Application Of Sulfonium And Sulfoxonium Ylides In Organocatalyzed Asymmetric Reaction

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Application of sulfonium and sulfoxonium ylides in organocatalyzed asymmetric reaction

Author : Zhen-Hua Wang
Publisher : OAE Publishing Inc.
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4./5 ( download)

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Book Synopsis Application of sulfonium and sulfoxonium ylides in organocatalyzed asymmetric reaction by : Zhen-Hua Wang

Download or read book Application of sulfonium and sulfoxonium ylides in organocatalyzed asymmetric reaction written by Zhen-Hua Wang and published by OAE Publishing Inc.. This book was released on 2023-03-01 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sulfur-based ylides are very important and valuable reagents in organic synthesis and have been widely applied in the preparation of cyclic compounds and the formation of C-X (X = C, N, O, S, B, P) bond. Since the early 2000s, asymmetric organocatalysis has become a powerful strategy in organic synthesis (even highlighted by the 2021 Nobel Prize in Chemistry) and has attracted widespread research interest among synthetic organic chemists. In this area, a large number of outstanding achievements have been registered in the novel chiral catalysts design, new compounds synthesis, various reagents application, and versatile reaction discovery. Given the extensive application of sulfonium and sulfoxonium ylides in organic synthesis, in this review, we mainly summarize the organocatalyzed asymmetric reactions involving these ylide reagents as one of the reactants. Detailed reaction mechanisms, transition states and some synthetic applications are highlighted. The challenges and opportunities of this field are also discussed in the outlook.

Organosulfur Chemistry in Asymmetric Synthesis

Author : Takeshi Toru
Publisher : John Wiley & Sons
ISBN 13 : 3527623248
Total Pages : 448 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Organosulfur Chemistry in Asymmetric Synthesis by : Takeshi Toru

Download or read book Organosulfur Chemistry in Asymmetric Synthesis written by Takeshi Toru and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this first book to gather the information on this hot topic otherwise widely spread throughout the literature, experienced editors and top international authors cover everything the reader needs -- from the synthesis of chiral organosulfur compounds to applications and catalysis: * Asymmetric synthesis of chiral sulfinates and sulfoxides * Synthesis and use of chiral dithioacetal derivatives, ylids, chiral sulfoximines and sulfinamides * Use of chiral sulfoxides as ligands in catalysis * Asymmetric reactions of alpha-sulfenyl, alpha-sulfinyl and alpha-sulfonyl carbanions. As a result, readers will be able to improve their own performance in asymmetric synthesis.

Comprehensive Chirality

Author :
Publisher : Newnes
ISBN 13 : 0080951686
Total Pages : 5635 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Comprehensive Chirality by :

Download or read book Comprehensive Chirality written by and published by Newnes. This book was released on 2012-12-31 with total page 5635 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although many books exist on the subject of chiral chemistry, they only briefly cover chiral synthesis and analysis as a minor part of a larger work, to date there are none that pull together the background information and latest advances in one comprehensive reference work. Comprehensive Chirality provides a complete overview of the field, and includes chiral research relevant to synthesis, analytic chemistry, catalysis, and pharmaceuticals. The individual chapters in each of the 9 volumes provide an in depth review and collection of references on definition, technology, applications and a guide/links to the related literature. Whether in an Academic or Corporate setting, these chapters will form an invaluable resource for advanced students/researchers new to an area and those who need further background or answers to a particular problem, particularly in the development of drugs. Chirality research today is a central theme in chemistry and biology and is growing in importance across a number of disciplinary boundaries. These studies do not always share a unique identifying factor or subject themselves to clear and concise definitions. This work unites the different areas of research and allows anyone working or researching in chiral chemistry to navigate through the most essential concepts with ease, saving them time and vastly improving their understanding. The field of chirality counts several journals that are directly and indirectly concerned with the field. There is no reference work that encompasses the entire field and unites the different areas of research through deep foundational reviews. Comprehensive Chirality fills this vacuum, and can be considered the definitive work. It will help users apply context to the diverse journal literature offering and aid them in identifying areas for further research and/or for solving problems. Chief Editors, Hisashi Yamamoto (University of Chicago) and Erick Carreira (ETH Zürich) have assembled an impressive, world-class team of Volume Editors and Contributing Authors. Each chapter has been painstakingly reviewed and checked for consistent high quality. The result is an authoritative overview which ties the literature together and provides the user with a reliable background information and citation resource.

Principles of Asymmetric Synthesis

Author : R.E. Gawley
Publisher : Elsevier
ISBN 13 : 0080514774
Total Pages : 395 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Principles of Asymmetric Synthesis by : R.E. Gawley

Download or read book Principles of Asymmetric Synthesis written by R.E. Gawley and published by Elsevier. This book was released on 1996-11-21 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: The world is chiral. Most of the molecules in it are chiral, and asymmetric synthesis is an important means by which enantiopure chiral molecules may be obtained for study and sale. Using examples from the literature of asymmetric synthesis (more than 1300 references), the aim of this book is to present a detailed analysis of the factors that govern stereoselectivity in organic reactions. It is important to note that the references were each individually checked by the authors to verify relevance to the topics under discussion. The study of stereoselectivity has evolved from issues of diastereoselectivity, through auxiliary-based methods for the synthesis of enantiomerically pure compounds (diastereoselectivity followed by separation and auxiliary cleavage), to asymmetric catalysis. In the latter instance, enantiomers (not diastereomers) are the products, and highly selective reactions and modern purification techniques allow preparation - in a single step - of chiral substances in 99% ee for many reaction types. After an explanation of the basic physical-organic principles of stereoselectivity, the authors provide a detailed, annotated glossary of stereochemical terms. A chapter on "Analytical Methods" provides a critical overview of the most common methods for analysis of stereoisomers. The authors then follow the 'tried-and-true' format of grouping the material by reaction type. Thus, there are four chapters on carbon-carbon bond forming reactions (enolate alkylations, organometal additions to carbonyls, aldol and Michael reactions, and cycloadditions and rearrangements), one chapter on reductions and hydroborations (carbon-hydrogen bond forming reactions), and one on oxidations (carbon-oxygen and carbon-nitrogen bond forming reactions). Leading references are provided to natural product synthesis that have been accomplished using a given reaction as a key step. In addition to tables of examples that show high selectivity, a transition state analysis is presented to explain - to the current level of understanding - the stereoselectivity of each reaction. In one case (Cram's rule) the evolution of the current theory is detailed from its first tentative (1952) postulate to the current Felkin-Anh-Heathcock formalism. For other reactions, only the currently accepted rationale is presented. Examination of these rationales also exposes the weaknesses of current theories, in that they cannot always explain the experimental observations. These shortcomings provide a challenge for future mechanistic investigations.

Asymmetric Synthesis and Mechanistic Investigation with Chiral Oxosulfonium Ylides

Author : Calvin William Schroeck
Publisher :
ISBN 13 :
Total Pages : 314 pages
Book Rating : 4.:/5 (181 download)

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Book Synopsis Asymmetric Synthesis and Mechanistic Investigation with Chiral Oxosulfonium Ylides by : Calvin William Schroeck

Download or read book Asymmetric Synthesis and Mechanistic Investigation with Chiral Oxosulfonium Ylides written by Calvin William Schroeck and published by . This book was released on 1971 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Heterocyclic N-Oxides

Author : Oleg V. Larionov
Publisher : Springer
ISBN 13 : 3319606875
Total Pages : 163 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Heterocyclic N-Oxides by : Oleg V. Larionov

Download or read book Heterocyclic N-Oxides written by Oleg V. Larionov and published by Springer. This book was released on 2017-07-12 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field. All chapters from Topics in Heterocyclic Chemistry are published Online First with an individual DOI. In references, Topics in Heterocyclic Chemistry is abbreviated as Top Heterocycl Chem and cited as a journal.

Catalytic Asymmetric Synthesis

Author : Takahiko Akiyama
Publisher : John Wiley & Sons
ISBN 13 : 1119736412
Total Pages : 798 pages
Book Rating : 4.1/5 (197 download)

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Book Synopsis Catalytic Asymmetric Synthesis by : Takahiko Akiyama

Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.

Part I. Asymmetric Organocatalysis

Author : John Robert Miller
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (663 download)

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Book Synopsis Part I. Asymmetric Organocatalysis by : John Robert Miller

Download or read book Part I. Asymmetric Organocatalysis written by John Robert Miller and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Part II. Asymmetric Synthesis of Bicyclic Analogues of the Antiosteoporotic Drug Risedronate An enantioselective synthesis of the potentially potent anti-osteoporotic drug 6,7-dihyro-5H-cyclopenta[c]pyridine-7-yl)methyldiphosphonic acid hydrochloride salt and 6,7-dihydro-5H-cyclopenta[c]pyridine-7-yl)-2-hyroxydiphosphonic acid hydrochloride salt were achieved. The molecules were both achieved by utilizing an enantioselective organocatalytic hydroxymethylation reaction and an intramolecular aza Diels-Alder reaction. The synthesis can be modified for the enantiomer of the bisphosphonic acid through use of the catalyst antipode. Short racemic syntheses of 2-(2,3-dihydro-1H-inden-1-yl)-bisphosphonic acid and 2-(2,3-dihydro-1H-inden-1-yl)-2-hydoxybisphosphonic acid were achieved for comparison of their activity to the nitrogen-containing analogues. The bisphosphonates synthesized will be used as molecular probes for nitrogen-containing bisphosphonate-mediated anti-osteoporosis studies."--Leaves vi-vii.

Sulfur Chemistry

Author : Xuefeng Jiang
Publisher : Springer Nature
ISBN 13 : 3030255980
Total Pages : 475 pages
Book Rating : 4.0/5 (32 download)

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Book Synopsis Sulfur Chemistry by : Xuefeng Jiang

Download or read book Sulfur Chemistry written by Xuefeng Jiang and published by Springer Nature. This book was released on 2019-08-28 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Superbases for Organic Synthesis

Author : Tsutomu Ishikawa
Publisher : John Wiley & Sons
ISBN 13 : 9780470740866
Total Pages : 336 pages
Book Rating : 4.7/5 (48 download)

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Book Synopsis Superbases for Organic Synthesis by : Tsutomu Ishikawa

Download or read book Superbases for Organic Synthesis written by Tsutomu Ishikawa and published by John Wiley & Sons. This book was released on 2009-01-26 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Guanidines, amidines and phosphazenes have been attracting attention in organic synthesis due to their potential functionality resulting from their extremely strong basicity. They are also promising catalysts because of their potential for easy molecular modification, possible recyclability, and reduced or zero toxicity. Importantly, these molecules can be derived as natural products – valuable as scientists move towards “sustainable chemistry”, where reagents and catalysts are derived from biomaterial sources. Superbases for Organic Synthesis is an essential guide to these important molecules for preparative organic synthesis. Topics covered include the following aspects: an introduction to organosuperbases physicochemical properties of organic superbases amidines and guanidines in organic synthesis phosphazene: preparation, reaction and catalytic role polymer-supported organosuperbases application of organosuperbases to total synthesis related organocatalysts: proton sponges and urea derivatives amidines and guanidines in natural products and medicines Superbases for Organic Synthesis is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers and those interested in the chemistry of natural products.

Chiral Sulfur Reagents

Author : Marian Mikolajczyk
Publisher : CRC Press
ISBN 13 : 9780849391200
Total Pages : 294 pages
Book Rating : 4.3/5 (912 download)

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Book Synopsis Chiral Sulfur Reagents by : Marian Mikolajczyk

Download or read book Chiral Sulfur Reagents written by Marian Mikolajczyk and published by CRC Press. This book was released on 1997-06-09 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last three decades, more than 40 different classes of chiral (mirror-image) sulfur compounds have been described, and a number of useful procedures and applications have been developed for their use. Emphasizing modern methodologies, Chiral Sulfur Reagents demonstrates the great potential of enantionmerically pure sulfur reagents in transmitting chirality to other centers. Each chapter highlights the synthesis and synthetic uses of a particular class of chiral sulfur reagent, followed by examples of the most important experimental procedures.

Amide Bond Activation

Author : Michal Szostak
Publisher : MDPI
ISBN 13 : 3039212036
Total Pages : 466 pages
Book Rating : 4.0/5 (392 download)

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Book Synopsis Amide Bond Activation by : Michal Szostak

Download or read book Amide Bond Activation written by Michal Szostak and published by MDPI. This book was released on 2019-07-12 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The amide bond represents a privileged motif in chemistry. The recent years have witnessed an explosion of interest in the development of new chemical transformations of amides. These developments cover an impressive range of catalytic N–C bond activation in electrophilic, Lewis acid, radical, and nucleophilic reaction pathways, among other transformations. Equally relevant are structural and theoretical studies that provide the basis for chemoselective manipulation of amidic resonance. This monograph on amide bonds offers a broad survey of recent advances in activation of amides and addresses various approaches in the field.

Asymmetric Synthesis of Three-Membered Rings

Author : Hélène Pellissier
Publisher : John Wiley & Sons
ISBN 13 : 3527341145
Total Pages : 606 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Asymmetric Synthesis of Three-Membered Rings by : Hélène Pellissier

Download or read book Asymmetric Synthesis of Three-Membered Rings written by Hélène Pellissier and published by John Wiley & Sons. This book was released on 2017-06-19 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first handbook to focus on the asymmetric synthesis of different types of three-membered rings. The outstanding and experienced authors have an excellent international reputation and cover cyclopropanes, epoxides and aziridines as well as chiral oxaziridines in equal measure. To this end, they describe in detail different synthetic approaches starting with chiral substrates as well as the application of chiral metal- or organocatalysts. Furthermore, methods for the kinetic resolution of initially racemic products are treated alongside recent advances and novel developments in established techniques for the synthesis of three-membered rings. With its structured composition this is of high interest to scientists in methodological and natural product synthesis as well as those in industrial and pharmaceutical chemistry.

Zinc Catalysis

Author : Stephan Enthaler
Publisher : John Wiley & Sons
ISBN 13 : 3527335986
Total Pages : 326 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Zinc Catalysis by : Stephan Enthaler

Download or read book Zinc Catalysis written by Stephan Enthaler and published by John Wiley & Sons. This book was released on 2015-04-27 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Filling the gap in the market for comprehensive coverage of this hot topic, this timely book covers a wide range of organic transformations, e. g. reductions of unsaturated compounds, oxidation reactions, Friedel-Crafts reactions, hydroamination reactions, depolymerizations, transformations of carbon dioxide, oxidative coupling reactions, as well as C-C, C-N, and C-O bond formation reactions. A chapter on the application of zinc catalysts in total synthesis is also included. With its aim of stimulating further research and discussion in the field, this is a valuable reference for professionals in academia and industry wishing to learn about the latest developments.

Tradition, Interpretation, and Science

Author : John S. Nelson
Publisher : SUNY Press
ISBN 13 : 9780887063718
Total Pages : 396 pages
Book Rating : 4.0/5 (637 download)

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Book Synopsis Tradition, Interpretation, and Science by : John S. Nelson

Download or read book Tradition, Interpretation, and Science written by John S. Nelson and published by SUNY Press. This book was released on 1986-01-01 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reassesses the academic field of political theory and brings into sharp relief its problems and opportunities. Here for the first time, diverse theorists coordinate their arguments through a common focus. This focus is the writing of John G. Gunnell. Gunnell attacks a set of myths said to plague almost every recent theory about politics: the myth of the given, the myth of science, myths of theory, the myth of tradition, and the myth of the political. He argues that these all alienate political theory from substantive inquiry and actual practice. Contributors include Richard E. Flathman, Russell L. Hanson, George Kateb, Paul F. Kress, J. Donald Moon, John S. Nelson, J.G.A. Pocock, Herbert G. Reid, Ira L. Strauber, Nathan Tarcov, and Sheldon S. Wolin. They respond on behalf of projects in the new history of political theory, epic theory, phenomenology, traditional theory, and political deconstruction. These discussions also address the theories of Hans-Georg Gadamer, Jürgen Habermas, Karl Marx, Leo Strauss, Alain Touraine, and Ludwig Wittgenstein. At the conclusion of the volume, Gunnell reconsiders his arguments in light of the respondent's remarks. His challenges thus provide a series of confrontations - both exciting and provocative - among major theorists. The result is a lively debate about what political theory is, how it relates to political history and practice, and how it involves epistemology. The authors probe a broad range of questions about practices of politics and traditions of discourse, and they identify priorities for the future of the field.

Strategies for Organic Drug Synthesis and Design

Author : Daniel Lednicer
Publisher : John Wiley & Sons
ISBN 13 : 9780470399590
Total Pages : 700 pages
Book Rating : 4.3/5 (995 download)

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Book Synopsis Strategies for Organic Drug Synthesis and Design by : Daniel Lednicer

Download or read book Strategies for Organic Drug Synthesis and Design written by Daniel Lednicer and published by John Wiley & Sons. This book was released on 2009-03-04 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines and evaluates the strategies utilized to design and synthesize pharmaceutically active agents. Significant updates over the last 10 years since the publication of the 1st edition include synthesis of enantiomerically pure isomers, novel chemical methodologies, and new pharmaceutical agents targeted at novel biological endpoints. Written by an experienced successful author, this book meets the needs of a growing community of researchers in pharmaceutical R &D, as well as medical professionals, by providing a useful guide for designing and synthesizing pharmaceutical agents. Additionally, it is a useful text for medicinal chemistry students.

N-Heterocyclic Carbenes in Organocatalysis

Author : Akkattu T. Biju
Publisher : John Wiley & Sons
ISBN 13 : 3527809058
Total Pages : 407 pages
Book Rating : 4.5/5 (278 download)

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Book Synopsis N-Heterocyclic Carbenes in Organocatalysis by : Akkattu T. Biju

Download or read book N-Heterocyclic Carbenes in Organocatalysis written by Akkattu T. Biju and published by John Wiley & Sons. This book was released on 2019-01-07 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Summarizing the emerging field of N-heterocyclic carbenes used in organocatalysis, this is an excellent overview of the synthesis and applications of NHCs focusing on carbon-carbon and carbon-heteroatom bond formation. Alongside comprehensive coverage of the synthesis, characteristics and applications, this handbook and ready reference also includes chapters on NHCs for polymerization reactions and natural product synthesis.