Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Biological Reactive Intermediates Ii full books in PDF, epub, and Kindle. Read online Biological Reactive Intermediates Ii ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Robert Snyder
Publisher : Springer
ISBN 13 : 147570674X
Total Pages : 832 pages
Book Rating : 4.4/5 (757 download)
Download or read book Biological Reactive Intermediates—II written by Robert Snyder and published by Springer. This book was released on 2014-11-14 with total page 832 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Patrick Dansette
Publisher : Springer Science & Business Media
ISBN 13 : 9780306466595
Total Pages : 748 pages
Book Rating : 4.4/5 (665 download)
Download or read book Biological Reactive Intermediates Vi written by Patrick Dansette and published by Springer Science & Business Media. This book was released on 2001-11-30 with total page 748 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, that is, toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Universite Rene Descartes, July 16-20, 2000.
Author : James J. Kocsis
Publisher : Springer Science & Business Media
ISBN 13 : 1468451340
Total Pages : 1028 pages
Book Rating : 4.4/5 (684 download)
Download or read book Biological Reactive Intermediates III written by James J. Kocsis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 1028 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the third in a series of conferences entitled, The International Symposium on Biological Reactive Intermediates. The first was held at the University of Turku in Finland, in 1975, the second at the University of Surrey in the United Kingdom, in 1980 and the most recent at the University of Maryland in the United States, in 1985. The significance of these conferences has been emphasized by the rapid growth of mechanistic toxicology over the last decade. These conferences were initially stimulated by the attempt to uncover the significance behind the observations that the toxicity of carcinogenic responses produced by many chemicals was associated with the observation that their metabolism led to the formation of chemcially reactive electrophiles which covalently bound to nucleophilic sites in cells such as proteins, nucleic acid or fats. Recently, newer concepts have arisen which have necessitated the expansion of subjects covered by the conference. For example, the application of newer knowledge of the role of active oxygen species in reactive metabolite formation, the concept of suicide substrates, examination of the function of glutathione in cells, application of immunological techniques and molecular biological probes to the solution of toxicological problems all had an impact on the study of the biological reactive intermediates.
Author : Patrick M. Dansette
Publisher : Springer Science & Business Media
ISBN 13 : 1461506670
Total Pages : 716 pages
Book Rating : 4.4/5 (615 download)
Download or read book Biological Reactive Intermediates Vi written by Patrick M. Dansette and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a discussion of the biological effects produced following the metabolism of xenobiotic chemicals to chemically reactive metabolites, i.e., toxic and carcinogenic effects, which have been the basis of all five earlier volumes in this series. In particular, this volume devotes sections to structure-activity relationships, recent advances in the understanding of the chemistry of reactive metabolites, and the generation and activity of reactive oxygen species with special emphasis on nitric oxide. There are also segments on DNA damage by reactive metabolites and DNA repair, tissue specific responses to BRIs, and human health effects of BRIs. The papers that comprise this volume were submitted by world class scientists who were in attendance at The Symposium on Biological Reactive Intermediates VI at the Université René Descartes, July 16-20, 2000.
Author : C. Chatgilialoglu
Publisher : Springer Science & Business Media
ISBN 13 : 1468458744
Total Pages : 448 pages
Book Rating : 4.4/5 (684 download)
Download or read book Sulfur-Centered Reactive Intermediates in Chemistry and Biology written by C. Chatgilialoglu and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wonderfully successful NATO Advanced Study Institute on "Sulfur-Centered Reactive Intermediates in Chemistry and Biology" was held 18-30 June, 1989, at the Hotel Villa del Mare in Maratea, Italy. Despite the beautiful setting with mountains behind us and over looking the clear blue Mediterranean Sea under a cloudless sky (and with a private beach available), the lectures were extremely well attended. While some credit can go to the seriousness of the students, more must go to the calibre of speakers and the high quality of C. Chatgilialoglu, and Co-Director, Professor K. -D. their presentations. The Director, Dr. Asmus, are to be congratulated for putting together such an outstanding scientific program. Dr. Chatgilialoglu is also to be commended for arranging an equally stimulating social pro gram which included bus, train and boat trips to many local sites of interest. It was particularly fitting that a meeting on the chemistry and biochemistry of sulfur should be held in Italy since Italian chemists have made major contributions to our under standing of the organic chemistry of sulfur, including the chemistry of its reactive inter mediates. The early Italian interest in sulfur chemistry arose from the fact that Italy, or more specifically, Sicily, was a major world producer of sulfur prior to the development and exploitation of the Frasch process in Texas and Louisiana.
Author : David Jollow
Publisher : Springer Science & Business Media
ISBN 13 : 1461341248
Total Pages : 513 pages
Book Rating : 4.4/5 (613 download)
Download or read book Biological Reactive Intermediates written by David Jollow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept that detoxication is the inevitable result of biotransformation of xenobiotic compounds by mammalian systems has undergone modification since it was first described. Indeed, despite the fact that R. T. Williams popularized the notion, he was among the first to caution that it was not possible to predict the biological activities of the resulting metabolites. It has become increasingly apparent in recent years that not only do many metabolites of drugs and other chemicals display biological activity but also in many instances these metabolites play an important role in initiating several forms of cancer and are the cause of a variety of types of toxicity. Thus it seems appropriate to collect in one volume a series of reports outlining advances in the study of the formation of chemically active intermediary metabolic products of chemicals, mechanisms of toxicity or carcinogenesis, and pathways for true detoxication of these chemicals. The work of R. T. Williams, beginning in the late 1920s and early 1930s, marked the first concerted effort to understand the biotransformation of foreign chemicals in animals. He investigated the metabolic pathway of numerous compounds in a wide variety of animal species while training large numbers of our colleagues who have been responsible for further advances in biochemistry, pharmacology, and toxicology. Another pioneer in the study of drug metabo lism, B. B.
Author : Charlotte M. Witmer
Publisher : Springer Science & Business Media
ISBN 13 : 1468458779
Total Pages : 848 pages
Book Rating : 4.4/5 (684 download)
Download or read book Biological Reactive Intermediates IV written by Charlotte M. Witmer and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 848 pages. Available in PDF, EPUB and Kindle. Book excerpt: The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.
Author : Robert R. Snyder
Publisher : Springer Science & Business Media
ISBN 13 : 1475794800
Total Pages : 449 pages
Book Rating : 4.4/5 (757 download)
Download or read book Biological Reactive Intermediates V written by Robert R. Snyder and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.
Author : A. Quintanilha
Publisher : Springer Science & Business Media
ISBN 13 : 1475704178
Total Pages : 233 pages
Book Rating : 4.4/5 (757 download)
Download or read book Reactive Oxygen Species in Chemistry, Biology, and Medicine written by A. Quintanilha and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NATO Advanced Study Institute on "Oxygen Radicals in Biological Systems: Recent Progress and New Methods of Study" was held in Braga, Portugal between Sep tember 1 and September 14, 1985, in order to consider the basic chemistry and biochem istry of activated oxygen (both radical and non-radical species) and their effect in biolog ical systems. This book summarizes the main lectures given at this meeting. While there is no attempt to cover all the major topics in the expanding subject of oxidative mechanisms in biology, an effort has been made to provide overviews on some key aspects of this field. The authors have attempted to convey a clear picture of both what is known and what remains unclear in their respective subjects. Not only are some of the techniques used for detecting activated oxygen species described, but also their strengths and limi tations. The chemistry of many of these species is discussed and the biological and/or pathological implications are carefully reviewed. The medical and therapeutic aspects of some of the well established pathways of damage and protection are analyzed. It is our hope that the material included in this book might be useful for both researchers and teachers at the graduate level. The success of this meeting was to a large extent due to the tireless committment of Professor Alberto Amaral and Dr. Concei~a:o Rangel; without their outstanding efforts in dealing with all the aspects of the organization, this summer school would not have been possible.
Author : Vera M. Kolb
Publisher : Elsevier
ISBN 13 : 1483193225
Total Pages : 595 pages
Book Rating : 4.4/5 (831 download)
Download or read book Teratogens written by Vera M. Kolb and published by Elsevier. This book was released on 2013-10-22 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: Teratogens Chemicals Which Cause Birth Defects, 2nd Revised Edition is a collection of papers that discusses the practical aspect of teratogens, particularly regarding information on the teratogenic potential of chemicals. This book describes the principles and mechanism of teratogenesis, including the initiating mechanisms during the subcellular or molecular level and the role of bio-activation in teratogenesis. Investigations have been done on the relationship between spontaneous abortion in women exposed to organic solvents, antineoplastic agents, and chemicals in plastics. Other studies also show that teratogenicity depends in part on enzymatic bio-activation to an embryotoxic reactive intermediate. This text also explains the legal and ethical aspects of fetal protection policies with emphasis on fetal protection. Protection to expecting women extends to pregnant students exposed to teratogenic chemicals in chemistry laboratories. The book explains how and where to get information about the teratogenic potential of chemicals and how to properly handle these chemicals in the laboratory. The book also provides a list from RTECs of toxic chemicals which can cause reproductive effects. This book can prove useful for chemists, pharmacologists, obstetricians, gynecologists, and practitioners of general medicine.
Author : National Library of Medicine (U.S.)
Publisher :
ISBN 13 :
Total Pages : 762 pages
Book Rating : 4.F/5 ( download)
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 762 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 508 pages
Book Rating : 4.:/5 (319 download)
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.3/5 ( download)
Download or read book Carcinogenic and Mutagenic N-substituted Aryl Compounds written by and published by . This book was released on 1994 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert G. Tardiff
Publisher : Springer Science & Business Media
ISBN 13 : 1468452908
Total Pages : 448 pages
Book Rating : 4.4/5 (684 download)
Download or read book Toxic Substances and Human Risk written by Robert G. Tardiff and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: As society has become increasingly aware of the potential threats to human health due to exposures to toxic chemicals in the environment and the workplace and in consumer products, it has placed increased demands upon the still-fledgling science of toxicology. As is often the case when science is called upon to supply firm answers when pertinent information and fundamental knowledge are lack ing, both the scientific and the social issues become confused and new tensions develop. One of the major purposes of this book is to focus on those aspects of the science of toxicology that pertain most to social issues-namely, analysis of risk for purposes of human health protection. Although it is apparent that the discipline of toxicology is not yet prepared to provide firm answers to many questions concerning human risk, it is important that the rigorously derived information be used in the most objective and logical way to yield the closest approximation to the truth. This book is designed to sup ply as much guidance for such tasks as is permitted by the current state of our knowledge. Its emphasis is thus placed on interpretation of toxicity data (broadly defined) for assessing risks to human health. In this way, it differs from other basic toxicology texts, most of which emphasize methods for performing studies or describe various toxicological endpoints and classes of toxic agents.
Author : Beatrice Singer
Publisher : Springer Science & Business Media
ISBN 13 : 1461337720
Total Pages : 352 pages
Book Rating : 4.4/5 (613 download)
Download or read book Molecular Biology of Mutagens and Carcinogens written by Beatrice Singer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro priate time to sit back and summarize the results of several decades of research in laboratories in different countries. We are very grateful to the Rockefeller Foundation for inviting us to formulate and begin writing the book at the Center for International Studies in Bellagio, Italy, where we were Resident Scholars. We are fortunate to have had the assistance of so many colleagues around the world who cheerfully sent original data, figures, and preprints and lis tened patiently to us as we worked out the various conflicting ideas in this fast-moving. field. The names of these scientists are found within the tables, figures, and references. There is one person whose contributions we especially wish to acknowl edge. Professor Heinz Fraenkel-Conrat was present at the inception of this book and throughout the writing encouraged and criticized in apprOximately equal proportion. Finally, his editing and amalgamation of our two styles gave us great comfort. B.S. D.G.
Author : A.B. Tarcher
Publisher : Springer Science & Business Media
ISBN 13 : 1489924477
Total Pages : 620 pages
Book Rating : 4.4/5 (899 download)
Download or read book Principles and Practice of Environmental Medicine written by A.B. Tarcher and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 620 pages. Available in PDF, EPUB and Kindle. Book excerpt: Throughout the world, scientists and the general with environmental illness. Part II presents an over public are concerned about the adverse effects of view of chemical and physical agents commonly toxic agents found in contaminated air, water, food, found in contaminated air, water, food, and soil. and soil. In the past, attention has focused on haz The problem of hazardous wastes is also discussed. ards originating in the workplace. As a consequence, Part III characterizes the body's defense against occupational medicine has become a well-recognized such exposure. Defenses at the portals of entry are and established clinical discipline. Much less atten discussed, with emphasis placed on the role of tion has been paid to nonoccupational hazards. There nutrition. Detoxication and immunologic defense is a growing awareness, however, of the dangers of mechanisms are described. Part IV indicates the exposure to toxic chemical and physical agents in importance of and provides instruction on the the homes, community, and general environment, method of including occupational and environmen especially for the fetus, the infant, the very young, tal factors in the routine medical history. The role of the elderly, and the chronically ill, those most sus enhanced susceptibility as a factor in an individual's ceptible. Environmental medicine, fOCUSing on the response to toxic exposure is discussed.
Author : Johannes Everse
Publisher : CRC Press
ISBN 13 : 9780849369643
Total Pages : 280 pages
Book Rating : 4.3/5 (696 download)
Download or read book Peroxidases in Chemistry and Biology written by Johannes Everse and published by CRC Press. This book was released on 1990-10-24 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second of two relatively independent volumes on the chemistry and biology of peroxidases. Volumes 2 covers the peroxidases isolated from plants and microorganisms, and includes detailed discussions of some of the unique reactions catalyzed by these enzymes. Volume one covered the peroxidases isolated from animal sources, as well as the "pseudo- peroxidase activity" of prostaglandin H synthase and of myoglobin and hemoglobin. Acidic paper. Annotation copyrighted by Book News, Inc., Portland, OR
