marburg Virus;Ebola Virus;Replication and Transcription;Virus Structure;Viral Pathogenesis;Epidemiology;Virus Entry;Virus Assembly and Budding;Cytopathogenesis;Neuronal Tracers;Viral Vectors;Oncolytic Viruses;Evolution;Emerging Viruses;Innate Immune Responses;Vaccines;Antivirals

Marburg- and Ebolaviruses

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Author :
Publisher : Springer
ISBN 13 : 3319689487
Total Pages : 460 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Marburg- and Ebolaviruses by : Elke Mühlberger

Download or read book Marburg- and Ebolaviruses written by Elke Mühlberger and published by Springer. This book was released on 2017-12-23 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an overview of recent advances in our understanding of the biology of marburg- and ebolaviruses. It focuses on four essential areas: 1) ecology, outbreaks and clinical management, 2) disease, pathogenesis and protection, 3) virus replication inside the cell, and 4) molecular tools for virus study and taxonomy. For 50 years, these viruses have spilled over sporadically and without warning from their wildlife reservoirs, often causing major outbreaks and high fatalities. The consequences can be devastating, with a clear potential for global reach, as demonstrated by the 2013 West African outbreak of Ebola virus, which led to over 28,000 reported cases across three continents and more than 11,000 deaths. Given the international threat posed by these viruses, the pace and scope of basic research have also greatly intensified, ranging from studies of virus emergence, epidemiology, antiviral countermeasures and human disease to detailed mechanistic studies of virus entry, replication, virion assembly and protein structure. Written by internationally respected experts, this book will appeal to a wide audience and be a valuable resource for basic researchers, clinicians and advanced students alike.

Encyclopedia of Virology

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Publisher : Academic Press
ISBN 13 : 0128145161
Total Pages : 4109 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Encyclopedia of Virology by :

Download or read book Encyclopedia of Virology written by and published by Academic Press. This book was released on 2021-02-24 with total page 4109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Virology, Fourth Edition, Five Volume Set builds on the solid foundation laid by the previous editions, expanding its reach with new and timely topics. In five volumes, the work provides comprehensive coverage of the whole virosphere, making this a unique resource. Content explores viruses present in the environment and the pathogenic viruses of humans, animals, plants and microorganisms. Key areas and concepts concerning virus classification, structure, epidemiology, pathogenesis, diagnosis, treatment and prevention are discussed, guiding the reader through chapters that are presented at an accessible level, and include further readings for those needing more specific information. More than ever now, with the Covid19 pandemic, we are seeing the huge impact viruses have on our life and society. This encyclopedia is a must-have resource for scientists and practitioners, and a great source of information for the wider public. Offers students and researchers a one-stop shop for information on virology not easily available elsewhere Fills a critical gap of information in a field that has seen significant progress in recent years Authored and edited by recognized experts in the field, with a range of different expertise, thus ensuring a high-quality standard

Negative Strand RNA Virus

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Publisher : World Scientific
ISBN 13 : 9814317233
Total Pages : 323 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis Negative Strand RNA Virus by : Ming Luo

Download or read book Negative Strand RNA Virus written by Ming Luo and published by World Scientific. This book was released on 2011 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ch. 1. Overview of negative-strand RNA viruses / Biao He -- ch. 2. Rhabdovirus entry into the host cell / Aurelie Albertini and Yves Gaudin -- ch. 3. Virus entry : parainfluenza viruses / Masato Tsurudome -- ch. 4. What controls the distinct VSV RNA synthetic processes of replication and transcription? / Gail Williams Wertz, Summer E. Galloway and Djamila Harouaka -- ch. 5. mRNA capping by vesicular stomatitis virus and other related viruses / Tomoaki Ogino and Amiya K. Banerjee -- ch. 6. Structural disorder within the measles virus nucleoprotein and phosphorprotein : functional implications for transcript and replication / Sonia Longhi -- ch. 7. Biochemical and structural insights into vesicular stomatitis virus transcription / Amal A. Rahmeh and Sean P.J. Whelan -- ch. 8. Transcription of vesicular stomatitis virus RNA genome / Debasis Panda and Asit K. Pattnaik -- ch. 9. Assembly of vesicular stomatitis virus / Ming Luo, Todd J. Green and Z. Hong Zhou -- ch. 10. Paramyxovirus budding mechanisms / Megan S. Harrison, Takemasa Sakaguchi and Anthony P . Schmitt -- ch. 11. Virus-host interaction by members of the family rhabdoviridae and filoviridae / Douglas S. Lyles -- ch. 12. Paramyxovirus and rig-like helicases : a complex molecular interplay driving innate immunity / Denis Gerlier -- ch. 13. The molecular and cellular biology of emerging bunyaviruses / John N. Barr -- ch. 14. Ebolaviruses : what we know and where we are on potential therapeutics / Peter Halfmann, Gabriele Neumann and Yoshihiro Kawaoak

RNA Viruses

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Publisher : World Scientific
ISBN 13 : 981283379X
Total Pages : 722 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis RNA Viruses by : Decheng Yang

Download or read book RNA Viruses written by Decheng Yang and published by World Scientific. This book was released on 2009 with total page 722 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book on human/animal gene responses to RNA viral infections, including prevalent, emerging and re-emerging RNA viruses such as HIV, SARS-CoV, West Nile virus, influenza virus and many others. Human gene responses are reviewed by leading virologists worldwide in the following aspects: (i) the altered gene expression profiles at the transcriptional and translational levels detected with cutting-edge technologies such as cDNA microarray and proteomics; (ii) host innate and adapted immune responses to viral replication in target organs; (iii) virus-activated signal transduction pathways in cell survival, apoptosis and autophagosomal pathways; and (iv) the small interfering RNA/microRNA-mediated gene silencing pathway, a recently characterized new host defense mechanism against viral infection. Organized into 29 highly accessible and well-illustrated chapters, this volume explores state-of-the-art knowledge of the molecular mechanisms of RNA virus infection and host?virus interactions. This comprehensive compilation of the altered gene expression profiles and signal transduction pathways in host cells in response to the majority of human/animal RNA viruses opens new directions for basic and clinical research on viral pathogenesis, and also provides valuable biomarkers for researchers to select gene targets in the development of diagnostic tests and antiviral therapeutics for a number of infectious diseases.

Fields Virology: Emerging Viruses

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975112555
Total Pages : 2597 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Fields Virology: Emerging Viruses by : Peter M. Howley

Download or read book Fields Virology: Emerging Viruses written by Peter M. Howley and published by Lippincott Williams & Wilkins. This book was released on 2020-02-11 with total page 2597 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in four convenient volumes, Field’s Virology remains the most authoritative reference in this fast-changing field, providing definitive coverage of virology, including virus biology as well as replication and medical aspects of specific virus families. This volume of Field’s Virology: Emerging Viruses, 7th Edition covers recent changes in emerging viruses, providing new or extensively revised chapters that reflect these advances in this dynamic field.

Replication-Competent Reporter-Expressing Viruses

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Publisher : MDPI
ISBN 13 : 3038422584
Total Pages : 339 pages
Book Rating : 4.0/5 (384 download)

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Book Synopsis Replication-Competent Reporter-Expressing Viruses by : Luis Martinez-Sobrido

Download or read book Replication-Competent Reporter-Expressing Viruses written by Luis Martinez-Sobrido and published by MDPI. This book was released on 2018-09-27 with total page 339 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Replication-Competent Reporter-Expressing Viruses" that was published in Viruses

Orchid Biotechnology Iii

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Publisher : World Scientific
ISBN 13 : 9813109238
Total Pages : 480 pages
Book Rating : 4.8/5 (131 download)

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Book Synopsis Orchid Biotechnology Iii by : Chen Hong-hwa

Download or read book Orchid Biotechnology Iii written by Chen Hong-hwa and published by World Scientific. This book was released on 2017-01-25 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a first hand and complete information on orchid biotechnology for orchid lovers, graduate students, researchers and industry growers. It contains comprehensive genomics and transcriptomics data, and a thorough discussion of the molecular mechanism of orchid floral morphogenesis. The contributors to the book are all orchid enthusiasts with more than 20 years' experience in the field. With more than 25,000 species, orchids are the most species-rich of all angiosperm families. They show wide diversity of epiphytic and terrestrial growth forms and have successfully colonized almost every habitat on earth. Orchids are fantastic for their spectacular flowers with highly evolved petal, labellum, and fused androecium and gynoecium, gynostemium, to attract pollinators for effective pollination. In addition, orchids have attracted the interest of many evolutionary biologists due to their highly specialized evolution and adaptation strategies. Orchid Biotechnology III covers the most update knowledge of orchid biotechnology research on Phalaenopsis, Oncidium, Cymbidium, Anoectohilus, Paphiopedilum, and Erycina pusilla. It will provide graduate students, researchers, orchid lovers and breeders with an opportunity to understand the mechanism why the orchids are so mysterious and spectacular. Hopefully, this information will be helpful for breeders to enhance orchid breeding and create even more elegant and grace flowers.

Spray Drying of Vaccines

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Publisher : Springer Nature
ISBN 13 : 3031243234
Total Pages : 610 pages
Book Rating : 4.0/5 (312 download)

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Book Synopsis Spray Drying of Vaccines by : Cordin Arpagaus

Download or read book Spray Drying of Vaccines written by Cordin Arpagaus and published by Springer Nature. This book was released on 2023-04-03 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the stabilization of vaccine powders by spray drying and provides an overview of the current state of the art on a laboratory and industrial scale. The book aims to familiarize readers with the advances in vaccine spray drying technology to understand its application potential better. In particular, the book addresses the design of aseptic spray dryers, parameters affecting the spray drying process, sterile powder processing, cleaning procedures, and powder filling. In addition, different drying technologies for the production of dry powder vaccines are compared to discuss the unique capabilities of spray drying as a particle technology for vaccines. Special attention is given to research studies on spray-dried vaccines published over the past 30 years, with key findings from laboratory research to clinical trials. Potential applications of spray-dried vaccines and routes of administration are presented in detail. Finally, an outlook is given on how close the aseptic spray-drying of vaccines is to the market and the challenges that need to be overcome to be commercially successful. The book's target audience is academics, researchers, vaccine developers, industry experts, students, and possibly funders, including government agencies, who are active in the field. In addition, the book is a reference source for those involved in the vaccine formulation and biopharmaceutical processing industry.

Brief History Of Bacteria, A: The Everlasting Game Between Humans And Bacteria

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Publisher : World Scientific
ISBN 13 : 9813225173
Total Pages : 296 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Brief History Of Bacteria, A: The Everlasting Game Between Humans And Bacteria by : Daijie Chen

Download or read book Brief History Of Bacteria, A: The Everlasting Game Between Humans And Bacteria written by Daijie Chen and published by World Scientific. This book was released on 2017-12-08 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how pathogenic bacteria cause diseases, how the human immune system launches timely and effective defense mechanisms against bacterial infection, why the discovery and application of penicillin and streptomycin are so important, how scientists have created medicines to defeat bacteria, and why these bacteria might outsmart modern medicine.On the other hand, bacteria can be beneficial to humans: some bacteria live in harmony with the human body, and they are indispensable to our health. They also help in refining biological energy in the post-fossil fuel era, and in producing fermented food.With accessible language, illustrations and comics, this book tells the story of our tumultuous relationship with bacteria and how it has shaped history.

From the Hallowed Halls of Herpesvirology

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Publisher : World Scientific
ISBN 13 : 9814338990
Total Pages : 726 pages
Book Rating : 4.8/5 (143 download)

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Book Synopsis From the Hallowed Halls of Herpesvirology by : John A. Blaho

Download or read book From the Hallowed Halls of Herpesvirology written by John A. Blaho and published by World Scientific. This book was released on 2012 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains a series of review chapters from the world''s leaders in herpesvirus research. It is designed as a tribute to the famous virologist Prof Bernard Roizman. Former trainees of Prof Roizman were invited to contribute to this volume. The chapters cover all eight of the human herpesviruses, and the topics discussed span the past six decades of this exciting research field.

Emerging Topics in Physical Virology

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Publisher : World Scientific
ISBN 13 : 1848164661
Total Pages : 333 pages
Book Rating : 4.8/5 (481 download)

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Book Synopsis Emerging Topics in Physical Virology by : Peter G. Stockley

Download or read book Emerging Topics in Physical Virology written by Peter G. Stockley and published by World Scientific. This book was released on 2010 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging Topics in Physical Virology is a state-of-the-art account of recent advances in the experimental analysis and modeling of structure, function and dynamics of viruses. It is the first interdisciplinary book that integrates a review of relevant experimental techniques, such as cryo-electron microscopy, atomic force microscopy and mass spectrometry with the latest results on the biophysical and mathematical modeling of viruses. The book comprehensively covers the structure and physical properties of the protein envelopes that encapsulate and hence protect the delicate viral genome, their assembly and disassembly, the organization of the viral genome, infection, evolution, as well as applications of viruses in Biomedical Nanotechnology. It is an essential primer for scientists working in all aspects of virology, including the increasing use of viruses and virus-like particles in bio- and nano-technology. Its review style makes it moreover suitable for non-experts as an introduction into this exciting research area.

A Guide to the Study of Basic Medical Mycology

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Publisher : Partridge Publishing Singapore
ISBN 13 : 1482824132
Total Pages : 92 pages
Book Rating : 4.4/5 (828 download)

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Book Synopsis A Guide to the Study of Basic Medical Mycology by : *pls see project notes - 3 authors*

Download or read book A Guide to the Study of Basic Medical Mycology written by *pls see project notes - 3 authors* and published by Partridge Publishing Singapore. This book was released on 2014-09-11 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycotic diseases are gaining importance because of the increase in opportunistic fungal infections in patients whose immune systems are compromised. The identification of fungi isolated from clinical material has posed a variety of problems to many laboratories because of lack of expertise and experience, especially in the identification of recently emerged rare fungi that had not been previously reported. A Guide to the Study of Basic Medical Mycology offers an overview of the basic characteristics of fungi frequently isolated from clinical specimens. This comprehensive guide, developed by authors Kee Peng Ng, Tuck Soon Soo-Hoo, and Shiang Ling Na from the Department of Medical Microbiology, University Malaya Medical Centre, Malaysia, details the macro- and microscopic features of each fungus through graphics and illustrations. Including specimens not often found in all teaching modules, A Guide to the Study of Basic Medical Mycology serves to help medical students identify and learn to deal with clinically important fungi and fungal pathogens.

Human Oncogenic Viruses

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Publisher : World Scientific
ISBN 13 : 9812833463
Total Pages : 354 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis Human Oncogenic Viruses by : Jing-hsiung James Ou

Download or read book Human Oncogenic Viruses written by Jing-hsiung James Ou and published by World Scientific. This book was released on 2010 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Viruses are the causes of approximately 25% of human cancers. Due to their importance in carcinogenesis, there is a desperate need for a book that discusses these viruses. This book is therefore timely, providing a comprehensive review of the molecular biology of oncogenic viruses and The cancers they cause. Viruses that are discussed in the individual chapters include hepatitis B virus, hepatitis C virus, human papilloma viruses, Epsteinndash;Barr virus, Kaposi's sarcoma virus and human T-cell leukemia virus type 1. This book provides up-to-date information for graduate students, postdoctoral fellows, medical students, physicians and non-experts who are interested in learning more about the oncogenic viruses and how they cause human cancers.

Structure-based Study of Viral Replication

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Publisher : World Scientific
ISBN 13 : 9812790853
Total Pages : 663 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Structure-based Study of Viral Replication by : R. Holland Cheng

Download or read book Structure-based Study of Viral Replication written by R. Holland Cheng and published by World Scientific. This book was released on 2008 with total page 663 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ch. 1. Human rhinovirus cell entry and uncoating / Renate Fuchs and Dieter Blaas -- ch. 2. Role of lipid microdomains in influenza virus multiplication / Makoto Takeda -- ch. 3. Functions of integrin alpha2beta1, a collagen receptor, in the internalization of echovirus 1 / Varpu Marjomäki [und weitere] -- ch. 4. Entry mechanism of murine and SARS coronaviruses - similarity and dissimilarity / Fumihiro Taguchi -- ch. 5. Hepatitis viruses, signaling events, and modulation of the innate host response / Syed Mohammad Moin, Anindita Kar-Roy and Shahid Jameel -- ch. 6. Virus-cell interaction of HCV / Hideki Tani [und weitere] -- ch. 7. RNA replication of hepatitis C virus / Hideki Aizaki and Tetsuro Suzuki -- ch. 8. Structure and dynamics in viral RNA packaging / Thorsten Dieckmann and Marta Zumwalt -- ch. 9. Rational design of viral protein structures with predetermined immunological properties / James Lara and Yury Khudyakov -- ch. 10. Bioinformatics resources for the study of viruses at the Virginia Bioinformatics Institute / Anjan Purkayastha [und weitere] -- ch. 11. Virus architecture probed by atomic force microscopy / A.J. Malkin [und weitere] -- ch. 12. Filovirus assembly and budding / Takeshi Noda and Yoshihiro Kawaoka -- ch. 13. Challenges in designing HIV Env immunogens for developing a vaccine / Indresh K. Srivastava and R. Holland Cheng -- ch. 14. Insights into the Caliciviridae family / Grant Hansman -- ch. 15. Mathematical approaches for stoichiometric quantification in studies of viral assembly and DNA packaging / Peixuan Guo, Jeremy Hall and Tae Jin Lee -- ch. 16. Virus-like particles of fish nodavirus / Chan-Shing Lin -- ch. 17. The assembly of the double-layered capsids of phytoreoviruses / Toshihiro Omura [und weitere] -- ch. 18. Structure and assembly of human herpesviruses: new insights from cryo-electron microscopy and tomography / Z. Hong Zhou and Pierrette Lo -- ch. 19. Human papillomavirus type 16 capsid proteins: immunogenicity and possible use as prophylactic vaccine antigens / Tadahito Kanda, Kei Kawana and Hiroyuki Yoshikawa -- ch. 20. Chimeric recombinant Hepatitis E virus-like particles presenting foreign epitopes as a novel vector of vaccine by oral administration / Yasuhiro Yasutomi -- ch. 21. Nucleocapsid protein of hantaviruses (Bunyaviridae): structure and functions / Alexander Plyusnin [und weitere] -- ch. 22. Astrovirus replication: an overview / Susana Guix, Albert Bosch and Rosa M. Pintó -- ch. 23. DNA vaccines against viruses / Britta Wahren and Margaret Liu -- ch. 24. Life cycles of polyomaviridae - DNA tumor virus / Masaaki Kawano, Hiroshi Handa and R. Holland Cheng

Virology

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Publisher :
ISBN 13 : 9781555814533
Total Pages : 0 pages
Book Rating : 4.8/5 (145 download)

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Book Synopsis Virology by : Leonard C. Norkin

Download or read book Virology written by Leonard C. Norkin and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Based on the author's experiences in teaching virology for more than 35 years, this new textbook enables readers to develop a deep understanding of fundamental virology by emphasizing principles and discussing viruses in the context of virus families.

Necessity, Use, and Care of Laboratory Dogs at the U.S. Department of Veterans Affairs

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Author :
Publisher : National Academies Press
ISBN 13 : 030967641X
Total Pages : 171 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Necessity, Use, and Care of Laboratory Dogs at the U.S. Department of Veterans Affairs by : National Academies of Sciences, Engineering, and Medicine

Download or read book Necessity, Use, and Care of Laboratory Dogs at the U.S. Department of Veterans Affairs written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-10-28 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, laboratory dogs have served as important animal models for biomedical research that has advanced human health. Conducted at the request of the U.S. Department of Veterans Affairs (VA), this report assesses whether laboratory dogs are or will continue to be necessary for biomedical research related to the VA's mission. The report concludes that using laboratory dogs in research at the VA is scientifically necessary for only a few areas of current biomedical research. The report recommends that the VA adopt an expanded set of criteria for determining when it is scientifically necessary to use laboratory dogs in VA biomedical research; that the VA promote the development and use of alternatives to laboratory dogs; and highlights opportunities for the VA to enhance the welfare of laboratory dogs that are being used in biomedical research areas for which they have been deemed necessary.