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Apoptosis In Health And Disease Part A
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Book Synopsis Apoptosis in Health and Disease by : Jr., Robert R. Ruffolo
Download or read book Apoptosis in Health and Disease written by Jr., Robert R. Ruffolo and published by CRC Press. This book was released on 2000-09-15 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The impact of Apoptosis, or programmed cell death, is thought to play a crucial role in the development and progression of disease. Whilst Apoptosis remains extensively studied in the context of immunology, the focus of research has greatly expanded to investigate the key role it is now believed to play in hematopoiesis, angiogenesis, inflammation
Book Synopsis Apoptosis in Health and Disease - Part B by : Rossen Donev
Download or read book Apoptosis in Health and Disease - Part B written by Rossen Donev and published by Academic Press. This book was released on 2021-06-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis in Health and Disease - Part B, Volume 126 in the Advances in Protein Chemistry and Structural Biology focuses on apoptotic responses in numerous conditions - from bacterial and parasite infections, to pathological states such as oxidative stress, pulmonary hypertension, and different cancer types, etc. In addition, the book provides therapeutic strategies for targeting apoptosis. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target the cell death process. Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. Vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases.
Book Synopsis Apoptosis in Health and Disease - Part A by : Rossen Donev
Download or read book Apoptosis in Health and Disease - Part A written by Rossen Donev and published by Academic Press. This book was released on 2021-04-28 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. A vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target this cell death process. These two thematic volumes 125 and 126 of the Advances in Protein Chemistry and Structural Biology focus on apoptotic responses in numerous conditions - from bacterial and parasite infections to pathological states such as oxidative stress, pulmonary hypertension, different cancer types, etc. Finally, therapeutic strategies for targeting apoptosis are also discussed. Integrates experimental and computational methods for studying apoptosis in health and different diseases, strategies for identification of suitable therapeutic targets, and design of treatments targeting key points in apoptotic cascade
Book Synopsis Apoptosis in Health and Disease by : Martin Holcik
Download or read book Apoptosis in Health and Disease written by Martin Holcik and published by Cambridge University Press. This book was released on 2012-01-26 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: A 2005 survey of the role of apoptosis in the pathogenesis of many significant human illnesses and injury states.
Book Synopsis Apoptosis in Health and Disease - Part B by : Rossen Donev
Download or read book Apoptosis in Health and Disease - Part B written by Rossen Donev and published by Academic Press. This book was released on 2021-06-02 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis in Health and Disease - Part B, Volume 126 in the Advances in Protein Chemistry and Structural Biology focuses on apoptotic responses in numerous conditions - from bacterial and parasite infections, to pathological states such as oxidative stress, pulmonary hypertension, and different cancer types, etc. In addition, the book provides therapeutic strategies for targeting apoptosis. These new advanced understandings are playing a major influence in drug discovery and the introduction of new therapies that target the cell death process. Apoptosis, or programmed cell death, is the mechanism by which cells die either physiologically or pathologically. Vast research in apoptosis has advanced our understanding of basic physiological and pathological processes occurring in cells, organs and organisms, and its role in a number of diseases. Integrates experimental and computational methods for studying apoptosis in health and different diseases Includes strategies for identification of suitable therapeutic targets Discusses the design of treatments targeting key points in the apoptotic cascade
Book Synopsis Cell Death Regulation in Health and Disease - Part C by :
Download or read book Cell Death Regulation in Health and Disease - Part C written by and published by Academic Press. This book was released on 2020-05-14 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Death Regulation in Health and Disease - Part C, Volume 353 in the International Review of Cell and Molecular Biology series, reviews and details current advances in cell and molecular biology. The IRCMB series maintains the highest standard by publishing timely topics authored by prominent cell and molecular biologists, with this release covering Developmental and seasonal regulation of neural cell death in birds, Post-translational modifications in cell death regulation, The role of cell death in tissue regeneration and fibrosis, Crosstalk between the apoptosis and autophagy signaling pathways, IP3 receptor signal integration in cell death and survival decisions, and more. Provides a comprehensive collection of front-of-the line research in the field of cell death regulation Authored by established and active cell and molecular biologists drawn from international sources Includes only invited review articles, covering selected topics in many different organisms and disease settings
Book Synopsis Cell Death Regulation in Health and Disease - Part A by :
Download or read book Cell Death Regulation in Health and Disease - Part A written by and published by Academic Press. This book was released on 2020-04-02 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cell Death Regulation in Health and Disease - Part A, Volume 351, the latest release in the International Review of Cell and Molecular Biology reviews current advances in cell and molecular biology. The series publishes timely topics authored by prominent cell and molecular biologists. This release is part of a 3-part series which comprises a comprehensive view of cell death regulation in a variety of biological contexts. Chapters cover Membrane dynamics in cell death regulation, The role of necroptosis in intestinal dysfunction, Regulation of cell death in the cardiovascular system, Cell death in bacterial and viral infection, and much more. Provides a comprehensive collection of front-of-the line research in the field of cell death regulation Authored by established and active cell and molecular biologists and drawn from international sources Includes invited review articles that cover selected topics in multiple organisms and disease settings
Book Synopsis Biochemistry of Apoptosis and Autophagy by : Lorrie A. Kirshenbaum
Download or read book Biochemistry of Apoptosis and Autophagy written by Lorrie A. Kirshenbaum and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most intriguing and compelling issues to impact contemporary biology to date is the concept that cell death is genetically regulated. Observations by Kerr and Wyllie, made more than 30 years ago on the basis of distinct morphological criteria, markedly distinguished apoptosis from classical cell death by necrosis. Apoptosis is a highly regulated, evolutionary conserved, genetic program of cell death essential for normal development and tissue homeostasis. The discovery of apoptosis as a regulated event and potentially amenable to therapeutic interventions has generated considerable excitement because it meant that disease entities resulting from either too much, or too little, apoptosis could be potentially cured with new therapies that target apoptosis. While there is little doubt that necrosis induced by massive cellular trauma is likely an unregulated event, several lines of investigation have challenged the dogma that necrotic cell death is merely unregulated. Emerging data has shifted the paradigm in our thinking about necrosis as a regulated event. Autophagy is another cellular process that has received considerable attention over the past two decades and its remarkable involvement in the processes of cell survival, death and tumorigenesis. Macro autophagy is a catabolic process that involves the selective and targeted removal of oxidized proteins, macromolecular structures and organelles through an elaborate cellular process involving a lysosome mediated pathway. Other forms of autophagy involving adapter proteins, commonly referred to as chaperone mediated autophagy, involves the selective removal of cellular cargo by the ubiquitin-proteasome pathway. The book will serve as a reference guide for basic and clinical scientists who are interested in understanding how these critical cellular processes impact the pathogenesis of human disease.
Book Synopsis Apoptosis and Cancer by : Seamus J. Martin
Download or read book Apoptosis and Cancer written by Seamus J. Martin and published by S. Karger AG (Switzerland). This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past five years have witnessed an explosion of research efforts in the study of how cells die. This book provides an up-to-date overview of our current knowledge of apoptosis and how discoveries in this area impact on our understanding of cancer. By synthesizing many of the recent developments in this area and placing them in perspective, it fulfills an important need. All the contributions are written by experts in their respective fields. The first two chapters give a basic introduction to the cell death machinery and its role in tumor development and progression; subsequent chapters cover current aspects of apoptosis research, including the involvement of cell cycle-related proteins (e.g. cyclin-dependent kinases) in apoptosis, the role of Bcl-2, Bcr-Abl, Rb, p53 and myc in the regulation of cell death, and apoptosis in the context of specific neoplasms such as cancer of the prostate, kidney, leukemia and neuroblastoma. It is also discussed how insights into the regulation of apoptosis may be exploited for designing new drugs aimed at eliminating malignant cells. Compiling the most recent research results on the relationship between apoptosis and cancer in one handy volume, this book will provide a valuable reference for scientists working in cancer research as well as newcomers to the field.
Download or read book Apoptosis written by Douglas R. Green and published by Cambridge University Press. This book was released on 2011-08-22 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt: Apoptosis, or cell death, can be pathological, a sign of disease and damage, or physiological, a process essential for normal health. This book, with contributions from experts in the field, provides a timely compilation of reviews of mechanisms of apoptosis. The book is organized into three convenient sections. The first section explores the different processes of cell death and how they relate to one another. The second section focuses on organ-specific apoptosis-related diseases. The third section explores cell death in non-mammalian organisms, such as plants. This comprehensive text is a must-read for all researchers and scholars interested in apoptosis.
Book Synopsis Apoptosis, Cell Signaling, and Human Diseases by : Rakesh Srivastava
Download or read book Apoptosis, Cell Signaling, and Human Diseases written by Rakesh Srivastava and published by Springer Science & Business Media. This book was released on 2007-11-05 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: These volumes present a concise synthesis of recent developments in the understanding of both cell survival and apoptotic pathways. Particular attention is given to apoptosis in human diseases, such as different forms of cancer and neurodegenerative diseases. These comprehensive volumes integrate the most innovative and current findings from several related disciplines of scientific research, including pathology, genetics, virology, cell biology, immunology, and molecular biology.
Book Synopsis The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease by : Concetta Bubici
Download or read book The Warburg Effect Regulation Under Siege: The Intertwined Pathways in Health and Disease written by Concetta Bubici and published by Frontiers Media SA. This book was released on 2019-10-17 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many cells, including immune, neuronal, cancer and stem cells, become dependent on aerobic glycolysis to escape apoptosis and accommodate their bioenergetics needs. How this metabolic change, also known as the Warburg effect, is regulated remains largely unknown. The Warburg effect has been widely investigated in cancer cells where it was first observed with the aim of decoding the molecular networks controlling its activation for therapeutic purposes. This Research Topic aimed to discuss and review all the intracellular signaling regulating the Warburg effect in cancerous and normal non-cancerous cells though original research articles, mini reviews and reviews.
Book Synopsis Clinical Perspectives and Targeted Therapies in Apoptosis by : Rupinder K. Sodhi
Download or read book Clinical Perspectives and Targeted Therapies in Apoptosis written by Rupinder K. Sodhi and published by Academic Press. This book was released on 2020-10-15 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research.
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Endoplasmic Reticulum Stress in Health and Disease by : Patrizia Agostinis
Download or read book Endoplasmic Reticulum Stress in Health and Disease written by Patrizia Agostinis and published by Springer Science & Business Media. This book was released on 2012-08-13 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as ‘ER stress’. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
Book Synopsis Magnesium in the Central Nervous System by : Robert Vink
Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.
Book Synopsis Janeway's Immunobiology by : Kenneth Murphy
Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.