Applications Of Nanomaterials In Sensors And Diagnostics

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Applications of Nanomaterials in Sensors and Diagnostics

Author : Adisorn Tuantranont
Publisher : Springer Science & Business Media
ISBN 13 : 3642360254
Total Pages : 285 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Applications of Nanomaterials in Sensors and Diagnostics by : Adisorn Tuantranont

Download or read book Applications of Nanomaterials in Sensors and Diagnostics written by Adisorn Tuantranont and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent progress in the synthesis of nanomaterials and our fundamental understanding of their properties has led to significant advances in nanomaterial-based gas, chemical and biological sensors. Leading experts around the world highlight the latest findings on a wide range of nanomaterials including nanoparticles, quantum dots, carbon nanotubes, molecularly imprinted nanostructures or plastibodies, nanometals, DNA-based structures, smart nanomaterials, nanoprobes, magnetic nanomaterials, organic molecules like phthalocyanines and porphyrins, and the most amazing novel nanomaterial, called graphene. Various sensing techniques such as nanoscaled electrochemical detection, functional nanomaterial-amplified optical assays, colorimetry, fluorescence and electrochemiluminescence, as well as biomedical diagnosis applications, e.g. for cancer and bone disease, are thoroughly reviewed and explained in detail. This volume will provide an invaluable source of information for scientists working in the field of nanomaterial-based technology as well as for advanced students in analytical chemistry, biochemistry, electrochemistry, material science, micro- and nanotechnology.

Biosensors and Nanotechnology

Author : Zeynep Altintas
Publisher : John Wiley & Sons
ISBN 13 : 1119065011
Total Pages : 421 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Biosensors and Nanotechnology by : Zeynep Altintas

Download or read book Biosensors and Nanotechnology written by Zeynep Altintas and published by John Wiley & Sons. This book was released on 2017-12-18 with total page 421 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a broad range of information from basic principles to advanced applications of biosensors and nanomaterials in health care diagnostics This book utilizes a multidisciplinary approach to provide a wide range of information on biosensors and the impact of nanotechnology on the development of biosensors for health care. It offers a solid background on biosensors, recognition receptors, biomarkers, and disease diagnostics. An overview of biosensor-based health care applications is addressed. Nanomaterial applications in biosensors and diagnostics are included, covering the application of nanoparticles, magnetic nanomaterials, quantum dots, carbon nanotubes, graphene, and molecularly imprinted nanostructures. The topic of organ-specific health care systems utilizing biosensors is also incorporated to provide deep insight into the very recent advances in disease diagnostics. Biosensors and Nanotechnology: Applications in Health Care Diagnostics is comprised of 15 chapters that are presented in four sections and written by 33 researchers who are actively working in Germany, the United Kingdom, Italy, Turkey, Denmark, Finland, Romania, Malaysia and Brazil. It covers biomarkers in healthcare; microfluidics in medical diagnostics; SPR-based biosensor techniques; piezoelectric-based biosensor technologies; MEMS-based cell counting methods; lab-on-chip platforms; optical applications for cancer cases; and more. Discusses the latest technology and advances in the field of biosensors and their applications for healthcare diagnostics Particular focus on biosensors for cancer Summarizes research of the last 30 years, relating it to state-of-the-art technologies Biosensors and Nanotechnology: Applications in Health Care Diagnostics is an excellent book for researchers, scientists, regulators, consultants, and engineers in the field, as well as for graduate students studying the subject.

Nanomaterials in Diagnostic Tools and Devices

Author : Suvardhan Kanchi
Publisher : Elsevier
ISBN 13 : 0128179244
Total Pages : 618 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Nanomaterials in Diagnostic Tools and Devices by : Suvardhan Kanchi

Download or read book Nanomaterials in Diagnostic Tools and Devices written by Suvardhan Kanchi and published by Elsevier. This book was released on 2020-06-04 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials in Diagnostic Tools and Devices provides a complete overview of the significance of nanomaterials in fabricating selective and performance enhanced nanodevices. It is an interdisciplinary reference that includes contributing subjects from nanomaterials, biosensors, materials science, biomedical instrumentation and medicinal chemistry. This book is authored by experts in the field of nanomaterial synthesis, modeling, and biosensor applications, and provides insight to readers working in various science fields on the latest advancements in smart and miniaturized nanodevices. These devices enable convenient real-time diagnosis of diseases at clinics rather than laboratories, and include implantable devices that cause less irritation and have improved functionality. Research in the field of nanomaterials is growing rapidly, creating a significant impact across different science disciplines and nanotechnology industries. This synthesis and modeling of nanomaterials has led to many technology breakthroughs and applications, especially in medical science. Provides a distinctive platform for the latest trends in the synthesis of smart nanomaterials for nanodevices in disease diagnostics Presents a broad range of advancements and applications of lateral-flow nanostrip for point-of-care applications Examines smart-phone based nanodevices for field-based diagnosis with accurate information Comprises more than 70 figures and illustrations that will help readers visualize and easily understand the role of nanodevices in the field of nanomedicine Serves as an ideal reference for those studying smart nanomaterials, biosensors, and nanodevices for real-time and in-situ clinical diagnosis and drug delivery

Nanobiotechnology for Sensing Applications

Author : Ajeet Kumar Kaushik
Publisher : CRC Press
ISBN 13 : 1315342200
Total Pages : 386 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Nanobiotechnology for Sensing Applications by : Ajeet Kumar Kaushik

Download or read book Nanobiotechnology for Sensing Applications written by Ajeet Kumar Kaushik and published by CRC Press. This book was released on 2016-11-03 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the potential of nanosystems as a multidisciplinary science with the aim of the design and development of smart sensing technologies using micro/nano electrodes and novel nanosensing material. It discusses their integration with MEMS, miniaturized transduction systems, novel sensing strategies, and wearable sensors performing at POC for diagnostics and personalized health care monitoring. It presents basic concepts pertaining to nanobiosensor fabrication, developments in the field of smart nanomaterials, nano-enabling technologies, micro-nano hybrind platforms, and their applications in healthcare.

Nanobiosensors for Personalized and Onsite Biomedical Diagnosis

Author : Pranjal Chandra
Publisher : IET
ISBN 13 : 1849199507
Total Pages : 637 pages
Book Rating : 4.8/5 (491 download)

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Book Synopsis Nanobiosensors for Personalized and Onsite Biomedical Diagnosis by : Pranjal Chandra

Download or read book Nanobiosensors for Personalized and Onsite Biomedical Diagnosis written by Pranjal Chandra and published by IET. This book was released on 2016-07-21 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: The critical goal of nanobiosensors is to detect any biochemical and/or biophysical signal related to a specific disease at the level of a single or few molecules. Nanobiosensors have been successful for in vitro as well as in vivo detection of several biomolecules. It is expected that this technology will revolutionize point-of-care and personalized diagnostics, and will be extremely applicable for early disease detection. This book starts with a brief introduction of the biosensors and then focuses mainly on the emerging nanobiosensor technologies which are geared towards onsite clinical applications and those which can be used as a personalized diagnostic device. Written by an international team of researchers who are actively developing these technologies, Nanobiosensors for Personalized and Onsite Biomedical Diagnosis covers the latest advances in the field of biosensors and biosensing applications. This important book includes an assessment of some current and emerging technologies for detecting protein biomarkers and other potential cancer biomarkers and is essential reading for researchers and graduate students in the field. Medics including radiologists and clinicians will also find it invaluable.

Nanomaterials for Chemical Sensors and Biotechnology

Author : Pelagia-Irene Gouma
Publisher : Pan Stanford Publishing
ISBN 13 : 9814267112
Total Pages : 177 pages
Book Rating : 4.8/5 (142 download)

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Book Synopsis Nanomaterials for Chemical Sensors and Biotechnology by : Pelagia-Irene Gouma

Download or read book Nanomaterials for Chemical Sensors and Biotechnology written by Pelagia-Irene Gouma and published by Pan Stanford Publishing. This book was released on 2010 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Nanomaterials, Sensors, Nanomedicine, and BiotechnologyNanostructured Materials for Resistive SensorsMetal Oxide based ChemosensorsHybrid Nanomaterials for SensorsNanomedicine Applications of NanomaterialsNanomedicine Applications of SensorsOverview and Future Trends.

Nanotechnology-Enabled Sensors

Author : Kourosh Kalantar-zadeh
Publisher : Springer Science & Business Media
ISBN 13 : 0387680233
Total Pages : 492 pages
Book Rating : 4.3/5 (876 download)

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Book Synopsis Nanotechnology-Enabled Sensors by : Kourosh Kalantar-zadeh

Download or read book Nanotechnology-Enabled Sensors written by Kourosh Kalantar-zadeh and published by Springer Science & Business Media. This book was released on 2007-09-19 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology provides tools for creating functional materials, devices, and systems by controlling materials at the atomic and molecular scales and making use of novel properties and phenomena. Nanotechnology-enabled sensors find applications in several fields such as health and safety, medicine, process control and diagnostics. This book provides the reader with information on how nanotechnology enabled sensors are currently being used and how they will be used in the future in such diverse fields as communications, building and facilities, medicine, safety, and security, including both homeland defense and military operations.

Medical Biosensors for Point of Care (POC) Applications

Author : Roger J Narayan
Publisher : Woodhead Publishing
ISBN 13 : 0081000782
Total Pages : 316 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Medical Biosensors for Point of Care (POC) Applications by : Roger J Narayan

Download or read book Medical Biosensors for Point of Care (POC) Applications written by Roger J Narayan and published by Woodhead Publishing. This book was released on 2016-08-21 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical Biosensors for Point of Care (POC) Applications discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care. Part 1 covers the fundamentals of medical biosensors for point-of-care applications. Chapters in part 2 go on to look at materials and fabrication of medical biosensors while the next part looks at different technologies and operational techniques. The final set of chapters provide an overview of the current applications of this technology. Traditionally medical diagnostics have been dependent on sophisticated technologies which only trained professionals were able to operate. Recent research has focused on creating point-of-care diagnostic tools. These biosensors are miniaturised, portable, and are designed to be used at the point-of-care by untrained individuals, providing real-time and remote health monitoring. Provides essential knowledge for designers and manufacturers of biosensors for point-of-care applications Provides comprehensive coverage of the fundamentals, materials, technologies, and applications of medical biosensors for point-of-care applications Includes contributions from leading international researchers with extensive experience in developing medical biosensors Discusses advances in this important and emerging field which has the potential to transform patient diagnosis and care

Nanomaterials for Biosensors

Author : Bansi D. Malhotra
Publisher : William Andrew
ISBN 13 : 0128135158
Total Pages : 332 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Nanomaterials for Biosensors by : Bansi D. Malhotra

Download or read book Nanomaterials for Biosensors written by Bansi D. Malhotra and published by William Andrew. This book was released on 2017-10-26 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomaterials for Biosensors: Fundamentals and Applications provides a detailed summary of the main nanomaterials used in biosensing and their application. It covers recent developments in nanomaterials for the fabrication of biosensor devices for healthcare diagnostics, food freshness and bioprocessing. The various processes used for synthesis and characterization of nanostructured materials are examined, along with the design and fabrication of bioelectronic devices using nanostructured materials as building blocks. Users will find the fundamentals of the main nanomaterials used in biosensing, helping them visualize a systematic and coherent picture of how nanomaterials are used in biosensors. The book also addresses the role of bio-conjugation of nanomaterials in the construction of nano-biointerfaces for application in biosensors. Such applications, including metal nanoparticles, metal oxide nanoparticles, nanocomposites, carbon nanotubes, conducting polymers and plasmonic nanostructures in biosensing are discussed relative to each nanomaterial concerned. Finally, recent advancements in protein functionalized nanomaterials for cancer diagnostics and bio-imaging are also included. Provides a detailed study on how nanomaterials are used to enhance sensing capabilities in biosensors Explains the properties, characterization methods and preparation techniques of the nanomaterials used in biosensing Arranged in a material-by-material way, making it clear how each nanomaterial should be used

Nanomedicine in Diagnostics

Author : Noemi Rozlosnik
Publisher : CRC Press
ISBN 13 : 1439899444
Total Pages : 246 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Nanomedicine in Diagnostics by : Noemi Rozlosnik

Download or read book Nanomedicine in Diagnostics written by Noemi Rozlosnik and published by CRC Press. This book was released on 2012-03-20 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on new sensing concepts has opened the door to a wide variety of microsystems for clinical applications. Such devices are extremely useful for delivering diagnostic information in a fast, simple, and low cost fashion. This book is one of the first to focus on the use of nanotechnology in diagnostics. Designed as a broad survey of the field, this book combines contributions by international experts from divergent fields of study ranging from single molecule diagnostics to cell based systems.

Nanobiomaterial Engineering

Author : Pranjal Chandra
Publisher : Springer Nature
ISBN 13 : 9813298405
Total Pages : 302 pages
Book Rating : 4.8/5 (132 download)

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Book Synopsis Nanobiomaterial Engineering by : Pranjal Chandra

Download or read book Nanobiomaterial Engineering written by Pranjal Chandra and published by Springer Nature. This book was released on 2020-01-25 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book comprehensively documents the application of Nanobiomaterials in the field of bio-medicine and diagnostics technologies by involving classical concepts/examples. Nanobiotechnology is an emerging area which encompasses all the facets of research of nano and biomaterials with their interaction with biological systems. The book briefly summarizes the various types of Nanomaterial’s, and highlights the recent developments in the synthesis of the nanomaterials for the diagnostic and therapeutic biomedical applications. It skilfully reviews the utilization of the nanomaterials alone or in combination with other bio-molecules as a contrast enhancer in in-vivo imaging, Nano-Theranostics, drug delivery, and sensing transducer matrix. It also discusses the current research on designing of the new Nanobiomaterials and their implementation in numerous fields including bio-medicine and diagnostics. Finally, it summarizes the future prospects and the commercial viability of Nanobiomaterials in the human health care.

Biosensors Nanotechnology

Author : Ashutosh Tiwari
Publisher : John Wiley & Sons
ISBN 13 : 1118773810
Total Pages : 552 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis Biosensors Nanotechnology by : Ashutosh Tiwari

Download or read book Biosensors Nanotechnology written by Ashutosh Tiwari and published by John Wiley & Sons. This book was released on 2014-06-26 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed reviews of a range of nanostructures used in the construction of biosensors as well as the applications of these biosensor nanotechnologies in the biological, chemical, and environmental monitoring fields Biological sensing is a fundamental tool for understanding living systems, but also finds practical application in medicine, drug discovery, process control, food safety, environmental monitoring, defense, and personal security. Moreover, a deeper understanding of the bio/electronic interface leads us towards new horizons in areas such as bionics, power generation, and computing. Advances in telecommunications, expert systems, and distributed diagnostics prompt us to question the current ways we deliver healthcare, while robust industrial sensors enable new paradigms in R&D and production. Despite these advances, there is a glaring absence of suitably robust and convenient sensors for body chemistries. This book examines some of the emerging technologies that are fueling scientific discovery and underpinning new products to enhance the length and quality of our lives. The 14 chapters written by leading experts cover such topics as: ZnO and graphene microelectrode applications in biosensing Assembly of polymers/metal nanoparticles Gold nanoparticle-based electrochemical biosensors Impedimetric DNA sensing employing nanomaterials Graphene and carbon nanotube-based biosensors Computational nanochemistry study of the BFPF green fluorescent protein chromophore Biosynthesis of metal nanoparticles Bioconjugated-nanoporous gold films in electrochemical biosensors The combination of molecular imprinting and nanotechnology Principles and properties of multiferroics and ceramics

Advanced Nanomaterials for Point of Care Diagnosis and Therapy

Author : Sushma Dave
Publisher : Elsevier
ISBN 13 : 0323900666
Total Pages : 596 pages
Book Rating : 4.3/5 (239 download)

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Book Synopsis Advanced Nanomaterials for Point of Care Diagnosis and Therapy by : Sushma Dave

Download or read book Advanced Nanomaterials for Point of Care Diagnosis and Therapy written by Sushma Dave and published by Elsevier. This book was released on 2022-03-11 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Nanomaterials for Point of Care Diagnosis and Therapy provides an overview of technological and emerging novel trends in how point-of-care diagnostic devices are designed, miniaturized built, and delivered at different healthcare set ups. It describes the significant technological advances in fundamental diagnostic components and recent advances in fully integrated devices designed for specific clinical use. The book covers state-of-the-art fabrication of advances materials with broad spectrum therapeutic applications. It includes drug delivery, biosensing, bioimaging and targeting, and outlines the development of inexpensive, effective and portable in vitro diagnostics tools for any purpose that can be used onsite. Sections also discuss drug delivery, biosensing, bioimaging and targeting and various metal, metal oxide and non-metal-based nanomaterials that are developed, surface modified, and are being explored for diagnosis, targeting, drug delivery, drug release and imaging. The book concludes with current needs and future challenges in the field. Outlines the needs and challenges of point-of-care diagnostics Describes the fundamentals of application of nanomaterials as interesting building blocks for biosensing Overviews the different detection methods offered by using nanomaterials Explains the advantages and drawbacks of nanomaterial-based sensing strategies Describes the opportunities offered by technology as a cost-efficient biosensing platform

Advances in Nanosensors for Biological and Environmental Analysis

Author : Akash Deep
Publisher : Elsevier
ISBN 13 : 0128174579
Total Pages : 160 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Advances in Nanosensors for Biological and Environmental Analysis by : Akash Deep

Download or read book Advances in Nanosensors for Biological and Environmental Analysis written by Akash Deep and published by Elsevier. This book was released on 2019-06-14 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Nanosensors for Biological and Environmental Analysis presents the current state-of-art in nanosensors for biological and environmental analysis, also covering commercial aspects. Broadly, the book provides detailed information on the emergence of different types of nanomaterials as transduction platforms used in the development of nanosensors. These include carbon nanotubes, graphene, 2-D transition metal dichalcogenides, conducting polymers and metal organic frameworks. Additional topics include sections on the way nanosensors have inspired new product development in various types of biological and environmental applications that are currently available and on the horizon. Features detailed information on various types of biological and environmental nanosensors Gives particular attention to the different categories of advanced functional interfaces, processes for their development, and application areas Includes the current state-of-the-art in terms of commercial aspects

Advanced Biosensors for Health Care Applications

Author : Dr. Inamuddin
Publisher : Elsevier
ISBN 13 : 0128165227
Total Pages : 432 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Advanced Biosensors for Health Care Applications by : Dr. Inamuddin

Download or read book Advanced Biosensors for Health Care Applications written by Dr. Inamuddin and published by Elsevier. This book was released on 2019-06-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Biosensors for Health Care Applications highlights the different types of prognostic and diagnostic biomarkers associated with cancer, diabetes, Alzheimer's disease, brain and retinal diseases, cardiovascular diseases, bacterial infections, as well as various types of electrochemical biosensor techniques used for early detection of the potential biomarkers of these diseases. Many advanced nanomaterials have attracted intense interests with their unique optical and electrical properties, high stability, and good biocompatibility. Based on these properties, advanced nanoparticles have been used as biomolecular carriers, signal producers, and signal amplifiers in biosensor design. Recent studies reported that there are several diagnostic methods available, but the major issue is the sensitivity and selectivity of these approaches. This book outlines the need of novel strategies for developing new systems to retrieve health information of patients in real time. It explores the potential of nano-multidisciplinary science in the design and development of smart sensing technology using micro-nanoelectrodes, novel sensing materials, integration with MEMS, miniaturized transduction systems, novel sensing strategy, that is, FET, CMOS, System-on-a-Chip (SoC), Diagnostic-on-a-Chip (DoC), and Lab-on-a-Chip (LOC), for diagnostics and personalized health-care monitoring. It is a useful handbook for specialists in biotechnology and biochemical engineering. Describes advanced nanomaterials for biosensor applications Relates the properties of available nanomaterials to specific biomarkers applications Includes diagnosis and electrochemical studies based on biosensors Explores the potential of nano-multidisciplinary science to design and develop smart sensing technologies Describes novel strategies for developing a new class of assay systems to retrieve the desired health information

Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics

Author : Gorachand Dutta
Publisher : Springer Nature
ISBN 13 : 9811971307
Total Pages : 252 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics by : Gorachand Dutta

Download or read book Next-Generation Nanobiosensor Devices for Point-Of-Care Diagnostics written by Gorachand Dutta and published by Springer Nature. This book was released on 2022-12-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the potential of next-generation point-of-care diagnosis in healthcare. It also discusses the printed chip-based assay (Lab-on-a-Chip, Lab-on-a-PCB) for rapid, inexpensive biomarkers detection. The book presents the development of sensory systems based on the use of nanomaterials. It examines different biosensors for medical diagnosis using surface modification strategies of transducers. It presents electrochemical concepts based on different nanobiomaterials and nanocomposites for cancer theranostics. Notably, the book examines the recent advances in wearable, cost-effective hemodynamic sensors to detect diseases at an early stage. It further explores the combination of redox cycling and electrochemical detection to develop ultrasensitive and reproducible biosensors for point-of-care testing. Finally, the book summarizes the significant challenges in the point of care diagnostics and its future opportunities in healthcare.

Disposable Electrochemical Sensors for Healthcare Monitoring

Author : Dr A. Pandikumar
Publisher : Royal Society of Chemistry
ISBN 13 : 1839163143
Total Pages : 466 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Disposable Electrochemical Sensors for Healthcare Monitoring by : Dr A. Pandikumar

Download or read book Disposable Electrochemical Sensors for Healthcare Monitoring written by Dr A. Pandikumar and published by Royal Society of Chemistry. This book was released on 2021-05-05 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disposable electrodes have been widely used as a sensing platform in electrical and electrochemical sensors owing to the possibility of quantitative detection using clinical biomarkers with high precision, sensitivity and reproducibility, which are necessary for accurate diagnosis of the health condition of an individual. This book focusses on the emerging disposable electrochemical sensors in the health sector and the advancement of analytical devices to monitor diabetic, cancer and cardiovascular patients using different nanomaterials. It discusses the upcoming strategies, advantages and the limitations of the existing devices using disposable electrodes. Uniquely, it covers in-depth knowledge of mechanistic features of various designs of screen-printing electrodes and the material aspects required of sensors developed for the healthcare field. It also looks at the portable devices using a variety of materials and the future directions for research in this area. Appealing to the health care industry, this book is aimed at academic and research institutes at both the graduate and postgraduate level. The contributors are leading experts in the field and they are providing guidance for the next decade of research in the field of disposable electrochemical biosensors.