Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download Biogenesis And Biomimetic Synthesis Of Marine Alkaloids full books in PDF, epub, and Kindle. Read online Biogenesis And Biomimetic Synthesis Of Marine Alkaloids ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Sudhir R. Shengule
Publisher :
ISBN 13 :
Total Pages : 346 pages
Book Rating : 4.:/5 (437 download)
Download or read book Biogenesis and Biomimetic Synthesis of Marine Alkaloids written by Sudhir R. Shengule and published by . This book was released on 2008 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Shota Kikuchi
Publisher :
ISBN 13 :
Total Pages : 388 pages
Book Rating : 4.:/5 (745 download)
Download or read book Studies Toward the Biomimetic Synthesis of Marine Alkaloids written by Shota Kikuchi and published by . This book was released on 2011 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Andrew Kalusa
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (555 download)
Download or read book Synthesis of Marine Alkaloids written by Andrew Kalusa and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Iman Mohammad Khalil
Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.:/5 (935 download)
Download or read book Inspirations from Nature written by Iman Mohammad Khalil and published by . This book was released on 2015 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine natural products are becoming widely recognised as novel sources of drug leads. Their structural complexity has attracted synthetic chemists to explore new synthetic strategies and reagents. More recently, biosynthetic considerations of natural product has led to the proposal of biogenetic precursors that may lead to a biomimetic synthesis of a particular family of compounds. If successful, biomimetic syntheses may lead to the synthesis of multiple compounds in a family of natural products from simple precursors in a short, stepwise fashion. Thiaplidiaquinone A (2.1) and B (2.2) were synthesised in a 5-step biomimetic reaction sequence where the dimeric core was constructed by allowing a simple benzoquinone to dimerise and cyclise in the presence of base. The installation of the dioxothiazine ring system allowed for the synthesis of the two natural products alongside their corresponding dioxothiazine regioisomers 2.58 and 2.59. Cytotoxicity bioassays revealed that the position of the geranyl sidechains determined the mode of cell death (necrosis versus apoptosis) whereas the dioxothiazine ring regulated the potency of the compounds. The synthesised regioisomers were found to be more potent than their natural product counterparts with one, 2.58, exhibiting sub-panel selectivity towards melanoma cancer cell lines and was selected for acute toxicity testing by the NCI. A biomimetic synthesis of pyridoacridine alkaloids amphimedine (3.3), deoxyamphimedine (3.16) and demethyldeoxyamphimedine (3.11) from the structurally simpler styelsamine D (3.13) was developed. Addition of formaldehyde to the proposed biosynthetic precursor, styelsamine D, gave the two natural products 3.11 and 3.16 in a one pot synthesis where subsequent oxidation of 3.16 gave amphimedine. It was found that pre-functionalisation of the dopamine precursor to styelsamine D allowed for the synthesis of N-ethyl analogues of amphimedine and deoxyamphimedine as well as an N-benzyl analogue of deoxyamphimedine. Biomimetic considerations of the neoamphimedine, arnoamine and alpkinidine scaffold were also investigated and the results highlighted herein. Biological evaluation of the amphimedine, deoxyamphimedine and demethyldeoxyamphimedine at the NCI identified deoxyamphimedine as a strong cytotoxic agent, exhibiting sub-panel selectivity towards central nervous system cancer cell lines.
Author : Sung Hoon Kim
Publisher :
ISBN 13 :
Total Pages : 512 pages
Book Rating : 4.:/5 (319 download)
Download or read book Studies on the Biosynthesis and Biomimetic Synthesis of Coca Alkaloids written by Sung Hoon Kim and published by . This book was released on 1988 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Paul Raymond Borkowski
Publisher :
ISBN 13 :
Total Pages : 566 pages
Book Rating : 4.:/5 (29 download)
Download or read book Biosynthesis and Biomimetic Synthesis of Thebaine written by Paul Raymond Borkowski and published by . This book was released on 1976 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chada Phisalaphong
Publisher :
ISBN 13 :
Total Pages : 125 pages
Book Rating : 4.:/5 (992 download)
Download or read book Biomimetic Synthesis of Indole Alkaloids written by Chada Phisalaphong and published by . This book was released on 1993 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David R. Spring
Publisher :
ISBN 13 :
Total Pages : 564 pages
Book Rating : 4.:/5 (43 download)
Download or read book Studies on the Biomimetic Synthesis of the Manzamine Alkaloids written by David R. Spring and published by . This book was released on 1998 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ryan Ashok Shenvi
Publisher : ProQuest
ISBN 13 : 9780549650959
Total Pages : 420 pages
Book Rating : 4.6/5 (59 download)
Download or read book Pure and Applied Science in the Chemical Synthesis of Marine Alkaloids Chartelline C and Cortistatin A written by Ryan Ashok Shenvi and published by ProQuest. This book was released on 2008 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Described herein are chemical syntheses of (")-chartelline C and (+)-cortistatin A, in Chapters 1 and 3, respectively. Described in Chapter 2 is a one-pot synthesis of 4,5-disubstituted pyrimidines using inexpensive reagents and simple techniques. The title of the thesis is derived primarily from the stark differences between the goals of the two major portions of this work, where 'pure science' is most aptly suited for the chartelline project, and 'applied science' for the cortistatin project. It should be noted that these simple monikers are not meant to encapsulate every detail of the chemistry, but rather orient the reader and neatly unify the thesis. A nice way to restate these concepts is to say that the major questions of interest to the scientific community in the chartelline alkaloids can best be answered by way of their syntheses, whereas the major questions of interest to the scientific community in the cortistatin steroids can best be answered as a result of their syntheses. Chapter 1 discusses a revised biosynthetic hypothesis for the halohistophan family, primarily regarding the chartelline alkaloids, whose syntheses from securine-like skeletons appear to proceed oxidatively via unique 1,5-sigmatropic shifts of dearomatized pyrrolo-2 H-indoles. This reactivity has profound implications for indole chemistry and the biosynthesis of indole alkaloids. In the cortistatin project, a short semisynthesis of cortistatin A is developed from the inexpensive, terrestrial steroid, prednisone. The synthesis traverses several unusual reactions, most notably the first demonstration of an alcohol-directed geminal dihalogenation of an unactivated hydrocarbon.
Author : Lawrence Evans Wolinsky
Publisher :
ISBN 13 :
Total Pages : 174 pages
Book Rating : 4.:/5 (179 download)
Download or read book Biomimetic Approaches to Marine Natural Products written by Lawrence Evans Wolinsky and published by . This book was released on 1975 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Erwan Poupon
Publisher : John Wiley & Sons
ISBN 13 : 3527634762
Total Pages : 1024 pages
Book Rating : 4.5/5 (276 download)
Download or read book Biomimetic Organic Synthesis written by Erwan Poupon and published by John Wiley & Sons. This book was released on 2011-05-09 with total page 1024 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this exciting 2 volume set, the approach and methodology of bio-inspired synthesis of complex natural products is laid out, backed by abundant practical examples from the authors' own work as well as from the published literature. Volume 1 describes the biomimetic synthesis of alkaloids. Volume 2 covers terpenes, polyketides, and polyphenols. A discussion of the current challenges and frontiers in biomimetic synthesis concludes this comprehensive handbook. Key features: Biomimetic Strategies have become an every-day tool not only for chemists but also for biologists. The synthetic applications are overwhelming, making this comprehensive 2 volume work a must-have for everyone working in the field. Unifying both synthetic and biosynthetic aspects, this book covers everything from organocatalysis and natural product synthesis to synthetic biology and even green chemistry.
Author : Baldev Kumar
Publisher : Alpha Science Int'l Ltd.
ISBN 13 : 9781842652824
Total Pages : 318 pages
Book Rating : 4.6/5 (528 download)
Download or read book Biogenesis of Natural Products written by Baldev Kumar and published by Alpha Science Int'l Ltd.. This book was released on 2005 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Starting with photosynthesis, the authors present a very lucid and logical approach from CO[subscript 2] and H[subscript 2]O to complicated structures of alkaloids, terpenes and many other natural products based on the basic principles of Organic reaction mechanism which though taken from other research studies, have been shown to be followed in nature. In addition to the basic formulations of Acetate hypothesis, and Mevlonic pathways, newer non-mevalonic paths have also been discussed and differences pointed out. This book discusses natural products in which basic principles are involved e.g. in alkaloids biosynthesis and basic amino acids which show their pathway in biosynthesis." "The material has been arranged in a sequence as to how a teacher of biosynthesis should/would teach this subject."--BOOK JACKET.
Author : Alexandros L. Zografos
Publisher : John Wiley & Sons
ISBN 13 : 1118751736
Total Pages : 585 pages
Book Rating : 4.1/5 (187 download)
Download or read book From Biosynthesis to Total Synthesis written by Alexandros L. Zografos and published by John Wiley & Sons. This book was released on 2016-04-18 with total page 585 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
Author : Christopher T. Walsh
Publisher : Royal Society of Chemistry
ISBN 13 : 1788010760
Total Pages : 787 pages
Book Rating : 4.7/5 (88 download)
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Author : Hans-Joachim Knoelker
Publisher : Springer Science & Business Media
ISBN 13 : 3642255280
Total Pages : 268 pages
Book Rating : 4.6/5 (422 download)
Download or read book Alkaloid Synthesis written by Hans-Joachim Knoelker and published by Springer Science & Business Media. This book was released on 2012-01-13 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lycopodium Alkaloids: Isolation and Asymmetric Synthesis, by Mariko Kitajima and Hiromitsu Takayama.- Synthesis of Morphine Alkaloids and Derivatives, by Uwe Rinner and Tomas Hudlicky.- Indole Prenylation in Alkaloid Synthesis, by Thomas Lindel, Nils Marsch and Santosh Kumar Adla.- Marine Pyrroloiminoquinone Alkaloids, by Yasuyuki Kita and Hiromichi Fujioka.- Synthetic Studies on Amaryllidaceae and Other Terrestrially Derived Alkaloids, by Martin G. Banwell, Nadia Yuqian Gao, Brett D. Schwartz and Lorenzo V. White.- Synthesis of Pyrrole and Carbazole Alkaloids, by Ingmar Bauer and Hans-Joachim Knölker.-
Author : S.W. Pelletier
Publisher : Elsevier
ISBN 13 : 0080526993
Total Pages : 447 pages
Book Rating : 4.0/5 (85 download)
Download or read book Alkaloids: Chemical and Biological Perspectives written by S.W. Pelletier and published by Elsevier. This book was released on 1996-05-20 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 10 of this series presents four timely reviews. Chapter 1 provides a fascinating account of the history of alkaloid discovery in Australia beginning with the isolation of the first alkaloid from an Australian plant, the Tasmanian sassafras (Atherosperma moschatum), by Zeyer in 1861. Also included is a comprehensive survey of alkaloid-bearing plants, and a section dealing with detection, estimation, extraction, and work-up procedures for alkaloids.Chapter 2 provides a comprehensive update to the chapter on "Pyridine and Piperidine Alkaloids" which appeared in volume 3 of this series. The focus of this chapter is on new alkaloids isolated, biosynthesis, and biological properties.Chapter 3 looks at "3-Alkylpiperidine Alkaloids Isolated from Marine Sponges in the Order Haplosclerida". Studies over the past thirty years have shown that sponges are a rich source of alkaloids. Many of these sponge alkaloids are related to each other by the presence of a 3-alkylpiperidine moiety in their structures and it happens that the sponges that have been reported to contain 3-alkylpiperidine alkaloids are all in the order Haplosclerida.Chapter 4 reviews &bgr;-carboline and isoquinoline alkaloids which are pharmacologically some of the most significant marine natural products. This chapter treats the isolation, structure elucidation, synthesis, biosynthesis, and pharmacological activity of these alkaloids.
Author :
Publisher : Academic Press
ISBN 13 : 0080923038
Total Pages : 278 pages
Book Rating : 4.0/5 (89 download)
Download or read book The Alkaloids written by and published by Academic Press. This book was released on 2008-11-21 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series is world-renowned as the leading compilation of current reviews of this vast field. Internationally acclaimed for more than 40 years, The Alkaloids: Chemistry and Biology, founded by the late Professor R.H.F. Manske, continues to provide outstanding coverage of this rapidly expanding field. Each volume provides, through its distinguished authors, up-to-date and detailed coverage of particular classes or sources of alkaloids. - Up-to-date reviews on a large and very important group of natural products from both a chemical and biological perspective - Comprehensive, dynamic reviews written by leading authors in the respective fields - Broad coverage on the biological aspects
