Bioinformatics Of Non Small Cell Lung Cancer And The Ras Proto Oncogene

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Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene

Author : Amita Kashyap
Publisher : Springer
ISBN 13 : 9814585084
Total Pages : 79 pages
Book Rating : 4.8/5 (145 download)

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Book Synopsis Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene by : Amita Kashyap

Download or read book Bioinformatics of Non Small Cell Lung Cancer and the Ras Proto-Oncogene written by Amita Kashyap and published by Springer. This book was released on 2014-09-08 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is initiated by activation of oncogenes or inactivation of tumor suppressor genes. Mutations in the K-ras proto-oncogene are responsible for 10–30% of adenocarcinomas. Clinical Findings point to a wide variety of other cancers contributing to lung cancer incidence. Such a scenario makes identification of lung cancer difficult and thus identifying its mechanisms can contribute to the society. Identifying unique conserved patterns common to contributing proto-oncogenes may further be a boon to Pharmacogenomics and pharmacoinformatics. This calls for ab initio/de novo drug discovery that in turn will require a comprehensive in silico approach of Sequence, Domain, Phylogenetic and Structural analysis of the receptors, ligand screening and optimization and detailed Docking studies. This brief involves extensive role of the RAS subfamily that includes a set of proteins, which cause an over expression of cancer-causing genes like M-ras and initiate tumour formation in lungs. SNP Studies and Structure based drug discovery will also be undertaken.

Integrative Genomics Methods for Personalized Treatment of Non-small-cell Lung Cancer

Author : Michael F. Sharpnack
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (17 download)

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Book Synopsis Integrative Genomics Methods for Personalized Treatment of Non-small-cell Lung Cancer by : Michael F. Sharpnack

Download or read book Integrative Genomics Methods for Personalized Treatment of Non-small-cell Lung Cancer written by Michael F. Sharpnack and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the most deadly form of cancer, responsible for over 1.6 million deaths annually, the majority of which are due to non-small cell lung cancer, of which adenocarcinoma and squamous cell carcinoma are the major subtypes. Standard chemotherapy produces responses in a small minority of patients, and despite the tremendous growth of personalized therapies in the last decade, only a minority of patients benefit from these treatments in the North American setting. A greater understanding of the biology of non-small cell lung cancer is desperately needed to develop novel targeted therapies and their accompanying biomarkers. Understanding the function of cancer-associated genes requires the integration and analysis of multiple modalities of biological data. Cancer associated genes can be activated or repressed by DNA somatic mutations, RNA alternative splicing, epigenetic changes, microRNA-mediated silencing, post-translational regulation, and other mechanisms. To understand how tumors form and grow, we have to be able to measure DNA, RNA, protein, metabolites, and lipids. Further, integrative and analytical methods are necessary to leverage these data together, collectively termed integrative genomics. Here, we leverage DNA mutations and copy number measurements, RNA transcriptomics, proteomics, and clinical data to discover regulatory relationships in tumors, develop prognostic biomarkers, and identify mediators of tumor mutation burden. First, we focus on the RNA editing protein ADAR, and propose an immune-mediated function in lung adenocarcinoma. Second, we develop a method to integrate RNA and protein expression data to predict binary clinical variables, and test its ability to predict tumor recurrence in surgically resected lung adenocarcinoma samples. Finally, we define the relationship between tumor mutation burden and genome stability protein inactivation to better understand tumor immunogenicity in non-small cell lung cancer. Taken together, these approaches present a comprehensive methodology to utilize integrative genomic data for clinical applications in non-small cell lung cancer.

Cancer of the Lung

Author : Alan Weitberg
Publisher : Springer Science & Business Media
ISBN 13 : 1592590934
Total Pages : 352 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Cancer of the Lung by : Alan Weitberg

Download or read book Cancer of the Lung written by Alan Weitberg and published by Springer Science & Business Media. This book was released on 2001-10-04 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alan B. Weitberg, MD, and a panel of internationally recognized basic scientists and clinicians present a comprehensive discussion of lung cancer, including a practice-oriented review of its diagnosis, evaluation, and treatment. The contributors offer not only an understandable description of its molecular origins-an essential key to developing future therapies and preventive measures-but also rigorously discuss well-tested approaches, as well as those that are currently being evaluated for future use in both the laboratory and clinic. The book also elucidates the creation and effective deployment of treatment guidelines introduced by third party payers to improve clinical outcomes, even while lowering healthcare costs.

Cancer Genomics

Author : Zhaolin Xu
Publisher : Elsevier Inc. Chapters
ISBN 13 : 012806109X
Total Pages : 49 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Cancer Genomics by : Zhaolin Xu

Download or read book Cancer Genomics written by Zhaolin Xu and published by Elsevier Inc. Chapters. This book was released on 2013-11-21 with total page 49 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer remains the leading cause of cancer-related death worldwide. Although surgical resections of these tumors are considered as one of the most effective treatments, most lung cancer patients present at an advanced stage of the disease at the time of diagnosis and are not candidates for surgical resection. Overall, the prognosis of lung cancer is very poor and the 5-year survival rate is only about 16 %, which has not significantly changed in the past several decades. Therefore, seeking new directions of treatment for this most deadly disease becomes crucial. Recent development in the understanding of the molecular pathogenesis of lung cancer has led to new strategies of treatment. Development of lung cancers is thought to be driven by gene mutations in most, if not all, cases. Detailed analysis at the molecular level to identify these gene mutations or alterations in lung cancer provides the insight for understanding the disease and is fundamental for establishment of personalized targeted therapy. Personalized targeted therapy based on particular gene mutations has shown to be effective and is believed to be one of the new directions of the treatment in dealing with this disease. In modern oncology, there is an increasing need to facilitate the development and implementation of biomarkers based on known gene mutations/alterations in clinical practice and identification of new gene mutations/alterations through high-throughput DNA sequencing technology to enter a new era of personalized targeted therapy for lung cancer patients.

Using Bioinformatics Tools to Identify New Treatment Strategy for Non Small Cell Lung Cancer

Author : 張牧新
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)

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Book Synopsis Using Bioinformatics Tools to Identify New Treatment Strategy for Non Small Cell Lung Cancer by : 張牧新

Download or read book Using Bioinformatics Tools to Identify New Treatment Strategy for Non Small Cell Lung Cancer written by 張牧新 and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cancer Informatics in the Post Genomic Era

Author : Igor Jurisica
Publisher : Springer Science & Business Media
ISBN 13 : 0387693211
Total Pages : 193 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Cancer Informatics in the Post Genomic Era by : Igor Jurisica

Download or read book Cancer Informatics in the Post Genomic Era written by Igor Jurisica and published by Springer Science & Business Media. This book was released on 2007-05-04 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Informatics in Post-Genomic Era provides both the necessary methodology and practical information tools for analyzing data in the field of medical information science. This, of course, requires analytic tools. Those tools are garnered by developing and assessing methods and systems for the acquisition, processing, and interpretation of patient data, aided by scientific discovery. Key challenges in this field include integrating research and clinical care, sharing data, and establishing partnerships within and across sectors of patient diagnosis and treatment.

Bioinformatic Analysis and Online Database Set-up for Circular RNAs in Non-small Cell Lung Cancer

Author : Yanhong Lyu
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)

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Book Synopsis Bioinformatic Analysis and Online Database Set-up for Circular RNAs in Non-small Cell Lung Cancer by : Yanhong Lyu

Download or read book Bioinformatic Analysis and Online Database Set-up for Circular RNAs in Non-small Cell Lung Cancer written by Yanhong Lyu and published by . This book was released on 2022* with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Genes and Cancer

Author : Karol Sikora
Publisher : Wiley
ISBN 13 : 9780471925835
Total Pages : 364 pages
Book Rating : 4.9/5 (258 download)

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Book Synopsis Genes and Cancer by : Karol Sikora

Download or read book Genes and Cancer written by Karol Sikora and published by Wiley. This book was released on 1990-10-26 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work serves as an introduction to the applications of molecular biology in the field of oncology. It provides a basic understanding of the genetic events involved in fully developed human cancer, including research into inherited and acquired gene defects initiating new neoplasms and the subsequent genetic alterations involved in tumor progression. Some of the specific topics explored include gene control, molecular therapy and antibodies, drug resistance, growth factors and receptors, and tumor biology. While intended primarily as an advanced text for oncologists, postgraduate molecular geneticists and molecular biologists, the book will certainly be of interest to other researchers who frequently encounter cancer in their practice.

Biochemistry and Molecular Biology Compendium

Author : Roger L. Lundblad
Publisher : CRC Press
ISBN 13 : 1351680536
Total Pages : 551 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis Biochemistry and Molecular Biology Compendium by : Roger L. Lundblad

Download or read book Biochemistry and Molecular Biology Compendium written by Roger L. Lundblad and published by CRC Press. This book was released on 2019-11-11 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an accessible resource offering practical information not found in more database-oriented resources. The first chapter lists acronyms with definitions, and a glossary of terms and subjects used in biochemistry, molecular biology, biotechnology, proteomics, genomics, and systems biology. There follows chapters on chemicals employed in biochemistry and molecular biology, complete with properties and structure drawings. Researchers will find this book to be a valuable tool that will save them time, as well as provide essential links to the roots of their science. Key selling features: Contains an extensive list of commonly used acronyms with definitions Offers a highly readable glossary for systems and techniques Provides comprehensive information for the validation of biotechnology assays and manufacturing processes Includes a list of Log P values, water solubility, and molecular weight for selected chemicals Gives a detailed listing of protease inhibitors and cocktails, as well as a list of buffers

Targeted Therapies for Lung Cancer

Author : Ravi Salgia
Publisher : Springer
ISBN 13 : 3030178323
Total Pages : 238 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Targeted Therapies for Lung Cancer by : Ravi Salgia

Download or read book Targeted Therapies for Lung Cancer written by Ravi Salgia and published by Springer. This book was released on 2019-06-26 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contextualizes translational research and provides an up to date progress report on therapies that are currently being targeted in lung cancer. It is now well established that there is tremendous heterogeneity among cancer cells both at the inter- and intra-tumoral level. Further, a growing body of work highlights the importance of targeted therapies and personalized medicine in treating cancer patients. In contrast to conventional therapies that are typically administered to the average patient regardless of the patient’s genotype, targeted therapies are tailored to patients with specific traits. Nonetheless, such genetic changes can be disease-specific and/or target specific; thus, the book addresses these issues manifested in the somatically acquired genetic changes of the targeted gene. Each chapter is written by a leading medical oncologist who specializes in thoracic oncology and is devoted to a particular target in a specific indication. Contributors provide an in-depth review of the literature covering the mechanisms underlying signaling, potential cross talk between the target and downstream signaling, and potential emergence of drug resistance.

Upper Tract Urothelial Carcinoma

Author : Shahrokh F. Shariat
Publisher : Springer
ISBN 13 : 1493915010
Total Pages : 206 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Upper Tract Urothelial Carcinoma by : Shahrokh F. Shariat

Download or read book Upper Tract Urothelial Carcinoma written by Shahrokh F. Shariat and published by Springer. This book was released on 2014-09-13 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. It's aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage and patient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy is covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.

Computational Intelligence Techniques in Diagnosis of Brain Diseases

Author : Sasikumar Gurumoorthy
Publisher : Springer
ISBN 13 : 9811065292
Total Pages : 81 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Computational Intelligence Techniques in Diagnosis of Brain Diseases by : Sasikumar Gurumoorthy

Download or read book Computational Intelligence Techniques in Diagnosis of Brain Diseases written by Sasikumar Gurumoorthy and published by Springer. This book was released on 2017-09-05 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights a new biomedical signal processing method of extracting a specific underlying signal from possibly noisy multi-channel recordings, and shows that the method is suitable for extracting independent components from the measured electroencephalogram (EEG) signal. The system efficiently extracts memory spindles and is also effective in Alzheimer seizures. Current developments in computer hardware and signal processing have made it possible for EEG signals or “brain waves” to communicate between humans and computers – an area that can be extended for use in this domain.

Fast Facts: Comprehensive Genomic Profiling

Author : Bernardo L. Rapoport
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318068187
Total Pages : 109 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Fast Facts: Comprehensive Genomic Profiling by : Bernardo L. Rapoport

Download or read book Fast Facts: Comprehensive Genomic Profiling written by Bernardo L. Rapoport and published by Karger Medical and Scientific Publishers. This book was released on 2020-10-20 with total page 109 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer is a multifaceted disease in which genetic changes induce uncontrolled tumor growth. Genomic characterization of cancer is now leading to better diagnostic, prognostic and predictive biomarkers, and effective individualized management. 'Fast Facts: Comprehensive Genomic Profiling' provides a crash course in the science, methods and application of genomic profiling. Assuming only the most basic knowledge – or memory – of cell biology, the authors provide an overview of DNA and RNA biology and next-generation sequencing. This sets in context the descriptions of prognostic and predictive biomarkers for different cancer types and genomic-based treatments. Finally, but importantly, some of the practicalities of gaining and interpreting genomic information are described. Whether you need a primer or a refresher, this short colorful book demystifies this complex subject. Contents: • Genetic mutations and biomarkers • Understanding next-generation sequencing • Elements of comprehensive genomic profiles • Role in precision oncology • Predictive and prognostic biomarkers • Overcoming barriers to genotype-directed therapy

Non-coding RNA and the Reproductive System

Author : Dagmar Wilhelm
Publisher : Springer
ISBN 13 : 940177417X
Total Pages : 201 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Non-coding RNA and the Reproductive System by : Dagmar Wilhelm

Download or read book Non-coding RNA and the Reproductive System written by Dagmar Wilhelm and published by Springer. This book was released on 2015-12-11 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of the role and function of regulatory RNAs that lack protein-coding potential in key reproductive tissues. This includes the role of small interfering RNAs (siRNAs), microRNAs (miRNAs), PIWI-interacting RNAs (piRNAs), small nucleolar RNAs (snoRNAs) and long non-coding RNAs (lncRNAs). Through clear, detailed and comprehensive debate, international leading experts discuss the role these novel regulators in normal development of sexual dimorphisms, including the differentiation of ovaries and testes, the genital tract including prostate, epididymis and uterus, as well as mammary glands. In addition, particular attention is paid on their role in pathophysiological processes within the reproductive tract. The power of next generation sequencing has proved to be an invaluable tool to discover new non-coding RNAs. While the identification of non-coding RNA is relatively easy, analysing their function represents still a challenge today. In this book, authors present historical and conceptual background information, highlight the ways in which non-coding RNAs function is analysed and present their vision of the future research in their key research area.

Advances in Biomedical and Bioinformatics Engineering

Author : Y. Yu
Publisher : IOS Press
ISBN 13 : 1643684337
Total Pages : 810 pages
Book Rating : 4.6/5 (436 download)

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Book Synopsis Advances in Biomedical and Bioinformatics Engineering by : Y. Yu

Download or read book Advances in Biomedical and Bioinformatics Engineering written by Y. Yu and published by IOS Press. This book was released on 2023-12-19 with total page 810 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedicine and bioinformatics engineering are interdisciplinary fields combining expertise from biology, mathematics, chemistry, computer science, and engineering to develop technologies which will address major problems at the forefront of biomedical and bio-industrial research. This book presents the proceedings of ICBBE 2023, the 3rd International Conference on Biomedicine and Bioinformatics Engineering, held as a hybrid event from 16-18 June 2023 in Nanjing, China. The aim of the conference was to create a forum for the multi-disciplinary discussion of recent developments in biomedicine and bioinformatics engineering. A total of 253 submissions were received for the conference, of which 92 were accepted after a thorough double-blind peer review. The book is divided into 3 parts, covering biomedical material and imaging technology application; cell biology and medical signal processing; and biomechanical modeling and drug analysis, and topics addressed include biomedical signal processing; medical information; bioinformatics and computational biology; medical imaging technology and its application; molecular biology; chemistry, pharmacology and toxicology. Addressing a number of highly relevant aspects of biomedicine and bioinformatics engineering and emphasizing the multi-disciplinary aspects of the field, the selected contributions in this book will provide valuable guidance for future interdisciplinary developments, and will be of interest to all those working in biomedicine and bioinformatics engineering.

The Chemical Biology of Long Noncoding RNAs

Author : Stefan Jurga
Publisher : Springer Nature
ISBN 13 : 303044743X
Total Pages : 545 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis The Chemical Biology of Long Noncoding RNAs by : Stefan Jurga

Download or read book The Chemical Biology of Long Noncoding RNAs written by Stefan Jurga and published by Springer Nature. This book was released on 2020-10-01 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a comprehensive and detailed overview of various aspects of long non-coding RNAs. It discusses their emerging significance in molecular medicine, ranging from human cancers to cardiovascular and metabolic diseases. Transcriptomic studies have demonstrated that the majority of genomes found in complex organisms are expressed in highly dynamic and cell-specific patterns, producing huge numbers of intergenic, antisense and intronic long non-protein-coding RNAs (lncRNAs). Thousands of lncRNAs have been identified, and unlike mRNA, they have no protein-coding capacity. A large repertoire of ncRNAs, actively transcribed from the mammalian genome, control diverse cellular processes, both in terms of development and diseases, through a variety of gene regulatory mechanisms. IncRNAs have emerged as a new paradigm in epigenetic regulation of the genome. Given its scope, the book will be of particular interest to molecular, chemical, cell and developmental biologists, as well as specialists in translational medicine involved in disease-oriented research. It also offers a valuable resource for in silico experts seeking a deeper understanding of lncRNA expression and function through computational analysis of the NGS data.

Application of Bioinformatics in Cancers

Author : Chad Brenner
Publisher : MDPI
ISBN 13 : 3039217887
Total Pages : 418 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Application of Bioinformatics in Cancers by : Chad Brenner

Download or read book Application of Bioinformatics in Cancers written by Chad Brenner and published by MDPI. This book was released on 2019-11-20 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of 25 research papers comprised of 22 original articles and 3 reviews is brought together from international leaders in bioinformatics and biostatistics. The collection highlights recent computational advances that improve the ability to analyze highly complex data sets to identify factors critical to cancer biology. Novel deep learning algorithms represent an emerging and highly valuable approach for collecting, characterizing and predicting clinical outcomes data. The collection highlights several of these approaches that are likely to become the foundation of research and clinical practice in the future. In fact, many of these technologies reveal new insights about basic cancer mechanisms by integrating data sets and structures that were previously immiscible. Accordingly, the series presented here bring forward a wide range of artificial intelligence approaches and statistical methods that can be applied to imaging and genomics data sets to identify previously unrecognized features that are critical for cancer. Our hope is that these articles will serve as a foundation for future research as the field of cancer biology transitions to integrating electronic health record, imaging, genomics and other complex datasets in order to develop new strategies that improve the overall health of individual patients.