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Beneficial And Detrimental Host Cellular Responses Against Mycobacterium Tuberculosis Infection
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Book Synopsis Beneficial and detrimental host cellular responses against Mycobacterium tuberculosis infection by : Veronica Edith Garcia
Download or read book Beneficial and detrimental host cellular responses against Mycobacterium tuberculosis infection written by Veronica Edith Garcia and published by Frontiers Media SA. This book was released on 2023-12-13 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection by : Vishwanath Venketaraman
Download or read book Understanding the Host Immune Response Against Mycobacterium tuberculosis Infection written by Vishwanath Venketaraman and published by Springer. This book was released on 2018-09-26 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: According to the World Health Organization, approximately one third of the world’s population is latently infected with Mycobacterium tuberculosis (M. tb [LTBI]), of whom about 9 million have active tuberculosis (TB). It is estimated that approximately 2 million individuals die each year from active TB. An estimated 14.4% of these individuals have HIV and M. tb co-infection. TB has long been known to be one of the leading causes of death in HIV-infected individuals. Recent evidence now indicates that individuals with type 2 diabetes, the elderly, and chronic smokers are also increasingly susceptible to TB infection, the ability of their immune system to fight off active TB infection having been compromised by their condition. This book therefore aims to provide a detailed review of recent advances in the research that involves characterizing the host’s immune responses against TB infection in conditions such as HIV, diabetes, chronic cigarette smoking and aging, and strategies to restore favorable immune responses against this deadly pathogen.
Book Synopsis Advances in Host-Directed Therapies Against Tuberculosis by : Petros C. Karakousis
Download or read book Advances in Host-Directed Therapies Against Tuberculosis written by Petros C. Karakousis and published by Springer Nature. This book was released on 2020-12-03 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses specific immune cell regulatory pathway(s), immune cell types, or other mechanisms involved in host responses to tuberculosis that can be potentially targeted for host-directed therapy (HDT). The pathways/mechanisms investigated are either protective – thus calling for pathway/factor enhancing drugs – or maladaptive – thus calling for pathway/factor inhibitory drugs. Discovery and development (pre-clinical and clinical) of candidate HDT agents will also be elucidated, as well as approaches for HDT of other diseases. The benefit to the reader will derive from learning about the biology of multiple host pathways involved in health and disease, how these pathways are disrupted or dysregulated during tuberculosis, and which druggable targets exist in these pathways. This book provides the reader with a roadmap of current and future directions of HDT against tuberculosis. Since the host pathways/factors involved in protective or maladaptive responses to tuberculosis are not disease-specific, information learned from the context of tuberculosis likely will be relevant to other infectious and non-infectious diseases.
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The New Paradigm of Immunity to Tuberculosis by : Maziar Divangahi
Download or read book The New Paradigm of Immunity to Tuberculosis written by Maziar Divangahi and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book illustrates the intimate relationship between alveolar macrophages and Mycobacterium tuberculosis (M.tb.), and the former’s role in both innate and adaptive immunity against M.tb. It covers research done over the last decade. It also explores the role of macrophage death following infection with M.tb. in determining whether successful immunity is stimulated, or whether clinical disease develops; furthermore, the function of host lipid mediators in macrophage death modality are addressed. The book also illustrates how the balance between prostaglandins and lipoxins determines whether infected macrophages undergo apoptosis or necrosis, which is the ultimate factor in the outcome of infection. Finally, it is a synthesis of the authors’ recent studies and the studies of others to offer a new understanding of immunity to tuberculosis.
Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes
Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Book Synopsis Tuberculosis in Adults and Children by : Dorothee Heemskerk
Download or read book Tuberculosis in Adults and Children written by Dorothee Heemskerk and published by Springer. This book was released on 2015-07-17 with total page 71 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Book Synopsis Immunopathogenesis of HIV Infection by : Anthony S. Fauci
Download or read book Immunopathogenesis of HIV Infection written by Anthony S. Fauci and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the last 5 years, major advances have been made in our understanding of the pathogenesis of human immunodeficiency virus (HIV) disease and in the development of new potent antiviral agents. With regard to HIV pathogenesis, several recent observations have not only changed our perspectives of HIV disease, but have been critical for the design of therapeutic strategies.
Book Synopsis Host-Directed Therapies for Tuberculosis by : Vishwanath Venketaraman
Download or read book Host-Directed Therapies for Tuberculosis written by Vishwanath Venketaraman and published by MDPI. This book was released on 2020-11-20 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt: TB is considered as one of the oldest documented infectious diseases in the world and is believed to be the leading cause of mortality due to a single infectious agent. Mtb, the causative agent responsible for TB, continues to afflict millions of people worldwide. Furthermore, one-third of the entire world's population has latent TB. Consequently, there has been a worldwide effort to eradicate and limit the spread of Mtb through the use of antibiotics. However, management of TB is becoming more challenging with the emergence of drug-resistant and multi-drug resistant strains of Mtb. Furthermore, when administered, many of the anti-TB drugs commonly present severe complications and side effects. Novel approaches to enhance the host immune responses to completely eradicate Mtb infection are urgently needed. This Special Issue will therefore cover most recent advances in the area of host-directed therapies for TB.
Book Synopsis Control of Innate and Adaptive Immune Responses during Infectious Diseases by : Julio Aliberti
Download or read book Control of Innate and Adaptive Immune Responses during Infectious Diseases written by Julio Aliberti and published by Springer Science & Business Media. This book was released on 2011-09-21 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Upon infection the host needs to mount vigorous immune response against pathogen in order to successfully control its replication. However, once the infectious agent is controlled or eliminated, host cells need to signal the immune system to slow or cease its activities. While vast knowledge has been accumulated through the years on the mechanisms involved in the initiation and effector phases of the immune responses, the pathways triggered in order to modulate or end innate and acquired immunity are becoming more evident as evidence for its relevance comes to surface. Due to its biological power, evidence has surfaced indicating that eventually pathogens may take advantage of such regulatory pathways in order to escape effector mechanisms and progress to persistence. This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases, their biological consequences and potential "hijack" of these pathways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance.
Book Synopsis Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism by : Jean Pieters
Download or read book Pathogenesis of Mycobacterium tuberculosis and its Interaction with the Host Organism written by Jean Pieters and published by Springer Science & Business Media. This book was released on 2013-12-09 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host’s innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
Book Synopsis The Role of Cell Specific Tumour Necrosis Factor in the Host's Immune Response Against Mycobacterium Tuberculosis Infection by : Nasiema Allie
Download or read book The Role of Cell Specific Tumour Necrosis Factor in the Host's Immune Response Against Mycobacterium Tuberculosis Infection written by Nasiema Allie and published by . This book was released on 2011 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Trained Immunity-based Vaccines by : Jose Luis Subiza
Download or read book Trained Immunity-based Vaccines written by Jose Luis Subiza and published by Frontiers Media SA. This book was released on 2021-08-25 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Jose Luis Subiza is the founder and CEO of Inmunotek SL. The other Topic Editors declare no competing interests with regard to the Research Topic subject.
Author :National Collaborating Centre for Chronic Conditions (Great Britain) Publisher :Royal College of Physicians ISBN 13 :9781860162770 Total Pages :232 pages Book Rating :4.1/5 (627 download)
Book Synopsis Tuberculosis by : National Collaborating Centre for Chronic Conditions (Great Britain)
Download or read book Tuberculosis written by National Collaborating Centre for Chronic Conditions (Great Britain) and published by Royal College of Physicians. This book was released on 2006 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Effect of N-3 Polyunsaturated Fatty Acids on the Immune Response to Mycobacterium Tuberculosis by : Diana L. Bonilla Escobar
Download or read book The Effect of N-3 Polyunsaturated Fatty Acids on the Immune Response to Mycobacterium Tuberculosis written by Diana L. Bonilla Escobar and published by . This book was released on 2009 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: ABSTRACT: Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), infects almost one third of the human population and kills almost 2 million people each year worldwide. Although great advances have been made in understanding the host-pathogen interaction in TB, enhanced knowledge of the factors that influence the host immune response again this pathogen, including nutritional components, would facilitate the development of new approaches to control the disease. Besides their health benefits, dietary omega-3 polyunsaturated fatty acids (n-3 PUFA) can impair host resistance to intracellular infections by creating an immunosuppressive environment. We hypothesized that n-3 PUFA impair host resistent Mtb, in part, by suppressing the activation of macrophage antimicrobial responses. We demonstrated that the incorporation of the n-3 PUFA docosahexaenoic acid (DHA) into membranes of murine J774A.1 macrophages reduced the ability to control Mtb, in part, by suppressing the activation of antibacterial responses induced by IFNy. Incorporation of DHA resulted in defective macrophage activation, as characterized by reduced production of pro-inflammatory cytokines, lower expression of co-stimulatory molecules, impaired oxidative metabolism, reduced phagolysosome maturation and increased bacterial survival. Furthermore, we showed that the endogenous production of n-3 PUFA in transgenic fat-1 mice increased their susceptibility to pulmonary TB. Bacteriological and histological analysis of lungs revealed that fat-1 mice were more susceptible to TB, as demonstrated by higher bacterial loads and poorly-organized inflammatory responses. We also observed reduced ability to control the infection in fat-1 macrophages infected ex vivo, as demonstrated by increased bacterial survival, reduced pro-inflammatory cytokine production (TNF[alpha], IL-6, Il-1[beta] and MCP-1), impaired oxidative metabolism and diminished Mtb-lysotracker colocalization within phagosomes. The impaired immunity was explained, in part, by diminished activation and antimycobacterial response in fat-1 macrophages. These data suggest that n-3 PUFA-supplemented diets could have a detrimental effect on host immunity to Mtb in humans, by interfering with protective cellular mechanisms.
Book Synopsis Global Tuberculosis Report 2016 by : World Health Organization
Download or read book Global Tuberculosis Report 2016 written by World Health Organization and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This global tuberculosis report is the first to be produced in the era of the SDGs and the End TB Strategy. It provides an assessment of the TB epidemic and progress in TB diagnosis, treatment, and prevention efforts as well as an overview of TB-specific financing and research. It also discusses the broader agenda of universal health coverage, social protection, and other SDGs that have an impact on health. Data was available for 202 countries and territories that account for over 99% of the world's population and TB cases.
