Author : Ganga Srinivasan
Publisher : LAP Lambert Academic Publishing
ISBN 13 : 9783848481859
Total Pages : 164 pages
Book Rating : 4.4/5 (818 download)
Book Synopsis Bioadhesive Drug Delivery System for a Cardiovascular Drug by : Ganga Srinivasan
Download or read book Bioadhesive Drug Delivery System for a Cardiovascular Drug written by Ganga Srinivasan and published by LAP Lambert Academic Publishing. This book was released on 2012-07 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Market for advanced drug delivery systems has undergone a period of innovation and significant expansion over the past decade.In this context worldwide market for transmucosal products is in excess of five billion annually and is expected to continue to grow at a rapid pace.Hence transmucosal drug delivery holds lot of promise in the coming era. Amongst various transmucosal routes buccal region of the oral cavity has got optimal attributes for transmucosal and modified drug delivery and has lot of promise and commercial viability.Present work encompasses development of extended release formulation of an antihypertensive drug Nisoldipine using bioadhesive polymers, to improve the bioavailability along with minimal variation in the therapeutic response. Nisoldipine is a calcium channel blocker of the dihydropyridine class. Nisoldipine is an ideal candidate for this work as its bioavailability is 4-8% and has high inter and intrasubject variability in response.Studies include formulation development using Progressive Hydration Technology, optimizing and validating the formulation approaches, stability studies and in-vivo evaluation in rabbits.