Bhlh Transcription Factors In Development And Disease

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bHLH Transcription Factors in Development and Disease

Author :
Publisher : Academic Press
ISBN 13 : 0124071546
Total Pages : 421 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis bHLH Transcription Factors in Development and Disease by :

Download or read book bHLH Transcription Factors in Development and Disease written by and published by Academic Press. This book was released on 2014-09-09 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Current Topics in Developmental Biology provides a comprehensive set of reviews on bHLH transcription factors. bHLH factors are vastly recognized for their diverse roles in developmental processes and their dysfunction underlies various human pathologies. Each chapter is authoritatively written by a leading expert in the field and discusses every possible aspect of this huge and diverse field. - Covers the area of basic helix-loop-helix (bHLH) transcription factors in development and disease - International board of authors - Provides a comprehensive set of reviews on our current understanding on the function of bHLH factors in development of various tissues and how de-regulation of these factors can cause, or is linked to, various human diseases

Transcriptional Control of Neural Crest Development

Author : Brian L. Nelms
Publisher : Morgan & Claypool Publishers
ISBN 13 : 161504048X
Total Pages : 227 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Transcriptional Control of Neural Crest Development by : Brian L. Nelms

Download or read book Transcriptional Control of Neural Crest Development written by Brian L. Nelms and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: The neural crest is a remarkable embryonic population of cells found only in vertebrates and has the potential to give rise to many different cell types contributing throughout the body. These derivatives range from the mesenchymal bone and cartilage comprising the facial skeleton, to neuronal derivatives of the peripheral sensory and autonomic nervous systems, to melanocytes throughout the body, and to smooth muscle of the great arteries of the heart. For these cells to correctly progress from an unspecifi ed, nonmigratory population to a wide array of dynamic, differentiated cell types-some of which retain stem cell characteristics presumably to replenish these derivatives-requires a complex network of molecular switches to control the gene programs giving these cells their defi ning structural, enzymatic, migratory, and signaling capacities. This review will bring together current knowledge of neural crest-specifi c transcription factors governing these progressions throughout the course of development. A more thorough understanding of the mechanisms of transcriptional control in differentiation will aid in strategies designed to push undifferentiated cells toward a particular lineage, and unraveling these processes will help toward reprogramming cells from a differentiated to a more naive state. Table of Contents: Introduction / AP Genes / bHLH Genes / ETS Genes / Fox Genes / Homeobox Genes / Hox Genes / Lim Genes / Pax Genes / POU Domain Genes / RAR/RXR Genes / Smad Genes / Sox Genes / Zinc Finger Genes / Other Miscellaneous Genes / References / Author Biographies

Transcription Factors and Human Disease

Author : Gregg L. Semenza
Publisher : Oxford Monographs on Medical G
ISBN 13 : 9780195112399
Total Pages : 396 pages
Book Rating : 4.1/5 (123 download)

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Book Synopsis Transcription Factors and Human Disease by : Gregg L. Semenza

Download or read book Transcription Factors and Human Disease written by Gregg L. Semenza and published by Oxford Monographs on Medical G. This book was released on 1998 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Several general principles have emerged from the study of human transcription factors. First, germline mutations in genes encoding transcription factors result in malformation syndromes in which the development of multiple body structures is affected. Second, somatic mutations involving many of the same genes contribute to tumorigenesis. Third, transcriptional regulatory mechanisms demonstrate remarkable evolutionary conservation. Fourth, prenatal development and postnatal physiology are unified by the demonstration that a single transription factor can control the proliferation of progenitor cells during development and the expression within the differentiated cells of gene products that participate in specific physiologic responses. Transcription Factors and Human Disease presents the basic science of transcriptional regulation and then describes inherited human diseases attributable to mutations in DNA sequences encoding transcription factors or their cognate binding sites. The involvement of transcription factors in somatic cell genetic diseases (cancer) and epigenetic disease (teratogenesis) is briefly discussed. The effect of specific mutations on transcription factor activity and the relationship between transcriptional dysregulation, dominant or recessive inheritance patterns, and disease pathogenesis are also explored. This book thus provides a direct connection between molecular defects in transcriptional regulation and human pathophysiology.

Atlas of Early Zebrafish Brain Development

Author : Dr. Thomas Mueller
Publisher : Academic Press
ISBN 13 : 0124172865
Total Pages : 260 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Atlas of Early Zebrafish Brain Development by : Dr. Thomas Mueller

Download or read book Atlas of Early Zebrafish Brain Development written by Dr. Thomas Mueller and published by Academic Press. This book was released on 2015-11-18 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Early Zebrafish Brain Development: A Tool for Molecular Neurogenetics, Second Edition, remains the only neuroanatomical expression atlas of important genetic and immunohistochemical markers of this vertebrate model system. It represents a key reference and interpretation matrix for analyzing expression domains of genes involved in Zebrafish brain development and neurogenesis, and serves as a continuing milestone in this research area. This updated volume provides in-situ hybridized and immunostained preparations of complete series of brain sections, revealing markers of the fundamental stages in the life history of neuronal cells in very high quality preparations and photographic plates. Specific additions to this edition include documentation on the distribution of neurons expressing GABA, dopamine and serotonin, material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon, new theories on the early organization of the telencephalon and thalamus, and integration of a comparative perspective on the mid- and hindbrain. - Documentation on the distribution of neurons expressing GABA, dopamine and serotonin - Material on the basal ganglia, hypothalamus, and the caudal, segmented part of the diencephalon - New theories about the early organization of the telencephalon and thalamus - Integration of a comparative perspective on the mid- and hindbrain

Patterning and Cell Type Specification in the Developing CNS and PNS

Author :
Publisher : Academic Press
ISBN 13 : 0123973481
Total Pages : 993 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Patterning and Cell Type Specification in the Developing CNS and PNS by :

Download or read book Patterning and Cell Type Specification in the Developing CNS and PNS written by and published by Academic Press. This book was released on 2013-05-06 with total page 993 pages. Available in PDF, EPUB and Kindle. Book excerpt: The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurological treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems. - Series offers 144 articles for 2904 full color pages addressing ways in which the nervous system and its components develop - Features leading experts in various subfields as Section Editors and article Authors - All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship - Volume 1 sections include coverage of mechanisms which: control regional specification, regulate proliferation of neuronal progenitors and control differentiation and survival of specific neuronal subtypes, and controlling development of non-neural cells

Gene Regulation in Eukaryotes

Author : Edgar Wingender
Publisher : Wiley-Blackwell
ISBN 13 :
Total Pages : 452 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Gene Regulation in Eukaryotes by : Edgar Wingender

Download or read book Gene Regulation in Eukaryotes written by Edgar Wingender and published by Wiley-Blackwell. This book was released on 1993 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: A much-needed guide through the overwhelming amount of literature in the field. Comprehensive and detailed, this book combines background information with the most recentinsights. It introduces current concepts, emphasizing the transcriptional control of genetic information. Moreover, it links data on the structure of regulatory proteins with basic cellular processes. Both advanced students and experts will find answers to such intriguing questions as: - How are programs of specific gene repertoires activated and controlled? - Which genes drive and control morphogenesis? - Which genes govern tissue-specific tasks? - How do hormones control gene expression in coordinating the activities of different tissues? An abundant number of clearly presented glossary terms facilitates understanding of the biological background. Speacial feature: over 2200 (!) literature references.

Fluorescence Correlation Spectroscopy

Author : R. Rigler
Publisher : Springer Science & Business Media
ISBN 13 : 3642595421
Total Pages : 503 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Fluorescence Correlation Spectroscopy by : R. Rigler

Download or read book Fluorescence Correlation Spectroscopy written by R. Rigler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book-length treatment of both the theoretical background to fluorescence correlation spectroscopy (FCS) and a variety of applications in various fields of science. The high spatial and temporal resolution of FCS has made it a powerful tool for the analysis of molecular interactions and kinetics, transport properties due to thermal motion, and flow. It contains an essential contribution from Nobel Prize winner M. Eigen, who is credited with inventing FCS.

Molecular Mechanisms of Neural Development and Insights into Disease

Author :
Publisher : Academic Press
ISBN 13 : 0128152826
Total Pages : 548 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Molecular Mechanisms of Neural Development and Insights into Disease by :

Download or read book Molecular Mechanisms of Neural Development and Insights into Disease written by and published by Academic Press. This book was released on 2021-03-09 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Development and Disease, Volume 142 in the Current Topics in Developmental Biology series highlights new advances in the field, with this new volume presenting interesting chapters by one or more members of an international board of authors. Sections in this new release cover The role of primary cilia in neural development and disease, Mechanisms of axon guidance receptor regulation and signaling, Synaptic recognition molecules in development and disease, The regulation of cortical neurogenesis, Axon guidance in the developing spinal cord, The role of astrocytes in synapse formation and maturation, Development of motor circuits, Molecular mechanisms that mediate dendrite morphogenesis, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in the Current Topics in Developmental Biology series

Epigenetics and Regeneration

Author :
Publisher : Academic Press
ISBN 13 : 0128148802
Total Pages : 544 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Epigenetics and Regeneration by :

Download or read book Epigenetics and Regeneration written by and published by Academic Press. This book was released on 2019-05-24 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. - Provides a foundational overview of epigenetics in regenerative medicine - Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice - Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways - Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Muscle Development in Drosophilia

Author : Helen Sink
Publisher : Springer Science & Business Media
ISBN 13 : 0387329633
Total Pages : 214 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Muscle Development in Drosophilia by : Helen Sink

Download or read book Muscle Development in Drosophilia written by Helen Sink and published by Springer Science & Business Media. This book was released on 2007-02-26 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: The different aspects of muscle development are considered from cellular, molecular and genetic viewpoints, and the text is supported by black/white and color illustrations. The book will appeal to those studying muscle development and muscle biology in any organism.

Helix-loop-helix Transcription Factors

Author : Trevor D. Littlewood
Publisher :
ISBN 13 :
Total Pages : 168 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Helix-loop-helix Transcription Factors by : Trevor D. Littlewood

Download or read book Helix-loop-helix Transcription Factors written by Trevor D. Littlewood and published by . This book was released on 1998 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Helix-Loop-Helix (HLH) proteins are involved in transcriptional regulation of gene expression. The HLH domain is a DNA-binding dimerization domain which mediates homodimerization and heterodimerization with other HLH proteins. This new volume in the Protein Profile series explores the sequence specificity of DNA binding, the nature of dimerization partners, the regulation of target genes by HLH proteins, and the negative regulation of some bHLH proteins by HLH proteins which lack a functional DNA-binding domain. Topics include the role of HLH proteins in such diverse areas as myogenesis, neurogenesis, haematopoeisis, and sex determination; tissue specific HLH proteins; the role of HLH proteins in yeast and plants; nuclear localization of HLH proteins, transactivation domains and post-translational modification.

Mouse Development

Author : Janet Rossant
Publisher : Gulf Professional Publishing
ISBN 13 : 9780125979511
Total Pages : 754 pages
Book Rating : 4.9/5 (795 download)

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Book Synopsis Mouse Development by : Janet Rossant

Download or read book Mouse Development written by Janet Rossant and published by Gulf Professional Publishing. This book was released on 2002-03 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference. *Broad-based overview of mouse development from fundamental to specialist levels *Extensive coverage of a wide range of developmental mutations of the mouse *Excellent benchmark illustrations of brain, craniofacial, gut and heart development *In-depth experiment-based assessment of concepts in mammalian development *Focus on models of specific relevance to human development *Comprehensive reference to key literature and electronic databases related to mouse development *High-quality full-color production

Neural Stem Cells and Adult Neurogenesis

Author : Arie S. Mobley
Publisher : Academic Press
ISBN 13 : 0128110147
Total Pages : 242 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Neural Stem Cells and Adult Neurogenesis by : Arie S. Mobley

Download or read book Neural Stem Cells and Adult Neurogenesis written by Arie S. Mobley and published by Academic Press. This book was released on 2019-03-05 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Stem Cells and Adult Neurogenesis provides graduate students and neuroscientists with a basic understanding of what neural stem cells are and the cell types they produce. This early graduate level reference describes their physiology and potential for medicine and provides students with fundamental stem cell information. An overview of stem cell sources in the human body and a brief mention of relevant diseases provide context for the value of this knowledge. The book also includes chapters on induced pluripotent stem cells (iPSCs), the methods used to obtain them, and a review of the ethical challenges associated with stem cell research. For each region, the book provides a description of its neurogenic niche, cellular and molecular biology, and information on the neurons' contribution to normal and diseased brain function. The level of information is appropriate for early graduate students, introducing technology and molecular biology in an accessible format.

Molecular Mechanisms of Glia in Development and Disease

Author : Ryan B. MacDonald
Publisher : Frontiers Media SA
ISBN 13 : 2832520405
Total Pages : 533 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Molecular Mechanisms of Glia in Development and Disease by : Ryan B. MacDonald

Download or read book Molecular Mechanisms of Glia in Development and Disease written by Ryan B. MacDonald and published by Frontiers Media SA. This book was released on 2023-04-11 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Transcription Factors

Author : Daniel H Gonzalez
Publisher : Academic Press
ISBN 13 : 0128011270
Total Pages : 435 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Plant Transcription Factors by : Daniel H Gonzalez

Download or read book Plant Transcription Factors written by Daniel H Gonzalez and published by Academic Press. This book was released on 2015-07-07 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant Transcription Factors: Evolutionary, Structural and Functional Aspects is the only publication that provides a comprehensive compilation of plant transcription factor families and their complex roles in plant biology. While the majority of information about transcription factors is based on mammalian systems, this publication discusses plant transcription factors, including the important aspects and unifying themes to understanding transcription factors and the important roles of particular families in specific processes. - Provides an entry point for transcription factor literature - Offers compilation of information into one single resource for rapid consultation on different plant transcription factor features - Integrates the knowledge about different transcription factors, along with cross-referencing - Provides information on the unique aspects surrounding plant transcription factors

Pathology of Heart Disease in the Fetus, Infant and Child

Author : Michael T. Ashworth
Publisher : Cambridge University Press
ISBN 13 : 1107116287
Total Pages : 361 pages
Book Rating : 4.1/5 (71 download)

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Book Synopsis Pathology of Heart Disease in the Fetus, Infant and Child by : Michael T. Ashworth

Download or read book Pathology of Heart Disease in the Fetus, Infant and Child written by Michael T. Ashworth and published by Cambridge University Press. This book was released on 2019-08-22 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearly presents the pathology of heart disease from fetus to adolescence, integrating histology and macroscopy with effects of treatment.

Genomic Control Process

Author : Isabelle S. Peter
Publisher : Academic Press
ISBN 13 : 0124047467
Total Pages : 461 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Genomic Control Process by : Isabelle S. Peter

Download or read book Genomic Control Process written by Isabelle S. Peter and published by Academic Press. This book was released on 2015-01-21 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. - Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life - Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework - Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature - Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type - Demonstrates the causal power of system-level understanding of genomic control process - Conceptually organizes a constellation of complex and diverse biological phenomena - Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models - Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome