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Anxiolytic B Carbolines
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Book Synopsis Anxiolytic β-Carbolines by : David N. Stephens
Download or read book Anxiolytic β-Carbolines written by David N. Stephens and published by Springer Science & Business Media. This book was released on 2013-03-07 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery some 15 years ago of benzodiazepine modulatory sites associated with GABA A receptors, great effort has gone into understanding their molecular pharmacology and into developing new anxiolytic drugs that interact selectively with them. Prominent in this research has beenthe discovery that ~-carbolines, a different chemical class from benzodiazepines, also act at these receptors but that their effects are sometimes quite different from those of the benzodiazepines.This book documents the latest discoveries in the molecular biology of the GABA A receptor and reveals how an integration of the results of research inmolecular biology, synthetic chemistry, biochemical and behavioral pharmacology, and clinical pharmacology has paved the way forthe development of ~-carbolines from substances inducing anxiety and convulsions to a novel therapy for anxiety states, achieving a behavioral selectivity through selective actions at subtypes of receptors.
Download or read book Anxiolytics written by Mike Briley and published by Birkhäuser. This book was released on 2012-12-06 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: For over thirty years the benzodiazepines monopolised not only the anxiolytic market but also clinical and animal research in anxiety. Indeed many animal tests developed since the 1960s have been optimised for the benzodiazepines and some programmes have even screened candidates as potential anxiolytics on their benzodiazepine-like side-effects rather than their anxiolytic activity. With the realisation of the drawbacks of the benzodiazepines, namely their potential for tolerance and dependency, there has been a renewed interest in alternative anxiolytics both from existing drugs such as the tricyclic and monoamine oxidase antidepressants and from newer agents such as buspirone. In addition anxiety is no longer considered to be a unique entity but rather an umbrella term for a series of specific anxiety disorders such as panic disorder without or with agoraphobia, generalised anxiety disorder (GAD), specific phobias, social phobias and post-traumatic stress disorder (PTSD). These new clinical categories have opened another dimension in the therapy of anxiety requiring the optimisation of treatments for different syndromes. This book is a critical review of today's anxiolytics and those that may become the anxiolytics of tomorrow. What is clear is that currently there are few clinically satisfactory alternatives to the benzodiazepines for the treatment of acute anxiety. For chronic anxiety, it is generally agreed that benzodi azepines are not the treatment of first choice. The tricyclic and monoamine oxidase antidepressants, the serotonin reuptake inhibitors and buspirone offer better solutions for chronic anxiety but they are still far from being ideal.
Book Synopsis β-Carbolines by : Keshav Lalit Ameta
Download or read book β-Carbolines written by Keshav Lalit Ameta and published by CRC Press. This book was released on 2024-11-29 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: β-Carbolines: A Privileged Scaffold for Modern Drug Discovery provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation. β-carboline and its derivatives have generated considerable interest in recent years for their versatile properties in chemistry and pharmacology. This is due to their ability to act as agonists to benzodiazepine receptors, hydroxy serotonin receptors, and intercalate into DNA and to inhibit CDK, topisomerase, and monoamine oxidase enzymes. Their pharmacological properties include anxiolytic, hypnotic, anticonvulsant, antiviral, antiparasitic, and antimicrobial attributes. This book provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carboline scaffold and their biological evaluation. Features: Focuses on the different application and therapies of β-carbolines. Provides a summary of methods for the synthesis of various natural products engineered with the diverse β-carbolines. Discusses methods of biological evaluation of β-carbolines. Explores different chemical transformations occurring with synthesis using β-carbolines. Covers both heterocyclic synthesis and multicomponent synthesis related to β-carboline. This text is key reading for researchers in medicinal chemistry and drug discovery looking to understand the broad potential of β-carbolines.
Book Synopsis Behavioural Models in Psychopharmacology by : Paul Willner
Download or read book Behavioural Models in Psychopharmacology written by Paul Willner and published by Cambridge University Press. This book was released on 1991-02-21 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Behavioural models in psychopharmacology are used for different purposes. The main concern of industrial psychopharmacologists is specifically to develop new and improved drugs for the treatment of mental disorders, while basic scientists use animal models to investigate the underlying nature of such conditions. The important distinction between these different perspectives is made explicit for the first time in this book. By considering such conditions as anxiety, depression, mania and schizophrenia, feeding disorders, dementia, and drug dependence, this book provides a comprehensive and critical review of the adequacy of the behavioural procedures used by psychopharmacologists to model psychiatric disorders. Graduate students and research workers in pscyhopharmacology, from both academic and industrial spheres, as well as clinicians, will find this book of considerable interest.
Book Synopsis Psychopharmacology of Anxiolytics and Antidepressants by : S.E. File
Download or read book Psychopharmacology of Anxiolytics and Antidepressants written by S.E. File and published by Elsevier. This book was released on 2016-04-20 with total page 285 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contributed volume reviewing the clinical and animal literature related to the pharmacology of anxiety and depression. The role of the hypothalmic-pituitary-adrenal axis in anxiety and depression is reviewed as well as the response of central catecholamines to chronic stress.
Book Synopsis Anxiety and the Anxiety Disorders by : A. H. Tuma
Download or read book Anxiety and the Anxiety Disorders written by A. H. Tuma and published by Routledge. This book was released on 2019-01-22 with total page 1132 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 1980s have been called the decade of anxiety. Not only is this true of the popular press, but students of behavior and psychopathology have contributed to the rather sudden reemergence of anxiety as a respectable and fascinating field of investigation. This volume is a culmination of more than two years of planning, literature reviews, writing, conference discussions, revising of original papers, and integrating the material for final publication. It is a series of interrelated statements about research on anxiety and the anxiety disorders written by many of the leading investigators currently active in this field. First published in 1985. Routledge is an imprint of Taylor & Francis, an informa company.
Download or read book Anxiety written by N. Sartorius and published by Taylor & Francis. This book was released on 1990 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1990. Routledge is an imprint of Taylor & Francis, an informa company.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1994 with total page 1364 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lexicon of Psychiatry, Neurology, and the Neurosciences by : Frank J. Ayd
Download or read book Lexicon of Psychiatry, Neurology, and the Neurosciences written by Frank J. Ayd and published by Lippincott Williams & Wilkins. This book was released on 2000 with total page 1138 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its thoroughly updated Second Edition, Dr. Ayd's highly acclaimed Lexicon is an indispensable desk reference for anyone working in psychiatry, neurology, or the underlying basic neurosciences. It provides succinct, detailed, and easily accessible definitions for the entire range of terms currently used in these fields, including drug categories, receptors, and the sites and mechanisms affected by pharmacologic treatments. This edition reflects the most recent developments in genetics and in psychopharmacology, including new drugs and current concepts on drug-drug interactions. Dr. Ayd has added over 1,000 new terms and rewritten nearly half of the entries in the original edition. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Book Synopsis Annual Reports in Medicinal Chemistry by :
Download or read book Annual Reports in Medicinal Chemistry written by and published by Academic Press. This book was released on 1983-09-01 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry
Download or read book Psychopharmacology Bulletin written by and published by . This book was released on 1988 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Methods in Behavioral Pharmacology by : F. van Haaren
Download or read book Methods in Behavioral Pharmacology written by F. van Haaren and published by Elsevier. This book was released on 2013-10-22 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Behavioral Pharmacology is unique in offering a complete description and critical evaluation of most, if not all, methods available to study the effects of drugs on behavior. It stands apart in that it is not limited to the analysis of a particular class of pharmacological agents in a limited number of paradigms. Methods in Behavioral Pharmacology covers all paradigms without reference to specific pharmacological compounds. The book provides a comprehensive overview of the methodology used to study the behavioral effects of legal and illegal drugs. It also provides an in-depth presentation of dependent variables, their quantification and a critical evaluation of their advantages and disadvantages. An excellent work, contributed to by well-known experts in the different fields of behavioral pharmacology.
Book Synopsis Foye's Principles of Medicinal Chemistry by : David A. Williams
Download or read book Foye's Principles of Medicinal Chemistry written by David A. Williams and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive Fifth Edition has been fully revised and updated to meet the changing curricula of medicinal chemistry courses. The new emphasis is on pharmaceutical care that focuses on the patient, and on the pharmacist a therapeutic clinical consultant, rather than chemist. Approximately 45 contributors, respected in the field of pharmacy education, augment this exhaustive reference. New to this edition are chapters with standardized formats and features, such as Case Studies, Therapeutic Actions, Drug Interactions, and more. Over 700 illustrations supplement this must-have resource.
Download or read book Anxiety written by Michel Hamon and published by John Libbey Eurotext. This book was released on 1993 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although everybody had and will experience anxiety, its intensity, frequency and characteristics may vary from what can be considered as "normal" to pathological. The development of benzodiazepine as anxiolytics has been a major step firstly in therapeutics and secondly in the understanding of the associated biological mechanisms. Recently, new drugs without secondary effects of benzodiazepines have been developed. The purpose of the book was to take stock of the present knowledge: clinical aspects of pathological anxiety, neurobiological mechanisms associated with stress and anxiety, molecular targets of potent anxiolytic drugs, new issues and directions.
Download or read book Anxiolytics written by Jeffrey B. Malick and published by Raven Press (ID). This book was released on 1983 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The GABA Receptors written by S. J. Enna and published by Springer Science & Business Media. This book was released on 2013-03-14 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this long-awaited 2nd edition of a classic book, leading neuroscientists critically review the latest advances made in our understanding of the fundamental molecular, biochemical, behavioral, and pharmacological properties of GABA receptors. The distinguished contributors clarify the approaches being taken to identify and develop new therapeutic agents for such neurological and psychiatric disorders as epilepsy, memory loss, affective illnesses, and psychosis. They also examine the therapeutic potential that remains in the cloning and expression of the GABA transporter, and in developing additional agents capable of regulating GABA receptor function. The book will play a key role in further expanding the list of drugs that interact with the GABA neurotransmitter system.
Download or read book Anxiety Disorders written by Yong-Ku Kim and published by Springer Nature. This book was released on 2020-01-30 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews all important aspects of anxiety disorders with the aim of shedding new light on these disorders through combined understanding of traditional and novel paradigms. The book is divided into five sections, the first of which reinterprets anxiety from a network science perspective, examining the altered topological properties of brain networks in anxiety disorders. The second section discusses recent advances in understanding of the neurobiology of anxiety disorders, covering, for example, gene-environmental interactions and the roles of neurotransmitter systems and the oxytocin system. A wide range of diagnostic and clinical issues in anxiety disorders are then addressed, before turning attention to contemporary treatment approaches in the context of novel bio-psychosocial-behavioral models, including bio- and neurofeedback, cognitive behavioral therapy, neurostimulation, virtual reality exposure therapy, pharmacological interventions, psychodynamic therapy, and CAM options. The final section is devoted to precision psychiatry in anxiety disorders, an increasingly important area as we move toward personalized treatment. Anxiety Disorders will be of interest for all researchers and clinicians in the field.
