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Bioconjugation Chemistry In Luminescent Gold Nanoparticles
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Book Synopsis Bioconjugation Chemistry in Luminescent Gold Nanoparticles by : Rodrigo D. Vinluan (III)
Download or read book Bioconjugation Chemistry in Luminescent Gold Nanoparticles written by Rodrigo D. Vinluan (III) and published by . This book was released on 2016 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the synthesis and biomedical applications of distinct metal nanoparticles (NPs) with excellent material properties have progressed considerably in the past decade, the NPs’ translation into the clinical practice still remains a challenge due to their heavy accumulation in the body. As will be discussed and summarized in Chapter 1, any NPs that are administered into the body will inevitably interact with proteins that are present in the vascular system. These protein-NP interactions are influenced by the NP’s physicochemical properties such as size, shape, surface charge, composition, and surface roughness. In addition, these interactions result in the formation of a protein corona, which serves as the binding site for macrophages, as well as many other agents of the immune system. As a consequence, many NPs suffer from severe accumulation in the organs of the body and extensive studies of the NP-protein interactions are still required. Chapter 2 discusses how orange-emitting glutathione-coated gold nanoparticles (GS-AuNPs) can be used as surface ligand to enhance the physiological stability and reduce the serum protein adsorption of superparamagnetic iron oxide nanoparticles (SPIONs). Multiple GS-AuNPs were incorporated onto the surface of a single SPION to form the hybrid nanoparticles (HBNPs). Compared with pure SPIONs, these HBNPs have ten-fold less amount of proteins adsorbed on their surface, suggesting that the GS-AuNPs can provide a stealth effect against serum proteins. Similarly, ~2 nm GS-AuNPs with near-infrared (NIR) luminescence also have reduced serum protein adsorption, even after the conjugation or attachment of insulin onto their surface. As discussed and investigated in Chapter 3, these NIR-emitting GS-AuNPs can be used as a labeling probe without affecting the biological function of the proteins that are labeled, in which insulin was used as a proof of concept. Chapter 4, which is the last chapter, introduces how the NIR-emitting GS-AuNPs’ surface ligand can affect the NPs’ cellular uptake. The glutathione-coated luminescent gold nanoparticles (GS-AuNPs) were conjugated with 4’,6-diamidino-2-phenylindole (DAPI), in which their cellular uptake was compared to those unconjugated GS-AuNPs. Our results show that that the DAPI-conjugated AuNPs were internalized by HeLa cells at a much higher extent than the GS-AuNPs. The mechanism of cellular uptake was also examined for the DAPI-AuNPs and found that these nanomaterials can passively diffuse into the cells and target the cell nucleus based on fluorescence imaging and elemental analysis. Overall, the content of this dissertation will provide guidelines for designing nanomaterials that are intended for imaging and drug delivery.
Book Synopsis Supramolecular Gold Chemistry by : Rodolphe Antoine
Download or read book Supramolecular Gold Chemistry written by Rodolphe Antoine and published by MDPI. This book was released on 2020-06-23 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about supramolecular gold chemistry. This book provides a unique international forum aimed at covering a broad description of results involving the supramolecular chemistry of gold with a special focus on the gold–sulfur interface leading to hybrid materials ranging from gold–thiolate complexes to thiolate-protected gold nanoclusters and gold–thiolate supramolecular assemblies or nanoparticles. The role of thiolates on the structure and optical features of gold nanohybrid systems (ranging from plasmonic gold nanoparticles and fluorescent gold nanoclusters to self-assembled Au-containing thiolated coordination polymers) is highlighted in the 12 papers presented in this book.
Book Synopsis Gold Nanoparticles For Physics, Chemistry And Biology (Second Edition) by : Catherine Louis
Download or read book Gold Nanoparticles For Physics, Chemistry And Biology (Second Edition) written by Catherine Louis and published by World Scientific. This book was released on 2017-06-02 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticles for Physics, Chemistry and Biology offers an overview of recent research into gold nanoparticles, covering their discovery, usage and contemporary practical applications.This Second Edition begins with a history of over 2000 years of the use of gold nanoparticles, with a review of the specific properties which make gold unique. Updated chapters include gold nanoparticle preparation methods, their plasmon resonance and thermo-optical properties, their catalytic properties and their future technological applications. New chapters have been included, and reveal the growing impact of plasmonics in research, with an introduction to quantum plasmonics, plasmon assisted catalysis and electro-photon conversion. The growing field of nanoparticles for health is also addressed with a study of gold nanoparticles as radiosensibiliser for radiotherapy, and of gold nanoparticle functionalisation. This new edition also considers the relevance of bimetallic nanoparticles for specific applications.World-class scientists provide the most up-to-date findings for an introduction to gold nanoparticles within the related areas of chemistry, biology, material science, optics and physics. It is perfectly suited to advanced level students and researchers looking to enhance their knowledge in the study of gold nanoparticles.
Book Synopsis Chemoselective and Bioorthogonal Ligation Reactions by : W. Russ Algar
Download or read book Chemoselective and Bioorthogonal Ligation Reactions written by W. Russ Algar and published by John Wiley & Sons. This book was released on 2017-03-17 with total page 923 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.
Book Synopsis Bioconjugation Via Click Chemistry: The Creation of Functional Hybrids of Lipases and Gold Nanoparticles by :
Download or read book Bioconjugation Via Click Chemistry: The Creation of Functional Hybrids of Lipases and Gold Nanoparticles written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Protected Metal Clusters: From Fundamentals to Applications by :
Download or read book Protected Metal Clusters: From Fundamentals to Applications written by and published by Elsevier. This book was released on 2015-09-06 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protected Metal Clusters: From Fundamentals to Applications surveys the fundamental concepts and potential applications of atomically precise metal clusters protected by organic ligands. As this class of materials is now emerging as a result of breakthroughs in synthesis and characterization that have taken place over the last few years, the book provides the first reference with a focus on these exciting novel nanomaterials, explaining their formation, and how, and why, they play an important role in the future of molecular electronics, catalysis, sensing, biological imaging, and medical diagnosis and therapy. - Surveys the fundamental concepts and potential applications of atomically precise metal clusters protected by organic ligands. - Provides well-organized, tutorial style chapters that are ideal for teaching and self-study - In-depth descriptions by top scientists in the field - Presents the state-of-the art of protected metal clusters and their future prospects
Book Synopsis Gold Nanoparticles by : Valerio Voliani
Download or read book Gold Nanoparticles written by Valerio Voliani and published by Walter de Gruyter GmbH & Co KG. This book was released on 2020-04-20 with total page 113 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold nanoparticles provide a platform for the development of new and efficient diagnostic and therapeutic tools.This book offers a general guide to the synthesis and coating of gold nanoparticles. It describes the links between optical features and geometries of gold nanoparticles and provides a readily comprehensible connection in all the chapters between the geometry of gold nanoparticles and their final applications.
Book Synopsis Update on Gold Nanoparticles by : Valerio Voliani
Download or read book Update on Gold Nanoparticles written by Valerio Voliani and published by Smithers Rapra. This book was released on 2013-01-29 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last decade, gold nanoparticles have provided a suitable platform for the development of novel and efficient diagnostic and therapeutic tools, which avoid the typical drawbacks of the old systems. They are biocompatible and they can be easily synthesised, encapsulated and functionalised with (bio)molecules. Nanoparticles produced by a wet chemistry synthesis have the geometry, which enables the complete control of their optical and physical properties. It is also possible to influence the targeting and stability/release behaviour by coating the nanoparticle surface. In this Update the reader can find in a single volume the methods used most often for the synthesis and coating of gold nanoparticles (spheres, cages, cubes, rods), the links between optical features and geometries of gold nanoparticles, and the novel applications in nanomedicine of gold nanoparticles determined by their geometry. One of the main objectives of this Update is to provide, a readily comprehensible connection in all the chapters between the geometry of gold nanoparticles and their final applications. Another target of this book is to provide information about efficient processes for the synthesis and the coating of gold nanoparticles, all of which have been directly tested by the author. This Update offers comprehensive information on the whole topic from the synthesis of the gold nanoparticles to their medical applications; this is accompanied by a complete and recent bibliography, in order to give to the readers the opportunity to research further the topics addressed in the book. In this way, students and researchers from academia and industry can have a complete picture of gold nanostructures, physicians and biologists can develop ideas and applications for the new nano-tools, and chemists can have a general guide to the synthesis of gold nanoparticles. This is a state-of-the-art guide for the synthesis and uses of gold nanoparticles.
Book Synopsis Luminescent Metal Nanoclusters by : Sabu Thomas
Download or read book Luminescent Metal Nanoclusters written by Sabu Thomas and published by Woodhead Publishing. This book was released on 2022-06-28 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: Luminescent Metal Nanoclusters: Synthesis, Characterization, and Applications provides a comprehensive accounting of various protocols used for the synthesis of metal nanoclusters, their characterization techniques, toxicity evaluation and various applications and future prospects. The book provides detailed experimental routes, along with mechanisms on the formation of benign metallic clusters using biomaterials and a comprehensive review regarding the preparation, properties and prospective applications of these nano clusters in various fields, including therapeutic applications. Various methods to protect nanocluster materials to increase their stability are emphasized, including the incorporation of ligands (protein, small molecule, DNA, thiols). This book addresses a gap in the current literature by bringing together the preparation, characterization and applications of all the possible types of reported metal nanoclusters and their hybrids. It is suitable for materials scientists and engineers in academia and those working in research and development in industry. It may also be of interest to those working in the interdisciplinary nanotechnology community, such as physical chemists. - Covers the most relevant material categories of luminescent nanoclusters such as metal nanoclusters, nano composites and alloy nanoclusters - Provides a comprehensive overview of the various available methods used for the protection of nanoclusters - Discusses the latest advances and future opportunities in addressing challenges in producing benign nanomaterials such as toxicity and stability
Book Synopsis Modern Supramolecular Gold Chemistry by : Antonio Laguna
Download or read book Modern Supramolecular Gold Chemistry written by Antonio Laguna and published by John Wiley & Sons. This book was released on 2008-09-26 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling a gap in our systematic knowledge of gold, this monograph covers the fundamental aspects, while also considering new applications of gold compounds in catalysis, as nanoparticles, and their potential application as luminescent compounds. Written by an eminent team of authors from academia, the book analyzes the current status of gold chemistry, its special characteristics, oxidation states and main type of complexes, before going on to look at the synthesis of supramolecular aggregates due to the formation of gold-gold, gold-metal interactions or other secondary bonds. Final sections deal with LEDs, solvoluminescent and electroluminescent materials, liquid crystals and catalysis. While of interest to advanced chemistry students, this book is also useful for researchers interested in the chemistry of gold and its applications, as well as those involved in metal-metal interactions, heteronuclear chemistry or in the optical properties of coordination compounds.
Book Synopsis Protein-Nanoparticle Interactions by : Masoud Rahman
Download or read book Protein-Nanoparticle Interactions written by Masoud Rahman and published by Springer Science & Business Media. This book was released on 2013-06-24 with total page 95 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the fabrication of nanomaterials and exploration of their properties have attracted the attention of various scientific disciplines such as biology, physics, chemistry, and engineering. Although nanoparticulate systems are of significant interest in various scientific and technological areas, there is little known about the safety of these nanoscale objects. It has now been established that the surfaces of nanoparticles are immediately covered by biomolecules (e.g. proteins, ions, and enzymes) upon their entrance into a biological medium. This interaction with the biological medium modulates the surface of the nanoparticles, conferring a “biological identity” to their surfaces (referred to as a “corona”), which determines the subsequent cellular/tissue responses. The new interface between the nanoparticles and the biological medium/proteins, called “bio-nano interface,” has been very rarely studied in detail to date, though the interest in this topic is rapidly growing. In this book, the importance of the physiochemical characteristics of nanoparticles for the properties of the protein corona is discussed in detail, followed by comprehensive descriptions of the methods for assessing the protein-nanoparticle interactions. The advantages and limitations of available corona evaluation methods (e.g. spectroscopy methods, mass spectrometry, nuclear magnetic resonance, electron microscopy, X-ray crystallography, and differential centrifugal sedimentation) are examined in detail, followed by a discussion of the possibilities for enhancing the current methods and a call for new techniques. Moreover, the advantages and disadvantages of protein-nanoparticle interaction phenomena are explored and discussed, with a focus on the biological impacts.
Book Synopsis Renal Clearable Luminescent Gold Nanoparticles Conjugated with Organic Dyes by : Shasha Sun
Download or read book Renal Clearable Luminescent Gold Nanoparticles Conjugated with Organic Dyes written by Shasha Sun and published by . This book was released on 2016 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: In chapter 1, we reviewed luminescent gold nanoparticles and organic fluorophores. Progresses of dye conjugated gold nanoparticles as well as their biomedical sensing and imaging applications were reviewed, demonstrating the significance of the work present in this dissertation. In chapter 2, we described 5(6)-Carboxytetramethylrhodamine (TAMRA) conjugated luminescent gold nanoparticles that can serve as an ultrasmall nanoindicator to fluorescently report local pH in a ratiometric way. This pH-dependent dimerization is not limited to pH-insensitive dye; it can also enhance the pH sensitivity of a well-known pH-sensitive dye, fluorescein, within a larger pH range, opening up a new pathway to design ultrasmall fluorescent ratiometric nanoindicators with tunable wavelengths and pH response ranges. In chapter 3, we synthesized an organic fluorophore, TAMRA conjugated gold nanoparticles, and did a series of comparison studies of their in vitro and in vivo behaviors with that of GS-AuNPs. Our study showed that the conjugation of TAMRA to GS-AuNPs could affect the cell membrane binding of GS-AuNPs; however, it has no impact on their serum protein binding affinity. The TG-AuNPs has longer normal tissue and tumor retention times than GS-AuNPs. Additionally, the fluorescence signals from TAMRA could not truly reflect the in vivo behaviors of TG-AuNPs. In chapter 4, we used renal clearable glutathione coated gold nanoparticles as a delivery vector to deliver the only FDA approved NIR dye – ICG to the targeting site. When we combined them together, the ICG-AuNPs showed interesting clearance kinetics in which the NPs dissociated in the body. Moreover, compared with clinically used ICG-HSA, ICG-AuNPs showed a tumor imaging time window more than three orders longer as well as a tumor area 40 times brighter, all the while maintaining their renal clearance property and low accumulation in RES organs. In chapter 5, by taking advantage of robust single-particle fluorescence and giant Raman enhancements of unique polycrystalline silver NPs (AgNPs), we quantitatively investigated the effects of two well-known surface chemistries, passive PEGylation and active c-RGD peptide conjugation, on in vitro behaviors of AgNPs at high temporal and spatial resolution as well as chemical level using fluorescence and Raman microscopy.
Book Synopsis Gold Nanoparticles for Physics, Chemistry and Biology by : Catherine Louis
Download or read book Gold Nanoparticles for Physics, Chemistry and Biology written by Catherine Louis and published by Wspc (Europe). This book was released on 2017 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gold Nanoparticles for Physics, Chemistry and Biology offers an overview of recent research into gold nanoparticles, covering their discovery, usage and contemporary practical applications. This Second Edition begins with a history of over 2000 years of the use of gold nanoparticles, with a review of the specific properties which make gold unique. Updated chapters include gold nanoparticle preparation methods, their plasmon resonance and thermo-optical properties, their catalytic properties and their future technological applications. New chapters have been included, and reveal the growing impact of plasmonics in research, with an introduction to quantum plasmonics, plasmon assisted catalysis and electro-photon conversion. The growing field of nanoparticles for health is also addressed with a study of gold nanoparticles as radiosensibiliser for radiotherapy, and of gold nanoparticle functionalisation. This new edition also considers the relevance of bimetallic nanoparticles for specific applications. World-class scientists provide the most up-to-date findings for an introduction to gold nanoparticles within the related areas of chemistry, biology, material science, optics and physics. It is perfectly suited to advanced level students and researchers looking to enhance their knowledge in the study of gold nanoparticles.
Book Synopsis Nanomaterials and Their Biomedical Applications by : Tuhin Subhra Santra
Download or read book Nanomaterials and Their Biomedical Applications written by Tuhin Subhra Santra and published by Springer Nature. This book was released on 2021-04-16 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the evolution of, and novel challenges currently facing, nanomaterials science, nanoengineering, and nanotechnology, and their applications and development in the biological and biomedical fields. It details different nanoscale and nanostructured materials syntheses, processing, characterization, and applications, and considers improvements that can be made in nanostructured materials with their different biomedical applications. The book also briefly covers the state of the art of different nanomaterials design, synthesis, fabrication and their potential biomedical applications. It will be particularly useful for reading and research purposes, especially for science and engineering students, academics, and industrial researchers.
Book Synopsis Supramolecular Chemistry in Water by : Stefan Kubik
Download or read book Supramolecular Chemistry in Water written by Stefan Kubik and published by John Wiley & Sons. This book was released on 2019-09-03 with total page 586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides deep insight into the concepts and recent developments in the area of supramolecular chemistry in water Written by experts in their respective field, this comprehensive reference covers various aspects of supramolecular chemistry in water?from fundamental aspects to applications. It provides readers with a basic introduction to the current understanding of the properties of water and how they influence molecular recognition, and examines the different receptor types available in water and the types of substrates that can be bound. It also looks at areas to where they can be applied, such as materials, optical sensing, medicinal imaging, and catalysis. Supramolecular Chemistry in Water offers five major sections that address important topics like water properties, molecular recognition, association and aggregation phenomena, optical detection and imaging, and supramolecular catalysis. It covers chemistry and physical chemistry of water; water-mediated molecular recognition; peptide and protein receptors; nucleotide receptors; carbohydrate receptors; and ion receptors. The book also teaches readers all about coordination compounds; self-assembled polymers and gels; foldamers; vesicles and micelles; and surface-modified nanoparticles. In addition, it provides in-depth information on indicators and optical probes, as well as probes for medical imaging. -Covers, in a timely manner, an emerging area in chemistry that is growing more important every day -Addresses topics such as molecular recognition, aggregation, catalysis, and more -Offers comprehensive coverage of everything from fundamental aspects of supramolecular chemistry in water to its applications -Edited by one of the leading international scientists in the field Supramolecular Chemistry in Water is a one-stop-resource for all polymer chemists, catalytic chemists, biochemists, water chemists, and physical chemists involved in this growing area of research.
Book Synopsis Nanofabrication for Smart Nanosensor Applications by : Fernando Gomes
Download or read book Nanofabrication for Smart Nanosensor Applications written by Fernando Gomes and published by Elsevier. This book was released on 2020-06-18 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanofabrication for Smart Nanosensor Applications addresses the design, manufacture and applications of a variety of nanomaterials for sensing applications. In particular, the book explores how nanofabrication techniques are used to create more efficient nanosensors, examines their major applications in biomedicine and environmental science, discusses the fundamentals of how nanosensors work, explores different nanofabrication techniques, and comments on toxicity and safety issues relating to the creation of nanosensors using certain nanomaterial classes. This book is an important resource for materials scientists and engineers who want to make materials selection decisions for the creation of new nansensor devices. - Summarizes current research and applications of a variety of nanofabrication techniques for the creation of efficient sensing devices - Provides readers with an understanding of surfaces and interfaces, a key challenge for those working on hybrid nanomaterials, carbon nanotubes, graphene, polymers and liquid crystal electro-optical imaging - Discusses the variability and sight recognition of biopolymers, such as DNA molecules, which offer a wide range of opportunities for the self-organization of nanostructures into much more complex patterns
Book Synopsis Immunosensors by : Minhaz Uddin Ahmed
Download or read book Immunosensors written by Minhaz Uddin Ahmed and published by Royal Society of Chemistry. This book was released on 2019-08-28 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunosensors are widely used and are particularly important for fast diagnosis of diseases in remote environments as well as point-of-care devices. In this book, expert scientists are covering a selection of high quality representative examples from the past five years explaining how this area has developed. It is a compilation of recent advances in several areas of immunosensors for multiple target analysis using laboratory based or point-of-care set-up, for example graphene-, ISFET- and nanostructure-based immunosensors, electrochemical magneto immunosensors and nanoimprinted immunosensors. Filling a gap in the literature, it showcases the multidisciplinary, innovative developments in this highly important area and provides pointers towards commercialisation. Delivering a single, comprehensive work, it appeals to graduate students and professional researchers across academia and industry.
