Biological Reactive Intermediates Iv

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Biological Reactive Intermediates IV

Author : Charlotte M. Witmer
Publisher : Springer Science & Business Media
ISBN 13 : 1468458779
Total Pages : 848 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Biological Reactive Intermediates IV by : Charlotte M. Witmer

Download or read book Biological Reactive Intermediates IV written by Charlotte M. Witmer and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.

Biological Reactive Intermediates—II

Author : Robert Snyder
Publisher : Springer
ISBN 13 : 147570674X
Total Pages : 844 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Biological Reactive Intermediates—II by : Robert Snyder

Download or read book Biological Reactive Intermediates—II written by Robert Snyder and published by Springer. This book was released on 2014-11-14 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological reactive Intermediates

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (163 download)

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Download or read book Biological reactive Intermediates written by and published by . This book was released on 1975 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Reactive Intermediates Vi

Author : Patrick M. Dansette
Publisher : Springer Science & Business Media
ISBN 13 : 1461506670
Total Pages : 716 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Biological Reactive Intermediates Vi by : Patrick M. Dansette

Download or read book Biological Reactive Intermediates Vi written by Patrick M. Dansette and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.

Biological Reactive Intermediates III

Author :
Publisher :
ISBN 13 :
Total Pages : 1059 pages
Book Rating : 4.:/5 (64 download)

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Download or read book Biological Reactive Intermediates III written by and published by . This book was released on 1986 with total page 1059 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Reactive Intermediates V

Author : Robert R. Snyder
Publisher : Springer Science & Business Media
ISBN 13 : 1475794800
Total Pages : 449 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Biological Reactive Intermediates V by : Robert R. Snyder

Download or read book Biological Reactive Intermediates V written by Robert R. Snyder and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

Biological Reactive Intermediates II

Author : Robert Snyder
Publisher :
ISBN 13 :
Total Pages : 846 pages
Book Rating : 4.:/5 (761 download)

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Book Synopsis Biological Reactive Intermediates II by : Robert Snyder

Download or read book Biological Reactive Intermediates II written by Robert Snyder and published by . This book was released on 1981 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Reactive Intermediates VI.

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (65 download)

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Book Synopsis Biological Reactive Intermediates VI. by :

Download or read book Biological Reactive Intermediates VI. written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Reactive Intermediates

Author : David Jollow
Publisher : Springer Science & Business Media
ISBN 13 : 1461341248
Total Pages : 513 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Biological Reactive Intermediates by : David Jollow

Download or read book Biological Reactive Intermediates written by David Jollow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate to collect in one volume a series of reports outlining advances in the study of the formation of chemically active intermediary metabolic products of chemicals, mechanisms of toxicity or carcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a wide variety of animal species while training large numbers of our colleagues who have been responsible for further advances in biochemistry, pharmacology, and toxicology. Another pioneer in the study of drug metabo lism, B. B.

Biological Reactive Intermediates II

Author :
Publisher :
ISBN 13 :
Total Pages : 1476 pages
Book Rating : 4.:/5 (81 download)

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Download or read book Biological Reactive Intermediates II written by and published by . This book was released on 1982 with total page 1476 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Reactive Intermediates—II

Author : Robert Snyder
Publisher : Springer
ISBN 13 :
Total Pages : 648 pages
Book Rating : 4.:/5 (311 download)

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Book Synopsis Biological Reactive Intermediates—II by : Robert Snyder

Download or read book Biological Reactive Intermediates—II written by Robert Snyder and published by Springer. This book was released on 1982-04 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gillette (USA), C.D. Klaassen (USA), J.J. Kocsis, (USA), D.B. Menzel (USA), M. Mercier (Belgium), R.A. Neal (USA), F. Oesch (BRD), S. Orrenius (Sweden), H. Remmer (BRD), M. Roberfroid (Belgium), H. Vainio (Finland) and C.M. Witmer (USA), acting 'as a committee under G.G. Gibson (UK), D.J. Jollow (USA), D.V. Parke (UK) and R. Snyder (USA), co-chairmen, THE SECOND INTERNATIONAL SYMPOSIUM ON BIOLOGICAL REACTIVE INTERMEDIATES was convened at the University of Surrey in the United Kingdom on July 14-17, 1980. This volume derives directly from the presentations at the symposium. The University of Surrey, which is located in Guildford, Surrey, provided a congenial atmosphere for this conference and we would like to take this opportunity to thank the local organizing committee and especially Dr. G. Gordon Gibson, for all their efforts in both scientific and social arrangements. Special thanks are extended also to the graduate students of the Biochemistry Department (especially Ms. Tricia Breacker and Mr. Paul Tamburini) and to the conference secretaries who unstintingly gave of their time in a variety of roles to ensure the smooth functioning of the symposium. We wish to acknowledge the tireless efforts of the distinguished scientists who agreed to chair the sessions of the symposium: A. Hildebrandt (BRD), H. Remmer (BRD), L. Goldberg (USA), S. Orrenius (Sweden), H. Uehleke (BRD), J.R. Gillette (USA), C. Netter (BRD), M. Mercier (Belgium), F. Oesch (BRD), E. Boyland (UK), J.E. Gibson (USA), C.D. Klaassen (USA) and J.W. Gorrod (UK). The mounting of a large scale international symposium is fraught with many impediments, not the least of which are the financial and logistical problems of assembling a group of internationally distinguished scientists in one place at the same time. Success in such endeavors requires concerned and active sponsors. The three sponsoring

Biological Reactive Intermediates III

Author : James J. Kocsis
Publisher : Springer Science & Business Media
ISBN 13 : 1468451340
Total Pages : 1028 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Biological Reactive Intermediates III by : James J. Kocsis

Download or read book Biological Reactive Intermediates III written by James J. Kocsis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1028 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.

Biological Reactive Intermediates

Author :
Publisher :
ISBN 13 :
Total Pages : 11 pages
Book Rating : 4.:/5 (14 download)

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Download or read book Biological Reactive Intermediates written by and published by . This book was released on 1977 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sulfur-Centered Reactive Intermediates in Chemistry and Biology

Author : C. Chatgilialoglu
Publisher : Springer Science & Business Media
ISBN 13 : 1468458744
Total Pages : 448 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Sulfur-Centered Reactive Intermediates in Chemistry and Biology by : C. Chatgilialoglu

Download or read book Sulfur-Centered Reactive Intermediates in Chemistry and Biology written by C. Chatgilialoglu and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wonderfully successful NATO Advanced Study Institute on "Sulfur-Centered Reactive Intermediates in Chemistry and Biology" was held 18-30 June, 1989, at the Hotel Villa del Mare in Maratea, Italy. Despite the beautiful setting with mountains behind us and over looking the clear blue Mediterranean Sea under a cloudless sky (and with a private beach available), the lectures were extremely well attended. While some credit can go to the seriousness of the students, more must go to the calibre of speakers and the high quality of C. Chatgilialoglu, and Co-Director, Professor K. -D. their presentations. The Director, Dr. Asmus, are to be congratulated for putting together such an outstanding scientific program. Dr. Chatgilialoglu is also to be commended for arranging an equally stimulating social pro gram which included bus, train and boat trips to many local sites of interest. It was particularly fitting that a meeting on the chemistry and biochemistry of sulfur should be held in Italy since Italian chemists have made major contributions to our under standing of the organic chemistry of sulfur, including the chemistry of its reactive inter mediates. The early Italian interest in sulfur chemistry arose from the fact that Italy, or more specifically, Sicily, was a major world producer of sulfur prior to the development and exploitation of the Frasch process in Texas and Louisiana.

National Library of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 968 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis National Library of Medicine Current Catalog by : National Library of Medicine (U.S.)

Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1991 with total page 968 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Teratogens

Author : Vera M. Kolb
Publisher : Elsevier
ISBN 13 : 1483193225
Total Pages : 595 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Teratogens by : Vera M. Kolb

Download or read book Teratogens written by Vera M. Kolb and published by Elsevier. This book was released on 2013-10-22 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teratogens Chemicals Which Cause Birth Defects, 2nd Revised Edition is a collection of papers that discusses the practical aspect of teratogens, particularly regarding information on the teratogenic potential of chemicals. This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and the role of bio-activation in teratogenesis. Investigations have been done on the relationship between spontaneous abortion in women exposed to organic solvents, antineoplastic agents, and chemicals in plastics. Other studies also show that teratogenicity depends in part on enzymatic bio-activation to an embryotoxic reactive intermediate. This text also explains the legal and ethical aspects of fetal protection policies with emphasis on fetal protection. Protection to expecting women extends to pregnant students exposed to teratogenic chemicals in chemistry laboratories. The book explains how and where to get information about the teratogenic potential of chemicals and how to properly handle these chemicals in the laboratory. The book also provides a list from RTECs of toxic chemicals which can cause reproductive effects. This book can prove useful for chemists, pharmacologists, obstetricians, gynecologists, and practitioners of general medicine.

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2000

Author : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies
Publisher :
ISBN 13 :
Total Pages : 1690 pages
Book Rating : 4.:/5 (5 download)

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Book Synopsis Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2000 by : United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies

Download or read book Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2000 written by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies and published by . This book was released on 1999 with total page 1690 pages. Available in PDF, EPUB and Kindle. Book excerpt: