Basic Research And Clinical Aspects Of Adamantinomatous Craniopharyngioma

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Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma

Author : Juan Pedro Martinez-Barbera
Publisher : Springer
ISBN 13 : 3319518909
Total Pages : 223 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma by : Juan Pedro Martinez-Barbera

Download or read book Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma written by Juan Pedro Martinez-Barbera and published by Springer. This book was released on 2017-04-19 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: This astute volume brings together the latest expert research on adamantinomatous craniopharyngiomas (ACPs). ACPs are histologically benign but clinically aggressive tumors exhibiting a high propensity for local invasion into the hypothalamus, optic and vascular structures. These tumors, as well as the current treatments, may result in pan-hypopituitarism, diabetes insipidus, morbid obesity followed by type II diabetes mellitus, blindness, as well as serious behavioral and psychosocial impairments. Exploring in detail advances in both the understanding of tumor biology as well as clinical advances in patient management are explored in detail, this book will also look towards potential new treatment approaches. Basic Research and Clinical Aspects of Adamantinomatous Craniopharyngioma is the first book compiling all current research on ACPs. Mouse and human studies have unequivocally demonstrated that mutations in CTNNB1 encoding -catenin underlie the etiology of the majority, if not all ACP tumors. Genetic studies in mice have shown that ACPs are tumors of the pituitary gland and not of the hypothalamus as previously thought, and are derived from Rathke’s pouch precursors. In addition, a role for tissue-specific adult pituitary stem cells has been revealed as causative of ACP. Together, these studies have provided novel insights into the molecular and cellular etiology as well as the pathogenesis of human ACP. Finally, this volume covers new treatment approaches that have been shown to be effective both in reducing ACP burden as well as reducing the morbidity associated with therapy.

Atlas of Pediatric Brain Tumors

Author : Adekunle M. Adesina
Publisher : Springer
ISBN 13 : 3319334328
Total Pages : 327 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Atlas of Pediatric Brain Tumors by : Adekunle M. Adesina

Download or read book Atlas of Pediatric Brain Tumors written by Adekunle M. Adesina and published by Springer. This book was released on 2016-10-03 with total page 327 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text was created to fill a void in the practice of pediatric neuropathology. It is a practical and well-illustrated book representing a collection of interesting, common and unusual tumors for a diagnostic exercise by the reader. The wide reception of the first edition by the pathology community is testament to its relevance and utility in the pathologic diagnosis of pediatric brain tumors. This edition covers topics ranging from neuroimaging, the use of crush and touch preps during intraoperative consultation, classic histological features of pediatric brain tumors, tumor variants, and a miscellaneous group of challenging tumors. Chapters consist of essential diagnostic information and features highlighting recognized variants and their differential diagnoses. A section on molecular pathology and electron microscopy is also included for each tumor category, along with a list of classic reviews and innovative articles on each of the tumor entities as suggested reading at the end of each chapter. Atlas of Pediatric Brain Tumors, Second Edition represents the state of the art in pediatric neuropathology with easy utility beside the microscope.

Neuropathology of Brain Tumors with Radiologic Correlates

Author : Meghana Chougule
Publisher : Springer Nature
ISBN 13 : 9811571260
Total Pages : 361 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Neuropathology of Brain Tumors with Radiologic Correlates by : Meghana Chougule

Download or read book Neuropathology of Brain Tumors with Radiologic Correlates written by Meghana Chougule and published by Springer Nature. This book was released on 2020-10-17 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: This highly illustrated book explores the pathological and radiological diagnosis of various brain tumors. Featuring nearly 500 high-quality colored images, it covers MR images, intra-operative squash cytology, histopathology and immunohistochemistry microphotographs of various brain and spine tumors, including differential diagnosis, as well as the molecular diagnosis and prognosis of each tumor. The book also presents case studies of typical and rare presentations, and introduces readers to a new procedure for intra-operative cytology: the modified fields stain, which stains the slide within 2 minutes, allowing quick, accurate reporting. This book uses concise text and a consistent point-wise format that makes reading and reviewing easy. The radiological and pathological correlates of brain and spine tumors serve as a ready-reference resource for residents, surgical and neuropathologists, neuroradiologists, neurosurgeons, neuro-oncologists and research scientists.

Adult Craniopharyngiomas

Author : Emmanuel Jouanneau
Publisher : Springer Nature
ISBN 13 : 3030411761
Total Pages : 233 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Adult Craniopharyngiomas by : Emmanuel Jouanneau

Download or read book Adult Craniopharyngiomas written by Emmanuel Jouanneau and published by Springer Nature. This book was released on 2020-04-09 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume focuses on adult craniopharyngiomas, offering various perspectives. The first part of the book provides an up-to-date overview of the pathogenesis and management of adult craniopharyngiomas, helping readers understand the pathogenesis and molecular pathways. It highlights the importance of animal models for addressing molecular keys and for developing targeted therapies. The second part deals with clinical management, detailing the latest results in the era of endoscopic surgery, including the major contribution of the extended nasal endoscopic approaches for suprasellar and retrochiasmatic tumors. The book also discusses the key aspects of these tumors and how to manage them. The last part of the book addresses the future therapies and recurrences after surgery and radiotherapy. This volume is of interest to neurosurgeons, endocrinologists, paediatricians, radiologists and oncologists.

Principles of Neurological Surgery E-Book

Author : Richard Ellenbogen
Publisher : Elsevier Health Sciences
ISBN 13 : 0323461271
Total Pages : 1063 pages
Book Rating : 4.3/5 (234 download)

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Book Synopsis Principles of Neurological Surgery E-Book by : Richard Ellenbogen

Download or read book Principles of Neurological Surgery E-Book written by Richard Ellenbogen and published by Elsevier Health Sciences. This book was released on 2017-12-13 with total page 1063 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perfect for anyone considering or training in this challenging specialty, Principles of Neurological Surgery, 4th Edition, by Drs. Richard G. Ellenbogen, Laligam N. Sekhar, and Neil Kitchen, provides a clear, superbly illustrated introduction to all aspects of neurosurgery–from general principles to specific techniques. Thorough updates from leading authors ensure that you'll stay abreast of the latest advances in every area of neurosurgery, including pre- and post-operative patient care, neuroradiology, pediatric neurosurgery, neurovascular surgery, trauma surgery, spine surgery, oncology, pituitary adenomas, cranial base neurosurgery, image-guided neurosurgery, treatment of pain, epilepsy surgery, and much more. - Offers comprehensive coverage without being encyclopedic – just the right amount of information for those in training or who need an introduction to the field. - Provides a strong visual understanding of the essentials of neurosurgery with abundant high-quality illustrations, including imaging, pathology, clinical and operative photographs, surgical line drawings, diagrams, tables, and figures. - Presents information in an easy-to-understand, well-written manner, helping you quickly grasp the principles and problems of today's neurosurgery. - Features new and improved videos, more emphasis on anatomy and radiology, and new evidence and techniques, keeping you up to date with the latest advances in the field. - Expert ConsultTM eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Evidence based practice in Neuro-oncology

Author : Supriya Mallick
Publisher : Springer Nature
ISBN 13 : 9811626596
Total Pages : 423 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Evidence based practice in Neuro-oncology by : Supriya Mallick

Download or read book Evidence based practice in Neuro-oncology written by Supriya Mallick and published by Springer Nature. This book was released on 2021-07-24 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides evidence-based management in neuro-oncology covering all aspects such as pathology, radiology, surgery, radiation, and chemotherapy.The field of neuro-oncology is rapidly evolving and new evidence is coming out every day towards the optimal management of brain tumors. This necessitates a requirement of a complete guide that shall provide an evidence-based and personalized approach towards dealing with patients. This book also covers recent advances in personalized treatment formed through the relevant basis of anatomy, imaging, radiology, surgical, radiation and systemic treatment of brain and spinal tumors. In addition it also covers the , practical aspects of the planning of the Gamma knife and other radio surgical aspects. The book shall provide valuable assistance to practicing neuro-oncologists to practice better evidence-based personalized medicine.

Oxford Textbook of Neurological Surgery

Author : Ramez Kirollos
Publisher : Oxford University Press, USA
ISBN 13 : 0198746709
Total Pages : 1177 pages
Book Rating : 4.1/5 (987 download)

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Book Synopsis Oxford Textbook of Neurological Surgery by : Ramez Kirollos

Download or read book Oxford Textbook of Neurological Surgery written by Ramez Kirollos and published by Oxford University Press, USA. This book was released on 2019-09-05 with total page 1177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurosurgery is a rapidly developing and technically demanding branch of surgery that requires a detailed knowledge of the basic neuro-sciences and a thorough clinical approach. The Oxford Textbook of Neurological Surgery is an up-to-date, objective and readable text that covers the full scope of neurosurgical practice. It is part of the Oxford Textbooks in Surgery series, edited by Professor Sir Peter Morris. The book is split into 20 overarching sections (Principles of Neurosurgery, Neuro-oncology of Intrinsic Tumours; Extra-axial Tumours and Skull Lesions; Cerebro-Pontine Angle Tumours; Sellar and Supra-Sellar Tumours; Posterior Fossa Tumours; Pineal tumours; Uncommon Tumours and Tumour Syndromes; Neurotrauma and Intensive Care; Vascular Neurosurgery; Principles of Spinal Surgery; Spinal Pathology; Spinal Trauma; Peripheral Nerve Surgery; Functional Neurosurgery; Epilepsy; Paediatric Neurosurgery; Neurosurgery for Cerebrospinal Fluid Disorders and Neurosurgical Infection). Each section takes a dual approach with, 'Generic Surgical Management' chapters that focus on specific clinical problems facing the neurosurgeon (e.g. sellar/supra-sellar tumour, Intradural Spina Tumours etc.) and 'Pathology-Specific' chapters (e.g. Glioma, Meningeal Tumours, Scoliosis and Spinal Deformity, Aneurysm etc.). Where appropriate, this division provides the reader with easily accessible information for both clinical problems which present in a regional fashion and specific pathologies. The generic chapters cover aspects such as operative approaches, neuroanatomy and nuances. Specifically each chapter in the book incorporates several strands. Firstly the fundamental neuroscience (anatomy, pathology, genetics etc.) that underlies the clinical practice. Secondly, a review of the requisite clinical investigations (e.g. angiography, electrodiagnostics, radiology). Thirdly, a thorough evidence based review of clinical practice. Following this a consideration of the key debates and controversies in the field with 'pro-' and 'con-' sections (e.g. minimally invasive spine surgery, microsurgical treatment of aneurysms) is provided. A summary of the key papers and clinical scales relevant to neurosurgery form the concluding part. The book is a 'one-stop' text for trainees and consultants in neurosurgery, residents, those preparing for sub-specialty exams and other professionals allied to surgery who need to gain an understanding of the field. It acts as both a point of reference to provide a focussed refresher for the experienced neurosurgeon as well as a trusted training resource.

Pituitary Disorders of Childhood

Author : Brenda Kohn
Publisher : Springer
ISBN 13 : 3030113396
Total Pages : 358 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Pituitary Disorders of Childhood by : Brenda Kohn

Download or read book Pituitary Disorders of Childhood written by Brenda Kohn and published by Springer. This book was released on 2019-03-27 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book presents an up-to-date discussion of clinical disorders of the pituitary gland in children with specific emphasis on state-of-the-art diagnostic and treatment modalities, highlighting the newest scientific advances in genomics and molecular biology that clinician-scientists caring for children need to know. Chapters focus on the current knowledge base in genomics, pathophysiology, diagnosis, and medical and surgical management, organized into thematic sections. Part I discusses embryologic and genetic disorders, including genomics and congenital disorders of the pituitary. Part II presents acquired pituitary disorders, such as prolactinomas, Cushing's Disease, and both hormone secreting and non-secreting pituitary tumors. Subsequent sections cover posterior pituitary disorders, such as diabetes insipidus, functional hormone deficiencies of the hypothalamic-pituitary axis, including delayed puberty and pubertal disorders and growth hormone disorders, neuro-opthalmic disease, CNS radiation, childhood cancer treatment and traumatic brain injury. Authoritative and comprehensive, Pituitary Disorders of Childhood will serve as a precise guide for clinical endocrinologists and will guide future investigation into translational and clinical research on the pediatric pituitary.

Epidemiology of Brain and Spinal Tumors

Author : Jahangir Moini
Publisher : Academic Press
ISBN 13 : 0128217553
Total Pages : 554 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Epidemiology of Brain and Spinal Tumors by : Jahangir Moini

Download or read book Epidemiology of Brain and Spinal Tumors written by Jahangir Moini and published by Academic Press. This book was released on 2021-04-09 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. - Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others - Includes full color figures, photos, tables, graphs and radioimaging - Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors - Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment

Epidemiology of Endocrine Tumors

Author : Jahangir Moini
Publisher : Elsevier
ISBN 13 : 0128232668
Total Pages : 570 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Epidemiology of Endocrine Tumors by : Jahangir Moini

Download or read book Epidemiology of Endocrine Tumors written by Jahangir Moini and published by Elsevier. This book was released on 2021-03-03 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology. - Supplies information about the epidemiology of various endocrine tumors, both benign and malignant, to endocrinologists, oncologists and related health care professionals - Focuses on the impact upon costs and patient deaths due to complications of these tumors - Describes how endocrine tumors affect various age groups and ethnicities, discussing the prevention of endocrine tumors - Presents chapters on Cancer Problem, Specific Endocrine Tumors, Prevention, Detection and Diagnosis, and Treatment of Endocrine Tumors - Provides review questions with an answer key and detailed glossary

Intracranial and Spinal Radiotherapy

Author : Lia M. Halasz
Publisher : Springer Nature
ISBN 13 : 3030645088
Total Pages : 208 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Intracranial and Spinal Radiotherapy by : Lia M. Halasz

Download or read book Intracranial and Spinal Radiotherapy written by Lia M. Halasz and published by Springer Nature. This book was released on 2021-03-08 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical, up-to-date guide to the treatment of patients with brain and spinal tumors. Leading experts in the field explain treatment techniques in detail, highlighting key considerations in the use of external beam radiation therapy, intensity-modulated radiation therapy, particle therapy, radiosurgery, and stereotactic body radiation therapy. Specific recommendations are described for different tumor types, and helpful information provided on other important issues, such as the interaction of radiotherapy and systemic therapy and the avoidance of treatment complications. With the development of modern technology, highly conformal radiotherapy techniques have become more complicated, yet also more widely employed. This book will equip readers with the knowledge required to set up practices to deliver quality brain and spinal radiation therapy appropriate to each patient. It will be of benefit to radiation oncologists, clinical oncologists, medical physicists, medical dosimetrists, radiation therapists, and senior nurses as well as medical oncologists and surgical oncologists with an interest in radiotherapy.

Endocrine and Metabolic Late Effects in Cancer Survivors

Author : Francesco Felicetti (Oncologist)
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318067911
Total Pages : 169 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Endocrine and Metabolic Late Effects in Cancer Survivors by : Francesco Felicetti (Oncologist)

Download or read book Endocrine and Metabolic Late Effects in Cancer Survivors written by Francesco Felicetti (Oncologist) and published by Karger Medical and Scientific Publishers. This book was released on 2021-11 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book analyzes in detail all aspects related to endocrine and metabolic late effects observed in patients treated for cancer, both in childhood and adulthood. The chapters focusing on the possible pathogenic mechanisms of late effects (i.e., premature aging and chronic inflammation) and on bone health in cancer survivors are particularly interesting and innovative. The volume also deals with hypothalamic-pituitary, thyroid and gonadal disorders, including infertility and how to prevent it. Finally, the relationship between metabolic alterations and cardiovascular diseases in cancer survivors is addressed. Thanks to advances in cancer treatment and supportive care, the five-year survival rate of cancer patients is constantly increasing. However, this undisputable success of medicine has a flip side: the late adverse effects of anticancer therapies. Pediatric oncologists were the first to cope with late complications of treatments, but today also adult oncologists and onco-hematologists recognize the relevance of this issue. Even though late effects observed in cancer survivors can affect any organ or system, endocrine and metabolic dysfunctions are the most frequently reported. Endocrine complications rarely influence life expectancy of cancer survivors, but they can significantly impact morbidity and quality of life. Among endocrine adverse effects, severe hypothalamic damage may be considered the most harmful in survivors, leading to morbid obesity, propensity to metabolic syndrome and cardiovascular disease. This book aims to disseminate the knowledge about endocrine and metabolic adverse effects of cancer therapies and about survivorship care. Since the number of cancer survivors is steadily growing in the general population, this publication is intended not only for endocrinologists but also for oncologists, onco-hematologists, internists, pediatric specialists in those areas and general practitioners, with the aim to better counsel and monitor cancer survivors.

Atlas of Gross Neuropathology Book and Online Bundle

Author : Kathreena M. Kurian
Publisher : Cambridge University Press
ISBN 13 : 1107038162
Total Pages : 243 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Atlas of Gross Neuropathology Book and Online Bundle by : Kathreena M. Kurian

Download or read book Atlas of Gross Neuropathology Book and Online Bundle written by Kathreena M. Kurian and published by Cambridge University Press. This book was released on 2014-08-21 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Unparalleled access to the entire central nervous system with over four hundred gross neuropathology images from adult and paediatric post-mortem tissues.

Differential Diagnosis in Cytopathology Book and Online Bundle

Author : Paolo Gattuso
Publisher : Cambridge University Press
ISBN 13 : 1107040299
Total Pages : 695 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Differential Diagnosis in Cytopathology Book and Online Bundle by : Paolo Gattuso

Download or read book Differential Diagnosis in Cytopathology Book and Online Bundle written by Paolo Gattuso and published by Cambridge University Press. This book was released on 2014-12-04 with total page 695 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated edition remains the essential text for pathologists seeking to make accurate diagnoses from the vast number of differentials.

Obesity and Mental Disorders

Author : Susan L. McElroy
Publisher : CRC Press
ISBN 13 : 0849374510
Total Pages : 487 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Obesity and Mental Disorders by : Susan L. McElroy

Download or read book Obesity and Mental Disorders written by Susan L. McElroy and published by CRC Press. This book was released on 2006-01-13 with total page 487 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently, there are a limited amount of guidelines to help clinicians manage patients with obesity and comorbid mental disorders. This expertly written source fills the gap in the literature by providing a clear overview of obesity and its relationship to mental illness while reviewing the most recent methods to manage and control the condition wi

Diagnostic Pathology: Neuropathology E-Book

Author : B.K. Kleinschmidt-DeMasters
Publisher : Elsevier Health Sciences
ISBN 13 : 0323713319
Total Pages : 1035 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Diagnostic Pathology: Neuropathology E-Book by : B.K. Kleinschmidt-DeMasters

Download or read book Diagnostic Pathology: Neuropathology E-Book written by B.K. Kleinschmidt-DeMasters and published by Elsevier Health Sciences. This book was released on 2022-02-07 with total page 1035 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering all aspects of neuropathology, this updated volume in the Diagnostic Pathology series is an excellent point-of-care resource for pathologists at all levels of experience and training—both as a quick reference and as an efficient review to improve knowledge and skills. The third edition is an easy-to-use, one-stop reference for the most recent clinical, pathological, histological, and molecular knowledge in the field. It offers complete information on lesions of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, vascular, and cortical dysplastic lesions, enabling you to arrive at the correct diagnosis and prepare actionable, useful reports. - Incorporates new WHO Classification of Tumors of the Central Nervous System, 5th Edition - Offers information on neoplasms of the brain, sellar region, and peripheral nerves, as well as benign cysts and selected infectious, inflammatory, reactive, and vascular lesions, aiding you in arriving at the correct diagnosis - Emphasizes surgical pathology but also provides significant content on nonneoplastic diseases that present with focal lesions, especially those that are potentially misinterpreted as neoplasms - Contains a detailed molecular diagnostics chapter with a section on methylation profiling, which has become indispensable as a method of tumor classification - Features new and updated chapters detailing several types of tumors that have been reclassified due to recent molecular driver information, cIMPACT-NOW recommendations, and the WHO Classification, 5th Edition

Childhood Cancer and Functional Impacts Across the Care Continuum

Author : National Academies of Sciences Engineering and Medicine
Publisher :
ISBN 13 : 9780309683494
Total Pages : pages
Book Rating : 4.6/5 (834 download)

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Book Synopsis Childhood Cancer and Functional Impacts Across the Care Continuum by : National Academies of Sciences Engineering and Medicine

Download or read book Childhood Cancer and Functional Impacts Across the Care Continuum written by National Academies of Sciences Engineering and Medicine and published by . This book was released on 2021-09-09 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the late 1960s, the survival rate in children and adolescents diagnosed with cancer has steadily improved, with a corresponding decline in the cancer-specific death rate. Although the improvements in survival are encouraging, they have come at the cost of acute, chronic, and late adverse effects precipitated by the toxicities associated with the individual or combined use of different types of treatment (e.g., surgery, radiation, chemotherapy). In some cases, the impairments resulting from cancer and its treatment are severe enough to qualify a child for U.S. Social Security Administration disability benefits. At the request of Social Security Administration, Childhood Cancer and Functional Impacts Across the Care Continuum provides current information and findings and conclusions regarding the diagnosis, treatment, and prognosis of selected childhood cancers, including different types of malignant solid tumors, and the effect of those cancers on childrenâ (TM)s health and functional capacity, including the relative levels of functional limitation typically associated with the cancers and their treatment. This report also provides a summary of selected treatments currently being studied in clinical trials and identifies any limitations on the availability of these treatments, such as whether treatments are available only in certain geographic areas.