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Approaches To The Enantioselective Total Synthesis Of The Natural Product Neoliacinic Acid
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Book Synopsis Approaches to the Enantioselective Total Synthesis of the Natural Product Neoliacinic Acid by : Steven D. Paget
Download or read book Approaches to the Enantioselective Total Synthesis of the Natural Product Neoliacinic Acid written by Steven D. Paget and published by . This book was released on 1997 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Chemical Synthesis by : Elias J. Corey
Download or read book Enantioselective Chemical Synthesis written by Elias J. Corey and published by Elsevier. This book was released on 2013-10-23 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by world-renowned and best-selling experts, Nobel Laureate E. J. Corey and Laszlo Kurti, Enantioselective Chemical Synthesis offers an authoritative and comprehensive overview of the field's progress; the processes and tools for key formations; future development for complex, stereocontrolled (enantiomeric or diastereoisomeric) molecules; and valuable examples of multi-step syntheses. Utilizing a color-coded scheme to illustrate chemical transformations, Enantioselective Chemical Synthesis provides clear explanation and guidance through vital asymmetrical syntheses and insight into the next steps for the field. Researchers, professionals, and academics will benefit from this valuable, thorough, and unique resource. - In Part I, the authors present clearly, comprehensively and concisely the most useful enantioselective processes available to synthetic chemists. - Part II provides an extensive discussion of the most logical ways to apply these new enantioselective methods to the planning of syntheses of stereochemically complex molecules. This hitherto neglected area is essential for the advancement of enantioselective synthesis to a more rational and powerful level. - Part III describes in detail many reaction sequences which have been used successfully for the construction of a wide variety of complex target molecules - Clearly explains stereochemical synthesis in theory and practice - Provides a handy tool box for scientists wishing to understand and apply chiral chemical synthesis - Describes almost 50 real life examples of asymmetric synthesis in practice and examines how the chiral centers were introduced at key synthetic stages
Book Synopsis Studies Towards the Total Synthesis of Neoliacinic Acid and Related Natural Products by : Carl Antony Baxter
Download or read book Studies Towards the Total Synthesis of Neoliacinic Acid and Related Natural Products written by Carl Antony Baxter and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies of Indanomycin, Neoliacinic Acid, and Nagilactone F by : Michael Eugene Kort
Download or read book Synthetic Studies of Indanomycin, Neoliacinic Acid, and Nagilactone F written by Michael Eugene Kort and published by . This book was released on 1994 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Synthesis of Beta-Amino Acids by : Eusebio Juaristi
Download or read book Enantioselective Synthesis of Beta-Amino Acids written by Eusebio Juaristi and published by John Wiley & Sons. This book was released on 2005-05-06 with total page 658 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers all facets of the synthesis of ß-amino acids As evidenced by an exponential increase in the literature published on the subject, interest in ß-amino acids has grown over the past several years. With major pharmaceutical applications, these amino acids are now studied across multiple lines of research, including combinatorial chemistry, medicinal chemistry, molecular design, proteomics, and others. This Second Edition of Enantioselective Synthesis of ß-Amino Acids updates reviews included in the First Edition while also covering new developments since its publication. The book presents detailed discussions of the most important methods for the synthesis of ß-amino acids. In most cases, the lead chemist who originally developed a method provides an authoritative description of it. In addition, Enantioselective Synthesis of ß-Amino Acids, Second Edition: * Features introductory overviews on the structural types of relevant ß-amino acid targets and salient ß-amino acids present in natural products * Dedicates several chapters to advances in the synthesis of oligomers from ß-amino acids * Includes general and practical procedures for the preparation of ß-amino acids in each chapter * Discusses the most important methods that have been recently developed for the asymmetric synthesis of cyclic and open-chain ß-amino acids * Includes a report on the preparation of libraries of enantiopure ß-amino acids using combinatorial approaches The only book of its kind available today, Enantioselective Synthesis of ß-Amino Acids, Second Edition offers upper-level students and professionals an essential resource for pharmaceutical development, medicinal chemistry, and biochemistry.
Book Synopsis An Approach to the Total Synthesis of Neoliacinic Acid, a Highly Oxygenated Sesquiterpene Lactone by : Alexander Graham Dossetter
Download or read book An Approach to the Total Synthesis of Neoliacinic Acid, a Highly Oxygenated Sesquiterpene Lactone written by Alexander Graham Dossetter and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1997 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Synthesis by : Tse-Lok Ho
Download or read book Enantioselective Synthesis written by Tse-Lok Ho and published by Wiley-Interscience. This book was released on 1992-02-18 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years the intense activities of enantioselective synthesis have been reflected in the burgeoning and ingenious applications of such natural substances as carbohydrates, -amino acids and terpenes. A comprehensive summary of terpene-based synthesis is offered, focusing on synthetic efforts using transformed chiral synthons. The author provides analysis of synthetic strategies and discusses the intricacies of reaction courses. Along with the number and variety of natural products derived from chiral terpenes, numerous flow-charts aid in clearly delineating synthetic pathways.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1998 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Approaches Toward the Enantioselective Total Synthesis of Amarogentic by : Anne Therese Stevens
Download or read book Approaches Toward the Enantioselective Total Synthesis of Amarogentic written by Anne Therese Stevens and published by . This book was released on 2001 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Enantioselective Total Synthesis Of Diverse, Bioactive Natural Products by :
Download or read book Enantioselective Total Synthesis Of Diverse, Bioactive Natural Products written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural product synthesis is one of the most creative branch of chemistry in terms of its boundless scope for innovation and has stimulated several generations of synthetic organic chemists. With advancement in the technology, particularly in the isolation and purification techniques, high-field NMR and X-ray crystallography, it has become fairly routine to isolate and assign the structures, high-field NMR and X-ray crystallography, it has become fairly routine to isolate and assign the structures, even to those complex molecules, which are available only in microscopic quantities from natural sources. Concurrently, one has witnessed tremendous advances in the availability of new synthetic methodologies with high region-, stereo-, and enantiocontrol for one or multiple C-C bond formations and rapid generation of molecular complexity. These developments have rekindled interest with total synthesis of natural products as platforms for testing and validating new reactions and strategies. Many natural products exhibit wide range of biological activities and thus provide good leads in drug discovery but quite often such bioactive compounds are obtained only in minute quantities from Nature. Hence, there is need to synthesize them to obtain requisite quantities and build diversity around their scaffold to further explore their therapeutic potential. Thus, natural product synthesis combines both intellectual challenge and possible application for human wellbeing. Our research group is actively engaged in the synthesis of structurally complex, bioactive natural products and as a part of this endeavour, total syntheses of several bioactive compounds have been accomplished in our laboratory in recent past. The present thesis has also evolved around the ongoing theme directed towards natural product synthesis and is organized under three chapters. Chapter I: Total synthesis of (+)-1S-Minwanenone Chapter II: Enantioselective total synthesis of the bioactive natural product (+)-
Book Synopsis Formation of Contiguous Stereogenic Quaternary Carbon Centers in Natural Products Synthesis by : Emily Anne Peterson
Download or read book Formation of Contiguous Stereogenic Quaternary Carbon Centers in Natural Products Synthesis written by Emily Anne Peterson and published by . This book was released on 2005 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of Novel Methods and Applications in Total Synthesis of Natural Products by : Gopal Sirasani
Download or read book Development of Novel Methods and Applications in Total Synthesis of Natural Products written by Gopal Sirasani and published by . This book was released on 2012 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: The olefin cross metathesis reaction has been sequenced with four common organic transformations in a one-pot manner to rapidly access useful building blocks. Those reactions are: (1) phosphorus-based olefination (e.g., Wittig and Horner- Wadsworth-Emmons); (2) hydride reduction; (3) Evans propionate aldol reaction; and (4) Brown allyl- and Roush crotylboration. The products of these reactions include stereodefined 2,4-dienoates, trans allylic alcohols, syn-propionate aldols and chiral non- racemic homoallylic alcohols, respectively, which can be carried further in the context of chemical synthesis. Two approaches toward the total synthesis of cytotoxic polyketide natural product (+)-crocacin C have been accomplished. The first-generation approach used a Crimmins aldol reaction and reagent-controlled double asymmetric crotylboration (Brown and Roush) reaction, which was not selective. The first-generation approach was replaced altogether with a second that afforded (+)-crocacin C in 10 steps from commercially available Evans' chiral propionimide (5% overall yield). The key reactions in the second-generation approach included an Evans dipropionamide aldol reaction, 1,3-anti reduction and a vinylogous Horner-Wadsworth- Emmons olefination. No protecting groups were utilized in the total synthesis of (+)- crocacin C. A novel method to access the ABCE tetracyclic framework of the Strychnos alkaloids has been developed. Five different strategies were utilized toward this goal, out of which the first four were unsuccessful. The fifth-generation strategy featured a novel sequential one-pot bis-cyclization method. Specifically, the AgOTf-mediated spirocyclization of an appropriately functionalized indole 3-carbinamide afforded a stable spiroindolenine intermediate; subsequent addition of DBU to the reaction mixture effected an unprecedented intramolecular aza-Baylis-Hillman reaction, delivering tetracyclic product in 70% isolated yield. The bis-cyclization was showcased in concise racemic total syntheses of akuammicine and strychnine in six and thirteen operations, respectively. Key steps include (1) the vinylogous Mannich reaction; (2) our sequential one-pot spirocyclization/intramolecular aza-Baylis-Hillman reaction; and (3) a Heck cyclization. The synthesis of strychnine proceeded via the Wieland-Gumlich aldehyde. We have also utilized our method to prepare other biologically active Strychnos alkaloids (-)- akuammicine, (-)-leuconicines A and B, (-)-norfluorocurarine, (-)-dehydrotubifoline, (-)- dihydroakuammicine, (-)-tubifoline and (-)-valparicine in a concise, asymmetric manner.
Book Synopsis Enantioselective Total Synthesis Of Bioactive Epoxyquinoid Natural Products by :
Download or read book Enantioselective Total Synthesis Of Bioactive Epoxyquinoid Natural Products written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Total synthesis of natural products with diverse architecture and varying degree of complexity is an area that has not only inspired and attracted several generations of organic chemists but also continues to enrich and refresh the foundations of organic chemistry itself, by offering new ideas and directions. Synthetic organic chemistry is perhaps the most formative and expressive enterprise of science in terms of its creative power and unlimited scope. Its impact on present day life and prosperity gets manifested when we see this science as the bedrock behind the production of pharmaceuticals, pesticides, fertilizers, nutritional products, high tech materials, polymers, cosmetics, plastics and clothing. Science of synthesis is also going to play an important role in the evolution of future societies based on the principles of the sustainable development. Being a precise science and a fine art, the endeavor of total synthesis is in a constant state of effervescence. Most significantly, the discipline is being continually challenged by new structures unraveled from the Nature bosom. The practice of total synthesis is being enriched constantly by new tools such as new reagents and catalysts as well as by analytical techniques. In fact, there has been a dramatic advancement in the recent past in the development of new synthetic protocols with high regio-, streo-, and enantiocontrol, which makes it possible to target natural product of any complexity. The demand for enantiomerically pure drugs, agrochemicals and food additives is growing, since pure enantiomers are often more target-specific and have fewer side effects than the recemic mixtures. As a result, synthesis of natural products in an enantioselective manner has been receiving increasing attention from synthetic chemists in recent years. Nature synthesizes a vast array of novel molecular structures in enantioselective fashion through several well-established biosynthetic pathways utilizing a few key building.
Book Synopsis Part I, the Enantioselective Total Synthesis of Antiulcerogenic Compound ( - ) Cassioside by : Yugang Liu
Download or read book Part I, the Enantioselective Total Synthesis of Antiulcerogenic Compound ( - ) Cassioside written by Yugang Liu and published by . This book was released on 1997 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards by :
Download or read book Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 2006 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis British National Bibliography for Report Literature by :
Download or read book British National Bibliography for Report Literature written by and published by . This book was released on 1998-07 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt:
