Antiviral Chemotherapy

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Chemotherapy of Viral Infections

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Author : P E. Came
Publisher : Springer Science & Business Media
ISBN 13 : 3642684874
Total Pages : 580 pages
Book Rating : 4.6/5 (426 download)

Book Synopsis Chemotherapy of Viral Infections by : P E. Came

Download or read book Chemotherapy of Viral Infections written by P E. Came and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: " . . . the motto for the therapeutics of the future will have to be de sedibus et causis pharmacorum. " P. EHRLICH, 1909 Exciting events in the basic disciplines of virology, immunology, and pharmacology continue to advance the understanding of the pathogenesis and control of virus diseases. At the same time, the rational development of antiviral agents is attracting, to an increasing extent, the interest of workers in other disciplines. Improvements in technology facilitate the definition of potential target sites for antiviral intervention and unmask new viral and host genes. The outcome is a further steady development of new antiviral agents which approach the "magic bullets" first proposed by PAUL EHRLICH. Remarkable advances in protein synthetic methods that yield polypeptides which inhibit active sites of viral proteins have aided substantially in the basic and clinical study of these antiviral agents. In addition, the extremely rapid progression in recombinant DNA techniques, leading to the synthesis of large quantities of gene products, is also increasing our opportunities at a dashing pace. New information and developing technology facilitate research on the mechanism of action, toxicity, pharmacokinetics, and pharmacodynamics of new agents. The list of clinically effective antiviral agents is expanding and the number of potentially useful compounds is growing rapidly. This book is a combined theoretical text and practical manual which, it is hoped, will be of use to all who have an interest in virus diseases, particularly scientists, physicians and graduate students.

Human Herpesviruses

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Author : Ann Arvin
Publisher : Cambridge University Press
ISBN 13 : 1139461648
Total Pages : 1325 pages
Book Rating : 4.1/5 (394 download)

Book Synopsis Human Herpesviruses by : Ann Arvin

Download or read book Human Herpesviruses written by Ann Arvin and published by Cambridge University Press. This book was released on 2007-08-16 with total page 1325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive account of the human herpesviruses provides an encyclopedic overview of their basic virology and clinical manifestations. This group of viruses includes human simplex type 1 and 2, Epstein–Barr virus, Kaposi's Sarcoma-associated herpesvirus, cytomegalovirus, HHV6A, 6B and 7, and varicella-zoster virus. The viral diseases and cancers they cause are significant and often recurrent. Their prevalence in the developed world accounts for a major burden of disease, and as a result there is a great deal of research into the pathophysiology of infection and immunobiology. Another important area covered within this volume concerns antiviral therapy and the development of vaccines. All these aspects are covered in depth, both scientifically and in terms of clinical guidelines for patient care. The text is illustrated generously throughout and is fully referenced to the latest research and developments.

Antiviral Chemotherapy

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Author : D. J. Jeffries
Publisher :
ISBN 13 :
Total Pages : 614 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Antiviral Chemotherapy by : D. J. Jeffries

Download or read book Antiviral Chemotherapy written by D. J. Jeffries and published by . This book was released on 1995-07-11 with total page 614 pages. Available in PDF, EPUB and Kindle. Book excerpt: Considerable advances have been made in the treatment of antiviral diseases over the last decade. Several new drugs have been introduced while new clinical information has been gathered on the efficacy of existing drugs. This study aims to provide an examination of the basic science (drug formulae, structure and biochemical activity) and clinical information (usage and efficacy) on chemotherapy, as well as describing future potentials.

Antiviral Chemotherapy 5

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Author : John Mills
Publisher : Springer Science & Business Media
ISBN 13 : 9780306461071
Total Pages : 288 pages
Book Rating : 4.4/5 (61 download)

Book Synopsis Antiviral Chemotherapy 5 by : John Mills

Download or read book Antiviral Chemotherapy 5 written by John Mills and published by Springer Science & Business Media. This book was released on 1999-03-31 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists and clinicians attending the last "New Directions in Antiviral Therapy" conference in late 1994 could hardly have predicted the revolution in the management of patients with HIV infection that has occurred since. Two new classes of antiretrovirals have been licensed, the second-site RT inhibitors and the protease inhibitors; the long in cubation period of active HIV infection, when the infection is clinically latent, is now un derstood to be a period of intense viral replication and turnover of CD4 lymphocytes; measurements of HI V RNA concentration in plasma have been shown to be essential tools for monitoring the course of HIV infection, deciding when to treat, and assessing the re sults of treatment; and finally, combinations of antiretrovirals, particularly combinations including protease inhibitors, have been shown to have dramatically beneficial effects on patients with HIV infection. These advances, coupled with new drugs for the management of herpesvirus infections, have made dramatic differences in the quality and length of life of HIV-infected patients. Additional advances have been made since 1994 in the prevention or management of influenza virus (zanamavir), respiratory syncytial virus (palvizumab), hepatitis B virus (lamivudine and famciclovir), and enterovirus infections (pleconaril). It is difficult to re member that only slightly more than a decade ago there were only a handful of antiviral agents available (none of which were antiretrovirals), and a number of those were either highly toxic, of dubious efficacy, or both.

Antiviral Chemotherapy 4

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Author : John Mills
Publisher : Springer Science & Business Media
ISBN 13 : 1475792093
Total Pages : 432 pages
Book Rating : 4.4/5 (757 download)

Book Synopsis Antiviral Chemotherapy 4 by : John Mills

Download or read book Antiviral Chemotherapy 4 written by John Mills and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three years since our last conference in San Francisco have again seen a dramatic expansion of the number of antivirals either licensed or in the late stages of clinical trials. d4T is now licensed for HIV infection, famciclovir and the oral pro-drug of acyclovir, valacyclovir, are now licensed for VZV infections in some countries. Moreover. oral ganciclovir, cidofovir, and sorivudine are not far behind. Clinical trials with the second-site reverse transcriptase inhibitors and the protease inhibitors for HlV infection are proceeding rapidly and on a broad scale, and the preliminary results would suggest that several of these classes of drugs will be licensed as well. Despite this optimism, however, there is increasing evidence that antiviral-resistant strains of pathogenic viruses will be a significant problem, perhaps especially with therapy of HIV infection, and there remains a desperate need for improved drugs (with either improved efficacy or decreased toxicity, or both) for CMV and HIV infections. This book is the edited proceedings of the Fourth Triennial Conference on Antiviral Chemotherapy, held in San Francisco, in November 1994. The conference was sponsored by the University of California, San Francisco, and co-sponsored by the International Society for Antiviral Research (ISAR), the Macfarlane Burnet Centre for Medical Research in Melbourne, Australia, and the Australian National Centre for HIV Virology Research. The conference had been organized to present an overview of the field of antiviral chemotherapy.

Antiviral Nucleosides

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Author : C.K. Chu
Publisher : Elsevier
ISBN 13 : 0080524540
Total Pages : 269 pages
Book Rating : 4.0/5 (85 download)

Book Synopsis Antiviral Nucleosides by : C.K. Chu

Download or read book Antiviral Nucleosides written by C.K. Chu and published by Elsevier. This book was released on 2003-10-15 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: • Up-to-date review on the chemistry and biology of nucleosides • Modern synthetic methodology • Comprehensive coverage of antiviral nucleosidesThis book summarizes the recent advances in nucleosides chemistry and chemotherapy over the past 10-15 years. It covers recently discovered nucleoside antiviral agents, their therapeutic aspects and biochemistry, and also extensive reviews on their chiral synthesis.

Recent Advances in Nucleosides: Chemistry and Chemotherapy

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Author : C.K. Chu
Publisher : Elsevier
ISBN 13 : 0080540368
Total Pages : 545 pages
Book Rating : 4.0/5 (85 download)

Book Synopsis Recent Advances in Nucleosides: Chemistry and Chemotherapy by : C.K. Chu

Download or read book Recent Advances in Nucleosides: Chemistry and Chemotherapy written by C.K. Chu and published by Elsevier. This book was released on 2002-09-11 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book covers up-to-date information on nucleosides and antiviral chemotherapy contributed by the world experts in the field of nucleoside. This book is the result of a meeting honoring Dr. Jack J. Fox, who was one of the pioneers in nucleoside chemistry and chemotherapy. This book consists of 15 excellent chapters in the area, which include topics from recent synthetic methodologies, nucleoside kinase implicated in chemotherapy and drug design, excellent reviews on antiviral agents, nucleoside metabolism/mode of action in parasites, new compounds under clinical and pre-clinical trials, IMPDH inhibitors to review on nucleoside prodrugs.

Fenner and White's Medical Virology

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Author : Christopher J. Burrell
Publisher : Academic Press
ISBN 13 : 0123751578
Total Pages : 605 pages
Book Rating : 4.1/5 (237 download)

Book Synopsis Fenner and White's Medical Virology by : Christopher J. Burrell

Download or read book Fenner and White's Medical Virology written by Christopher J. Burrell and published by Academic Press. This book was released on 2016-11-09 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. - Features updated and expanded coverage of pathogenesis and immunity - Contains the latest laboratory diagnostic methods - Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control

Katzung & Trevor's Pharmacology Examination and Board Review

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Author : Anthony J. Trevor
Publisher : McGraw Hill Professional
ISBN 13 : 0071488693
Total Pages : 641 pages
Book Rating : 4.0/5 (714 download)

Book Synopsis Katzung & Trevor's Pharmacology Examination and Board Review by : Anthony J. Trevor

Download or read book Katzung & Trevor's Pharmacology Examination and Board Review written by Anthony J. Trevor and published by McGraw Hill Professional. This book was released on 2008 with total page 641 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bestselling USMLE study tool -- packed with everything you need to ace the exam on your first try 4 STAR DOODY'S REVIEW! "This is one of the better board review books in pharmacology and it closely follows the most widely used textbook for teaching pharmacology . . . This eighth edition is needed to keep pace with this rapidly growing discipline." -- Doody's Review Service From the authors of the leading pharmacology textbook comes the newest edition of the best pharmacology review in the field. Ideal for medical pharmacology course review and USMLE Step 1 preparation, this skill-building guide comes with more than 1000 USMLE-type questions with answers -- nearly 3 times as many as any other pharmacology review! Features: A concise yet thorough review of basic and clinical pharmacology, covering every must-know concept Organized to reflect course syllabi, focusing on the clinical use and pharmacology of drug categories rather than individual drugs Two USMLE-style Practice Exams with 120 questions each In each chapter, "Skill Keepers" sharpen your recall of key principles from earlier chapters A series of 15-20 USMLE-style questions in each chapter Key terms with definitions Strategies for improving test performance A detailed index and appendices allow you to look up drugs and side effects in an instant All chapters fully updated with the latest drug information Numerous figures and tables, such as those designed to delineate the differences between similar drugs

Antiviral Drug Strategies

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Author : Erik De Clercq
Publisher : John Wiley & Sons
ISBN 13 : 3527635963
Total Pages : 632 pages
Book Rating : 4.5/5 (276 download)

Book Synopsis Antiviral Drug Strategies by : Erik De Clercq

Download or read book Antiviral Drug Strategies written by Erik De Clercq and published by John Wiley & Sons. This book was released on 2011-04-08 with total page 632 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on general molecular mechanisms of antiviral drugs rather than therapies for individual viruses, this ready reference provides the critical knowledge needed to develop entirely novel therapeutics and to target new viruses. It begins with a general discussion of antiviral strategies, followed by a broad survey of known viral targets, such as reverse transcriptases, proteases, neuraminidases, RNA polymerases, helicases and primases, as well as their known inhibitors. The final section contains several cases studies of recent successful antiviral drug development. Edited by Erik de Clercq, the world authority on small molecule antiviral drugs, who has developed more new antivirals than anyone else.

Antibiotic and Chemotherapy E-Book

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Author : Roger G. Finch
Publisher : Elsevier Health Sciences
ISBN 13 : 0702047651
Total Pages : 913 pages
Book Rating : 4.7/5 (2 download)

Book Synopsis Antibiotic and Chemotherapy E-Book by : Roger G. Finch

Download or read book Antibiotic and Chemotherapy E-Book written by Roger G. Finch and published by Elsevier Health Sciences. This book was released on 2010-11-30 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: Well-respected and widely regarded as the most comprehensive text in the field, Antibiotic and Chemotherapy, 9th Edition by Drs. Finch, Greenwood, Whitley, and Norrby, provides globally relevant coverage of all types of antimicrobial agents used in human medicine, including all antiviral, antiprotozoan and anthelminthic agents. Comprehensively updated to include new FDA and EMEA regulations, this edition keeps you current with brand-new information about antiretroviral agents and HIV, superficial and mucocutaneous myscoses and systemic infections, management of the immunocompromised patient, treatment of antimicrobial resistance, plus coverage of new anti-sepsis agents and host/microbe modulators. Reference is easy thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. Offer the best possible care and information to your patients about the increasing problem of multi-drug resistance and the wide range of new antiviral therapies now available for the treatment of HIV and other viral infections. Stay current with 21 new chapters including the latest information on superficial and mucocutaneous mycoses, systemic infections, anti-retroviral agents, and HIV. Get fresh perspectives and insights thanks to 21 newly-authored and extensively re-written chapters. Easily access information thanks to a unique 3-part structure covering general aspects of treatment; reviews of every agent; and details of treatments of particular infections. Apply the latest treatments for anti-microbial organisms such as MRSA, and multi-drug resistant forms of TB, malaria and gonorrhea. Keep up on the latest FDA and EMEA regulations.

New Drug Development for Known and Emerging Viruses

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Author : Helga Rübsamen-Schaeff
Publisher : John Wiley & Sons
ISBN 13 : 3527810706
Total Pages : 530 pages
Book Rating : 4.5/5 (278 download)

Book Synopsis New Drug Development for Known and Emerging Viruses by : Helga Rübsamen-Schaeff

Download or read book New Drug Development for Known and Emerging Viruses written by Helga Rübsamen-Schaeff and published by John Wiley & Sons. This book was released on 2021-11-30 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discusses how to fight Ebola, SARS Corona, and other known or emerging human viruses by building on the successes in antiviral therapy of the past decades Written by leading medicinal chemists from academia and industry, this book discusses the entire field of antiviral drug discovery and development from a medicinal chemistry perspective, focusing on antiviral drugs, targets, and viral disease mechanisms. It provides an outlook on emerging pathogens such as Ebola, Zika, West Nile, Lassa, and includes a chapter on SARS Coronoavirus-2 causing the present pandemic. New Drug Development for Known and Emerging Viruses describes the discovery and development process for antiviral agents for different classes of viruses and targets based on the experiences from the nine human viruses for which approved drugs are on the market (HIV, HCV, Influenza, RSV, HBV, HPV, HCMV, HSV, and VZV). It covers the properties and potential of 20 classes of currently approved antivirals, including combination drugs, and looks at novel antiviral strategies against emerging viruses. Covers the entire field of antiviral drug discovery and development Addresses the need for antiviral drugs to combat major health threats such as Ebola, Zika, West Nile, and SARS Coronavirus-2 Summarizes the successes of the past 15 years in developing ground-breaking medicines against 9 major human viruses, both from the medicinal chemistry and the pharmacological angle Discusses practical and strategic challenges in the drug discovery and development process, including screening technologies, latency, and toxicity issues New Developments in Antiviral Drugs is an important book for medicinal chemists, pharmaceutical chemists, virologists, and epidemiologists, and will be of great interest to those in the ;pharmaceutical industry and public health agencies.

Antiviral Strategies

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Author : Hans-Georg Kräusslich
Publisher : Springer Science & Business Media
ISBN 13 : 3540790861
Total Pages : 386 pages
Book Rating : 4.5/5 (47 download)

Book Synopsis Antiviral Strategies by : Hans-Georg Kräusslich

Download or read book Antiviral Strategies written by Hans-Georg Kräusslich and published by Springer Science & Business Media. This book was released on 2008-12-02 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: A crucial issue for antiviral therapy is the fact that all antiviral substances rapidly select for resistance; thus, monitoring and overcoming resistance has become a most important clinical paradigm of antiviral therapy. This calls for cautious use of antiviral drugs and implementation of combination therapies. In parallel, efforts in drug discovery have to be continued to develop compounds with novel mode-of-action and activity against resistant strains. This book reviews the current status of antiviral therapy, from the roads to development of new compounds to their clinical use and cost effectiveness. Individual chapters address in more detail all available drug classes and outline new approaches currently under development.

Antibiotic and Chemotherapy

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Author : Roger G. Finch
Publisher :
ISBN 13 : 9780443071294
Total Pages : 0 pages
Book Rating : 4.0/5 (712 download)

Book Synopsis Antibiotic and Chemotherapy by : Roger G. Finch

Download or read book Antibiotic and Chemotherapy written by Roger G. Finch and published by . This book was released on 2003 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The completely revised and updated New Edition of this respected resource presents globally-relevant coverage of all types of antimicrobial agents used in human medicine, providing authoritative guidance on the principles and practice of antimicrobial chemotherapy. In addition to full coverage of every commonly used antibiotic agent, it includes complete coverage of all antiviral, antiprotozoan and anthelminthic agents. And, its unique 3-part structure makes it easy to locate information: Part I covers general aspects of treatment; Part II reviews every agent, including antimicrobial activity, pharmacokinetics, clinical use, and available preparations; Part III details the treatment of particular infections. Discusses the increasing problem of multi-drug resistance and the wide range of new antiviral therapies now available for the treatment of HIV and other viral infections. Reviews all of the new antimicrobial agents in detail. Features more clinically focused sections on Pharmacokinetics. Details new antifungal therapies, including voriconazole, liposomal, and amphotericin B. Presents new tables on major drug interactions, placental transfer, and concentrations of agents in breast milk. Features new sections on liver failure, drug development and licensing, and the implications of xenotransplantation. Presents expanded coverage of Quinolone as well as new antimalarial combination therapies. Offers cross-references to key web sites, for up-to-date information on treatment and drug resistance.

Antiviral Chemotherapy 5

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Author : John Mills
Publisher : Springer Science & Business Media
ISBN 13 : 1461547431
Total Pages : 266 pages
Book Rating : 4.4/5 (615 download)

Book Synopsis Antiviral Chemotherapy 5 by : John Mills

Download or read book Antiviral Chemotherapy 5 written by John Mills and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientists and clinicians attending the last "New Directions in Antiviral Therapy" conference in late 1994 could hardly have predicted the revolution in the management of patients with HIV infection that has occurred since. Two new classes of antiretrovirals have been licensed, the second-site RT inhibitors and the protease inhibitors; the long in cubation period of active HIV infection, when the infection is clinically latent, is now un derstood to be a period of intense viral replication and turnover of CD4 lymphocytes; measurements of HI V RNA concentration in plasma have been shown to be essential tools for monitoring the course of HIV infection, deciding when to treat, and assessing the re sults of treatment; and finally, combinations of antiretrovirals, particularly combinations including protease inhibitors, have been shown to have dramatically beneficial effects on patients with HIV infection. These advances, coupled with new drugs for the management of herpesvirus infections, have made dramatic differences in the quality and length of life of HIV-infected patients. Additional advances have been made since 1994 in the prevention or management of influenza virus (zanamavir), respiratory syncytial virus (palvizumab), hepatitis B virus (lamivudine and famciclovir), and enterovirus infections (pleconaril). It is difficult to re member that only slightly more than a decade ago there were only a handful of antiviral agents available (none of which were antiretrovirals), and a number of those were either highly toxic, of dubious efficacy, or both.

Antiviral Therapy

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Author : Dr Eddie Blair
Publisher : Taylor & Francis
ISBN 13 : 1000951057
Total Pages : 140 pages
Book Rating : 4.0/5 (9 download)

Book Synopsis Antiviral Therapy by : Dr Eddie Blair

Download or read book Antiviral Therapy written by Dr Eddie Blair and published by Taylor & Francis. This book was released on 2023-05-31 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise summary of vital information on drug targets and current therapy regimes for all of the major viral infections. The book brings together in a single volume aspects of antiviral therapy from diverse areas of research and practice, providing up-to-date coverage of recent developments. Starting from an overview of the history of antiviral chemotherapy, the book goes on to describe the development of drugs against HIV, herpesvirus, respiratory viruses, papillomaviruses and hepatitis virus infections. The drugs currently available are reviewed and possible therapies and drug targets for future prophylactic and therapeutic use are discussed.

Pharmacology

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Author : Bertram G. Katzung
Publisher : McGraw-Hill/Appleton & Lange
ISBN 13 :
Total Pages : 436 pages
Book Rating : 4.3/5 (91 download)

Book Synopsis Pharmacology by : Bertram G. Katzung

Download or read book Pharmacology written by Bertram G. Katzung and published by McGraw-Hill/Appleton & Lange. This book was released on 1993 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: