Biological Activities of Steroids in Relation to Cancer

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Author :
Publisher : Academic Press
ISBN 13 : 1483270572
Total Pages : 546 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Biological Activities of Steroids in Relation to Cancer by : Gregory Pincus

Download or read book Biological Activities of Steroids in Relation to Cancer written by Gregory Pincus and published by Academic Press. This book was released on 2013-09-17 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Activities of Steroids in Relation to Cancer covers the proceedings of the conference sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, and the U. S. Department of Health, Education and Welfare. The text focuses on the influence of steroids on medical approaches to the cure of cancer, including steroid chemistry, estrogen metabolism, and mammary cancer. The selection first offers information on steroids growth and cancer, advances in steroid chemistry, and the physiology and pharmacology of steroids affecting tumor growth. Discussions focus on rapid development of mammary cancer, pituitary functions, androgens, estrogens, and progestins. The book also ponders on the binding of steroid hormones by plasma proteins; the effects of steroids on the levels of the plasma 17-hydroxycorticosteroids and the serum protein-bound iodine; and the metabolism of dehydroisoandrosterone. The text evaluates studies on estrogen metabolism, biochemical parameters of estrogen action, and enzymatic transport of hydrogen by estrogenic hormones. The manuscript also elaborates on the fate of steroid estrogens in target tissues, effect of steroids on calcium dynamics, and steroids and experimental mammary cancer. The selection is a valuable source of information for readers interested in the use of steroids in treating cancer.

Biological Activities of Steroids in Relation to Cancer

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Publisher :
ISBN 13 :
Total Pages : 530 pages
Book Rating : 4.:/5 (146 download)

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Book Synopsis Biological Activities of Steroids in Relation to Cancer by : Gregory Pincus

Download or read book Biological Activities of Steroids in Relation to Cancer written by Gregory Pincus and published by . This book was released on 1960 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Activities of Steroids in Relation to Cancer

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Author :
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)

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Book Synopsis Biological Activities of Steroids in Relation to Cancer by :

Download or read book Biological Activities of Steroids in Relation to Cancer written by and published by . This book was released on 1960 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Activities of Steroids in Relation to Cancer

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Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Book Synopsis Biological Activities of Steroids in Relation to Cancer by : Gregory Pincus

Download or read book Biological Activities of Steroids in Relation to Cancer written by Gregory Pincus and published by . This book was released on 1960 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Biological Activities of Steroids in Relation to Cancer

Download Biological Activities of Steroids in Relation to Cancer PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)

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Book Synopsis Biological Activities of Steroids in Relation to Cancer by : Gregory Pincus

Download or read book Biological Activities of Steroids in Relation to Cancer written by Gregory Pincus and published by . This book was released on 1960 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chemistry and Biological Activity of Steroids

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789855152
Total Pages : 144 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Chemistry and Biological Activity of Steroids by : Jorge António Ribeiro Salvador

Download or read book Chemistry and Biological Activity of Steroids written by Jorge António Ribeiro Salvador and published by BoD – Books on Demand. This book was released on 2020-02-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. Chemistry and Biological Activity of Steroids aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book. Furthermore, the diverse physiopathological roles of oxysterols and their therapeutic value are also discussed.

Steroids and their Medicinal Potential

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Publisher : Bentham Science Publishers
ISBN 13 : 9815049348
Total Pages : 330 pages
Book Rating : 4.8/5 (15 download)

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Book Synopsis Steroids and their Medicinal Potential by : Abid Hussain Banday

Download or read book Steroids and their Medicinal Potential written by Abid Hussain Banday and published by Bentham Science Publishers. This book was released on 2023-07-18 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroids are an important class of biomolecules with diverse roles and functions. Besides being important as structural and signaling molecules, these molecules hold promise against numerous disorders, including cardiovascular conditions, cancer, inflammation, and autoimmune disorders. Many investigations have demonstrated that steroidal frameworks may provide lipid solubility, receptor selectivity, or membrane binding properties to non-steroidal pharmacophores. However, the therapeutic use of steroids can be dangerous when they're used incorrectly. Additionally, misconceptions about steroids among athletes or recreational users can lead to steroid abuse and poor health outcomes. Steroids and their MedicinalPotential discusses the classification, distribution, biosynthesis, chemical synthesis, and semi-synthesis of different steroids. The medicinal potential of each class is exhaustively discussed in different chapters. The latest advances and developments in steroid-based drug discovery are also discussed thoroughly. The book aims to address general questions and concerns about steroids, providing readers with a useful resource on the subject. Key Features -Provides comprehensive coverage on all aspects of steroids including steroid chemistry, biochemistry, medicinal potential, drug discovery, and advances in target-binding interactions of steroid-based drugs -Includes chapters dedicated to anabolic steroids and their abuse -Designed as an accessible source of information for understanding steroidal drugs with structured chapters-Includes references for advanced readers.

Advances in Rapid Sex-Steroid Action

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1461417643
Total Pages : 271 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Advances in Rapid Sex-Steroid Action by : Gabriella Castoria

Download or read book Advances in Rapid Sex-Steroid Action written by Gabriella Castoria and published by Springer Science & Business Media. This book was released on 2011-12-15 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast and prostate cancers are both hormone-dependent, at least in some stages of their progression. Hormonal manipulation represents an important therapeutic approach. Although most of breast and prostate cancers initially respond to hormone therapy, most tumors reinitiate to growth. Finally, hormone-resistant and metastatic breast and prostate cancers may develop. Thus, the challenge is the dissection of mechanisms by which steroid receptor signaling pathways continue to influence cell growth and invasiveness. Compelling evidence indicates that steroid hormones elicit non-genomic responses in extra-nuclear compartment of target cells. In this cellular location, steroid-coupled receptors rapidly recruit signaling effectors or scaffold proteins and activate multiple pathways leading to proliferation, survival, migration and invasiveness. The immediate challenge is the dissection of key events regulating the steroid response of target tissues to prevent progression and improve treatment of breast and prostate cancers.

Steroid Hormones and Cell Cycle Regulation

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Publisher : Springer Science & Business Media
ISBN 13 : 9781402070488
Total Pages : 290 pages
Book Rating : 4.0/5 (74 download)

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Book Synopsis Steroid Hormones and Cell Cycle Regulation by : Kerry L. Burnstein

Download or read book Steroid Hormones and Cell Cycle Regulation written by Kerry L. Burnstein and published by Springer Science & Business Media. This book was released on 2002-05-31 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the tissue culture dish to genetically modified mice, this volume explores the long recognized role of steroid hormones in regulating cell proliferation and differentiation. Many striking effects of steroid hormones are apparent during development and neoplasia and these topics are covered extensively. Several chapters address the pharmacological uses of steroid and related hormones, their analogs and antagonists in controlling growth of endocrine cancers. This book also highlights the complex role of cross talk between steroid hormones and signals initiated at the cell surface in the regulation of cell cycle in hormone responsive tissues.

Steroid Receptors in Breast Cancer

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Author :
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.3/5 (121 download)

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Book Synopsis Steroid Receptors in Breast Cancer by :

Download or read book Steroid Receptors in Breast Cancer written by and published by . This book was released on 1983 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Hormones and Cancer

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Publisher : Springer Science & Business Media
ISBN 13 : 1461242665
Total Pages : 618 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Hormones and Cancer by : Wayne V. Vedeckis

Download or read book Hormones and Cancer written by Wayne V. Vedeckis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series, Hormones in Health and Disease, was launched in 1993 to provide a scientific platform for investigators engaged in research on the biological actions of hormones and to anticipate relevance for their findings in clinical applications. The first volume of the series was dedicated to the discussion and understanding of molecular mechanisms by which steroid hormones influence target cells in normal and pathological conditions. With the diversity of information and the vast amount of literature on steroid hormone physiology, a more thorough treatment of Hormones and Cancer was identified as a timely topic. In this second volume in the series, Dr. Wayne V. Vedeckis has success fully undertaken the monumental task of editing the findings of the leading investigators in hormone and cancer research. Dr. Vedeckis brings to this project two decades of research experience in hormone action; he is actively engaged in elucidating hormone and cancer interrelations. It is a pleasure to welcome him to the series as an editor and congratulate him and all contribu tors in presenting this comprehensive treatise. The 20 chapters include discussions on contemporary topics relating control of cell division and signal transduction to the basic mechanisms of carcinogenesis by cloning patient genes, and recognizing the importance of steroid receptors in treatment protocols of various endocrine abnormalities.

Steroid Enzymes and Cancer, Volume 1155

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Author :
Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 360 pages
Book Rating : 4.F/5 ( download)

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Book Synopsis Steroid Enzymes and Cancer, Volume 1155 by : H. Leon Bradlow

Download or read book Steroid Enzymes and Cancer, Volume 1155 written by H. Leon Bradlow and published by Wiley-Blackwell. This book was released on 2009-03-30 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The expression and activity of key enzymes of sex steroid metabolism have major implications in both development and progression of various human hormone-related tumors, including breast, prostate, lung, and liver cancer. This volume explores the role of local synthesis of steroid hormones, a process that has assumed an increasing importance in our understanding about several malignancies originating from steroid target tissues, wherein abnormal levels of individual steroids may promote tumor growth. In this framework, a divergent expression and/or activity of key gonadal steroid enzymes (including dehydrogenases, hydroxylases, sulfotransferases, sulfatases, and aromatase) may eventually lead to a differential accumulation of hormone derivatives with divergent biological activities in individual target tissues. This is of crucial importance in predicting the overall biological impact that sex steroids have on peripheral target tissues and, hence, on their potential role in cancer development and/or progression. The volume focuses on five key enzymes in the metabolism of sex steroids: (1) 17βhydroxysteroid dehydrogenase; (2) 5αreductase; (3) hydroxylases and catechol-oxy methyltransferase; (4) sulfatase, sulfotransferases, and glucuronidase; and (5) aromatase. The organization of the volume is designed to provide an updated picture of the existing knowledge about the association between steroid enzyme expression/function and the development and/or progression of major human cancers, including classical (breast, prostate) and nonclassical (lung, liver) hormone-related tumors. The resulting inferences for diagnosis, prognosis, and treatment are also presented, along with the experimental basis for developing preventive measures. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

Holland-Frei Cancer Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Glucocorticoid Signaling

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Publisher : Springer
ISBN 13 : 1493928953
Total Pages : 385 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Glucocorticoid Signaling by : Jen-Chywan Wang

Download or read book Glucocorticoid Signaling written by Jen-Chywan Wang and published by Springer. This book was released on 2015-07-27 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.

Antitumor Steroids

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Publisher : Academic Press
ISBN 13 : 0323139167
Total Pages : 295 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Antitumor Steroids by : R T Blickenstaff

Download or read book Antitumor Steroids written by R T Blickenstaff and published by Academic Press. This book was released on 2012-12-02 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antitumor Steroids examines the use of steroids, along with nonsteroidal antiestrogens and some benzo[a]carbazoles, in the treatment of cancer. It explains the mechanism by which steroids and their receptors work together to affect their physiological functions in general and their antitumor activity in particular. It also describes the systematic screening of antitumor compounds isolated from natural sources. Organized into nine chapters, this book begins with an overview of the role of steroids in cancer treatment. It then discusses the estrogens, antiestrogens, and compounds (all containing an aromatic A-ring). The next chapters consider androgens, some antiandrogens, derivatives based on C-19 steroids, progestins and corticoids, bile acids, and compounds with a side-chain carboxyl group. The book explains the biogenesis and metabolism of androgens; the pharmacology of medroxyprogesterone acetate; the antitumor properties of naturally occurring corticosteroids; sterols and cucurbitacins; vitamin D and its metabolites; and cardenolides, bufadienolides, and withanolides. The book concludes with a chapter on bile acids, sapogenins and its analogs, and miscellaneous steroids. This book is a valuable resource for organic and medicinal chemists biochemists, and pharmacologists interested in the use of steroids in treating cancer.

Childhood Acute Lymphoblastic Leukemia

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Publisher : Springer
ISBN 13 : 3319397087
Total Pages : 342 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Childhood Acute Lymphoblastic Leukemia by : Ajay Vora

Download or read book Childhood Acute Lymphoblastic Leukemia written by Ajay Vora and published by Springer. This book was released on 2017-04-21 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive and up-to-date review of all aspects of childhood Acute Lymphoblastic Leukemia, from basic biology to supportive care. It offers new insights into the genetic pre-disposition to the condition and discusses how response to early therapy and its basic biology are utilized to develop new prognostic stratification systems and target therapy. Readers will learn about current treatment and outcomes, such as immunotherapy and targeted therapy approaches. Supportive care and management of the condition in resource poor countries are also discussed in detail. This is an indispensable guide for research and laboratory scientists, pediatric hematologists as well as specialist nurses involved in the care of childhood leukemia.

Cancer Chemotherapy Reports

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Author :
Publisher :
ISBN 13 :
Total Pages : 1184 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Cancer Chemotherapy Reports by :

Download or read book Cancer Chemotherapy Reports written by and published by . This book was released on 1959 with total page 1184 pages. Available in PDF, EPUB and Kindle. Book excerpt: