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Antitumor Steroids
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Book Synopsis Antitumor Steroids by : R T Blickenstaff
Download or read book Antitumor Steroids written by R T Blickenstaff and published by Academic Press. This book was released on 2012-12-02 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antitumor Steroids examines the use of steroids, along with nonsteroidal antiestrogens and some benzo[a]carbazoles, in the treatment of cancer. It explains the mechanism by which steroids and their receptors work together to affect their physiological functions in general and their antitumor activity in particular. It also describes the systematic screening of antitumor compounds isolated from natural sources. Organized into nine chapters, this book begins with an overview of the role of steroids in cancer treatment. It then discusses the estrogens, antiestrogens, and compounds (all containing an aromatic A-ring). The next chapters consider androgens, some antiandrogens, derivatives based on C-19 steroids, progestins and corticoids, bile acids, and compounds with a side-chain carboxyl group. The book explains the biogenesis and metabolism of androgens; the pharmacology of medroxyprogesterone acetate; the antitumor properties of naturally occurring corticosteroids; sterols and cucurbitacins; vitamin D and its metabolites; and cardenolides, bufadienolides, and withanolides. The book concludes with a chapter on bile acids, sapogenins and its analogs, and miscellaneous steroids. This book is a valuable resource for organic and medicinal chemists biochemists, and pharmacologists interested in the use of steroids in treating cancer.
Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Book Synopsis Biological Activities of Steroids in Relation to Cancer by : Gregory Pincus
Download or read book Biological Activities of Steroids in Relation to Cancer written by Gregory Pincus and published by Academic Press. This book was released on 2013-09-17 with total page 547 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Activities of Steroids in Relation to Cancer covers the proceedings of the conference sponsored by the Cancer Chemotherapy National Service Center, National Cancer Institute, National Institutes of Health, and the U. S. Department of Health, Education and Welfare. The text focuses on the influence of steroids on medical approaches to the cure of cancer, including steroid chemistry, estrogen metabolism, and mammary cancer. The selection first offers information on steroids growth and cancer, advances in steroid chemistry, and the physiology and pharmacology of steroids affecting tumor growth. Discussions focus on rapid development of mammary cancer, pituitary functions, androgens, estrogens, and progestins. The book also ponders on the binding of steroid hormones by plasma proteins; the effects of steroids on the levels of the plasma 17-hydroxycorticosteroids and the serum protein-bound iodine; and the metabolism of dehydroisoandrosterone. The text evaluates studies on estrogen metabolism, biochemical parameters of estrogen action, and enzymatic transport of hydrogen by estrogenic hormones. The manuscript also elaborates on the fate of steroid estrogens in target tissues, effect of steroids on calcium dynamics, and steroids and experimental mammary cancer. The selection is a valuable source of information for readers interested in the use of steroids in treating cancer.
Book Synopsis Steroid Dimers by : Professor Satyajit D. Sarker
Download or read book Steroid Dimers written by Professor Satyajit D. Sarker and published by John Wiley & Sons. This book was released on 2012-04-13 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroid dimers are an important group of compounds produced by various marine organisms, and also synthesized in the laboratories. This group of compounds possesses various pharmacological and biological properties, and can also be used to create “molecular umbrellas” for drug delivery. Steroid Dimers: Chemistry and Applications in Drug Design and Delivery provides an up-to-date overview on the chemistry and applications of steroid dimers of natural and synthetic origins. The book includes easy-to-follow synthetic protocols for various classes of important dimeric steroids, source details, valuable spectroscopic data and depiction of unique structural features of natural steroidal dimers, and the Structure-Activity-Relationships (SARs) of some pharmacologically active dimeric steroids. Topics covered include: introduction to steroid dimers synthesis and chemistry of noncyclic and cyclic steroid dimers naturally occurring steroid dimers – cephalostatins, ritterazines and crellastatins biological and pharmacological functions of steroid dimers and their application in drug design and discovery steroid dimers as “molecular umbrellas” for drug delivery Steroid Dimers: Chemistry and Applications in Drug Design and Delivery is an essential guide to this important class of natural and synthetic compounds for researchers and students of natural products chemistry and biochemistry, synthetic organic and medicinal chemistry, and drug design, discovery and delivery.
Book Synopsis Medicinal Chemistry of Anticancer Drugs by : Carmen Avendaño
Download or read book Medicinal Chemistry of Anticancer Drugs written by Carmen Avendaño and published by Elsevier. This book was released on 2015-06-11 with total page 767 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design. - Presents information in a clear and concise way using a large number of figures - Historical background provides insights on how the process of drug discovery in the anticancer field has evolved - Extensive references to primary literature
Author :Andrea Giustina Publisher :Karger Medical and Scientific Publishers ISBN 13 :3805572964 Total Pages :213 pages Book Rating :4.8/5 (55 download)
Book Synopsis Glucocorticoid-induced Osteoporosis by : Andrea Giustina
Download or read book Glucocorticoid-induced Osteoporosis written by Andrea Giustina and published by Karger Medical and Scientific Publishers. This book was released on 2002 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: Osteoporosis is one of the most clinically relevant disabling chronic disease encountered in clinical practice. A common cause of osteoporosis is glucocorticoid excess, as glucocorticoids may increase bone resorption, inhibit bone formation, have indirect actions on bone by decreasing intestinal calcium absorption and induce hypercalciuria. This book presents a comprehensive overview of the effects of glucocorticoids on bone metabolism and structure and on the diagnosis and treatment of glucocorticoid-induced osteoporosis. It aims at providing updated information on the pathogenesis, diagnosis and treatment of this often dramatic complication of glucocorticoid excess. Being one of the few publications completely devoted to glucocorticoid-induced osteoporosis it will heighten the awareness of specialists who prescribe glucocorticoids of the clinical relevance of this treatment complication. 'Glucocorticoid-Induced Osteoporosis' is addressed to clinical experts as well as to general practitioners who will both benefit from the comprehensive and integrative view of the management of patients exposed to glucocorticoids.
Book Synopsis Chemistry and Biological Activity of Steroids by : Jorge António Ribeiro Salvador
Download or read book Chemistry and Biological Activity of Steroids written by Jorge António Ribeiro Salvador and published by BoD – Books on Demand. This book was released on 2020-02-26 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: The steroid scaffold continues to be the structural basis of new drugs for a variety of targets and diseases. Indeed, steroids interact with enzymes and receptors in a strikingly specific manner. Chemistry and Biological Activity of Steroids aims to provide an updated overview of recent advances in the medicinal chemistry of steroids. Novel synthetic methods in the steroids field, including steroid biotransformations, new steroids able to tackle steroid receptors, and steroid enzymes with clinical relevance, are critically reviewed in this book. Furthermore, the diverse physiopathological roles of oxysterols and their therapeutic value are also discussed.
Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Research Awards Index written by and published by . This book was released on with total page 1268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Research Grants Index by : National Institutes of Health (U.S.). Division of Research Grants
Download or read book Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and published by . This book was released on 1962 with total page 1472 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Withrow and MacEwen's Small Animal Clinical Oncology by : Stephen J. Withrow
Download or read book Withrow and MacEwen's Small Animal Clinical Oncology written by Stephen J. Withrow and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on cancer in dogs and cats, this extensively updated 4th edition provides comprehensive coverage of the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. Ideal for students, practitioners, and those involved in academic research, this book's full-color images and user-friendly format provide quick and easy access to today's most important information on cancer in the small animal patient. Full-color format throughout and full-color illustrations make information more accessible and provide accurate representations of clinical appearance.Chapters are clustered into four major sections: The Biology and Pathogenesis of Cancer, Diagnostic Procedures for the Cancer Patient, Therapeutic Modalities for the Cancer Patient, and Specific Malignancies in the Small Animal Patient.The consistent format includes incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies in the small animal cancer patient.Features cutting edge information on the complications of cancer, pain management, and the latest treatment modalities. The latest information on the etiology of cancer, including genetic, chemical, physical, and hormonal factors, as well as cancer-causing viruses.Coverage of molecular-targeted therapy of cancer, plus new and emerging therapeutic techniques.New information on molecular diagnostic procedures for the cancer patient.The latest diagnostic imaging techniques in clinical oncology.Discussions of compassion and supportive care, from chronic pain management and nutrition to end-of-life issues and grief support.
Download or read book Cancer Treatment Reports written by and published by . This book was released on 1978 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dermatologic Principles and Practice in Oncology by : Mario E. Lacouture
Download or read book Dermatologic Principles and Practice in Oncology written by Mario E. Lacouture and published by John Wiley & Sons. This book was released on 2013-11-26 with total page 764 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first book focusing specifically on frequent and frequently disabling side effects involving the skin, hair and nails in cancer patients According to the World Health Organization, there are approximately thirty million people living with a diagnosis of cancer – the majority of whom will receive surgery, systemic therapy, and/or radiation, and who will suffer from dermatologic adverse events. Dermatologists and oncologists are only beginning to grapple with these events, which pose serious quality-of-life issues with so many patients, and will become more prevalent as survival rates improve, thanks in part to new cancer treatments and drug regimens. Concentrating on a topic that has only been briefly touched upon by other texts, this book offers a focused perspective on the clinical presentation, underlying pathophysiologic mechanisms, and management of skin, hair, and nail conditions for oncologists, dermatologists, and allied practitioners. Dermatologic Principles and Practice in Oncology: Conditions of the Skin, Hair, and Nails in Cancer Patients: • Covers in detail the dermatologic adverse events of oncologic therapies, clinical presentations, and treatment recommendations • Enables dermatologists and other practitioners to significantly improve the care of patients with cancer • Addresses the dermatologic adverse events of cancer therapies used globally, of which a large number are found in developing countries • Emphasizes prophylactic measures – based on treatments used and type of cancer – to prevent the appearance of adverse events • Provides built-in discussions on patient education for practical counseling during therapies • Offers rapid-reference sections on topical dermatology drugs The first book to present dermatologic conditions in cancer patients and survivors in a uniform and in-depth manner, Dermatologic Principles and Practice in Oncology is ideal for oncologists, oncology nurses, and dermatologists who wish to take better care of those with adverse skin, hair, and nail conditions.
Book Synopsis The ASCRS Textbook of Colon and Rectal Surgery by : Scott R. Steele
Download or read book The ASCRS Textbook of Colon and Rectal Surgery written by Scott R. Steele and published by Springer. This book was released on 2016-03-24 with total page 1269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This third edition text provides a completely revised and updated new version of this unique, modern, practical text that covers the strategic evaluation, specific approaches, and detailed management techniques utilized by expert colorectal surgeons caring for patients with complex problems–whether they result from underlying colorectal disease or from complications arising from previous surgical therapy. The format follows that of both a “how to” manual as well as an algorithm-based guide to allow the reader to understand the thought process behind the proposed treatment strategy. By making use of evidence-based recommendations, each chapter includes not only background information and diagnostic/therapeutic guidelines, but also provides a narrative by the author on his/her operative technical details and perioperative “tips and tricks” that they utilize in the management of these complex surgical challenges. Distinctive to this book, is the reliance on experts in the field including past presidents of the ASCRS, as well as multiple other national and internationally recognized surgeons, to lend their personal insight into situations where data may be more sparse, but individual and collective experience is paramount to making sound decisions and thereby optimizing patient outcomes. The text includes chapters on the assessment of risk and methods utilized to minimize perioperative complications. In addition, it incorporates sections covering the medical and surgical therapies for abdominal, pelvic and anorectal disease. Moreover, the technical challenges of managing complications resulting from the original or subsequent operations is addressed. The underlying focus throughout the text is on providing pragmatic and understandable solutions that can be readily implemented by surgeons of varying experience to successfully treat complex colorectal problems. However, it also goes beyond the technical aspects of colorectal surgery and includes special sections highlighting the essence of a surgeon; covering aspects involving the medical-legal, ethical, and economic challenges confronting surgeons. Throughout the text, each author provides an ongoing narrative of his/her individual surgical techniques along with illustrations and diagrams to “personally” take the reader through the crucial steps of the procedure, and key points of patient care inherent to that topic. Additionally, where appropriate, links to online videos give the reader an up-front look into technical aspects of colorectal surgery.
Book Synopsis Withrow and MacEwen's Small Animal Clinical Oncology by : Stephen J. Withrow
Download or read book Withrow and MacEwen's Small Animal Clinical Oncology written by Stephen J. Withrow and published by Elsevier Health Sciences. This book was released on 2012-11-13 with total page 775 pages. Available in PDF, EPUB and Kindle. Book excerpt: With a unique focus on the most effective interventional techniques, Withrow & MacEwen's Small Animal Clinical Oncology, 5th Edition tells the full story of cancer in dogs and cats - what it is, how to diagnose it, and how to treat many of the most common cancers encountered in clinical practice. Nearly 500 color photographs, diagrams, x-rays, and gross views depict the clinical manifestations of various cancers. This edition covers the latest advances in clinical oncology, including chemotherapy, surgical oncology, and diagnostic techniques. With contributions from 65 veterinary oncology experts, this authoritative reference is a must-have for current, evidence-based therapeutic strategies on canine and feline oncology. "I really love this book. If you are interested in veterinary oncology, have a flick through this book online or at a conference when you get the chance. I hope that you agree with me that this is the definitive oncology reference source for the early 21st century and that you feel compelled to buy it. Your patients will thank you for it." Reviewed by: Gerry Polton MA VetMB MSc(Clin Onc) DipECVIM-CA(Onc) MRCVS, UK Date: July 2014 Cutting-edge information on the complications of cancer, pain management, and the latest treatment modalities prepares you to diagnose and treat pets with cancer rather than refer cases to a specialist. A consistent format for chapters on body system tumors includes coverage of incidence and risk factors, pathology, natural behavior of tumors, history and clinical signs, diagnostic techniques and workup, treatment options, and prognosis for specific malignancies. A systems approach to the diagnosis and management of cancer facilitates access to information about the many malignancies affecting small animal patients. Nearly 500 color images provide accurate depictions of specific diseases and procedures. Helpful drug formularies provide quick access to information on indications, toxicities, and recommended dosages for chemotherapeutic and analgesic drugs used in cancer treatment. Expert contributors provide in-depth coverage of the most current information in his or her respective specialty in veterinary oncology. Chemotherapy protocols are included when case studies prove clinical efficacy. Discussion of compassion and supportive care for the management of pain, nutritional needs, and grief includes methods for handling the pet's pain and nutritional complications as well as the pet owner's grief when treatment is not successful. Thoroughly UPDATED chapters cover the most recent changes in the clinical management of melanoma, mast cell tumors, tumors of the skeletal system, tumors of the endocrine system, tumors of the mammary gland, urinary cancers, nervous system cancers, lymphoma, and histiocytic diseases. NEW Clinical Trials and Developmental Therapeutics chapter discusses the various phases of clinical trials as well as current challenges and opportunities in oncology drug development. NEW! A focus on the best recommended treatment options highlights therapeutic strategies that have been vetted by veterinary oncology experts. NEW co-author Dr. Rodney L. Page adds his valuable perspective, expertise, and research experience.
Book Synopsis Relevance of Steroid Biosynthesis, Metabolism and Transport in Pathophysiology and Drug Discovery by : Tea Lanišnik Rižner
Download or read book Relevance of Steroid Biosynthesis, Metabolism and Transport in Pathophysiology and Drug Discovery written by Tea Lanišnik Rižner and published by Frontiers Media SA. This book was released on 2019-07-10 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Steroid hormones have important roles in human physiology, but they are also implicated in the development of hormone-dependent cancers and various non-maligant diseases. Furthermore, changes in the concentrations of steroid hormones have important effects on the homeostasis of pre- and post-menopausal women, as well as of men in andropause. The associations of steroid hormones with pathophysiological processes and the altered mechanisms of their actions in disease are still not completely understood. It has been known for more than thirty years that in addition to their endocrine activity, steroid hormones act in an intracrine manner. In target organs, active androgens and estrogens can be formed from inactive, or less active, precursor steroid hormones, mainly dehydroepiandrosterone-sulfate (DHEA-S), and estrone-sulfate (E1-S) after their translocation into cells through the transporter proteins of the organic anion-transporting polypeptide (OATP) and organic anion-transporter (OAT) families. The combination of altered uptake of precursors, changed activation and action of estrogens and androgens, in concert with the changes in the metabolism and excretion may thus have major roles in the development of hormone-dependent malignant and non-malignant diseases. To date, the salient roles of the individual players in disease pathophysiology have not been precisely defined. The aim of this Research Topic is thus to highlight the progress made in the field of steroid transport and intracrine actions and metabolism, with special emphasis on the involvement of these processes in the pathophysiology of hormone-dependent disorders and on the identification of novel drug targets.
Download or read book Hematology written by Bernadette F. Rodak and published by Elsevier Health Sciences. This book was released on 2007-01-01 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Textbook explores key aspects of hematology from normal hematopoiesis through diseases of erythroid, myeloid, lymphoid, and megakaryocytic origin. Includes a revised section on hemostasis and thrombosis. Case studies and chapter summaries are included.
